Asphyxia (Suffocation)

09/01/2006 - "The data demonstrate that both epinephrine and transoesophageal cardiac pacing are effective within 10 minutes of asphyxia in rats. "
11/01/1990 - "The fetal adrenaline response to asphyxia did not change with increasing gestational age and after 130 days gestation fetal plasma adrenaline increased significantly from 1.48 +/- 0.46 pmol/ml (-15 min) to 4.05 +/- 1.22 pmol/ml (+10 min). "
11/01/1989 - "Since old times, a hypothesis based on hypersecretion of adrenaline at agonal stage in asphyxia is well-known. "
01/01/1988 - "The epinephrine concentration in newborns with moderate HIE is lower than in newborns with mild HIE, which may reflect decreased sympathetic-adrenal function due to prolonged asphyxia. "
09/01/1967 - "[The effect of cholinergic substances and adrenaline on the duration of the bioelectric activity of the heart in acute asphyxia]."

03/01/1952 - "[Physiological mechanism of the efficacy of oxygen therapy of so-called secondary asphyxias neonatorum]."
10/01/1991 - "In a previous study on acute asphyxia in unanesthetized fetal sheep near term we showed that reduced oxygen delivery to peripheral organs reduces total oxygen consumption, suggesting that oxygen itself may be a determinant of oxygen consumption (Jensen, Hohmann & Künzel, 1987). "
07/01/1991 - "In a previous study we suggested that--unlike other forms of asphyxia--acute asphyxia caused by arrest of uterine blood flow is accompanied by a fall in oxygen delivery to the fetal brain (Jensen et al., 1987). "
01/01/1988 - "1. This study analyzes variations of oxygen tension induced by asphyxia in the myocardium (MpO2) and coronary sinus blood (CSpO2) of the anesthetized open-chest dog. "
08/01/2015 - "Head louse control by suffocation due to blocking their oxygen uptake."

04/04/2005 - "This study was designed to investigate the postnatal developmental plasticity of the mesostriatal and mesolimbic dopamine systems that occurs following perinatal asphyxia. "
01/01/2002 - "There is currently insufficient evidence from randomised controlled trials that the use of dopamine in term infants with suspected perinatal asphyxia improves mortality or long-term neurodevelopmental outcome. "
01/01/2002 - "No study was found that examined the effect of dopamine in infants with evidence of cardiovascular compromise, nor were any studies identified in which dopamine was compared to other inotropic agents for term infants with suspected asphyxia. "
03/01/2013 - "Dopamine infusion for postresuscitation blood pressure support after profound asphyxia in near-term fetal sheep."
02/01/2009 - "Dopamine D(1) and D(2) receptor protein expression was examined by Western blotting in newborn infants dying from cerebral asphyxia between 31 and 42 weeks' gestation, and matched controls. "

01/01/2007 - "Our objective was to establish a nonhuman primate model of perinatal asphyxia appropriate for preclinical evaluation of neuroprotective treatment strategies under conditions that closely resemble human neonatal emergencies, and to begin testing the safety and efficacy of erythropoietin neuroprotective treatment. "
01/01/2011 - "There are mixed reports on the neuroprotective properties of erythropoietin (EPO) in animal models of birth asphyxia. "
03/01/2005 - "Expression of erythropoietin and its receptor in the brain of late-gestation fetal sheep, and responses to asphyxia caused by umbilical cord occlusion."
11/01/2008 - "Erythropoietin treatment improved the 3-day survival and left ventricular dP/dt40 and peak negative dP/dt after 6.5 mins asphyxia-induced cardiac arrest. "
10/01/2013 - "The rats in the EPO-treated asphyxia group received intraperitoneal injection of recombinant human erythropoietin (500 U/mL) immediately after the model was established, while the other two groups received the same volume of normal saline (0.9%). "

01/01/1998 - "During progressive asphyxia, CO-treated animals had a significantly greater VT than did controls from 1-8% CO2. "
03/01/2011 - "To study the possible role of brain pH changes, we used a rodent model that mimics the alterations in systemic CO(2) and O(2) levels during and after intrapartum birth asphyxia. "
12/01/1992 - "In the present study, the possibility of diagnosis of asphyxia by CO-oximeter was examined experimentally using rabbits. "
06/01/1990 - "Experimental studies on asphyxia due to the hypoxic state produced by carbon monoxide gas were achieved. "
06/01/2015 - "Co-sleeping and suffocation."

07/01/2008 - "The aim of the present study was (1) to evaluate the relationship between umbilical cord arterial blood lactate and pH, standard base excess (SBE), and actual base excess (ABE) at delivery and (2) to suggest a cut-off level of umbilical cord arterial blood lactate in predicting fetal asphyxia using ROC-curves, where an ABE value less than -12 was used as "gold standard" for significant intrapartum asphyxia. "
01/01/1984 - "The main findings were as follows: (a) myocardium: a release of HX early during asphyxia, the magnitude of which paralelled the amount of mechanical work performed by the heart; a significant lactate influx into the heart during normoxia and recovery period; (b) liver: hepatic HX release even during normoxia, increasing to substantial amounts in connection with increasing asphyxia; (c) hindleg: release of HX only during the recovery period; lactate efflux during all periods apart from severe asphyxia, when an influx was seen for both substances; (d) placenta: production of lactate during normoxia, and an efficient clearance of both lactate and HX from the fetal plasma in combination with their concentration increasing during asphyxia. "
06/01/2013 - "Intrapartum fetal asphyxia: study of umbilical cord blood lactate in relation to fetal heart rate patterns."
01/01/2015 - "Determination of lactate concentrations in serum of term newborns associated with risk factors for the perinatal asphyxia is a useful tool in diagnosing metabolic disorders and ischemic damage, particularly severe clinical forms (Tab. "
06/01/2013 - "There was no significant correlation between the Apgar score and blood lactate in all groups; however, the sensitivity and specificity of cord lactate to predict low score at 5 min were higher in comparison to cord pH. Umbilical cord blood lactate is a reliable marker for intrapartum fetal asphyxia compared to cord acid-base status with better prediction for newborns with low Apgar score."

02/01/2002 - "As a different myocardial pathology is speculated to exist between the VF model and the asphyxia model, we investigated whether vasopressin is also effective in a rat asphyxia model. "
03/01/2012 - "We hypothesize that vasopressin will improve mean arterial pressure (MAP), without compromising cardiac, mesenteric, or carotid hemodynamics using a swine model of neonatal asphyxia. "
06/01/1990 - "The vasopressin response to severe birth asphyxia."
07/01/1987 - "The Rm decreased when the EP decreased by vasopressin recovered above the pre-asphyctic level after the termination of temporary asphyxia. "
03/01/1986 - "Abolition of the effect of vasopressin upon the EP by the resumption of respiration after transient asphyxia was observed. "

06/01/1999 - "We have set up a pilot study for an international RCT of mature babies with severe asphyxia (defined by an Apgar score of 5 or less at 10 minutes) and have shown that we can recruit from 120 centers in 17 countries an average of three babies a week, which is the required number to undertake a study over a 2-year period with sufficient power to show a significant improvement in outcome. "
04/01/2012 - "There were no significant differences in all mentioned indexes between two groups at 10 minutes before and 10 minutes after asphyxia. "
06/01/2001 - "If the shift occurred at 10 or 5 min of asphyxia, the LD50 increased to 80 or 110 min, respectively. "
05/04/2001 - "C 18:0 FFA showed a trend to increase with the length of PA reaching significance at 10 min of asphyxia only and were declining at 20 min, however, not significantly. "
04/01/1989 - "Of complications at delivery, intrapartum asphyxia, as evident from Apgar scores of less than 7 at 1 minute and less than 10 at 10 minutes in particular, was a strong predictor of a later handicap. "

11/01/2001 - "The results indicate that the melatonin may be beneficial in the treatment of newborn infants with asphyxia. "
03/01/2015 - "Animal work has confirmed a neuroprotective effect of melatonin, suggesting a role in minimising neuronal damage from birth asphyxia; results from human studies are awaited. "
01/01/2009 - "In this study, we determined if low-dose melatonin (0.1 mg/kg/day), administered to the mother over 7 days at the end of pregnancy, could protect against the effects of birth asphyxia in a precocial species - the spiny mouse (Acomys cahirinus). "
02/01/2007 - "In conclusion, this study shows that melatonin attenuates cell death in the fetal brain in association with a reduced inflammatory response in the blood and the brain following intrauterine asphyxia in mid-gestation fetal sheep."
02/01/2007 - "The aim of this study was to investigate the protective and anti-inflammatory effects of melatonin in the immature brain following intrauterine asphyxia. "

01/01/2000 - "However, the recent availability of a clinically related animal model of perinatal asphyxia and the fact that no concomitant determination of glucose transporters, parameters for glucose utilization, brain glucose, and cerebral blood flow (CBF) have been reported and the early phase of perinatal asphyxia has never been studied led us to perform the following study. "
01/01/1996 - "The aim of the present study was to reveal the effect of neonatal asphyxia on the regulation of I and glucose (G) metabolism in plasma and cerebrospinal fluid (CSF) in newborn piglets. "
12/01/2003 - "The objective was to investigate how early electrocortical background pattern, as recorded with amplitude integrated EEG (aEEG), correlates with global and regional cerebral glucose metabolism (CMRgl) measured by positron emission tomography during the subacute phase after birth asphyxia. "
12/01/2001 - "Changes in cerebral glucose metabolism may be an early postnatal indicator of fetal asphyxia. "
12/01/2001 - "Reduced postnatal cerebral glucose metabolism measured by PET after asphyxia in near term fetal lambs."

10/01/2006 - "Basic neonatal resuscitation in this setting decreased the incidence of asphyxia (defined as failure to initiate and sustain breathing or an APGAR score of <7 at 5 min), improved APGARS and a decrease in the mortality of babies weighing more than 2 kg. The resuscitation team reduced the incidence of and mortality from asphyxia and improved the outcome of babies greater than 2 kg. This pilot study provides evidence of the beneficial effect of basic neonatal resuscitation in this setting."
03/01/2002 - "Despite longer asphyxia, shorter and more effective resuscitation was associated with significantly improved long-term outcomes and higher cerebral perfusion at the early stage of reperfusion. "
10/01/2010 - "Neonatal disorders related to perinatal asphyxia remain a serious clinical problem, which calls for sustained education of advanced neonatal resuscitation and improvement in the quality of perinatal-neonatal care."
06/01/2008 - "Compliance with guidelines for resuscitation of severely asphyctic newborn may be improved, especially concerning ventilation and prompt paging for skilled personnel in cases of imminent asphyxia. "
02/01/1987 - "All three experienced severe postnatal asphyxia and improved following resuscitation. "

11/01/2010 - "Neonatal pigs with asphyxia-induced cardiac arrest did not respond to a compression:ventilation ratio of 9:3 better than to 3:1. Future research should address if alternative compression:ventilation ratios offer advantages over the current gold standard of 3:1."
10/01/2014 - "The model of PCAS was established by asphyxia-induced cardiac arrest. "
12/01/2011 - "Forty male Wistar rats were resuscitated after cardiac arrest induced by 8.5 min of asphyxia. "
08/01/2011 - "Here, using a newborn piglet model of asphyxia-induced cardiac arrest, we investigated the effect of ASIC1a-specific blocker psalmotoxin-1 on neuronal injury. "
08/01/2010 - "SSEPs were recorded during baseline, during the first 4 hrs, and at 24, 48, and 72 hrs postasphyxia from animals subjected to asphyxia-induced cardiac arrest for 7 or 9 mins (n = 8/group). "

03/01/2013 - "All of these acute life-threatening asphyxia events rapidly improved within 1 min of CPR. "
04/01/2012 - "[An experimental study on the effects of rhythmic abdominal lifting and compression during cardiopulmonary resuscitation in a swine model of asphyxia]."
10/01/2004 - "The Posner cue-target paradigm for the study of shifts in visual attention was used to assess focused attention and shifts in attention in 43 young adults, 19 to 28 years of age, who had been in need of cardiopulmonary resuscitation at birth because of perinatal asphyxia (n=31) or who were born small for gestational age (n= 12). "
01/01/2002 - "The aim of this study was therefore to investigate whether children who needed cardiopulmonary resuscitation because of presumed mild and moderate intra-partum asphyxia with no evidence of neurological impairments at 18 mo of age may display neuropsychological impairments later in life. "
03/01/2013 - "NPO(2) -NC-AC is a simple and effective CPR technique for severe acute cardiopulmonary asphyxia in piglets. "

06/01/1987 - "Fourteen of these patients presented with impending asphyxia and in 11 cases this was dramatically relieved with emergency laser treatment. "
01/01/2006 - "Infrared laser radiation of adrenal projection region reduced the number of asphyxia attacks, improved bronchial drainage, shortened the disease duration. "
05/01/2000 - "Percutaneous cardiopulmonary support was used during the laser procedure due to asphyxia. "
01/01/1981 - "Depending on the duration of the laser application, especially when using low intensities, a distinct endolaryngeal oedema developed which led to death by suffocation of some animals."
01/01/1996 - "Laser bronchoscopic resection was performed in one patient and tracheotomy one other avoid imminent asphyxia. "

12/01/2003 - "A reduction in the number of preterm deliveries and improved perinatal care to avoid and treat perinatal asphyxia would be the two most important measures in reducing neonatal mortality in this setting."
01/01/1991 - "Some of these factors affecting the response to the surfactant can be eliminated by improving perinatal care including maternal transport, prevention of birth asphyxia and initial stabilization of the neonates with respect to the cardiocirculatory system, and by treating with surfactant at or soon after birth."
01/01/2012 - "In countries with a high level of perinatal care, the incidence of asphyxia responsible for moderate or severe encephalopathy is still 2-3 per 1000 term newborns. "
06/01/2011 - "Perinatal asphyxia occurs still with great incidence whenever delivery is prolonged, despite improvements in perinatal care. "
12/01/2004 - "Whether advances in perinatal care have altered the incidence of birth asphyxia is unknown. "