Ascariasis

Infection by nematodes of the genus ASCARIS. Ingestion of infective eggs causes diarrhea and pneumonitis. Its distribution is more prevalent in areas of poor sanitation and where human feces are used for fertilizer.

Also Known As:

Networked: 445 relevant articles (24 outcomes, 37 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Trichuriasis
2.	Ancylostomiasis
3.	Infection
4.	Hymenolepiasis
5.	Enterobiasis

Experts

1.	Wang, Jun: 3 articles (09/2013 - 11/2011)
2.	Caraballo, Luis: 2 articles (01/2015 - 01/2011)
3.	Hotez, Peter J: 2 articles (03/2014 - 01/2014)
4.	Cooper, Philip J: 2 articles (01/2012 - 10/2004)
5.	Chico, Martha E: 2 articles (01/2012 - 10/2004)
6.	Nejsum, Peter: 2 articles (11/2011 - 01/2006)
7.	Wang, Tao: 2 articles (11/2011 - 12/2008)
8.	Dekumyoy, Paron: 2 articles (07/2010 - 01/2005)
9.	Waikagul, Jitra: 2 articles (07/2010 - 01/2005)
10.	Malla, Nancy: 2 articles (03/2006 - 07/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Ascariasis:

1.	Albendazole (Albenza)FDA Link 07/01/2001 - "[Ascariasis: comparison of the therapeutic efficacy between paico and albendazole in children from Huaraz]." 07/01/2001 - "A therapeutical clinical trial was designed to study the effectiveness of Paico and Albendazole, for the treatment of ascariasis in a group of 60 children, between 3 and 14 years old, from a rural community in Huaraz. " 01/01/2012 - "Vaccinated children had active ascariasis (n = 20) or had been infected but received short- (n = 13) or long-term (n = 15) repeated treatments with albendazole prior to vaccination to treat ascariasis. " 07/01/2010 - "Biliary ascariasis after worm removal from the duodenum and single-dose albendazole treatment." 01/01/2002 - "Based on these findings, and presuming a diagnosis of gallbladder ascariasis, we administered antiparasitic medication (albendazole 400 mg/day for 1 day). "
2.	Mebendazole (Vermin)FDA Link 12/01/2001 - "The two patients who had ascariasis were treated with mebendazole. " 01/01/2000 - "Mebendazole was administered in the dose of 200 mg per day: for 3 days in ascariasis, for 5 days in A. " 10/01/1979 - "Although mebendazole is an effective agent against ascariasis, there are preferable alternatives. " 12/01/1975 - "A clinical trial with mebendazole in ascariasis and ankylostomiasis." 07/01/1992 - "A case of massive ascariasis in a three and a half years old girl who eliminated 104 worms after treatment with mebendazole is reported from a riverside sector of Riñihue Lake, Chile. "
3.	PyrantelIBA 01/01/1978 - "The best results were obtained using oxantel, either alone or in combination with pyrantel, at 15 to 20mg/kg. Only 2 of 152 patients with ascariasis were not cured after a single dose of pyrantel (given as oxantel-pyrantel) of 10, 15 or 20mg/kg, and both these patients were from the group given the lowest dose. " 03/01/1989 - "A multicentre, randomized trial was carried out to compare the efficacy of two single-dose treatments for ascariasis: mebendazole 200 mg, and pyrantel 10 mg/kg. Each centre enrolled 200 patients with a suspected diagnosis of ascariasis, 100 for each treatment, and the treatments were randomized for each centre. " 03/01/1989 - "Thus pyrantel was found to be significantly more efficacious than mebendazole for single-dose treatment of ascariasis." 03/01/1989 - "Single dose therapy of ascariasis--a randomized comparison of mebendazole and pyrantel." 08/01/1975 - "Comparison of pyrantel and tetramisole in ascariasis."
4.	Levamisole (Decaris)FDA Link 01/01/2015 - "This first reported sporadic case of pancreatic duct ascariasis in Lithuania was successfully treated with ERCP and Levamisole." 08/01/1980 - "Levamisole is a drug of choice for treatment of ascariasis. " 03/01/1979 - "It is concluded that mass treatment with single oral doses of levamisole repeated at 3-month intervals might help control ascariasis, and that population coverages between 60 and 90% might be appropriate. " 03/01/1979 - "Mass control of ascariasis with single oral doses of levamisole. " 10/01/1978 - "Levamisole meets the requirements of individual and mass treatment of ascariasis."
5.	Praziquantel (Biltricide)FDA Link 01/01/1994 - "The authors point to high efficacy of the drugs mebendazol, albendazol, medaminol (against ancylostomiasis, ascariasis, trichocephaliasis), praziquantel (against schistosomiasis and hymenolepiasis)." 03/01/2002 - "Three randomized clinical studies were conducted in 2000 to evaluate the efficacy of nitazoxanide paediatric suspension compared to albendazole in the treatment of ascariasis and trichuriasis and praziquantel in the treatment of hymenolepiasis in children from Cajamarca, Peru. " 03/01/2002 - "Comparative clinical studies of nitazoxanide, albendazole and praziquantel in the treatment of ascariasis, trichuriasis and hymenolepiasis in children from Peru." 05/15/1987 - "Mebendazole can be used against numerous nematode-infections (Ascariasis, Trichuriasis, Oxyuriasis, Ancylostomiasis), Niclosamide against cestode-infections (Taeniasis, Hymenolepiasis, Diphyllobothriasis), whereas, Praziquantel is applied against trematode-infections." 10/01/2001 - "Examples include thiabendazole for cutaneous larva migrans, mebendazole for ascariasis, trichiuriasis and hookworm, albendazole for inoperable cases of cystic hydatid disease, DEC for Toxocara induced visceral larva migrans and loiasis, ivermectin for onchocerciasis, praziquantel for schistosomiasis and niridazole for Dracunculus medinensis. "
6.	Pyrantel Pamoate (Pyrantel Embonate)IBA 03/01/1993 - "The drugs were prescribed in a single dose of 10 mg/kg. No significant differences in the efficacies of the drugs were revealed: combatrin and embovin efficacies in ascariasis were 94.3 and 98.0%, respectively (p > 0.05), in ankylostomiasis 76.3 and 58.3%, respectively (p > 0.05)." 09/01/1975 - "With pyrantel pamoate administered in one oral dose of 10 mg by kg of weight, results are excellent in ascariasis with 97-7 0/0 success. " 09/15/1974 - "[Use of pyrantel embonate (Combantrin) in the treatment of ascariasis in children]." 10/01/1972 - "Treatment of ascariasis with pyrantel pamoate in Iran." 01/01/1974 - "Single oral dose of combantrin (pyrantel pamoate) in the treatment of enterobiasis and ascariasis."
7.	oxantelIBA 01/01/1978 - "The best results were obtained using oxantel, either alone or in combination with pyrantel, at 15 to 20mg/kg. Only 2 of 152 patients with ascariasis were not cured after a single dose of pyrantel (given as oxantel-pyrantel) of 10, 15 or 20mg/kg, and both these patients were from the group given the lowest dose. " 01/01/1978 - "In a pilot study in 17 children, oxantel-pyrantel as one single dose of 10 to 20mg/kg of each, gave good results in ascariasis but poor cure rates in both trichuriasis and necatoriasis. " 01/01/1978 - "204 individuals from a rural community were given a single dose of oxantel-pyrantel at 15mg/kg bodyweight and if still infected, 20mg/kg bodyweight, with cure rates of 100%, 53% and 71% for ascariasis, trichuriasis and hookworm infection, respectively. " 01/01/1978 - "32 elementary school children were treated for multiple intestinal helminthiasis (ascariasis, trichuriasis and hookworm infections) with a combination of the pamoate salts of oxantel and pyrantel in a dose of 15 to 20mg/kg body weight of each in 1 daily dose for 3 consecutive days. "
8.	piperazineIBA 03/31/1962 - "An improved piperazine preparation in the treatment of ascariasis." 07/01/1982 - "Piperazine administration decreased the prevalence of ascariasis to 33.8% at the end of the study but growth remained unaltered. " 02/01/1966 - "Field trials with piperazine derivatives against ascariasis in pigs and calves." 10/01/2006 - "Piperazine (diethylenediamine) is an anthelmintic widely used against animal and bird ascariasis. " 12/01/1973 - "[Technical piperazine hexahydrate in ascariasis of chickens]."
9.	TetramisoleIBA 08/01/1970 - "A trial of Ketrax (the laevo-isomer of tetramisole) in the treatment of ascariasis." 05/01/1966 - "[Therapeutical trial in ascariasis with a single dose of a new anthelmintic drug (R-8299 or Tetramisole)]." 12/01/1971 - "[Nilverm during neo-ascariasis in calves and buffaloes]." 11/01/1970 - "A clinical trial of tetramisole (R 8299) in cases of ascariasis." 02/01/1970 - "[Treatment of ascariasis using tetramisole. "
10.	AnthelminticsIBA 09/01/1976 - "The use of anthelmintics in the treatment of ascariasis." 11/01/1967 - "[The use of feed mixtures containing anthelmintics in ascariasis and heterakiasis of chickens]." 09/01/1981 - "[Clinical and epidemiological efficacy of new anthelmintics in foci of ascariasis and trichuriasis]." 04/01/1997 - "A retrospective clinical study to evaluate the effects of paralyzing vermifuges on the course of intestinal obstructions complicating ascariasis was performed. " 12/01/1980 - "Clinical trials on the three broad spectrum anthelmintics against trichuriasis, ascariasis and hookworm infection were carried out in a rural community in Irosin, Sorsogon. "

Therapies and Procedures

1.	Aftercare (After-Treatment) 04/01/2001 - "In the following year after treatment on humans, ascariasis among villagers was studied cross-sectionally five times with Kato-katz technique. " 01/01/1994 - "The overall cure rate for ascariasis was 93.2% and reduction of egg load after treatment was 89.8% in persistent positive cases. " 09/01/1980 - "Absorption of macronutrients from a rice-vegetable diet before and after treatment of ascariasis in children." 02/01/1978 - "The reduction rates as seen by mean egg counts four weeks after treatment were 94.9% for hookworm infection, 100% for ascariasis and 93.9% for trichuriasis; the reduction rates of the mean larval count in 15 cases of strongyloidiasis was 82.1%. " 07/01/1992 - "A case of massive ascariasis in a three and a half years old girl who eliminated 104 worms after treatment with mebendazole is reported from a riverside sector of Riñihue Lake, Chile. "
2.	Enema (Enemas) 09/01/1999 - "The use of hypertonic saline enema is safe and effective in the conservative treatment of gastrointestinal ascariasis. " 09/01/1999 - "Hypertonic saline enema in gastrointestinal ascariasis."
3.	Drug Therapy (Chemotherapy) 07/14/2014 - "suum, knowledge about the parasite/host relationship in porcine ascariasis at the molecular level is scarce and chemotherapy is the only effective option for parasite control. " 06/01/2012 - "Chemotherapy-based control of ascariasis and hookworm in highly endemic areas of China: field observations and a modeling analysis." 05/01/2003 - "In areas where ascariasis is common, the directly attributable benefits of chemotherapy may be minimal, but it can facilitate the entry of other health care programmes in children, because deworming for ascariasis is often much desired and appreciated by the community. " 01/01/2002 - "Evaluation of two years of mass chemotherapy against ascariasis in Hamadan, Islamic Republic of Iran." 02/01/2001 - "Pharmacotherapy of ascariasis."
4.	Cholecystectomy 09/01/2010 - "We present a very rare manifestation of ascariasis in which the worms came out through the T-tube tract of a 36 years old patient who had undergone cholecystectomy with choledocholithotomy." 04/01/2009 - "In endemic countries, ascariasis should be suspected in patients with biliary disease, especially if a cholecystectomy or sphincterotomy has been performed in the past. " 09/24/2004 - "[Biliary ascariasis after cholecystectomy and papillotomy in a non-endemic area]." 03/01/2004 - "A case of ascariasis of the common bile duct in the postoperative period of cholecystectomy and choledocholithotomy with T-tube drainage is reported. " 01/01/2004 - "Routine deworming of patients undergoing cholecystectomy both preoperatively and postoperatively should be done in all patients in endemic areas of ascariasis. "
5.	Laparoscopic Cholecystectomy 01/01/1999 - "We report a case of biliary ascariasis which was detected fortuitously during a routine intraoperative cholangiography following laparoscopic cholecystectomy. " 02/01/1993 - "Laparoscopic cholecystectomy for gallbladder ascariasis." 10/01/2008 - "We are reporting a case of gall bladder ascariasis causing acute cholecystitis treated by laparoscopic cholecystectomy. "