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Infectious Arthritis (Septic Arthritis)

Subscribe to New Research on Infectious Arthritis

Arthritis caused by BACTERIA; RICKETTSIA; MYCOPLASMA; VIRUSES; FUNGI; or PARASITES.

Also Known As:

Septic Arthritis; Suppurative Arthritis; Arthritis, Infectious; Arthritides, Bacterial; Bacterial Arthritides; Bacterial Arthritis; Arthritides, Infectious; Arthritides, Septic; Arthritides, Suppurative; Arthritides, Viral; Arthritis, Suppurative; Infectious Arthritides; Septic Arthritides; Suppurative Arthritides; Viral Arthritides; Viral Arthritis; Arthritis, Bacterial; Arthritis, Septic; Arthritis, Viral

Networked: 1107 relevant articles (51 outcomes, 65 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Osteomyelitis
2.	Infection
3.	Abscess
4.	Inflammation
5.	Neoplasms (Cancer)

Experts

1.	Josefsson, Elisabet: 10 articles (10/2015 - 02/2004)
2.	Tarkowski, Andrej: 9 articles (05/2010 - 05/2002)
3.	Tarkowski, Andrzej: 9 articles (11/2007 - 03/2002)
4.	Jonsson, Ing-Marie: 7 articles (05/2010 - 05/2002)
5.	Tarkowski, A: 6 articles (10/2003 - 02/2000)
6.	Jin, Tao: 4 articles (10/2015 - 05/2010)
7.	Bishayi, Biswadev: 4 articles (07/2015 - 08/2011)
8.	Tanaka, Masamitsu: 4 articles (05/2013 - 03/2011)
9.	Hamblin, Michael R: 4 articles (05/2013 - 03/2011)
10.	Morimoto, Yuji: 4 articles (05/2013 - 03/2011)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Infectious Arthritis:

1.	Anti-Bacterial Agents (Antibiotics)IBA 09/01/2014 - "The first-line class of antibiotics remains the appropriate antibiotic choice for these patients because they are still effective for treatment of septic arthritis in up to 70% of all cases." 12/01/2006 - "Four patients developed pin track discharges and there was one case of septic arthritis of the knee joint which was cured after arthrotomy for wash-out and adapted antibiotics. " 09/01/2014 - "The present study will investigate the incidence of culture-negative septic arthritis and the outcomes based on the use of first-line drug antibiotics for the treatment of sub-acute and chronic septic arthritis. " 01/01/2014 - "The aim of this study is to highlight the importance of early diagnosis in suspected cases of septic arthritis of sterno-clavicular joint and institution of intravenous antibiotics. " 07/01/2012 - " This study demonstrated how the management of patients with suspected cases of septic arthritis of the knee may be compromised by empirical administration of antibiotics. "
2.	Dexamethasone (Maxidex)FDA LinkGeneric 09/01/2014 - "In this study, the effect of intravenous dexamethasone on septic arthritis, and the recovery process of the disease have been evaluated. " 03/01/2011 - "Dexamethasone therapy for septic arthritis in children: results of a randomized double-blind placebo-controlled study." 10/01/2003 - "Double blind, randomized, placebo-controlled study of dexamethasone therapy for hematogenous septic arthritis in children." 10/01/2015 - "Prospective studies of children with septic arthritis report that adding dexamethasone to antibiotic therapy contributes significantly to clinical and laboratory improvement. " 10/01/2015 - "Dexamethasone Therapy for Septic Arthritis in Children."
3.	DNA (Deoxyribonucleic Acid)IBA 06/01/2009 - "kingae real-time PCR applied to DNA extracted from joint fluid samples, but not from blood samples, markedly improved the etiological diagnosis of septic arthritis in children. " 11/01/2009 - "In this study, we analyzed the putative diagnostic value of synovial cf-DNA/NETs for identification of septic arthritis. " 11/01/2009 - "Diagnostic accuracy of neutrophil-derived circulating free DNA (cf-DNA/NETs) for septic arthritis." 10/01/2007 - "Indeed, PCR represents an undeniable benefice for the diagnosis of paediatric septic arthritis, particularly for the DNA detection of K. " 01/01/2007 - "We could detect DNA from various bacterial pathogens including fastidious bacteria (Kingella kingae, Streptococcus pneumoniae, Streptococcus pyogenes, Salmonella spp, Staphylococcus aureus) from 23% of cases of septic arthritis giving negative culture results. "
4.	Penicillin G (Benzylpenicillin)FDA LinkGeneric 04/01/1993 - "Her suppurative arthritis gradually improved by treatment with penicillin G. " 10/01/1983 - "Despite exquisite in vitro sensitivity of group G streptococci to penicillin G, the in vivo clinical response was disappointing in six of nine patients with either endocarditis or septic arthritis. " 11/01/1981 - "This report describes a patient with group B streptococcal (GBS) bacteremia with pyelonephritis and septic arthritis whose condition failed to improve after two weeks of therapy with penicillin G sodium. " 02/01/1992 - "Hematogenous infections (in this case septic arthritis) by Streptococcus bovis may present in patients without gastrointestinal diseases or endocarditis, possibly have a low damage to skeletal structures and respond adequately to conventional treatment with penicillin G." 09/01/1995 - "In vivo efficacy of azithromycin in treatment of systemic infection and septic arthritis induced by type IV group B Streptococcus strains in mice: comparative study with erythromycin and penicillin G."
5.	Doxycycline (Vibramycin)FDA LinkGeneric 02/01/2008 - "In vitro cell compatibility and antibacterial activity of microencapsulated doxycycline designed for improved localized therapy of septic arthritis." 10/01/2012 - "We report the first case of Kytococcus schroeteri implant-related septic arthritis and osteomyelitis, identified by phenotypic tests and 16S rRNA sequencing, which responded to implant removal and doxycycline. " 06/22/1991 - "A 37-year-old patient had fever, diffuse maculopapular rash and acute suppurative arthritis of both knees, which was totally cured with doxycycline without sequelae. " 06/01/1991 - "In addition to general measures for septic arthritis, antibiotic therapy using a combination of intravenous cotrimoxazole, doxycycline, and chloramphenicol was generally satisfactory. " 03/01/1999 - "A case of septic arthritis caused by Corynebacterium amycolatum in a native hip joint occurred in an adult man following contralateral vascular graft sepsis, and was successfully treated with intravenous vancomycin followed by oral doxycycline and rifampicin. "
6.	Ciprofloxacin (Cipro)FDA LinkGeneric 10/01/1985 - "We investigated the in vivo efficacy of ciprofloxacin in a rabbit model of septic arthritis due to Escherichia coli. " 08/01/1993 - "The role of ciprofloxacin in septic arthritis caused by Gram-negative bacilli is also reviewed." 07/01/1986 - "Ciprofloxacin was compared with ceftriaxone in a rabbit model of septic arthritis caused by Escherichia coli. " 04/27/1987 - "The antibacterial efficacy of some of the newer quinolone antimicrobial agents in general, and ciprofloxacin in particular, in animal models of experimental septic arthritis, burn wound sepsis, empyema, chronic gastroenteritis, granuloma pouch infection, intraabdominal abscess, osteomyelitis, prostatis, sinusitis, urinary tract infection, and severe septicemia caused by Pseudomonas aeruginosa is reviewed. " 08/01/2014 - "Septic arthritis of the hip in a Cambodian child caused by multidrug-resistant Salmonella enterica serovar Typhi with intermediate susceptibility to ciprofloxacin treated with ceftriaxone and azithromycin."
7.	1-phenyl-3,3-dimethyltriazene (PDT)IBA 04/01/2008 - "These findings indicate that PDT using Na-Phde a caused minimal but reversible changes in joint tissue, suggesting that it would be a safe and useful treatment for bacterial septic arthritis." 03/01/2011 - "Recently, as a new clinical approach against septic arthritis, an experimental in vivo and in vitro model for the inactivation of methicillin-resistant-Staphylococcus aureus by PDT using Na-Phde a has been developed. " 12/01/2009 - "Recently, as a new clinical approach against septic arthritis, an experimental in vivo and in vitro model for the inactivation of MRSA by PDT using the photosensitizer Na-Phde a has been developed. " 12/01/2009 - "These findings indicated that PDT using Na-Phde a could be a useful treatment for septic arthritis and soft tissue infection." 07/01/2012 - "We used bioluminescence imaging to noninvasively monitor murine bacterial arthritis and found that PDT with intra-articular methylene blue was not only effective, but when used before infection, could protect the mice against a subsequent bacterial challenge. "
8.	C-Reactive ProteinIBA 04/01/2011 - "Previous studies in post-operative orthopedic and pediatric patients suggest that erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) testing may be helpful in ruling out septic arthritis. " 06/01/2006 - "In our study group, a C-reactive protein level of >2.0 mg/dL (>20 mg/L) was a strong independent risk factor and a valuable tool for assessing and diagnosing children suspected of having septic arthritis of the hip." 06/01/2006 - "This study differs from previous work in three ways: data were collected prospectively, C-reactive protein levels were recorded, and the focus was on children in whom the findings were so suspicious for septic arthritis that hip aspiration was performed. " 05/01/2003 - "The purpose of this study was to determine the test characteristics of C-reactive protein (CRP) in the diagnosis of septic arthritis in children and to compare with erythrocyte sedimentation rate (ESR). " 11/15/2015 - "Septic arthritis of the hip should be suspected in a child with an oral temperature more than 101.3°F (38.5°C), refusal to bear weight, erythrocyte sedimentation rate more than 40 mm per hour, peripheral white blood cell count more than 12,000 per mm3 (12 × 109 per L), or C-reactive protein level more than 20 mg per L (180.96 nmol per L). "
9.	Adrenal Cortex Hormones (Corticosteroids)IBA 03/01/1996 - "Further study is needed to prove safety and efficacy of corticosteroids before recommending their clinical use in the treatment of septic arthritis." 01/01/2015 - "This study therefore set out to review current literature with regards to a possible beneficial effect for corticosteroids in Septic Arthritis. " 01/01/2015 - "A computerised search of the databases MEDLINE and CINAHL was conducted during November 2014 using the EBSCOhost web search engine in order to identify research articles relating to the use of corticosteroids in the treatment of septic arthritis. " 01/01/2015 - "A systematic review and meta-analysis regarding the use of corticosteroids in septic arthritis." 03/01/2000 - "Intra-articular corticosteroids in septic arthritis: beneficial or barmy?"
10.	Lactic Acid FDA LinkGeneric 04/01/1982 - "The results of lactic acid estimation on sequential samples were helpful in assessing the response of septic arthritis to treatment." 08/01/2008 - "The aim of this study was to differentiate septic from non-septic arthritis by measuring lactate concentration with (1)H magnetic resonance spectroscopy (HMRS) and by estimating total protein content with the assessment of T (2) values. " 06/01/2015 - "Synovial lactate levels > 10 mmol/l or an SFWBC > 50 × 10(3)/μl substantially increased disease probability, while SFWBC < 1.0 × 10(3)/μl or CRPS < 0.5 mg/dl diminished the post-test probability of septic arthritis considerably. " 06/01/2015 - "The SFWBC, CRPS, %PMN and synovial lactate were the best inflammatory markers in predicting septic arthritis. " 01/01/2015 - "Lactate concentration was found to be a useful predictor of septic arthritis, with a low concentration pointing towards exclusion rather than a high concentration to the diagnosis of septic arthritis. "

Therapies and Procedures

1.	Debridement 03/01/2015 - "Arthroscopic debridement combined with infusion-drainage is effective in septic arthritis after arthroscopic anterior cruciate ligament reconstruction." 04/01/2014 - "Arthroscopic lavage and debridement is a safe and effective procedure for septic arthritis of the hip joint." 01/01/2016 - "The gold standard for treatment of septic arthritis is urgent surgical debridement. " 01/01/2013 - "The gold standard treatment of septic arthritis is joint debridement, antibiotic therapy according to the culture results, and physiotherapy, which should start in the early postoperative period to prevent limitation of motion. " 03/01/2005 - "To evaluate the efficacy of a treatment protocol including arthroscopic irrigation and debridement in resolving acute periprosthetic septic arthritis of the knee. "
2.	Arthroplasty 05/01/1987 - "This patient's disease course shows that gram-negative septic arthritis, effectively treated, does not preclude successful total joint arthroplasty." 01/01/2011 - "This study presents the medium-term results of a new, standardized two-stage arthroplasty with preformed hip spacers and cementless implants in a consecutive series of adult patients with septic arthritis of the hip treated according to a same protocol. " 12/01/2010 - "The aim of the present study was to analyze the results of arthroplasties after septic arthritis of native knee and hip joints, in terms of functional results and infection control and to seek eventual risk factors of failure. " 05/01/1987 - "Successful joint arthroplasty following Proteus morganii (Morganella morganii) septic arthritis: a four-year study." 06/01/2014 - "Seven shoulders in as many patients were treated for infected arthroplasty or septic arthritis without previous surgery. "
3.	Transplants (Transplant) 06/01/2014 - "Arthroscopic I & D with graft retention is an effective treatment for patients with septic arthritis after ACL reconstruction. " 08/01/2005 - "This cultured MSC and IP-CHA hybrid material transplant represents a novel treatment for a severe osteochondral defect after septic arthritis." 06/01/2014 - "The purpose of the study was to determine the incidence of septic arthritis after primary ACL reconstruction with hamstring auto-graft and the risk factors that may be associated. " 12/01/2015 - "Septic Arthritis After Arthroscopic Anterior Cruciate Ligament Reconstruction: Evaluation of an Arthroscopic Graft-Retaining Treatment Protocol." 07/01/2015 - "Functional Outcome and Graft Retention in Patients With Septic Arthritis After Anterior Cruciate Ligament Reconstruction: A Systematic Review."
4.	Catheters 01/01/1990 - "Our experience suggests that suppurative arthritis can be successfully treated with drainage of the joint via a percutaneous catheter in combination with antibiotic therapy." 01/01/2015 - "Sternoclavicular septic arthritis due to methicillin-resistant Staphylococcus aureus in a patient with a suprapubic catheter." 01/01/2008 - "We report a rare case of bilateral sternoclavicular joint septic arthritis in an elderly patient secondary to an indwelling right subclavian vein catheter. " 01/01/2008 - "Bilateral sternoclavicular joint septic arthritis secondary to indwelling central venous catheter: a case report." 04/01/2003 - "An old lady having septic arthritis of right knee joint underwent arthrotomy under three in one block for femoral, obturator and lateral cutaneous nerve of thigh in inguinal region, with catheter in situ. "
5.	Drug Therapy (Chemotherapy) 01/01/2009 - "A bistrategical approach with surgical drainage and frequent retesting and antimicrobial chemotherapy may lead to a good result in the treatment of pneumococcal septic arthritis." 03/01/1997 - "The case of a 77-year-old woman with acute myeloid leukemia who developed Candida tropicalis septic arthritis of the knee after remission-inducing chemotherapy is reported. " 01/01/2014 - "Septic and gouty arthritis show the same clinical symptoms, but septic arthritis is an orthopedic emergency and needs immediate surgical intervention, whereas a systemic drug therapy is needed in acute gouty arthritis. " 03/01/1988 - "A 26-year-old man with acute leukemia, treated with chemotherapy, developed emphysematous septic arthritis, due to Streptococcus milleri, affecting the right knee and both shoulders. " 08/01/2015 - "In this article, we present a three-year-old child patient with elbow septic arthritis related to acute leukemia, diagnosed promptly by bone marrow aspiration on the same day as emergency surgical debridement of the septic elbow joint due to the maintenance of a high index of suspicion, and treated with chemotherapy as soon as possible. "