Asparagine

A non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue. It is biosynthesized from ASPARTIC ACID and AMMONIA by asparagine synthetase. (From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed)

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Networked: 670 relevant articles (14 outcomes, 52 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Miyoshi, Eiji: 6 articles (01/2015 - 03/2004)
2.	Avramis, Vassilios I: 4 articles (07/2015 - 03/2004)
3.	Lambiase, A: 4 articles (01/2013 - 07/2009)
4.	Bordignon, C: 4 articles (01/2013 - 07/2009)
5.	Ratcliffe, Peter J: 4 articles (03/2011 - 07/2002)
6.	Schofield, Christopher J: 4 articles (03/2011 - 07/2002)
7.	Pinto, John T: 3 articles (12/2015 - 08/2009)
8.	Cooper, Arthur J L: 3 articles (12/2015 - 08/2009)
9.	Krasnikov, Boris F: 3 articles (12/2015 - 08/2009)
10.	Taniguchi, Naoyuki: 3 articles (01/2015 - 03/2004)

Related Diseases

1.	Neoplasms (Cancer) 06/01/2011 - "To study the influence of natural L-asparagine on the efficacy of cytostatic therapy for malignant tumors in experimental investigations. " 06/01/2011 - "Efficacy of natural L-asparagine in the complex therapy for malignant tumors in experimental studies." 01/15/2015 - "This finding might have implication for treatment individualization in ALL and other cancers using asparagine depletion strategies. " 04/15/2013 - "Identifying the roles of ASNS in fetal development, tissue differentiation, and tumor growth may reveal that ASNS function extends beyond asparagine biosynthesis." 08/28/2012 - "The new understanding of hASNase3 will serve to guide the design of variants that possess a decreased K(m) value for asparagine, making the human enzyme a suitable replacement for the bacterial asparaginases in cancer therapy."
2.	Leukemia 05/01/1979 - "Depletion of circulating L-asparagine has proved beneficial in the treatment of some acute lymphoyctic leukemias. " 02/01/1971 - "Studies on the utilization of asparagine by mouse leukemia cells." 06/01/2013 - "Furthermore these immobilization techniques have been applied for the detection of asparagine in normal and leukemia serum samples." 09/01/2010 - "Its antitumor effect results from the depletion of asparagine, an amino acid essential to leukemia cells, and subsequent inhibition of protein synthesis leading to cytotoxicity. " 10/01/2009 - "The cytotoxic effect of ASNase is derived from its ability to deplete asparagine, an essential amino acid required by certain types of leukemia cells for protein synthesis and survival. "
3.	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 05/15/2007 - "We conclude that effective asparagine depletion with PEG-ASP is feasible as part of an intensive multiagent therapeutic regimen in adult acute lymphoblastic leukemia and appears associated with improved outcomes." 06/01/2013 - "It is a novel diagnostic for monitoring asparagine levels in patients suffering from acute lymphoblastic leukemia (ALL). " 01/01/2006 - "Modern clinical treatments of childhood acute lymphoblastic leukemia (ALL) employ enzyme-based methods for depletion of blood asparagine in combination with standard chemotherapeutic agents. " 08/15/2004 - "Intensive PEG-ASNase therapy in the treatment of relapsed acute lymphoblastic leukemia reliably results in high-level serum PEG-ASNase activity, and asparagine depletion in serum and CSF is usually achieved. " 05/01/1987 - "This suggests that human malignancies other than acute lymphoblastic leukemia which exhibits an obligate dependence on extracellular asparagine might be manageable by enzymatic degradation in vivo or by dietary restriction of indispensable AAs."
4.	Starvation 01/01/2010 - "Its antineoplastic activity toward malignant cells is due to their characteristic nature in slow synthesis of L-asparagine (Asn), which causes starvation for this amino acid, while normal cells are protected from Asn starvation due to their ability to produce this amino acid. " 01/01/2005 - "Taken together, the changes seem to reflect a consistent coordinated response to asparagine starvation in both cell lines and clinical samples. " 12/01/1995 - "For the development of an expression system with an amino-acid-inducible promoter, the influence of extracellular stress, by starvation of the non-essential amino acid asparagine, on the extra- and intracellular amino acid pool was investigated. " 12/01/1995 - "Influence of targeted asparagine starvation on extra- and intracellular amino acid pools of cultivated Chinese hamster ovary cells." 04/01/1980 - "The synchrony was carried out by a partial asparagine starvation of cells for 24 hours. "
5.	Lymphoma (Lymphomas) 06/01/1983 - "These particles were used in C3H mice bearing the L-asparagine-dependent lymphoma (6C3HED). " 06/01/1968 - "An explanation for this contrast between the two types of lymphoma is provided by the finding that resistant cells have not only a higher asparagine synthetic capacity than sensitive cells but appear able to utilize endogenous asparagine preferentially for protein synthesis. " 06/01/1968 - "During treatment, normal tissues and resistant 6C3HED lymphomas survive unharmed with intracellular asparagine levels which are critically low for sensitive lymphomas. " 01/01/1966 - "Hence it seems likely that heated guinea pig serum in this way brings about a state of asparagine deprivation that is responsible for the sequential metabolic and morphologic alterations that become manifest in asparagine-dependent Lymphoma 6C3HED-OG cells following their exposure to the effects of guinea pig serum in vivo, as here described." 06/01/1965 - "A METABOLIC DIFFERENCE BETWEEN TWO LINES OF LYMPHOMA 6C3HED CELLS IN RELATION TO ASPARAGINE."

Related Drugs and Biologics

1.	Asparaginase (Elspar)
2.	Glycine (Aminoacetic Acid)
3.	Arginine (L-Arginine)
4.	Glutamic Acid (Glutamate)
5.	Glutamine (L-Glutamine)
6.	Serine (L-Serine)
7.	Amino Acids
8.	pegaspargase (Oncaspar)
9.	Threonine (L-Threonine)
10.	Immunoglobulin M (IgM)

Related Therapies and Procedures

1.	Remission Induction
2.	Intraperitoneal Injections
3.	Intravenous Injections
4.	Drug Therapy (Chemotherapy)
5.	Fluid Therapy (Oral Rehydration Therapy)