Aurovertins

Very toxic and complex pyrone derivatives from the fungus Calcarisporium arbuscula. They bind to and inhibit mitochondrial ATPase, thereby uncoupling oxidative phosphorylation. They are used as biochemical tools.

Also Known As:

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Grover, Gary J: 2 articles (01/2008 - 10/2004)
2.	Brakhage, Axel A: 1 article (01/2021)
3.	Heinekamp, Thorsten: 1 article (01/2021)
4.	Meloni, Giovanna Roberta: 1 article (01/2021)
5.	Piombo, Edoardo: 1 article (01/2021)
6.	Schroeckh, Volker: 1 article (01/2021)
7.	Spadaro, Davide: 1 article (01/2021)
8.	Valente, Silvia: 1 article (01/2021)
9.	Abu-Asab, Mones: 1 article (01/2015)
10.	Eiden, Lee: 1 article (01/2015)

Related Diseases

1.	Epilepsy (Aura) 03/31/2023 - "Moreover, there were 39 up-regulated lncRNAs and 10 down-regulated lncRNAs in the ΔaurA mutant, which lacks the aurovertin biosynthetic enzyme AurA. " 01/01/2021 - "By similarity analysis with the polyketide synthase (PKS) genes for the α-pyrones aurovertin (AurA) and citreoviridin (CtvA), 16 PKS genes for putative α-pyrones were identified in the P. "
2.	Myocardial Ischemia (Ischemic Heart Diseases) 01/01/2008 - "Oligomycin and aurovertin cannot be used for treating myocardial ischemia as they will reduce ATP production in healthy tissue. "
3.	Neoplasms (Cancer) 01/01/2015 - "Angiostatin, aurovertin, resveratrol, and antibodies against the α and β subunits of ATP synthase were shown to bind and selectively inhibit cell surface ATP synthase, promoting tumor cell death. "
4.	Ischemia 10/01/2004 - "In isolated rat hearts, aurovertin (1-10 microM) and oligomycin (10 microM), at concentrations inhibiting ATPase activity, reduced ATP concentration and contractile function in the nonischemic heart but significantly reduced the rate of ATP depletion during ischemia. "

Related Drugs and Biologics

1.	Adenosine Triphosphate (ATP)
2.	Oligomycins
3.	Polyketide Synthases
4.	Angiostatins
5.	Pyrones
6.	Enzymes
7.	Antibodies
8.	Adenosine Triphosphatases (ATPase)
9.	Resveratrol
10.	citreoviridin