Aspergillosis

03/01/2010 - "The patient showed remarkable improvement with voriconazole suggesting aspergillosis. "
02/01/2004 - "Voriconazole currently offers the best prospect for success and tolerance as a first-line treatment for aspergillosis. "
09/01/2020 - "Voriconazole (VCZ) is currently the first-line treatment for invasive aspergillosis, although the doses are limited by its poor solubility and high hepatic toxicity. "
09/01/2008 - "Clinical application of voriconazole for the treatment of aspergillosis in birds appears to be promising, because this drug has a high effectiveness and wide tissue distribution, and long-term treatment did not cause clinical signs of adverse effects or organ damage in chickens."
10/01/2007 - "Invasive tracheal aspergillosis treated successfully with voriconazole: clinical report and review of the literature."

09/01/2016 - "Inhaled formulations of amphotericin B remain the most widely studied option for universal prophylaxis and have been shown to be effective in reducing the incidence of invasive Aspergillosis as compared with no prophylaxis. "
12/01/2006 - "Although the clinical evidence supporting the use of inhaled amphotericin B has some limitations, its use still may be beneficial for the prophylaxis of invasive Aspergillus infections, especially in solid-organ transplant recipients where the evidence is strongest. "
01/01/1993 - "He subsequently developed central nervous system aspergillosis that was treated successfully with surgery and amphotericin B. "
05/01/2005 - "In clinical trials it demonstrated superior efficacy in addition to a survival benefit when compared with the then current treatment standard, amphotericin B, for primary treatment of invasive aspergillosis. "
07/01/1991 - "On the basis of these results, we conclude that a single low dose of aerosolized amphotericin B prophylaxis is effective in preventing an exogenous aspergillus infection of the lung. "

01/01/2022 - "The efficacy of caspofungin in the treatment of cerebral aspergillosis documented here, if confirmed in other animal models (especially immunosuppressed murine models) and by using additional Aspergillus isolates across a range of CAS minimal effective concentrations (MECs), would suggest that caspofungin merits further study as a treatment option for patients suffering from aspergillosis disseminated to the brain."
01/01/2022 - "Caspofungin Cerebral Penetration and Therapeutic Efficacy in Experimental Cerebral Aspergillosis."
01/01/2022 - "In this study, we assessed cerebral drug exposure and efficacy of caspofungin (CAS) using a lethal infant rat model of cerebral aspergillosis. "
12/01/2011 - "In first-line treatment of invasive aspergillosis, daily doses of up to 200 mg caspofungin were well tolerated and the maximum tolerated dose was not reached. "
01/15/2006 - "Efficacy of caspofungin against invasive Candida or invasive Aspergillus infections in neutropenic patients."

11/01/2016 - "Aspergillosis is the most common and most lethal disease in captive falcons, which is most effectively treated with the poorly soluble drug Itraconazole. "
06/01/2006 - "Because detection rate of the fungus is very low, itraconazole in combination with surgical excision of focus is the best treatment of lung and brain invasive aspergillosis."
03/01/1994 - "The data indicate that itraconazole is highly effective in preventing true invasive aspergillosis. "
10/01/1999 - "The successful therapy indicated that itraconazole has a significant role in the treatment of advanced cerebral aspergillosis if it is used in high doses (16 mg/kg/d for adults)."
12/01/1995 - "Serum concentrations of the drug ranged from 2 micrograms/mL to 30 micrograms/mL. Review of 20 cases of cerebral aspergillosis that were treated with itraconazole revealed that three of the four patients who received high doses (800 mg/d in the adults) of the drug responded favorably, while only two of the 16 patients who received a dose of 400 mg/d were cured. "

09/01/2005 - "Several important obstacles underlie the correlation of in vitro susceptibility testing with in vivo efficacy of individual antifungal agents in the treatment of invasive aspergillosis. "
05/01/2013 - "This immune-competent patient showed multiple enhancing CNS aspergillosis in the cerebral hemisphere, which had a good outcome with antifungal agents. "
02/01/2012 - "Over the last decade, advances in diagnostic systems and the introduction of new antifungal agents have significantly improved outcomes in immunocompromised patients who develop invasive aspergillosis. "
12/01/2001 - "Because of its much larger dynamic range, the qPCR assay is superior to traditional CFU determination for monitoring the progression of disseminated aspergillosis and evaluating the activity of antifungal antibiotics against A. "
01/01/1987 - "Improved diagnostic methods for earlier definitive diagnosis of invasive aspergillosis as well as more efficacious and less toxic antifungal agents are needed to allow early treatment."

07/01/2005 - "Abelcet proved to be efficacious, but not curative, in the treatment of CNS aspergillosis and was equivalent overall to conventional AmB. "
12/01/2007 - "Standard dosing regimen of liposomal amphotericin B is as effective as a high-loading dose for patients with invasive aspergillosis: AmBiLoad trial."
12/20/2022 - "Intratracheal instillation of liposomal amphotericin B is safe, and liposomal amphotericin B instillation allowed a targeted high local drug concentration, which led to improvement in the invasive bronchial aspergillosis. "
12/01/2003 - "Efficacy of high doses of liposomal amphotericin B in the treatment of experimental aspergillosis."
12/01/1989 - "Liposomal amphotericin-B in the control of experimental aspergillosis in mice: Part I--Relative therapeutic efficacy of free and liposomal amphotericin-B."

10/01/2017 - "Secondary resistance is a significant clinical concern, as invasive aspergillosis with drug-susceptible strains is already difficult to treat, and exclusion of azole-based antifungals from prophylaxis or first-line treatment of invasive aspergillosis in high-risk patients would dramatically limit drug choices, thus increasing mortality rates for immunocompromised patients. "
01/01/2022 - "IMPORTANCE First-line treatment of aspergillosis typically involves the use of azole antifungals. "
11/26/2021 - "Azoles are the first-line treatment for aspergillosis, but in recent years, the emergence of azole resistance in A. "
01/10/2020 - "The first-line treatment of confirmed invasive aspergillosis (IA) consists of drugs in the azole family; however, the emergence of azole-resistant isolates has negatively impacted the management of IA. "
01/01/2020 - "fumigatus populations and to safeguard the efficacy of azoles for future treatment of invasive aspergillosis."

01/01/2018 - "In recent years, galactomannan detection has markedly improved the diagnosis of invasive aspergillosis, but very little is known on how physicians deal with this test in clinical practice. "
09/01/2017 - "Our study shows that PTX3 measurements in BAL samples were significantly higher among patients with invasive aspergillosis and may help to identify patients with Aspergillus colonization and false-positive galactomannan in BAL samples."
12/01/2013 - "Screening with serum galactomannan might be associated with better outcome than symptom-triggered galactomannan testing in allogeneic HSCT recipients with invasive aspergillosis."
01/01/2015 - "The Platelia Aspergillus Ag assay (Bio-Rad) is designed for detecting Aspergillus galactomannan (GM) and is widely used for diagnosing invasive aspergillosis but is hampered by variable occurrences of unreproducible positive results. "
02/01/2014 - "Nowadays, the galactomannan (GM) assay has been widely used as an indication of invasive aspergillosis, even though the test is known to generate false-positive results. "

01/01/2015 - "However, studies demonstrating the clinical effectiveness of echinocandins in comparison with antifungals currently recommended for first-line treatment of invasive aspergillosis are still lacking. "
01/01/2021 - "Although considered effective treatment for many yeast fungi, the therapeutic efficacy of the echinocandin class of antifungals for invasive aspergillosis (IA) is limited. "
01/01/2011 - "Combination regimens incorporating an echinocandin showing promise in the treatment of aspergillosis. "
12/15/2006 - "This echinocandin has demonstrated efficacy (45% success) as salvage monotherapy of invasive aspergillosis (IA). "
01/01/2009 - "Furthermore pharmacodynamic studies suggest that echinocandin doses currently in widespread clinical use may optimize outcomes in invasive aspergillosis. "

06/01/1990 - "Clinical improvement has been reported in a few cases of pulmonary Aspergillus infection but the overall efficacy of conventional dosages of fluconazole in this mycosis has not been as impressive. "
06/01/1997 - "Treatment with fluconazole was effective in this case of semi-invasive aspergillosis."
01/01/1997 - "For this indication, fluconazole may also be effective in patients not receiving fluconazole prophylaxis, in whom Aspergillus infection is unlikely."
12/01/2005 - "The results showed that 11 out of 14 cases had the respiratory manifestations, sputum was sticky and difficult to be expectorated in 7 cases, X rays in chests showed shadows with features of stigma and sheet in 11 cases, Candida albicans and aspergillus infection were observed in 10 and 2 cases respectively, the numbers of neutrophil were below 0.5 x 10(9)/L in 8 cases and below 1.0 x 10(9)/L in 3 cases respectively, fluconazole was used for 12 cases and clinical symptoms of 11 cases were improved within two weeks. "
09/01/1991 - "The efficacy of fluconazole against Aspergillus fumigatus was assessed in an immunosuppressed temporarily leukopenic rabbit model of invasive aspergillosis. "

03/01/2011 - "Most of the available data on the efficacy of these combinations are from experimental models, in vitro data and retrospective observational studies or studies with a small number of patients that have included both patients in first-line treatment and those receiving rescue therapy; in addition there are many patients with possible forms of aspergillosis and few with demonstrated or probable forms. "
01/01/2020 - "Moreover, SB-AF-1002 was very effective in an aspergillosis model as a prophylactic therapy. "
04/01/2017 - "Surgical intervention, with adjuvant antifungal therapy, aiming for safe total removal of the fungal burden, whenever feasible, has a major role in the management of invasive sinonasal aspergillosis with orbitocranial extension with minimal morbidity and good outcomes."
06/01/2009 - "Early diagnosis and transsphenoidal removal provides good results without the need for systemic antifungal therapy in non-invasive aspergillosis."
08/01/2005 - "These newer antifungal therapies, combined with improved early diagnosis due to the introduction of newer microbiologic techniques, offer the hope that there will be a significant improvement in the substantial morbidity and mortality associated with invasive aspergillosis over the next 5 years."

01/01/2015 - "Invasive aspergillosis remains associated with significant morbidity and mortality, necessitating new options for salvage therapy. "
01/01/2008 - "Salvage therapy for invasive aspergillosis."
10/01/2007 - "We discuss primary and salvage therapy of invasive aspergillosis with focus on cerebral involvement. "
06/01/2006 - "Combined treatment can be used in refractory aspergillosis as a salvage therapy. "
09/15/2005 - "Salvage therapy for aspergillosis."

05/01/2008 - "Extradural aspergillosis does not need chemotherapy preloading, whereas intradural variant may have improved survival chances after preloading. "
01/01/1999 - "Though clinical and radiological findings indicated that the patient's symptoms had gone into remission, aspergillosis recurred 4 months after the cessation of antifungal chemotherapy, requiring that the patient undergo an operation. "
02/01/2022 - "In patients with relapsed/refractory acute myeloid leukaemia (R/R AML) who received salvage chemotherapy, limited and not updated studies explored the incidence of invasive aspergillosis (IA) and the role of antifungal prophylaxis (AP). "
01/01/2021 - "Aspergillus fumigatus is an opportunistic fungus, capable of causing Invasive Aspergillosis in immunocompromised patients, recently transplanted or undergoing chemotherapy. "
04/01/2014 - "In 7 (78%) of these 9 patients, invasive aspergillosis occurred during the first course of chemotherapy. "

08/01/2002 - "Aspergillosis in liver transplant recipients: successful treatment and improved survival using a multistep approach."
07/04/2014 - "This study included 75 liver transplant recipients with and without histologically confirmed aspergillosis after liver transplantation. "
09/01/2010 - "This study found the incidence rate of invasive aspergillosis as an uncommon complication of liver transplant recipient cases but associated with poor outcomes. "
09/01/2010 - "This study seeks to determine the incidence of invasive aspergillosis in liver transplant recipients using routine and molecular methods in a teaching hospital in Shiraz, the unique center for liver transplant in Iran. "
11/01/1985 - "Studies on a liver transplant recipient with fatal disseminated aspergillosis are described. "

03/01/2019 - "Early surgical debridement is crucial to confirm the diagnosis of cavernous sinus-orbital apex aspergillosis and prevent mortality. "
12/01/2018 - "Completeness of endoscopic debridement before infusion is an important step for the success of treatment in canine sinonasal aspergillosis."
01/01/2017 - "Injection of antifungal cream into the frontal sinuses using the bone marrow needle resulted in good diffusion into the ipsilateral nasal cavity and could be used to treat aspergillosis when debridement or sinusoscopy is not deemed necessary. "
09/01/2014 - "The role of surgical debridement in different clinical manifestations of invasive aspergillosis."
12/01/2012 - "In this patient, bacteriological data positive for Pseudomonas delayed correct diagnosis of Aspergillus infection, which was obtained after surgical debridement and biopsy of the infra-temporal space. "