Atrazine

A selective triazine herbicide. Inhalation hazard is low and there are no apparent skin manifestations or other toxicity in humans. Acutely poisoned sheep and cattle may show muscular spasms, fasciculations, stiff gait, increased respiratory rates, adrenal degeneration, and congestion of the lungs, liver, and kidneys. (From The Merck Index, 11th ed)

Also Known As:

Networked: 198 relevant articles (3 outcomes, 37 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Hayes, Tyrone B: 5 articles (10/2011 - 04/2002)
2.	Kiran, Ravi: 5 articles (03/2011 - 07/2008)
3.	Sandhir, Rajat: 5 articles (03/2011 - 07/2008)
4.	Singh, Mohan: 5 articles (03/2011 - 07/2008)
5.	Matavulj, Milica: 4 articles (04/2014 - 08/2010)
6.	Rajkovic, Vesna: 4 articles (04/2014 - 08/2010)
7.	Koprivnikar, Janet: 4 articles (10/2011 - 04/2006)
8.	Blair, Aaron: 3 articles (09/2015 - 09/2004)
9.	Farombi, Ebenezer O: 3 articles (02/2015 - 04/2010)
10.	Abarikwu, Sunny O: 3 articles (02/2015 - 04/2010)

Related Diseases

1.	Neoplasms (Cancer) 03/01/2013 - "A weight-of-evidence approach leads to the conclusion that there is no causal association between atrazine and cancer and that occasional positive results can be attributed to bias or chance. " 03/01/2013 - "The aim of this study was to evaluate the conflicting reports from the Environmental Protection Agency and the Scientific Advisory Panel (Panel) on the carcinogenicity of atrazine in order to determine whether the results from epidemiologic studies support a causal relationship between atrazine and any specific cancer. " 09/01/2011 - "Atrazine and cancer incidence among pesticide applicators in the agricultural health study (1994-2007)." 05/01/2007 - "This study highlights the importance of atrazine as a risk factor in endocrine disruption in wildlife and reproductive cancers in laboratory rodents and humans." 04/01/2005 - "In acute toxicity studies, atrazine caused developmental toxicity in the rabbit [no observed effect level (NOEL) 5 mg kg(-1) day(-1)] and cardiotoxicity in a dog chronic study (NOEL 0.5 mg kg(-1) day(-1)); cancer (mammary glands) resulted from lifetime exposure. "
2.	Premature Birth (Birth, Premature) 01/01/2012 - "Still, our findings suggest a positive association between atrazine and preterm birth, and illustrate the need for an improved assessment of environmental exposures to accurately address this important public health issue." 10/01/2009 - "Two studies on potential association of atrazine with small-for-gestational-age (SGA) and preterm birth prevalence found inconsistent results. " 01/01/2012 - "An increase in the odds of preterm birth was found for women residing in the counties included in the highest atrazine exposure group compared with women residing in counties in the lowest exposure group, while controlling for covariates. " 01/01/2012 - "We examined the relationship between preterm birth and exposure to a commonly used herbicide, atrazine, in drinking water. " 01/01/2012 - "Atrazine exposure in public drinking water and preterm birth."
3.	Starvation 05/01/1998 - "The bacteria exposed to atrazine in unsaturated sterile soil were still active after starvation period of 240 days: 15 mg newly added atrazine kg soil-1 was eliminated within 5 days." 02/01/2016 - "The two HR96 activators tested, atrazine and LA adversely reduce post-reproduction survival 70% during starvation and in turn show poor fecundity. " 09/10/2005 - "However, hyperactivity and faster active swimming speeds of exposed larvae indicated that naturally occurring sublethal levels of atrazine will result in an elevated rate of energy utilization (doubling the total metabolic rate), which is likely to increase the risk of death by starvation. " 02/01/2016 - "We compared the effects of additional lipid resources, docosahexaenoic acid (n-3; DHA) or linoleic acid (n-6; LA), or the effects of the toxicants, atrazine or triclosan on post-treatment starvation survival, reproduction, and lipid profiles. "
4.	Body Weight (Weight, Body) 09/01/2010 - "These studies have shown that short term exposure to atrazine during the freshwater phase of their lifecycle had no effects on subsequent survival, body weight, relative gonad size or various measures of iono-regulatory performance in juvenile Atlantic salmon upon transfer to seawater. " 04/01/2010 - "To study the effects of atrazine on reproductive functions and testicular and epididymal antioxidant defense, rats were exposed to 0, 120, or 200 mg/kg body weight atrazine orally for 7 and 16 days. " 09/01/2009 - "In the present study, we investigated the effects of oral dosing of atrazine (2-chloro-4-ethylamino-6-isopropylamino-s-triazine) to peripubertal male rats (50 and 200 mg/kg body weight daily from postnatal days 23-50) on ex vivo Leydig cell steroidogenesis. " 01/01/2001 - "At the termination of the study, the average body weight of rats receiving atrazine at 100 mg/kg per day was found to be reduced by approximately 9%. " 04/01/2014 - "Atrazine was administered orally at 50 or 200 mg/kg of body weight dose for 28 consecutive days. "
5.	Chromosome Aberrations (Chromosome Abnormalities) 01/01/2004 - "The present study was undertaken to add new data on the genotoxic potential of atrazine using the Allium cepa chromosome aberration test. " 01/01/2004 - "Atrazine produced a concentration-related increase in the number of total somatic chromosome aberrations, although this increase was statistically significant (p<0.05) only at the highest test concentration (5 microg/L). " 05/01/2006 - "Quercetin reduces chromosome aberrations induced by atrazine in the Allium cepa test." 11/20/2000 - "Although there are several contradictory genotoxicity studies in the literature, our previous in vitro studies with human lymphocytes showed that atrazine, simazine, and cyanazine did not induce sister chromatid exchanges (SCEs) or chromosome aberrations (CAs) up to the limits of solubility in aqueous medium using 0.5% dimethyl sulfoxide. " 02/16/2000 - "Because of this and the prevalence of contradictory cytogenetic studies in the literature on atrazine, simazine, and cyanazine, a series of in vitro experiments was performed to investigate the ability of these three triazines to induce sister chromatid exchanges (SCEs) and chromosome aberrations (CAs) in human lymphocyte cultures. "

Related Drugs and Biologics

1.	Simazine
2.	Herbicides
3.	cyanazine
4.	Estrogens (Estrogen)
5.	Hormones
6.	glyphosate (Roundup)
7.	Carbaryl (Sevin)
8.	Carbon Monoxide
9.	Triazines
10.	Maneb

Related Therapies and Procedures

1.	Castration
2.	Prenatal Care