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Allergic Bronchopulmonary Aspergillosis

Subscribe to New Research on Allergic Bronchopulmonary Aspergillosis

Hypersensitivity reaction (ALLERGIC REACTION) to fungus ASPERGILLUS in an individual with long-standing BRONCHIAL ASTHMA. It is characterized by pulmonary infiltrates, EOSINOPHILIA, elevated serum IMMUNOGLOBULIN E, and skin reactivity to Aspergillus antigen.

Also Known As:

Aspergillosis, Allergic Bronchopulmonary; Allergic Bronchopulmonary Aspergilloses; Aspergilloses, Allergic Bronchopulmonary; Aspergillosis, Bronchopulmonary Allergic; Bronchopulmonary Aspergilloses, Allergic; Bronchopulmonary Aspergillosis, Allergic; Allergic Aspergilloses, Bronchopulmonary; Allergic Aspergillosis, Bronchopulmonary; Aspergilloses, Bronchopulmonary Allergic; Bronchopulmonary Allergic Aspergilloses; Bronchopulmonary Allergic Aspergillosis

Networked: 440 relevant articles (25 outcomes, 28 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Cystic Fibrosis (Mucoviscidosis)
2.	Asthma (Bronchial Asthma)
3.	Dyspnea (Shortness of Breath)
4.	Bronchopulmonary Dysplasia
5.	Aspergillosis

Experts

1.	Agarwal, Ritesh: 14 articles (01/2016 - 01/2010)
2.	Madan, Taruna: 8 articles (11/2015 - 05/2003)
3.	Kurup, Viswanath P: 8 articles (02/2012 - 06/2002)
4.	Aggarwal, Ashutosh N: 7 articles (01/2016 - 02/2010)
5.	Chakrabarti, Arunaloke: 7 articles (01/2016 - 02/2010)
6.	Kurup, V P: 7 articles (05/2005 - 07/2000)
7.	Sarma, P Usha: 6 articles (11/2015 - 10/2003)
8.	Denning, David W: 5 articles (04/2015 - 01/2007)
9.	Greenberger, Paul A: 5 articles (05/2012 - 06/2002)
10.	Gibson, P G: 5 articles (01/2004 - 01/2000)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Allergic Bronchopulmonary Aspergillosis:

1.	Adrenal Cortex Hormones (Corticosteroids)IBA 12/01/2007 - "The mainstay of treatment for allergic bronchopulmonary aspergillosis is systemic corticosteroids. " 01/01/2004 - "The mainstay of treatment for allergic bronchopulmonary aspergillosis remains oral corticosteroids, though this does not completely prevent exacerbations and may not prevent the decline in lung function. " 01/01/2003 - "The mainstay of treatment for allergic bronchopulmonary aspergillosis remains oral corticosteroids, though this does not completely prevent exacerbations and may not prevent the decline in lung function. " 05/01/1993 - "We conclude that inhaled corticosteroids may be useful in the treatment of allergic bronchopulmonary aspergillosis." 07/01/2001 - "Although no well-designed studies have been carried out, the available data support the use of corticosteroids for acute exacerbations of allergic bronchopulmonary aspergillosis (ABPA). "
2.	Immunoglobulin E (IgE)IBA 02/01/2010 - "The total serum IgE level is a marker of immunological activity in allergic bronchopulmonary aspergillosis (ABPA), and a 35% decline beyond six weeks is traditionally taken as criteria for remission. " 12/01/1988 - "However, measurement of IgE may be helpful in CEP, as it has been in allergic bronchopulmonary aspergillosis, to guide the dosage and duration of corticosteroid therapy." 01/01/2016 - "The role of total and specific IgE in monitoring treatment responses in allergic bronchopulmonary aspergillosis (ABPA) remains poorly studied. " 01/01/2016 - "Utility of IgE (total and Aspergillus fumigatus specific) in monitoring for response and exacerbations in allergic bronchopulmonary aspergillosis." 05/01/2015 - "Therapeutic bronchoalveolar lavage may be a useful adjunct to treatment in patients with allergic bronchopulmonary aspergillosis, serum in terms of IgE level reduction."
3.	Itraconazole (Sporanox)FDA LinkGeneric 09/01/1998 - "[Allergic bronchopulmonary aspergillosis effectively treated with itraconazole]." 01/01/2010 - "An 18-year-old male diagnosed with CF at the age of eight (F508 del/G85E) had been treated for allergic bronchopulmonary aspergillosis in 1998 with itraconazole, and a first colonization with Pseudomonas aeruginosa was eradicated in 2003. " 03/16/2000 - "For patients with corticosteroid-dependent allergic bronchopulmonary aspergillosis, the addition of itraconazole can lead to improvement in the condition without added toxicity." 03/16/2000 - "We conducted a randomized, double-blind trial of treatment with either 200 mg of itraconazole twice daily or placebo for 16 weeks in patients who met immunologic and pulmonary-function criteria for corticosteroid-dependent allergic bronchopulmonary aspergillosis. " 03/16/2000 - "A randomized trial of itraconazole in allergic bronchopulmonary aspergillosis."
4.	Immunoglobulin G (IgG)IBA 05/01/1981 - "A study of immunoglobulin G subclasses in patients with allergic bronchopulmonary aspergillosis." 02/01/1993 - "Using human sera from patients with aspergilloma and allergic bronchopulmonary aspergillosis (ABPA), more than 13 IgG binding components were identified. " 11/01/2008 - "Serologic diagnosis of allergic bronchopulmonary aspergillosis in patients with cystic fibrosis through the detection of immunoglobulin G to Aspergillus fumigatus." 01/01/1999 - "Specific IgG subclass antibody pattern to Aspergillus fumigatus in patients with cystic fibrosis with allergic bronchopulmonary aspergillosis (ABPA)." 01/01/1992 - "Thirty nine of these had a mycetoma or allergic bronchopulmonary aspergillosis, 34 having specific IgG antibody to A fumigatus more than the control range. "
5.	AntigensIBA 05/01/2004 - "Use of a synthetic peptide epitope of Asp f 1, a major allergen or antigen of Aspergillus fumigatus, for improved immunodiagnosis of allergic bronchopulmonary aspergillosis." 10/01/2015 - "T helper 2 response in allergic bronchopulmonary aspergillosis is not driven by specific Aspergillus antigens." 01/01/2015 - "Allergic bronchopulmonary aspergillosis (ABPA) is a pulmonary disorder resulting from immune responses directed against inhaled Aspergillus fumigatus antigens. " 11/01/2013 - "Allergic bronchopulmonary aspergillosis (ABPA) is a complex pulmonary disorder caused by immunologic reactions to antigens released by Aspergillus fumigatus, a ubiquitous fungi colonizing the tracheobronchial tree of asthmatic patients. " 12/01/2011 - "To evaluate the frequency of sensitization to Aspergillus antigens and the prevalence of allergic bronchopulmonary aspergillosis (ABPA) in asthmatic patients. "
6.	omalizumab (Xolair)FDA Link 11/01/2015 - "Omalizumab in the treatment of allergic bronchopulmonary aspergillosis: One center's experience with 14 cases." 09/01/2015 - "Omalizumab, an additional therapy for allergic bronchopulmonary aspergillosis." 03/01/2015 - "Clinical efficacy and immunologic effects of omalizumab in allergic bronchopulmonary aspergillosis." 01/01/2015 - "Omalizumab may reduce corticosteroid dependence in patients with allergic bronchopulmonary aspergillosis for patients unable to tolerate antifungals, though use may be limited by cost. " 01/01/2015 - "Steroid sparing effect of omalizumab in seropositive allergic bronchopulmonary aspergillosis."
7.	AzolesIBA 01/01/2004 - "The purpose of this review was to determine the efficacy of azoles in the treatment of allergic bronchopulmonary aspergillosis. " 01/01/2003 - "The purpose of this review was to determine the efficacy of azoles in the treatment of allergic bronchopulmonary aspergillosis. " 01/01/2015 - "Azoles in Allergic Bronchopulmonary Aspergillosis." 10/01/2004 - "Pathogenesis of allergic bronchopulmonary aspergillosis and an evidence-based review of azoles in treatment." 01/01/2000 - "Azoles for allergic bronchopulmonary aspergillosis."
8.	Antigen-Antibody Complex (Immune Complex)IBA 08/01/1982 - "[Relationship between the clinical course and changes of circulating immune-complex levels in a case of allergic bronchopulmonary aspergillosis]." 07/01/2011 - "Allergic bronchopulmonary aspergillosis (ABPA) is a complex immune hypersensitivity reaction to Aspergillus fumigatus, usually complicating the course of patients with asthma and cystic fibrosis. " 08/01/2009 - "Allergic bronchopulmonary aspergillosis (ABPA) is a complex immune hypersensitivity reaction to the fungus Aspergillus fumigatus, which occurs in patients with asthma and cystic fibrosis. " 10/01/1988 - "The efficacy of the IgG immune complex-dependent stimulation of eosinophils suggests a possible physiologic mechanism whereby these cells could participate in the inflammatory changes associated with allergic bronchopulmonary aspergillosis and similar allergic disorders." 01/01/1997 - "Identification of 45 kD antigen in immune complexes of patients of allergic bronchopulmonary aspergillosis."
9.	AntibodiesIBA 12/27/2001 - "fumigatus was screened with antibodies of allergic bronchopulmonary aspergillosis (ABPA) patients. " 09/01/1995 - "Serology for allergic bronchopulmonary aspergillosis and serum precipitating antibodies to finch extract were positive. " 01/01/1987 - "Aspergillus fumigatus-specific antibodies in allergic bronchopulmonary aspergillosis and aspergilloma: evidence for a polyclonal antibody response." 09/01/1970 - "Allergic bronchopulmonary aspergillosis: characterization of antibodies and results of treatment." 05/01/1994 - "Serum anti-Aspergillus fumigatus antibodies by immunoblot and ELISA in cystic fibrosis with allergic bronchopulmonary aspergillosis."
10.	anti-IgEIBA 03/01/2007 - "Successful treatment of allergic bronchopulmonary aspergillosis with recombinant anti-IgE antibody." 01/01/2015 - "There is a need for large prospective randomized controlled studies of anti-IgE therapy in people with cystic fibrosis and allergic bronchopulmonary aspergillosis with both clinical and laboratory outcome measures such as steroid requirement, allergic bronchopulmonary aspergillosis exacerbations and lung function." 01/01/2015 - "Randomized and quasi-randomized controlled trials comparing anti-IgE therapy to placebo or other therapies for allergic bronchopulmonary aspergillosis in people with cystic fibrosis. " 01/01/2013 - "There is a need for large prospective randomized controlled trials of anti-IgE therapy in people with cystic fibrosis and allergic bronchopulmonary aspergillosis with both clinical and laboratory outcome measures such as steroid requirement, allergic bronchopulmonary aspergillosis exacerbations and lung function." 01/01/2013 - "Randomized and quasi-randomized controlled trials comparing anti-IgE therapy to placebo or other therapies for allergic bronchopulmonary aspergillosis in people with cystic fibrosis. "

Therapies and Procedures

1.	Aftercare (After-Treatment) 12/01/2011 - "After treatment with etanercept or tocilizumab, suspicious allergic bronchopulmonary aspergillosis (ABPA) repeatedly occurred and then rapidly improved after the withdrawal of each drug. "
2.	Transplants (Transplant) 11/01/2008 - "Yeasts and filamentous fungi are beginning to emerge as significant microbial pathogens in patients with cystic fibrosis (CF), particularly in relation to allergic-type responses, as seen in patients with allergic bronchopulmonary aspergillosis (ABPA), Aspergillus bronchitis and in invasive fungal disease in lung transplant patients. " 11/01/2002 - "Allergic bronchopulmonary aspergillosis in a lung transplant patient successfully treated with nebulized amphotericin."
3.	Enteral Nutrition (Feeding, Tube) 10/01/2014 - "cepacia or Aspergillus, need enteral feeding, are diagnosed as suffering from allergic bronchopulmonary aspergillosis (ABPA), developed massive hemoptysis, and their respiratory function is seriously compromised. " 08/01/2005 - "The principal risks associated with an increased occurrence of pneumothorax included the presence of Pseudomonas aeruginosa (odds ratio [OR], 2.3), Burkholderia cepacia (OR, 1.8), or Aspergillus (OR, 1.3) in sputum cultures, FEV1 < 30% predicted (OR, 1.5), enteral feeding (OR, 1.7), Medicaid insurance (OR, 1.1), pancreatic insufficiency (OR, 1.4), allergic bronchopulmonary aspergillosis (OR, 1.5), and massive hemoptysis (OR, 1.4). "
4.	Canes (Cane) 06/01/1977 - "Allergic bronchopulmonary aspergillosis in a cane-sugar mill." 11/01/1981 - "In view of the epidemiological significance of Aspergillus fumigatus in allergic bronchopulmonary aspergillosis (ABPA) and its abundance in sugar-cane bagasse the antigenic properties of 11 strains isolated from bagasse have been studied. "
5.	Organ Transplantation 02/01/2010 - "Independent risk factors for death included diabetes (hazard ratio 1.31 [95% CI 1.03-1.67], female sex (1.71 [1.36-2.14]) plus poorer pulmonary function, lower BMI, Burkholderia cepacia infection, absence of Staphylococcus aureus infection, allergic bronchopulmonary aspergillosis, liver disease, prior organ transplantation, and corticosteroid use. "