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Atropine (Hyoscyamine)

An alkaloid, originally from Atropa belladonna, but found in other plants, mainly SOLANACEAE.

Also Known As:

Hyoscyamine; Anaspaz; AtroPen; Atropin Augenöl; Atropine Sulfate; Atropine Sulfate, 3(S)-endo-Isomer; Atropine, 3(S)-endo-Isomer; Atropinol; Chauvin Brand of Atropine; Cytospaz; Hyoscyamine Sulfate; Survival Technology Brand of Atropine; Winzer Brand of Atropine; Atropine Chauvin Brand; Atropine Winzer Brand; Augenöl, Atropin; Sulfate, Atropine; Sulfate, Hyoscyamine; Benzeneacetic acid, alpha-(hydroxymethyl)- 8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester endo-(+-)-

Networked: 4582 relevant articles (286 outcomes, 351 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Pediatric Eye Disease Investigator Group: 22 articles (02/2015 - 08/2001)
2.	Holmes, Jonathan M: 17 articles (02/2015 - 11/2003)
3.	Repka, Michael X: 16 articles (02/2015 - 11/2003)
4.	Kraker, Raymond T: 12 articles (02/2015 - 11/2003)
5.	Thiermann, Horst: 12 articles (06/2014 - 01/2003)
6.	Beck, Roy W: 12 articles (07/2011 - 10/2002)
7.	Kuca, Kamil: 12 articles (01/2011 - 01/2004)
8.	Worek, Franz: 11 articles (01/2015 - 01/2003)
9.	Kassa, Jiri: 9 articles (09/2013 - 01/2007)
10.	Worek, F: 9 articles (04/2012 - 01/2000)

Related Diseases

1.	Poisoning 06/01/2014 - "Cases of organophosphate poisoning treated with high-dose of atropine in an intensive care unit and the novel treatment approaches." 06/01/2013 - "This study aimed to clarify the efficacy of 2 therapies for patients with severe acute organophosphorus pesticide poisoning, including atropine adverse effects, the length of intensive care unit (ICU) stay, complications, and mortality. " 07/01/2015 - "The objectives of our study were to measure serum CPK level, correlate CPK levels with severity of poisoning and estimate atropine dose used. " 03/01/2014 - "In this study, sixty-four OP-poisoning patients, all of whom accepted routine treatments but who did not attain atropinization after high doses of atropine for 12 h, were enrolled. " 06/01/2012 - "A study was therefore undertaken to determine the optimal dosing regimen for atropine in the treatment of OPC poisoning. "
2.	Bradycardia 12/01/1987 - "These data evidence that the atropine test is not very helpful in discriminating between an organic and an autonomic involvement of sinus automaticity in patients with sinus bradycardia." 09/01/2015 - "The positive results of atropine test and results of esophageal electrophysiological examination in different ages showed that as age grows, false positive rate of atropine test was significantly reduced, presenting statistically significant difference (x² =6.2821, P<0.05); The positive results of atropine test and results of esophageal electrophysiological examination in different heart rates showed that false positive rate of atropine test on those with bradycardia was smaller than those with significant bradycardia, presenting statistically significant difference (x² =5.1792, P<0.05). " 10/01/2012 - "Bradycardia caused by a vagal response during surgery is not uncommon and routinely treated successfully with administration of atropine-like agents. " 01/01/2001 - "The protective effects of atropine against bradycardia lasted 50 minutes. " 05/01/1992 - "Atropine given i.v. almost totally eliminated the bradycardia and partially prevented the hypotensive responses to intra-HF DA1-8. "
3.	Myopia 01/01/2009 - "Numerous studies, including those using animal models of myopia development and human clinical trials, have shown that the non-selective muscarinic antagonist atropine is effective in preventing the axial elongation that leads to myopia development. " 02/01/2006 - "The results of this study demonstrate that, with regular instillation, topical 0.05% atropine is an effective agent for controlling myopia progression in a majority of school-aged children for at least a period of 1 year." 08/01/2012 - "The broadband muscarinic antagonist atropine is effective in stopping the progression of myopia in animals and humans. " 04/01/2010 - "To investigate whether seasonal modification in the concentration of atropine drops is effective in retarding the progression of myopia. " 12/01/2006 - "Topical atropine was well tolerated and effective in slowing the progression of low and moderate myopia and ocular axial elongation in Asian children."
4.	Amblyopia (Lazy Eye) 10/01/2004 - "We enrolled 156 children with successfully treated anisometropic or strabismic amblyopia (145 completed follow-up), who were younger than 8 years of age and who received continuous amblyopia treatment for the previous 3 months (prescribed at least 2 hours of daily patching or prescribed at least one drop of atropine per week) and who had improved at least 3 logMAR levels during the period of continuous treatment. " 10/01/2004 - "Although amblyopia can be successfully treated with patching or atropine, there have been few prospective studies of amblyopia recurrence once treatment is discontinued. " 09/01/2011 - "Studies that have investigated the role of atropine occlusion as a first-line treatment for amblyopia have shown "weekend atropine" to be as effective as patching for children with both moderate and severe amblyopia. " 03/01/2013 - "In children with moderate amblyopia, patching for two hours daily is as effective as patching for six hours daily, and daily atropine is as effective as daily patching. " 02/16/2011 - "In moderate amblyopia, penalization with atropine is as effective as patching. "
5.	Hypotension (Low Blood Pressure) 01/01/2007 - "Although the exact hypoglycaemic and hypotensive mechanisms of action of the plant extract still remain speculative, it is unlikely that the extract induced hypotension in the mammalian experimental animal model via cholinergic mechanisms, since its cardiovascular effects were resistant to atropine pretreatment. " 09/01/2006 - "Although the exact hypoglycaemic and hypotensive mechanisms of action of the plant extract remain speculative at the moment, it is unlikely that the herb causes hypotension in the mammalian experimental animal model used via cholinergic mechanisms, since its cardiovascular effects are resistant to atropine pretreatment. " 03/01/2006 - "Although the exact mechanisms of action of the plant extract still remain obscure at the moment, it is unlikely that the plant causes hypotension in the mammalian experimental animal model used, via the cholinergic mechanism, since its hypotensive effect was resistant to atropine pretreatment. " 12/01/2005 - "Although the exact mechanisms of action of the plant's extract still remain speculative at present, it is unlikely that the extract causes hypotension in the mammalian experimental animal model used via cholinergic mechanisms, since its cardiodepressant effects are resistant to atropine pretreatment. " 11/01/2004 - "Hypotension and conduction disorders resolved with atropine treatment, resulting in complete recovery within 24 hours."

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Related Therapies and Procedures

1.	Premedication
2.	Vagotomy
3.	Intravenous Injections
4.	Injections
5.	Denervation