Asbestosis

A form of pneumoconiosis caused by inhalation of asbestos fibers which elicit potent inflammatory responses in the parenchyma of the lung. The disease is characterized by interstitial fibrosis of the lung, varying from scattered sites to extensive scarring of the alveolar interstitium.

Also Known As:

Networked: 933 relevant articles (15 outcomes, 99 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Pulmonary Fibrosis (Hamman Rich Syndrome)
2.	Silicosis
3.	Pneumoconiosis
4.	Interstitial Lung Diseases (Interstitial Lung Disease)
5.	Inflammation

Experts

1.	Kamp, David W: 10 articles (05/2015 - 05/2002)
2.	Kishimoto, Takumi: 9 articles (02/2014 - 10/2006)
3.	Mossman, Brooke T: 8 articles (03/2015 - 03/2003)
4.	Schneider, Joachim: 8 articles (04/2014 - 07/2007)
5.	Yates, Deborah H: 7 articles (12/2014 - 05/2006)
6.	Otsuki, Takemi: 7 articles (05/2013 - 10/2006)
7.	Maeda, Megumi: 7 articles (05/2013 - 10/2006)
8.	Nishimura, Yasumitsu: 7 articles (05/2013 - 10/2006)
9.	Hayashi, Hiroaki: 6 articles (01/2012 - 10/2006)
10.	Karjalainen, Antti: 6 articles (03/2011 - 02/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Asbestosis:

1.	AsbestosIBA 03/01/2010 - "Asbestosis represents a significant respiratory problem despite the improvement in the workplace hygiene and a decrease in use of asbestos. " 06/01/1989 - "Significantly greater numbers of BAL neutrophils were also found in asbestos-exposed workers without asbestosis than in either smoking or nonsmoking control subjects. " 01/01/2009 - "The radiographic gold-standard for diagnosis of asbestosis has been the plain chest radiograph, and in many asbestosis-screening clinics, chest radiograph abnormalities in conjunction with a history of asbestos exposure have been the mainstay of diagnosis. " 01/01/2011 - "First, the narrow definition of asbestosis forged by medical experts in interwar Britain helped shape a public perception of the asbestos issue as finite and controllable. " 07/01/1985 - "Bronchoalveolar lavage and clearance of 99m-Tc-DTPA in asbestos workers without evidence of asbestosis."
2.	OxygenIBA 03/01/2003 - "Radiographic (ILO) readings predict arterial oxygen desaturation during exercise in subjects with asbestosis." 05/01/1989 - "In 30 males of a mean age 45.6 years suspected of asbestosis the author compared maximal oxygen consumption symptom limited, ventilation during consumption of oxygen (1 L per min) VE1.0 pulse rate on this level (HR1.0) and respiratory volume during ventilation 30 L X min.-1 (VT30) registered during exercise tests with an increasing load of 30 W every 3 minutes (group A) and 15 W every 1 minute (group B). " 01/01/1989 - "The asbestosis and diffuse pleural thickening groups showed significant oxygen desaturation on exertion, confirming that both these conditions give rise to appreciable respiratory disability." 05/01/1994 - "In fact, among study subjects without asbestosis, significant decreases in gas exchange (higher VD/VT and increased alveolar-arterial oxygen pressure difference) were observed at maximal exercise among subjects with pleural fibrosis. " 09/01/1988 - "The impairment of lung function in the two disorders has been compared in more detail in 29 patients with asbestosis and 25 with fibrosing alveolitis, arterial oxygen desaturation during exercise being used to define the severity of the disorders. "
3.	CollagenIBA 01/01/1997 - "Asbestosis is characterized by increased collagen deposition along the walls of terminal respiratory bronchioles that extends into the alveolar ducts and septae. " 07/01/2004 - "Although autoimmune serological abnormalities are common in asbestosis, clinical autoimmune/collagen vascular diseases are not commonly reported. " 09/01/1999 - "Markers of collagen metabolism may possibly be used in the assessment of pulmonary involvement in asbestosis-related pulmonary diseases. " 09/01/1989 - "Neutrophil predominant disorders are seen in idiopathic pulmonary fibrosis, asbestosis and collagen vascular disorders. " 02/01/2010 - "The diagnosis of idiopathic pulmonary fibrosis is based on the CT or pathologic criteria of usual interstitial pneumonia, in the absence of asbestosis, chronic hypersensitive pneumonitis, and collagen vascular disease. "
4.	Biological Markers (Surrogate Marker)IBA 03/01/2011 - "To identify biomarkers for cancer in asbestosis patients. " 03/01/2011 - "Proteomic detection of cancer in asbestosis patients using SELDI-TOF discovered serum protein biomarkers." 01/01/2007 - "The serum marker was analysed in 109 healthy subjects never exposed to asbestos, 26 healthy subjects exposed to asbestos, 33 patients with asbestosis, 33 with asbestos-related pleural plaques, 10 with non-malignant pleural diseases, 30 with lung cancer and 24 with histological diagnosis of pleural mesothelioma. " 03/01/2011 - "We identified two Kinesin proteins that can be potentially used as blood biomarkers to identify asbestosis patients at risk of developing lung cancer." 06/01/2012 - "To screen differently expressed proteins for serum biomarkers by studying serum proteome of population with asbestosis, population exposed to asbestos without asbestosis and population never exposed to asbestos, to further understand the mechanisms of asbestosis. "
5.	GalliumIBA 05/01/1993 - "While only 21% of the subjects satisfied commonly accepted criteria for the diagnosis of asbestosis, 75% had evidence of disease by both HRCT and gallium scanning. " 05/01/1993 - "A diagnostic approach to asbestosis, utilizing clinical criteria, high resolution computed tomography, and gallium scanning." 08/01/1981 - "However, in view of the reports of abnormal gallium accumulation, and occasional elevation of SACE activity in silicosis, asbestosis and miliary tuberculosis, it is still necessary to require histological evidence of noncaseating granuloma to confirm the diagnosis of sarcoidosis." 01/01/1985 - "To analyze the clinical features of asbestos-induced alveolitis and stage its activity, we evaluated 217 asbestos workers by the usual clinical, radiological, and functional parameters and computerized gallium 67(Ga) lung scan; we obtained bronchoalveolar lavage (BAL) in 33 and lung biopsy in 6. In addition, we scored the profusion of lung rales and correlated it with other parameters of severity of asbestosis. " 12/31/1991 - "Improved imaging techniques may assist in the diagnosis of early asbestosis, such as could occur from "asbestos in place." These include (1) increased visualization of visceral pleural thickening, (2) high-resolution computed tomography (HRCT), and (3) gallium scanning, combined with evidence of serum markers indicating inflammation-associated pulmonary collagen formation. "
6.	Antineutrophil Cytoplasmic Antibodies (ANCA)IBA 06/01/2004 - "As the interstitial pneumonia improved after this treatment, the correct diagnosis may have been, not asbestosis, but MPO-ANCA-related interstitial pneumonia." 07/01/2004 - "A case of pulmonary asbestosis complicated by perinuclear-antineutrophil cytoplasmic antibody (myeloperoxidase) positive probable microscopic polyangiitis (glomerulonephritis, pericarditis, alveolitis, multineuritis multiplex) is described and the possible immunological mechanisms whereby asbestosis fibres might be relevant in induction of antineutrophil cytoplasmic antibodies are reviewed in the present report." 10/01/2003 - "The influence of asbestos appears stronger than that of silica because ANCA positivity was found among subjects who had histories of exposure to asbestos but who did not exhibit typical radiographic signs of asbestosis on their chest x-rays. "
7.	Leukotriene B4IBA 06/01/1989 - "Cell-free BAL supernatants from asbestos-exposed patients with or without asbestosis also contained significantly greater amounts of LTB4 than did those from control subjects, indicating enhanced in vivo production of this inflammatory mediator.(ABSTRACT TRUNCATED AT 250 WORDS)" 07/01/2007 - "Patients with asbestosis have an increased alveolar NO concentration and high levels of leukotriene B4 and 8-isoprostane in exhaled breath. " 07/01/2007 - "Exhaled NO and inflammatory markers (leukotriene B(4) and 8-isoprostane) in exhaled breath condensate were measured in 15 non-smoking patients with asbestosis and in 15 healthy controls. " 06/01/1989 - "For example, basal, unstimulated LTB4 production was 3.1 +/- 0.8 ng/10(6) alveolar macrophages for patients with asbestosis, 1.05 +/- 0.2 ng/10(6) cells in asbestos workers without asbestosis, 0.9 +/- 0.2 ng/10(6) cells in control nonsmokers, and 0.2 +/- 0.05 ng/10(6) cells in control smokers. " 07/01/2007 - "Increased alveolar nitric oxide concentration and high levels of leukotriene B(4) and 8-isoprostane in exhaled breath condensate in patients with asbestosis."
8.	P-2 (P 2)IBA 06/01/1993 - "The most frequent densities were significantly greater in the advanced asbestosis group (-567 HU) when compared with both the early asbestosis group (-719 HU; p = 2 x 10(-6)), and controls (-799 HU; p = 0), and they also discriminated significantly between the early asbestosis group and controls (p = 0.0002). " 01/01/2007 - "Asbestosis, s/s, p/p, 2/2. Pleural asbestosis. "
9.	Reducing AgentsIBA 08/01/1986 - "Various reducing agents, metals, asbestoses, polyphenols, aminophenols, and X-ray were effective for hydroxylation, and an oxygen radical seems to be the reactive species. "
10.	Serum AlbuminIBA 11/01/1985 - "The mean BAL:serum albumin ratio in patients with asbestosis was 2.3 X 10(-3) (range, 0.2 to 9.5 X 10(-3), significantly greater than the ratio of 1.2 X 10(-3) (0.5 to 2.0 X 10(-3] in control subjects (p less than 0.02). " 11/01/1985 - "The t1/2LB was significantly shorter in both smokers and nonsmokers with asbestosis, compared with 31 normal nonsmoking controls, but there were no relationships between t1/2LB and BAL:serum albumin ratio or any other BAL protein levels in either smokers or nonsmokers with asbestosis."

Therapies and Procedures

1.	Gamma Cameras (Gamma Camera) 01/01/1985 - "The half-time clearance of an inhaled aerosol of 99m-technetium-labelled diethylene triamine pentacetate from lung to blood (T1/2LB) was measured using a gamma camera in 20 non-smoking subjects (mean age 54, range 40-69 years) with previous occupational asbestos exposure, but no clinical or radiological evidence of asbestosis, and 20 non-smoking normal subjects (mean age 54, range 40-62). "
2.	Exercise Therapy (Therapy, Exercise) 03/01/2010 - "The aim of this study was to evaluate the effects of an outpatient medical rehabilitation (OMR) mainly composed of exercise therapy and sports for patients with asbestosis. " 02/01/2010 - "The aim of this study was to evaluate the effects of outpatient medical rehabilitation (OMR) mainly composed of exercise therapy and sports for patients with asbestosis. "
3.	X-Ray Film 10/01/1989 - "X-ray films and asbestosis." 02/08/1969 - "In the first 100 of a series of 600 consecutive necropsies for which a chest x-ray film had been taken within a year of death the features of asbestosis were observed in eight of the nine cases where the asbestos count at subsequent necropsy exceeded 40. " 12/31/1991 - "6. The health care program focuses on the identification of asbestosis and asbestos-related cancer through periodic X-ray films, lung function tests, and electrocardiographic and physical examination screening. " 04/01/1991 - "In this population, excess risk of lung cancer was restricted to workers with x ray film evidence of asbestosis, a finding consistent with the view that asbestos is a lung carcinogen because of its fibrogenicity." 02/01/1992 - "The following signs of asbestosis and asbestos-related pleural disease were observed in the chest X-ray film: small opacities in the lower zones of both lungs, diffuse pleural thickening, a plaque on the right diaphragm, and small bilateral pleural effusions. "
4.	Thoracoscopes 09/01/1975 - "Biopsy via the pleuroscope was unsuccessful in two patients, one with pleural fibrosis, probably related to asbestosis, and one with mesothelioma. "
5.	Lung Transplantation 02/01/1994 - "Not only due to lack of donors single-lung transplantation has developed to be the favorite treatment for patients with interstitial lung disease (idiopathic, sarcoidosis, asbestosis etc.) and even for pulmonary hypertension unless irreversible damage to the myocardium is present. "