Exercise-Induced Asthma (Asthma, Exercise Induced)

Asthma attacks following a period of exercise. Usually the induced attack is short-lived and regresses spontaneously. The magnitude of postexertional airway obstruction is strongly influenced by the environment in which exercise is performed (i.e. inhalation of cold air during physical exertion markedly augments the severity of the airway obstruction; conversely, warm humid air blunts or abolishes it).

Also Known As:

Networked: 645 relevant articles (73 outcomes, 92 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Asthma (Bronchial Asthma)
2.	Rhinitis
3.	Bronchial Spasm
4.	Hyperventilation
5.	Atopic Dermatitis (Atopic Eczema)

Experts

1.	Lavaud, François: 3 articles (08/2012 - 01/2007)
2.	Brannan, J D: 3 articles (05/2002 - 06/2000)
3.	Anderson, S D: 3 articles (05/2002 - 06/2000)
4.	Keens, Thomas G: 2 articles (10/2015 - 11/2004)
5.	Raherison, Chantal: 2 articles (08/2012 - 01/2007)
6.	Annesi-Maesano, Isabella: 2 articles (08/2012 - 01/2012)
7.	Tock, Lian: 2 articles (04/2012 - 01/2012)
8.	Dâmaso, Ana R: 2 articles (04/2012 - 01/2012)
9.	de Mello, Marco Túlio: 2 articles (04/2012 - 01/2012)
10.	Oyama, Lila M: 2 articles (04/2012 - 01/2012)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Exercise-Induced Asthma:

1.	Cromolyn Sodium (Cromoglicic Acid)FDA LinkGeneric 09/01/1996 - "Hypotonic disodium cromoglycate seems to be clinically effective for prevention of exercise-induced bronchospasm and treatment of asthmatic children." 06/01/1985 - "Exercise-induced asthma can be effectively treated, preferably with preventive medications such as beta 2 agonists or cromolyn (Intal). " 09/01/1996 - "We conclude that the efficacy of hypotonic and isotonic disodium cromoglycate solutions is similar for protection against exercise-induced bronchospasm. " 01/01/1984 - "Eight patients with exercise-induced asthma participated in a single blind dose-duration study comparing the protective effect of inhaled sodium cromoglycate (SCG) in increasing concentrations from 2 to 40 g/l. " 09/01/1982 - "Ten patients with exercise-induced asthma participated in a single-blind dose-response study comparing the protective effect of inhaled sodium cromoglycate in increasing concentrations from 2 to 40 mg/ml. Saline was used as a control. "
2.	Albuterol (Salbutamol)FDA LinkGeneric 11/01/1991 - "Beta-adrenoceptor agonists such as albuterol are very effective in preventing exercise-induced asthma (EIA) when they are given as an aerosol immediately before exercise. " 07/01/1978 - "Inhaled salbutamol was less effective in protecting against exercise-induced asthma at the end of the treatment period in the patients who had received tablet therapy, but otherwise there was no significant change in beta-receptor function of either airways or lymphocytes. " 05/01/2002 - "To compare the efficacy of albuterol HFA to albuterol CFC and placebo HFA in protecting patients from exercise-induced bronchospasm (EIB). " 01/01/1995 - "The purpose of this study was to determine the safety and effectiveness of albuterol aerosol 180 micrograms and albuterol powder 200 micrograms in the prevention of exercise-induced bronchospasm in children. " 11/01/2007 - "An evaluation of levalbuterol HFA in the prevention of exercise-induced bronchospasm."
3.	montelukast (Singulair)FDA Link 07/16/1998 - "As compared with placebo, once-daily treatment with montelukast provided significant protection against exercise-induced asthma over a 12-week period. " 01/01/2001 - "Montelukast has also demonstrated protective effects against exercise-induced bronchospasm in both adults and children, and this protection was maintained during the trough period at the end of the once-daily administration interval (namely, 20-24 h post-dose). " 12/01/2002 - "Time efficacy of a single dose of montelukast on exercise-induced asthma in children." 12/01/2002 - "The aim of this study was to evaluate the timing of onset and the duration of action of a single oral-dose treatment with montelukast in comparison to placebo on exercise-induced asthma (EIA) in asthmatic children. " 01/01/2009 - "Exercise-induced asthma: critical analysis of the protective role of montelukast."
4.	salmeterol (Serevent)FDA Link 01/01/1993 - "Salmeterol seems especially effective in patients with nocturnal symptoms, exercise induced asthma, and in patients sensitive to inhaled irritants such as cold air. " 07/16/1998 - "Protection against exercise-induced asthma is maintained with long-term administration of salmeterol, but the length of time that the drug remains active after a single dose decreases." 11/01/1995 - "Thus, inhaled salmeterol 25 and 50 micrograms offered similar overnight protection against exercise-induced asthma and improved baseline lung function in the morning as compared to placebo." 11/01/1995 - "The main aim of the present study was to evaluate whether inhaled salmeterol given in the evening protected against exercise-induced asthma the next morning. " 08/01/1992 - "The effect of inhaled salmeterol xinafoate, a long acting beta 2 agonist, on exercise induced asthma was studied in a double blind, crossover, and placebo controlled trial. "
5.	formoterol (Oxis)FDA Link 01/01/2000 - "Although formoterol, a new long-acting beta(2)-adrenergic agonist, has a rapid bronchodilating action, no studies have previously examined whether it can provide equally rapid protection against exercise-induced bronchospasm (EIB). " 10/01/2002 - "Formoterol provides long-lasting protection against exercise-induced bronchospasm." 09/01/1997 - "Sixteen children aged 8-15 yrs with exercise-induced asthma (EIA) took part in the main trial comparing the protective effect of 12 micrograms formoterol inhaled at 60 and 120 L.min-1. " 07/01/1991 - "Noncomparative studies indicate formoterol also provides effective prophylaxis of exercise-induced asthma. " 01/01/2001 - "Formoterol is a highly effective therapeutic agent in the prevention of exercise-induced bronchospasm (EIB). "
6.	Nedocromil (Alocril)FDA Link 12/01/1995 - "Our findings suggest that nedocromil sodium is effective in the prevention of exercise-induced asthma, in pediatric age." 03/01/1996 - "This open labelled, group comparative, cross over study, was carried out to analyze the efficacy of two dosages of Nedocromil sodium (NS) in the prophylaxis of Exercise Induced Asthma (EIA). " 07/01/2000 - "The Cochrane Airways Group trials register, the Cochrane Controlled Trials Register, Current Contents, reference lists of relevant articles, review articles and textbooks were searched for randomized trials comparing a single dose of nedocromil to placebo to prevent exercise-induced asthma in people >6 yrs of age. " 09/01/1995 - "In view of the high incidence of exercise-induced asthma (EIA) in asthmatic adolescents and adults, the aim of the present study was to examine the preventive effect of nedocromil sodium administered prior to an exercise provocation test. " 10/01/1989 - "Dose-response study of nebulised nedocromil sodium in exercise induced asthma."
7.	FenoterolIBA 01/01/1983 - "Eighteen adult asthmatics participated in a placebo controlled, double-blind, randomised study comparing the efficacy of pretreatment with fenoterol administered by pressurized aerosol and as a dry powder on exercise-induced asthma. " 01/01/1983 - "Fifteen adult asthmatics participated in a controlled open randomized study to compare the efficacy on exercise-induced asthma of pretreatment with 1 mg fenoterol administered as inhalation powder and from a pressurized aerosol. " 05/01/1993 - "The effect of 10, 50 and 200 micrograms inhaled fenoterol on exercise induced asthma." 04/01/1984 - "The effectiveness of inhaled fenoterol doses of 0.4 mg and 0.8 mg in preventing exercise-induced asthma was investigated in 12 patients. " 04/01/1984 - "Fenoterol in exercise-induced asthma. "
8.	Terbutaline (Brethaire)FDA LinkGeneric 09/26/1994 - "It is concluded that continuous treatment, even with high doses or oral terbutaline, does not offer clinically useful protection against exercise-induced asthma." 04/01/1993 - "It is concluded that continuous treatment, even with high doses of oral terbutaline, does not offer clinically useful protection against exercise-induced asthma." 09/26/1994 - "We wanted to assess the protective effects on exercise-induced asthma as well as the clinical efficacy and safety of increasing doses of a new sustained-release formulation of terbutaline sulphate in 17 asthmatic children aged 6-12 years (mean 9 years). " 04/01/1993 - "We wanted to assess the protective effects on exercise-induced asthma as well as the clinical efficacy and safety of increasing doses of a new sustained-release formulation of terbutaline sulphate, in 17 asthmatic children aged 6-12 yrs (mean 9 yrs). " 04/01/1993 - "No protection by oral terbutaline against exercise-induced asthma in children: a dose-response study."
9.	Ipratropium (Ipratropium Bromide)FDA LinkGeneric 07/01/1985 - "Atrovent did not abolish exercise-induced bronchospasm but improved preexercise lung function and thereby caused a parallel upward shift in the response curves. " 07/01/2010 - "Effects of ipratropium on exercise-induced bronchospasm." 09/01/1980 - "The contribution of vagal mechanisms to exercise-induced asthma has been studied in 10 adult asthmatic patients using the anticholinergic drug ipratropium bromide. " 11/14/1986 - "Protection against exercise-induced asthma with this drug has been variable, but ipratropium has been found particularly useful in psychogenic asthma. " 01/01/1986 - "Until now very few studies have been performed on the prevention of exercise-induced asthma (EIA) in children with ipratropium bromide + fenoterol. "
10.	Ketotifen (Ketotifene)FDA Link 03/01/1999 - "Ketotifen is poorly effective against exercise-induced asthma, and unable to reduce bronchial hyperactivity. " 10/01/1980 - "We were unable to confirm previous reports that ketotifen is as effective as DSCG in preventing exercise-induced asthma." 04/01/1981 - "The efficacy of ketotifen, a tricyclic benzocycloheptathiophene derivative, was assessed in an outpatient clinical trial and in a group of 12 asthmatic subjects with exercise-induced asthma. " 01/01/1988 - "In a parallel, double-blind, placebo-controlled study we investigated the effect of the antiallergic drug Ketotifen on bronchial resistance (determined body plethysmographically) and beta 2-adrenoceptor density of lymphocytes (determined by 125-iodo-cyano-pindolol binding) in asthmatic children suffering from exercise-induced asthma (EIA). " 10/01/1980 - "A controlled trial of ketotifen in exercise-induced asthma."

Therapies and Procedures

1.	Metered Dose Inhalers (Metered Dose Inhaler) 11/01/1982 - "Both pre-treatment with 2 mg SCG delivered by pressurized aerosol and 20 mg delivered by Spinhaler is superior to placebo in conferring protection against exercise-induced asthma (EIA). " 07/01/1994 - "Metered-dose inhalers for young athletes with exercise-induced asthma. " 10/01/1989 - "Ten patients with exercise induced asthma, in whom inhaled nedocromil sodium 4 mg by metered dose inhaler attenuated the exercise fall in forced expiratory volume in one second (FEV1) by at least 40%, participated in a double blind dose response study to compare the protective effect of nedocromil sodium given 15 minutes before exercise challenge via a nebuliser (Wright) in concentrations of 0.5, 5, 10, and 20 mg/ml with that of placebo (saline). " 11/01/1984 - "A double-blind, placebo controlled study of the effects of disodium cromoglycate (DSCG), administered as a dry powder via the spinhaler, in established exercise-induced asthma, was carried out. " 05/01/1993 - "In 12 mild to moderate asthmatics with exercise induced asthma (mean age: 26 [range 19-25] years), mean FEV1 87% of predicted, exercise challenges were performed under control conditions and 30 min after the inhalation from a metered dose inhaler of either placebo, or 10, 50, and 200 micrograms fenoterol within a 4 week period. "
2.	Nebulizers and Vaporizers (Inhaler) 08/01/2012 - "Challenges in management include evaluation of the child's ability to use inhalers and peak flow meters and the management of exercise-induced asthma." 09/01/2007 - "The second patient suffered an attack of exercise-induced asthma so severe that his inhaler could not control the symptoms enough for him to resume play. " 01/01/1989 - "Also in children, broxaterol 0.25 mg as nebulizer solution significantly prevented exercise-induced bronchospasm versus placebo, and this effect was seen to be associated with an improvement in maximal working capacity. " 07/01/1994 - "The present study compared the bronchodilating effect of inhalation from the Turbuhaler (0.5 mg terbutaline x 2) with the effect of inhalation from the chlorofluorocarbon (CFC) inhaler (0.25 mg terbutaline x 4) in children aged 9-17 years with reproducible, exercise-induced asthma (EIA). " 07/01/1994 - "A comparison of terbutaline inhaled by Turbuhaler and by a chlorofluorocarbon (CFC) inhaler in children with exercise-induced asthma."
3.	Lasers (Laser) 04/01/1993 - "Efficacy of laser-acupuncture in the prevention of exercise-induced asthma." 04/01/1993 - "The results of this study indicate that one such method, laser acupuncture, does not prevent exercise-induced asthma." 03/01/2002 - "Laser acupuncture in children and adolescents with exercise induced asthma." 03/01/2002 - "A double blind, placebo controlled, crossover study was performed to investigate the possible protective effect of a single laser acupuncture treatment on cold dry air hyperventilation induced bronchoconstriction in 44 children and adolescents of mean age 11.9 years (range 7.5-16.7) with exercise induced asthma. "
4.	Sodium-Restricted Diet (Diet, Sodium Restricted) 11/01/2001 - "In conclusion, the low salt diet improved and the high salt diet exacerbated pulmonary function during exercise in individuals with exercise-induced asthma. " 01/01/2011 - "There was some evidence from the exercise-induced asthma studies that a low sodium diet may improve lung function after exercise and possibly baseline lung function, but this is based on findings from a very small numbers of participants. " 11/01/2001 - "We have previously shown that a low salt diet improves and a high salt diet exacerbates post-exercise pulmonary function in individuals with exercise-induced asthma. "
5.	Positive-Pressure Respiration (PEEP) 02/01/1981 - "PEEP during and PEEP post conditions significantly (P less than 0.01) decreased the severity of exercise-induced asthma (EIA) as PEFR and FEV1.0 values remained within 20% of rest levels and MEF50 within 30%. " 02/01/1981 - "Effects of positive end-expiratory pressure breathing on exercise-induced asthma."