Aspartate Carbamoyltransferase

An enzyme that catalyzes the conversion of carbamoyl phosphate and L-aspartate to yield orthophosphate and N-carbamoyl-L-aspartate. (From Enzyme Nomenclature, 1992) EC 2.1.3.2.

Also Known As:

Co(II)-Aspartate Transcarbamoylase; Ni(II)-Aspartate Transcarbamoylase; Carbamoyltransferase, Aspartate; Transcarbamylase, Aspartate; Aspartate Transcarbamylase; Carbamoyl-phosphate:L-aspartate carbamoyltransferase

Networked: 43 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - One-Carbon Group Transferases
      - Carboxyl and Carbamoyl Transferases: 52
        Aspartate Carbamoyltransferase: 43
        CAD trifunctional enzyme
        carbamoyl phosphate synthase-aspartatecarbamoyl transferase complex
        E coli pyrB protein
        S cerevisiae URA2 protein
  - Multifunctional Enzymes: 108
    - Aspartate Carbamoyltransferase: 43

Experts

1.	Adler, Lital: 2 articles (01/2018 - 11/2015)
2.	Brandis, Alexander: 2 articles (01/2018 - 11/2015)
3.	Dimmock, David: 2 articles (01/2018 - 11/2015)
4.	Erez, Ayelet: 2 articles (01/2018 - 11/2015)
5.	Helbling, Daniel: 2 articles (01/2018 - 11/2015)
6.	Rabinovich, Shiran: 2 articles (01/2018 - 11/2015)
7.	Ruppin, Eytan: 2 articles (01/2018 - 11/2015)
8.	Silberman, Alon: 2 articles (01/2018 - 11/2015)
9.	Stettner, Noa: 2 articles (01/2018 - 11/2015)
10.	Sun, Qin: 2 articles (01/2018 - 11/2015)

Related Diseases

1.	Neoplasms (Cancer) 10/01/1987 - "Aspartate transcarbamylase, which is undetectable in normal brain tissue, is present in all tumor samples and in some cases rises to very high activities. " 11/01/1968 - "[Aspartate-transcarbamylase acitivity in some human malignant tumors]." 11/25/1983 - "This recovery of flux through the de novo pyrimidine biosynthetic pathway did not correlate with the measurement of recovery of aspartate transcarbamylase activity in similarly treated tumors. " 01/01/1981 - "Since administration of PALA was shown to produce long-lasting inhibition of aspartate carbamoyltransferase in liver and tumor and since its ultimate half-life in the plasma of mice, following a single 400-mg/kg administration of the drug, is 8 days, it is suggested that bone serves as a reservoir from which PALA is released at a slow rate into plasma and other tissues." 02/01/1978 - "Effects of N-(phosphonacetyl)-L-aspartate on murine tumors and normal tissues in vivo and in vitro and the relationship of sensitivity to rate of proliferation and level of aspartate transcarbamylase."
2.	Hepatocellular Carcinoma (Hepatoma) 11/01/1962 - "Feedback inhibition of aspartate transcarbamylase in liver and in hepatoma." 02/01/1977 - "Aspartate carbamoyltransferase inhibition and uridylate trapping result in a synergistic depression of uridine triphosphate in hepatoma cells." 01/01/1978 - "A multienzyme complex of carbamoyl-phosphate synthase (glutamine): aspartate carbamoyltransferase: dihydoorotase (rat ascites hepatoma cells and rat liver)." 07/15/1982 - "Combined treatment of hepatoma cells with d-galactosone and N-(phosphonoacetyl)-l-aspartate, an inhibitor of aspartate carbamoyltransferase, prevented the expansion of the uridylate pool and led to a synergistic reduction of UTP to 10% of the content in control cells. " 07/01/1975 - "Purification of homogeneous glutamine-dependent carbamyl phosphate synthetase from ascites hepatoma cells as a complex with aspartate transcarbamylase and dihydroorotase."
3.	Ascites 01/01/1978 - "A multienzyme complex of carbamoyl-phosphate synthase (glutamine): aspartate carbamoyltransferase: dihydoorotase (rat ascites hepatoma cells and rat liver)." 07/01/1975 - "Purification of homogeneous glutamine-dependent carbamyl phosphate synthetase from ascites hepatoma cells as a complex with aspartate transcarbamylase and dihydroorotase." 04/25/1980 - "We have studied factors affecting the catalytic activity of dihydroorotase (EC 3.5.2.3), purified as part of a multienzymatic protein which contains carbamyl phosphate synthetase, aspartate transcarbamylase, and dihydroorotase (ME pyr1-3) and which initiates de novo pyrimidine biosynthesis in mouse Ehrlich ascites carcinoma. " 05/16/1978 - "Multi-enzyme complex of glutamine-dependent carbamoyl-phosphate synthetase with aspartate carbamoyltransferase and dihydroorotase from rat ascites-hepatoma cells. " 05/01/1981 - "Carbamoyl-phosphate synthetase II [EC 6.3.5.5] of rat ascites hepatoma cells (AH 13), the first and regulatory enzyme of de novo pyrimidine nucleotide biosynthesis, exists as a multienzyme complex (molecular weight, 870,000) with aspartate carbamoyltransferase [EC 2.1.3.2] and dihydroorotase [EC 3.5.2.3] (Mori, M. "
4.	Starvation 08/01/1970 - "The synthesis of CPS(pyr) and aspartate transcarbamylase (ATC), the initial enzymatic steps of the pyrimidine pathway, are co-derepressed by pyrimidine starvation. " 07/01/1988 - "To learn more about the relationship of this pathway to cellular proliferation, we have studied changes in levels of CAD RNA, rates of CAD protein synthesis, and levels of aspartate transcarbamylase activity in Syrian hamster ts13 cells in response to serum starvation and serum stimulation. " 06/01/1993 - "This conclusion was based on the findings that (i) the strains grew 10 to 15% more slowly in pyrimidine-free medium than in medium containing uracil; (ii) their levels of aspartate transcarbamylase were highly derepressed, as is characteristic for pyrimidine starvation conditions; and (iii) their levels of orotate phosphoribosyltransferase were low. " 02/01/1985 - "The mutant exhibited many of the predicted consequences of a decreased PRPP pool and a defective PRPP synthetase enzyme, including: poor growth on purine bases; decreased accumulation of 5-aminoimidazole ribonucleotide (the substrate of the blocked purE reaction) under conditions of purine starvation; excretion of anthranilic acid when grown in medium lacking tryptophan; increased resistance to inhibition by 5-fluorouracil; derepressed levels of aspartate transcarbamylase and orotate phosphoribosyltransferase, enzymes involved in the pyrimidine de novo biosynthetic pathway; growth stimulation by PRPP-sparing compounds (e.g. "
5.	Infections 05/01/1964 - "1964.-A two- to three-fold increase in aspartate transcarbamylase (ATCase) activity was observed in type 5 adenovirus-infected HeLa cells 18 hr after infection. " 03/31/2004 - "The levels of arylsulfatases A and B, alpha-amylase, aspartate transcarbamylase, and gamma-glutamyl transpeptidase were investigated during the infection of mice with schistosoma mansoni. " 01/01/2020 - "In addition, the immunoblot analysis revealed that the expression of glutamate dehydrogenase (GDH) and trifunctional carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase (CAD) increased during infection. "

Related Drugs and Biologics

1.	Carbamyl Phosphate (Carbamoyl Phosphate)
2.	Dihydroorotase
3.	Ligases (Synthetase)
4.	Dihydroorotate Dehydrogenase
5.	Uridine
6.	pyrimidine
7.	Enzymes
8.	sparfosic acid (PALA)
9.	Uridine Triphosphate (UTP)
10.	Proteins (Proteins, Gene)