Ascorbic Acid Deficiency (Vitamin C Deficiency)

A condition due to a dietary deficiency of ascorbic acid (vitamin C), characterized by malaise, lethargy, and weakness. As the disease progresses, joints, muscles, and subcutaneous tissues may become the sites of hemorrhage. Ascorbic acid deficiency frequently develops into SCURVY in young children fed unsupplemented cow's milk exclusively during their first year. It develops also commonly in chronic alcoholism. (Cecil Textbook of Medicine, 19th ed, p1177)

Also Known As:

Networked: 414 relevant articles (5 outcomes, 30 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Scurvy (Scorbutus)
2.	Parkinsonian Disorders (Parkinsonism)
3.	Hyperlipidemias (Hyperlipidemia)
4.	Wounds and Injuries (Trauma)
5.	Atherosclerosis

Experts

1.	Lykkesfeldt, Jens: 10 articles (09/2014 - 05/2002)
2.	Tveden-Nyborg, Pernille: 6 articles (09/2014 - 09/2009)
3.	May, James M: 4 articles (02/2013 - 06/2003)
4.	Harrison, Fiona E: 3 articles (02/2015 - 01/2012)
5.	Horio, Fumihiko: 3 articles (01/2014 - 02/2003)
6.	Zuo, Li: 3 articles (01/2013 - 01/2011)
7.	Jeong, Kyu-Shik: 3 articles (10/2012 - 05/2010)
8.	Park, Jin-Kyu: 3 articles (10/2012 - 05/2010)
9.	Hara, Kuniko: 3 articles (08/2011 - 11/2007)
10.	Akiyama, Yasuhiro: 3 articles (08/2011 - 11/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Ascorbic Acid Deficiency:

1.	Ascorbic Acid (Vitamin C)FDA LinkGeneric 12/10/2013 - "Increased insights into vitamin C deficiency-mediated CVD progression will enable the design of future randomized controlled trials that are better suited to test the efficacy of vitamin C in disease prevention as well as the identification of high-risk individuals which could possibly benefit from supplementation." 11/01/2009 - "In NHANES 2003-2004, vitamin C status improved, and the prevalence of vitamin C deficiency was significantly lower than that during NHANES III, but smokers and low-income persons were among those at increased risk of deficiency." 12/01/2010 - "This study aimed to determine whether the Hp polymorphism modifies the association between dietary vitamin C and serum ascorbic acid deficiency (<11 μmol/L). " 04/01/2007 - "Subjects with vitamin C deficiency (14.7% of the study population) had more attachment loss compared with those with depletion or normal plasma vitamin C values. " 04/01/2001 - "We could not find a vitamin C deficiency during the study and no association between low levels of vitamin C in plasma and the presence of deformed forelegs of these 40 pigs."
2.	CollagenIBA 08/01/2011 - "In summary, collagen mineralization seems unaffected by ascorbic acid deficiency in spite of the fine, fragile collagenous fibrils identified in the bones of our animal model." 01/01/2011 - "Neither UVB exposure nor ascorbic acid deficiency caused any change in the average diameter or D-periodicity of the stromal collagen fibrils. " 04/01/2010 - "Ascorbate is essential for collagen production, and vitamin C deficiency will result in defective connective tissue, including reductions in collagen synthesis and structural stability. " 03/01/2003 - "Comparison of vitamin C deficiency with food restriction on collagen cross-link ratios in bone, urine and skin of weanling guinea-pigs." 03/01/1996 - "The effect of severe ascorbic acid deficiency on bone remodeling and collagen synthesis was evaluated in a 21 day experiment, using the scorbutic guinea pig model. "
3.	Proline (L-Proline)FDA Link 11/01/2007 - "Preclinical studies regarding bone quality reported that VK(2) improved the trabecular microarchitecture (connectivity and width) in an ovariectomized model, and that VK(2) increased the bone strength without influencing the bone mineral content in a model fed a low-Mg diet and a vitamin C deficiency model, increasing the collagen level and proline hydroxylation. " 04/01/1995 - "Poor wound healing during vitamin C deficiency is thought to be due to decreased hydroxylation of proline residues in collagen. " 06/01/2006 - "Vitamin C deficiency had no significant effect on the hydroxylation of proline and collagen production during tumor growth or in angiogenesis associated with tumor or mammary gland growth. " 12/01/1974 - "Methods controlling tissue fibrosis are classified into those specifically inhibiting various metabolic aspects of collagen selectively in the injured tissue (ascorbic acid deficiency, effect of agent chelating Fe(2+), proline analogs, lathyrogens). " 06/01/1969 - "4. Incorporation of labelled proline into aortic elastin isolated from the same animals did not indicate a decrease in elastin biosynthesis in ascorbic acid deficiency, beyond that attributable to the inanition accompanying the vitamin deficiency. "
4.	CholesterolIBA 10/01/1990 - "Effect of vitamin C deficiency and excess on the liver: a histopathological and biochemical study in guinea pigs fed normal or high cholesterol diet." 01/01/1999 - "Vitamin C-deficiency is known to cause a disturbance of cholesterol metabolism. " 09/01/1983 - "These data demonstrate that short-term subclinical ascorbic acid deficiency near the scorbutic range has no significant effect on bile acid and cholesterol metabolism in man." 01/01/1982 - "The activity of the cholesterol 7 alpha-hydroxylating system containing cyto-chrome P-450 is depressed in the liver of guinea-pigs with chronic marginal vitamin C deficiency. " 07/01/1976 - "Strong clinical and experimental evidence suggests that chronic latent vitamin C deficiency leads to hypercholesterolaemia and the accumulation of cholesterol in certain tissues. "
5.	Vitamin EFDA LinkGeneric 03/07/2014 - "The proteomics-driven study revealed that in vitamin-E-deficient fish, vitamin C deficiency is associated with induction of stress response, astrogliosis, and a shift from glycolysis to glutaminolysis as an alternative mechanism to satisfy cellular energy requirements. " 06/01/2003 - "A distinct clinical syndrome of combined vitamin E and vitamin C deficiency occurs in guinea pigs. " 03/01/2001 - "The deficient group had higher serum vitamin E concentration than the sufficient group at 3 and 6 months of ascorbic acid deficiency. " 04/01/1996 - "[Effect of vitamin E and vitamin C deficiency on the development of alcoholic liver diseases]." 06/01/2004 - "In general, the pathological effects of gossypol in tilapia (low haemoglobin and haematocrit levels, abundance of immature red blood cells or polychromatocytes, abnormal spleen morphology) were similar to the effects of vitamin E and/or vitamin C deficiencies observed in other studies."
6.	VitaminsIBA 08/01/1976 - "Previous in vivo studies indicate that hepatic microsomal drug metabolism decreases in ascorbic acid deficiency and is augmented when high supplements of the vitamin are given to guinea pigs. " 06/01/1992 - "Ascorbic acid deficiency was suspected and therapy was initiated that consisted of vitamin supplements, diet change, cage rest, and support bandages. " 01/01/1985 - "Analysis of tissue ascorbate values in mice also indicated that an enhanced rate of utilization of this vitamin occurs during malignancy, as does an increased rate of excretion, and both events may be responsible for vitamin C deficiency. " 08/01/1981 - "[The effect of long-term vitamin C deficiency on the metabolism of fat-soluble vitamins A and E in guinea pigs]." 01/01/1955 - "[Effect of vitamin P on capillary resistance in vitamin C deficiency in guinea pigs]."
7.	EnzymesIBA 01/01/1982 - "The effect of vitamin C deficiency on various enzymes of the intestinal epithelium has been studied in guinea pigs. " 04/01/1973 - "The effect of protein quality and ascorbic acid deficiency stimulation of hepatic microsomal enzymes in guinea pigs." 05/01/1971 - "Ascorbic acid deficiency and induction of hepatic microsomal hydroxylative enzymes by organochlorine pesticides." 12/01/1945 - "The enzymes of healing wounds; the effect of different degrees of vitamin C-deficiency on the phosphatase activity in experimental wounds in the guinea-pig." 11/01/2009 - "Individuals with GST null genotypes had an increased risk of deficiency if they did not meet the Recommended Dietary Allowance for vitamin C, which suggests that the GST enzymes protect against serum ascorbic acid deficiency when dietary vitamin C is insufficient."
8.	Proteins (Proteins, Gene)IBA 01/01/1999 - "Therefore, we examined the possibility that vitamin C deficiency affects the expression of these proteins. " 09/01/1967 - "Effect of ascorbic acid deficiency on the in vivo incorporation of 14C-leucine into proteins of different tissues of the guinea-pig." 11/01/1997 - "To investigate this role of ascorbic acid, we surveyed proteins whose tissue levels are changed by ascorbic acid deficiency by using ODS rats with a hereditary defect in ascorbic acid biosynthesis. " 01/01/1964 - "[ON DISORDERS OF GLUTAMINE SYNTHESIS AND AMINATION OF BRAIN PROTEINS IN VITAMIN C DEFICIENCY]." 01/01/1962 - "[Effect of vitamin C deficiency on the incorporation of S35-labelled methionine into tissue proteins in guinea pigs]."
9.	Lipoproteins (Lipoprotein)IBA 02/01/1981 - "Ascorbic acid deficiency appears to contribute to disorders of lipoprotein metabolism in the aged. " 10/01/1990 - "These results suggest that vitamin C deficiency delays low density lipoprotein metabolism and produces hypercholesterolemia in male od/od rats." 04/01/2002 - "These results suggest that lipid peroxidation and some distinct features of lipoprotein metabolism resulting from vitamin C deficiency become more significant when vitamin E is also deficient along with vitamin C deficiency." 01/01/1980 - "The balance shift between the rate of the uptake and removal of very low density lipoprotein triglycerides (VLDL-TG) in the plasma compartment (greater retardation of the catabolic phase of kinetics) is probably the reason why triglycerides accumulate in the plasma and liver compartment of guinea-pigs with borderline vitamin C deficiency." 02/01/1991 - "The effect of ascorbic acid deficiency on serum levels of high density lipoprotein- (HDL-), low density lipoprotein- (LDL-), very low density lipoprotein- (VLDL-) and chylomicron-cholesterol was examined in ODS-od/od rat (ODS rat), that is a rat mutant unable to synthesize ascorbic acid. "
10.	Methionine (L-Methionine)FDA Link 01/01/1962 - "[Effect of vitamin C deficiency on the incorporation of S35-labelled methionine into tissue proteins in guinea pigs]." 02/17/1973 - "ABNORMALITIES OF TYROSINE METABOLISM ARE DISCUSSED UNDER FOUR HEADINGS: (1) accumulation of tyrosine and its metabolites secondary to severe liver damage, vitamin C deficiency, etc.; (2) transient neonatal tyrosinemia; (3) hereditary tyrosinosis with hepatorenal dysfunction where elevation of tyrosine and methionine levels in the plasma may be a secondary manifestation of an unknown disease process; and (4) "essential tyrosinemia" or tyrosinosis without hepatorenal dysfunction which may represent a kkrimary fault in the metabolism of tyrosine.A new case of tyrosinosis without hepatorenal dysfunction in a 13-year-old mentally retarded girl is reported. " 02/01/1985 - "In animals with an ascorbic acid deficiency, histopathology of muscles and spinal cord were also prevented by L-cysteine, L-methionine and L-hydroxyproline. " 03/10/1957 - "The influence of ascorbic acid deficiency in guinea pigs on the synthesis of purines, serine, and methionine." 03/01/1981 - "A study was made of the effect of ascorbic acid deficiency and low levels of lysine, methionine and threonine on the cancerogenic effect of nitrosopiperidine which was fed to guinea-pigs with drinking water in a single dose of 4.25 mg/kg bw. "

Therapies and Procedures

1.	Oral Administration 01/01/2013 - "The inflammatory status in MHD patients with plasma vitamin C deficiency and high levels of inflammatory markers could be partially improved by long-term oral administration of small doses of vitamin C. "
2.	Renal Dialysis (Hemodialysis) 01/01/2011 - "This study showed a high incidence of vitamin C deficiency in extended hours hemodialysis patients, suggesting that supplementation is warranted. " 01/01/2013 - "Both vitamin C deficiency and inflammation are prevalent in maintenance hemodialysis (MHD) patients. "
3.	Continuous Ambulatory Peritoneal Dialysis (CAPD) 07/01/2015 - "vitamin C deficiency was more prevalent in HD versus continuous ambulatory peritoneal dialysis patients (P = 0.128). " 01/01/2011 - "The investigation indicates that vitamin C deficiency is common in both MHD patients and CAPD patients. " 01/01/2001 - "Our results show that, in CAPD patients, ascorbic acid deficiency can be reliably detected only with SAA measurements, and oral intake may influence SAA level. " 07/01/2012 - "  We designed a cross-sectional study to investigate plasma vitamin C level in patients who underwent maintenance haemodialysis (MHD) and continuous ambulatory peritoneal dialysis (CAPD) to explore whether there is a difference in vitamin C deficiency between MHD patients and CAPD patients. "
4.	Transplantation (Transplant Recipients) 09/01/1996 - "Multilocational hepatocyte transplantation for treatment of congenital ascorbic acid deficiency rats." 05/01/1995 - "[Hepatocellular transplantation in rats with congenital ascorbic acid deficiency]." 01/01/2002 - "The causes, consequences and treatment of the vitamin B6 and vitamin C deficiencies in renal transplant recipients need further investigation."
5.	Gastric Bypass (Roux-en-Y Gastric Bypass) 02/01/2012 - "The results demonstrated that vitamin C deficiency and increased vomiting after gastric bypass for morbid obesity may contribute to increased periodontal disease. " 04/01/2012 - "If gastric bypass surgery is followed by a vitamin deficient diet the patients have a risk of developing vitamin-C deficiency. "