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Asparaginase (Elspar)

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A hydrolase enzyme that converts L-asparagine and water to L-aspartate and NH3. EC 3.5.1.1.

Also Known As:

Elspar; Asparaginase II; Asparaginase medac; Asparagine Deaminase; Bayer Brand of Asparaginase; Bellon Brand of Asparaginase; Christiaens Brand of Asparaginase; Colaspase; Crasnitin; Erwinase; Ispen Brand of Asparaginase; Kidrolase; Leunase; Merck Brand of Asparaginase; Paronal; Rhône-Poulenc Rorer Brand of Asparaginase; Sanfer Brand of Asparaginase; Speywood Brand of Asparaginase; medac Brand of Asparaginase; Asparaginase Bayer Brand; Asparaginase Bellon Brand; Asparaginase Christiaens Brand; Asparaginase Ispen Brand; Asparaginase Merck Brand; Asparaginase Sanfer Brand; Asparaginase Speywood Brand; Asparaginase medac Brand; Deaminase, Asparagine; Rhône Poulenc Rorer Brand of Asparaginase; medac, Asparaginase; L-Asparagine amidohydrolase

Networked: 1395 relevant articles (117 outcomes, 155 trials/studies)

Relationship Network

Drug Context: Research Results

Enzymes and Coenzymes
- Enzymes: 34502
  - Hydrolases: 639
    - Amidohydrolases: 12
      - Asparaginase: 1395
        pegaspargase: 73
        PVDA protocol: 26
        polyethylene glycol-glutaminase-asparaginase: 7
        ALL-BFM-95 protocol: 3
        FRALLE 93 protocol: 3
        New York protocol: 3
        CCG-141 protocol: 2
        ABLE protocol: 1
        ACOPA II protocol: 1
        AIEOP acute lymphoblastic leukemia protocol: 1
        ALL-VI protocol: 1
        Berlin-Frankfurt-Muenster protocol II: 1
        IVAP protocol: 1
        PM-asparaginase: 1
        protocol 8001: 1
        Stanford University protocol: 1
        ADA protocol
        AIEOP 8703 protocol
        AIEOP protocol 8202
        AL851 protocol
        ALHR88 protocol
        ALL-1 protocol
        BFM-86 protocol
        BFM-ALL 81 protocol
        CART protocol
        COPAD protocol
        DCVP-1-asp protocol
        DFCI 85-01 protocol
        DFCI 91-01 protocol
        DFCI 95-01 protocol
        EMLP protocol
        GIMEMA LAL 0288 protocol
        HEAVD protocol
        HR-2 protocol
        HR-3 protocol
        human ASRGL1 protein
        LL-IV-81 protocol
        LLA-IV-AR protocol
        LOP protocol
        LSA(2)L(2) protocol
        MAPO protocol
        MLL-93 protocol
        modified MSK-NY-II protocol
        monomethoxypolyethylene glycol-conjugated asparaginase
        MOPA-6 protocol
        non-Hodgkin's lymphoma protocol 8503
        OPAL protocol
        palmitoyl-L-asparaginase
        PETHEMA ALL-96 protocol
        POG 8602 protocol
        rat asparaginase-like protein
        Stanford-NCOG protocol
        succinylated glutaminase-asparaginase
        TGAP protocol
        TRAMPCOL protocol
        TSOP protocol
        UKALL X protocol
        VAA protocol
        VAMA protocol
        VCAA protocol
        VEPA-L protocol
        VPDA protocol

Experts

1.	Pieters, Rob: 20 articles (11/2014 - 04/2003)
2.	Pui, Ching-Hon: 15 articles (07/2015 - 12/2002)
3.	Asselin, Barbara L: 12 articles (12/2015 - 03/2007)
4.	Relling, Mary V: 12 articles (07/2015 - 08/2004)
5.	Avramis, Vassilios I: 12 articles (07/2015 - 03/2002)
6.	Silverman, Lewis B: 11 articles (12/2015 - 03/2007)
7.	Sallan, Stephen E: 10 articles (12/2015 - 03/2007)
8.	Rizzari, Carmelo: 9 articles (08/2015 - 10/2005)
9.	Hunger, Stephen P: 9 articles (07/2015 - 02/2008)
10.	Relling, M V: 9 articles (06/2014 - 04/2000)

Related Diseases

1.	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 12/01/2008 - "The outcome of pediatric acute lymphoblastic leukemia (ALL) has improved dramatically over the last 40 years through a systematic approach of well-designed large trials including use of asparaginase. " 06/01/2012 - "The use of L-asparaginase (ASNase) to modify amino acid metabolism is one of the most effective chemotherapeutic means of inducing remission in acute lymphoblastic leukemia (ALL). " 02/01/2008 - "L-asparaginase (ASNase) is one of the most effective chemotherapeutic means for inducing remission in acute lymphoblastic leukemia. " 03/27/2014 - "This study prospectively analyzed the efficacy of very prolonged courses of pegylated Escherichia coli asparaginase (PEGasparaginase) and Erwinia asparaginase in pediatric acute lymphoblastic leukemia (ALL) patients. " 05/01/1987 - "We studied platelet function and plasma coagulation parameters in 12 pediatric patients with acute lymphoblastic leukemia (ALL) receiving daily L-asparaginase as a single agent when in complete remission. "
2.	Neoplasms (Cancer) 03/01/1982 - "Similarly, the polymeric form of L-asparaginase is more effective in inhibiting cell growth of human pancreatic tumor cells grown in tissue culture. " 07/01/2014 - "Class II asparaginase from Escherichia coli (EcA), a homotetramer with a mass of 138 kDa, is especially effective in cancer therapy. " 01/01/2014 - "The present work could be seen as producing a modified L-asparaginase with improved activity and stability and can be a potential source for developing therapeutic agents for cancer treatment." 12/01/1969 - "Of 28 coliforms, five strains of Escherichia coli were particularly active in elaborating L-asparaginase 2, the form of the enzyme useful in the treatment of some forms of cancer. " 06/01/1983 - "After injection of 5.0 IU ip of L-asparaginase in microparticles, partial remission was induced, generally, however, the cancer relapsed and killed the mice within 2-3 weeks. "
3.	Lymphoma (Lymphomas) 06/01/1982 - "In addition, preimmunization with the native enzyme prevented the antitumor activity of the native enzyme but did not affect the therapeutic efficacy of the modified L-asparaginase against the lymphoma." 01/01/2013 - "coli-derived asparaginase as a therapeutic option for pets with lymphoma." 01/01/2013 - "Effects of cold-stored asparaginase on cell proliferation and cytotoxicity were measured in feline (MYA-1, F1B) and canine (17-71, OSW) lymphoma cells. " 01/01/2013 - "coli-derived asparaginase retains enzymatic and antineoplastic activity in canine and feline lymphoma cells after cold storage. " 01/01/2013 - "coli-Derived L-Asparaginase Retains Enzymatic and Cytotoxic Activity In Vitro for Canine and Feline Lymphoma after Cold Storage."
4.	Leukemia 06/01/1968 - "l-Asparaginase is now known to be a potent antineoplastic agent in animals and has given complete remission in some human leukemias. " 01/01/1981 - "Asparaginase is markedly more effective against human leukemia T-cells in vitro than against several types of B-lymphocytes. " 01/01/1979 - "The results of this study demonstrate that the intramuscular method of administering L-asparaginase is as effective, but less toxic, than the intravenous method for children with advanced leukemia. " 01/01/1979 - "A study was done to evaluate intramuscular versus intravenous administration of L-asparaginase in childhood leukemia. " 01/01/1971 - "[Results of the treatment of acute leukemias in children with asparaginase (critical study of 34 cases)]."
5.	Hypersensitivity (Allergy) 12/01/1999 - "The 4-year EFS rate for patients with a first complete remission >/= 18 months was 83.3% +/- 5.3%, and for those with a first complete remission less than 18 months, it was 46.2% +/- 10.2% (P =.0002.) There was a low incidence of neurologic toxicity and an unexpectedly high rate of allergic reactions to L-asparaginase. " 07/01/2010 - "L-asparaginase is effective in the treatment of malignant diseases, but it has been associated with hypersensitivity reactions in 5% to 45% of the patients. " 10/01/2012 - "Hypersensitivity reactions limit the use and efficacy of asparaginase products. " 01/01/1997 - "In addition, its use in patients with silent hypersensitivity may maintain the efficacy of asparaginase. " 07/01/2014 - "This study further established the safety profile of asparaginase Erwinia chrysanthemi in patients with ALL or LBL who had a hypersensitivity reaction to an E. "

Related Drugs and Biologics

1.	Vincristine (Oncovin)
2.	Prednisone (Sone)
3.	Cytarabine (Cytosar-U)
4.	Dexamethasone (Maxidex)
5.	Methotrexate (Mexate)
6.	Etoposide (VP 16)
7.	Cyclophosphamide (Cytoxan)
8.	Prednisolone (Predate)
9.	Asparagine
10.	Ifosfamide

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Combination Drug Therapy (Combination Chemotherapy)
3.	Radiotherapy
4.	Stem Cell Transplantation
5.	Remission Induction