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Aspartame (NutraSweet)

Flavoring agent sweeter than sugar, metabolized as PHENYLALANINE and ASPARTIC ACID.

Also Known As:

NutraSweet; Canderel; Diététiques et Santé Brand of Aspartame; Fuca Brand of Aspartame; Goldswite; Hermes Brand of Aspartame; Hermesetas Gold; Methyl Aspartylphenylalanine; Milisucre; Muro Brand of Aspartame; Nozucar; Prodes Brand of Aspartame; SC-18862; Tri-Sweet; Aspartame Fuca Brand; Aspartame Hermes Brand; Aspartame Muro Brand; Aspartame Prodes Brand; Aspartylphenylalanine, Methyl; Gold, Hermesetas; Methyl Ester, Aspartylphenylalanine; SC 18862; SC18862; Tri Sweet; TriSweet; Aspartylphenylalanine Methyl Ester; L-Phenylalanine, N-L-alpha-aspartyl-, 1-methyl ester

Networked: 237 relevant articles (6 outcomes, 40 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Peptides: 22950
  - Oligopeptides: 168
    - Dipeptides: 137
      - Aspartame: 237
        alpha,beta-poly(N-2-hydroxyethyl)(2-aminoethylcarbamate)-d,l-aspartamide: 1
        asparaginyl-3-phenyllactic acid methyl ester
        aspartyl-alanyl-2,2,5,5-tetramethylcyclopentanyl ester
        aspartyl-methylphenylalanine methyl ester
        beta-hydroxyaspartame
        N-(trifluoroacetyl)aspartame

Experts

1.	Belpoggi, Fiorella: 4 articles (12/2010 - 03/2006)
2.	Soffritti, Morando: 4 articles (12/2010 - 03/2006)
3.	Roberts, H J: 4 articles (08/2009 - 01/2004)
4.	Tibaldi, Eva: 3 articles (12/2010 - 03/2006)
5.	Gallus, Silvano: 2 articles (10/2013 - 08/2009)
6.	La Vecchia, Carlo: 2 articles (10/2013 - 08/2009)
7.	Bosetti, Cristina: 2 articles (10/2013 - 08/2009)
8.	Al-Rabiah, Rana: 2 articles (01/2012 - 01/2012)
9.	Makhoul, Nadine J: 2 articles (01/2012 - 01/2012)
10.	Collison, Kate S: 2 articles (01/2012 - 01/2012)

Related Diseases

1.	Body Weight (Weight, Body) 10/01/2005 - "9-MONTH STUDY IN Tg.AC HEMIZYGOUS MICE: Groups of 15 male and 15 female Tg.AC hemizygous mice were fed diets containing 0, 3,125, 6,250, 12,500, 25,000, or 50,000 ppm aspartame (equivalent to average daily doses of approximately 490, 980, 1,960, 3,960, or 7,660 mg aspartame/kg body weight to males and 550, 1,100, 2,260, 4,420, or 8,180 mg/kg to females) for 40 weeks. " 03/01/2015 - "The effects of long-term administration of aspartame (40 mg/kg body weight/day) were tested in Wistar Albino rats. " 04/01/2013 - "Male Wistar rats weighing 150-175 g were randomly divided into three groups as follows: The first group was given aspartame at a dose of 500 mg/kg body weight (b.w.); the second group was given aspartame at dose of 1,000 mg/kg b.w., respectively, in a total volume of 3 mL of water; and the control rats received 3 mL of distilled water. " 01/01/2010 - "Swiss Albino male mice were exposed to aspartame (3.5, 35, 350 mg/kg body weight). " 10/01/2005 - "Exposure to aspartame had no effect on survival or mean body weights. "
2.	Obesity 10/01/2014 - "Taken together, these data suggest that aspartame may be a potent substance to alter adipocyte differentiation and control obesity." 10/01/2014 - "However, the potential role of aspartame in obesity is not clear. " 08/01/2008 - "Food reformulation is commonly used as a strategy to produce foods for improved health; for example, replacing sugar with aspartame, and salt (NaCl) with KCl may help to reduce the incidence of obesity and heart disease. " 01/01/2014 - "Aspartame consumption is implicated in the development of obesity and metabolic disease despite the intention of limiting caloric intake. " 01/01/2007 - "replacing sugar with aspartame and salt (NaCl) with KCl), to reduce the incidence of obesity and heart disease, potential food safety risks arising from such reformulations have received considerably less attention. "
3.	Vertigo (Positional Vertigo) 09/01/1992 - "One of us (AJG) treated a patient whose symptoms of episodic vertigo and continuous unsteadiness resolved upon ceasing aspartame intake. " 09/01/1992 - "As an initial attempt to ascertain the prevalence of aspartame-related dizziness in an otolaryngologic clinic, we elected to study prospectively all patients entering with the complaint of vertigo by means of a standardized questionnaire. " 01/01/2009 - "Even though the yield may be low, asking patients with dizziness, vertigo, tinnitus, or high-frequency hearing loss about their aspartame consumption and suggesting cessation of its use, may prove helpful for some."
4.	Dizziness (Lightheadedness) 09/01/1992 - "A literature review revealed that although dizziness has been associated with aspartame intake, no systematic study of the problem exists. " 09/01/1992 - "Aspartame and dizziness: preliminary results of a prospective, nonblinded, prevalence and attempted cross-over study." 09/01/1992 - "As an initial attempt to ascertain the prevalence of aspartame-related dizziness in an otolaryngologic clinic, we elected to study prospectively all patients entering with the complaint of vertigo by means of a standardized questionnaire. " 01/01/2009 - "Even though the yield may be low, asking patients with dizziness, vertigo, tinnitus, or high-frequency hearing loss about their aspartame consumption and suggesting cessation of its use, may prove helpful for some."
5.	Migraine Disorders (Migraine) 02/01/1988 - "The effect of aspartame on migraine headache." 08/14/1986 - "Migraine provoked by aspartame." 10/01/2001 - "Migraine MLT-down: an unusual presentation of migraine in patients with aspartame-triggered headaches." 11/01/1997 - "Herein, we describe three cases of young women with migraine who reported their headaches could be provoked by chewing sugarless gum containing aspartame." 02/01/1989 - "Patients with migraine were significantly more likely to report alcohol as a triggering factor and also reported aspartame as a precipitant three times more often than those having other types of headache. "

Related Drugs and Biologics

1.	Sweetening Agents (Sweeteners)
2.	Saccharin
3.	Sodium Glutamate (Accent)
4.	Food Additives (Food Additive)
5.	Copper
6.	Tea
7.	Enzymes
8.	Coffee
9.	Aspirin (Acetylsalicylic Acid)
10.	Antioxidants

Related Therapies and Procedures

1.	Oral Administration
2.	Renal Dialysis (Hemodialysis)
3.	Fluid Therapy (Oral Rehydration Therapy)
4.	Analgesia