Arterial Occlusive Diseases (Arterial Occlusive Disease)

Pathological processes which result in the partial or complete obstruction of ARTERIES. They are characterized by greatly reduced or absence of blood flow through these vessels. They are also known as arterial insufficiency.

Also Known As:

Arterial Occlusive Disease; Arterial Obstructive Disease; Arterial Occlusions; Disease, Arterial Obstructive; Disease, Arterial Occlusive; Obstructive Disease, Arterial; Occlusion, Arterial; Occlusive Disease, Arterial; Arterial Obstructive Diseases; Arterial Occlusion

Networked: 3346 relevant articles (162 outcomes, 300 trials/studies)

Relationship Network

Disease Context: Research Results

Cardiovascular Diseases: 91362
- Vascular Diseases: 15138
  - Arterial Occlusive Diseases: 3346

Related Diseases

1.	Ischemic Stroke
2.	Ischemia
3.	Stroke (Strokes)
4.	Thrombosis (Thrombus)
5.	Myocardial Infarction

Experts

1.	Buising, Charisse M: 10 articles (04/2019 - 05/2013)
2.	Wall, Piper L: 10 articles (04/2019 - 05/2013)
3.	Liebeskind, David S: 10 articles (01/2018 - 12/2002)
4.	Zuo, Zhiyi: 9 articles (12/2020 - 05/2004)
5.	Demchuk, Andrew M: 8 articles (01/2022 - 04/2005)
6.	Sahr, Sheryl M: 8 articles (01/2019 - 05/2013)
7.	Ouriel, Kenneth: 8 articles (06/2006 - 01/2002)
8.	Nogueira, Raul G: 7 articles (11/2021 - 04/2008)
9.	Alexandrov, Andrei V: 7 articles (01/2020 - 08/2008)
10.	Hill, Michael D: 6 articles (01/2022 - 04/2005)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Arterial Occlusive Diseases:

1.	Tissue Plasminogen Activator (Alteplase)FDA Link 01/01/2010 - "Intravenous tissue plasminogen activator thrombolysis in patients without major arterial occlusion seems to be safe and effective." 11/02/2017 - "Patients were randomized using a real-time, dynamic, Internet-based, minimal sufficient balance randomization method that balanced the study arms with respect to baseline covariates including age, sex, baseline NIHSS score, site of arterial occlusion, baseline ASPECTS score and treatment with intravenously administered alteplase. " 11/02/2017 - "Permutation-based tests of group differences confirmed group balance across several baseline covariates including sex (p = 1.00), baseline NIHSS score (p = 0.95), site of arterial occlusion (p = 1.00), baseline ASPECTS score (p = 0.28), treatment with intravenously administered alteplase (p = 0.31), and age (p = 0.67). " 09/01/2016 - "Up to 313 patients from CLOTBUST data bank with demonstrable intracranial arterial occlusion and having received intravenous recombinant tissue plasminogen activator (rt-PA) were included. " 08/01/2015 - "Restricting recombinant tissue Plasminogen Activator use to patients with evidence of still salvageable tissue, or with definite arterial occlusion, might help reduce risk, increase benefit and identify patients for treatment at late time windows. "
2.	Streptokinase FDA Link 12/19/2013 - "There is some evidence to suggest that intra-arterial rt-PA is more effective than intra-arterial streptokinase or intravenous rt-PA in improving vessel patency in people with peripheral arterial occlusion. " 03/17/2010 - "There is some evidence to suggest that intra-arterial rt-PA is more effective than intra-arterial streptokinase or intravenous rt-PA in improving vessel patency in people with peripheral arterial occlusion. " 09/01/1988 - "A retrospective study of the efficacy of local low-dose intraarterial streptokinase for the treatment of peripheral arterial occlusion was performed in 60 cases. " 01/15/1999 - "In a prospective randomized study two groups of patients with acute and subacute arterial occlusions of the lower limbs (Stage III, IV) were treated with a continuous infusion of local low dose of streptokinase (SK). " 03/01/1986 - "The purpose of this study was to examine the role of low-dose streptokinase in arterial occlusion. "
3.	Fibrinolytic Agents (Antithrombotic Agents)IBA 06/01/1993 - "Systemic thrombolysis yields the best results in recent arterial occlusions, while local intrathrombotic infusion of thrombolytic agents is also effective in chronic occlusions. " 08/15/2017 - "We provide evidence that NAC is an effective and safe alternative to currently available antithrombotic agents to restore vessel patency after arterial occlusion." 12/19/2013 - "RCTs comparing fibrinolytic agents to treat peripheral arterial occlusion. " 12/19/2013 - "Fibrinolytic agents for peripheral arterial occlusion." 03/17/2010 - "RCTs comparing fibrinolytic agents to treat peripheral arterial occlusion. "
4.	Retinaldehyde (Retinal)IBA 04/01/2023 - "Authors intended to find out the prevalence of retinal arterial occlusion and its association with vascular embolic occlusion elsewhere in the body among CAM patients in this study. " 12/01/2007 - "OCT measurements of the macular/peripapillary RNFL thickness provide useful indicators to reflect the severity of the disease in retinal arterial occlusion and serve as a new paradigm to study and monitor the disease longitudinally." 08/01/1999 - "The aim of our study was to evaluate the causes of retinal arterial occlusive disease in African American patients and to compare these etiologies with those observed in Caucasian patients with retinal ischemic symptoms. " 01/01/1991 - "Venous retinal obstructions with only 16% positive findings did not show any correlation with arterial occlusive disease of extracranial vessels based on demographic aspects and clinicopathological studies. " 01/01/1981 - "Previous studies have suggested an association between hyperlipidaemia and retinal venous and arterial occlusion. "
5.	Urokinase-Type Plasminogen Activator (Urokinase)FDA Link 01/01/2006 - "The literature was systematically searched to identify prospective comparative trials of urokinase and rt-PA for the treatment of peripheral arterial occlusion. " 08/01/2004 - "The English-language literature between 1985 and 2002 was searched for studies that used tissue-derived urokinase or rtPA in the treatment of peripheral arterial occlusions. " 08/01/1998 - "The Thrombolysis or Peripheral Arterial Surgery Trial of intraarterial recombinant urokinase or immediate operation for acute lower extremity arterial occlusion provided data on 544 patients randomized at 113 centers. " 06/01/1994 - "This study evaluates the potential of intraarterial urokinase infusion to provide clinical benefits in patients with acute peripheral arterial occlusion. " 10/15/1987 - "In this study, we successfully performed local thrombolysis in 6 patients with peripheral arterial occlusions by using a novel high-molecular-weight urokinase. "
6.	Alprostadil (Muse)FDA LinkGeneric 01/01/1989 - "The study also demonstrated that PGE1 is more effective in the treatment of severe arterial occlusive disease than PX. " 08/23/1985 - "These findings substantiate the view that PGE1 is also effective when applied intravenously distal from the arterial occlusion." 01/01/1985 - "These results suggested that the favourable features of lipo PGE1 depended on protection against inactivation in the lung and its targeting effect to tissues injured by arterial occlusion." 02/01/2003 - "In this study, we measured serum levels of MCP-1 in patients with peripheral arterial obstructive disease (PAOD) and investigated whether intravenous prostaglandin E1 (PGE1) treatment, which produces clinical benefits in PAOD, might decrease such levels. " 01/01/1991 - "[Placebo controlled study of the effect of intravenous PGE1 on macro- and microcirculation in patients with stage III/IV arterial occlusive disease]."
7.	Platelet Aggregation Inhibitors (Antiplatelet Drugs)IBA 01/01/2016 - "The hyperfunction and activation of platelets have been strongly implicated in the development and recurrence of arterial occlusive disease, and various antiplatelet drugs are used to treat and prevent such diseases. " 01/01/2013 - "Sarpogrelate hydrochloride is an antiplatelet drug, and expected to be useful in the treatment of chronic arterial occlusive diseases. " 11/01/1999 - "Sarpogrelate hydrochloride is an antiplatelet drug, and expected to be useful in the treatment of chronic arterial occlusive diseases. " 01/01/2023 - "Therefore, we herein investigated the relationship between [Ca2+]i and the intensity of platelet aggregation after a thrombin stimulation, the relationship between [Ca2+]i and the intensity of platelet aggregation by antiplatelet agents, and the effects of antiplatelet agents on thrombin-activated platelets as a surrogate platelet model for arterial occlusive disease. " 11/01/2018 - "The use of platelet aggregation tests has also been advocated to monitor the treatment with antiplatelet agents (mostly the P2Y12 antagonist clopidogrel) of patients with thrombotic arterial occlusions, with the aim of improving their efficacy and safety. "
8.	Cilostazol (Pletal)FDA LinkGeneric 03/15/2001 - "Cilostazol, which increases intracellular cAMP in platelets, may be useful in the treatment of arterial occlusive diseases." 01/01/1997 - "This study demonstrates that cilostazol is an effective inhibitor of SIPA, which may be important for the prevention and the treatment of arterial occlusive diseases." 01/01/2023 - "Do Patients With Arterial Occlusive Disease of Different Etiologies Benefit Equally From Cilostazol?" 05/01/2012 - "[Role of cilostazol in the sequential therapeutic spectrum of the peripheral arterial occlusion disease (PAOD)]." 12/01/2000 - "Cilostazol was marketed first in Japan in 1988 and later in seven other countries for the treatment of chronic arterial occlusion. "
9.	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 08/01/2015 - "The key search terms ("aspirin," "PAD," "peripheral arterial occlusive diseases," and "claudication") produced 9 high-quality randomized controlled trials (RCTs) of aspirin versus placebo/control. " 02/01/1989 - "For the prophylaxis of peripheral arterial occlusion with aspirin, a dosage of one to 1.5 gram daily would seem appropriate until studies are available to document the effects of lower dosages.(ABSTRACT TRUNCATED AT 400 WORDS)" 11/01/2004 - "Pretreatment with the new oral NO-releasing aspirin derivative stimulates reparative angiogenesis and prevents apoptosis and oxidative stress, thereby alleviating the consequences of supervening arterial occlusion." 03/01/1994 - "With aspirin, arterial occlusion persisting for 2 hours occurred in 5 of 10 dogs and cyclic occlusion and reflow in 4 animals; arterial occlusion was observed in all dogs at 24 hours. " 01/01/1983 - "AIA and aspirin (10 mg/kg/d X 10, s.c.) had no effect on laurate-induced arterial occlusive disease in rats. "
10.	MetalsIBA 10/01/2017 - "The objective of this study is to perform a noninferiority analysis of DEBs with provisional bare-metal stenting and primary stenting with DESs in the treatment of femoropopliteal arterial occlusive disease. " 01/01/2021 - "Randomized controlled trials of BSV, bypass surgery with prosthetic graft, bare metal stents, endoluminal bypass (covered stent), percutaneous transluminal angioplasty, and DCDs treating femoropopliteal arterial occlusive disease were collected. " 12/01/2011 - "This trial was conducted to determine if covered stents offer a patency advantage over bare-metal stents in the treatment of aortoiliac arterial occlusive disease. " 09/01/2017 - "Evolution of patency rates of self-expandable bare metal stents for endovascular treatment of femoro-popliteal arterial occlusive disease: Does stent design matter?" 09/01/2002 - "From 1987 to 1990, 110 patients (mean age, 57 years) with iliac arterial occlusive disease (Fontaine stage IIa, seven patients; IIb, 95 patients; III, four patients; IV, four patients) underwent implantation of a self-expanding metal stent. "

Therapies and Procedures

1.	Therapeutics 06/01/2001 - "The best therapy for ALI is the one that is instituted early; intervention should be tailored based on the initial clinical presentation, and surgery remains the gold standard with CDT, an adjunctive tool for the vascular surgeon dealing with acute peripheral arterial occlusion (PAO)." 01/01/1990 - "For arterial occlusions of the retina or the optic nerve, no therapy is available so far that has unequivocally proven effective. " 05/01/2016 - "There was a significant reduction of cortical and hemispherical volume and hippocampal area, ipsilateral to arterial occlusion in HI animals; combinational therapy had no effect on these morphological measurements. " 04/01/1993 - "In two of the cases in which therapy was started less than 100 minutes after the acute onset of visual loss and one case in which therapy was started during the course of central arterial occlusion, considerable improvement in visual acuity was observed, while in the fourth case in which therapy was started six hours after the acute onset of visual loss, no improvement appeared. " 01/01/1997 - "[The efficacy of antithrombotic therapy after total obliteration-reversing therapy in atherosclerotic arterial occlusion of the lower extremities]."
2.	Stents 03/01/2008 - "Endovascular stents have proven effective in treating coronary and peripheral arterial occlusions. " 08/01/2003 - "Angioplasty with the Sinus stent seems safe and effective in the treatment of peripheral arterial occlusive diseases, giving excellent results at the iliac and common femoral artery levels. " 10/01/2023 - "Outcomes were equally effective in patients with pre-existing stents or denovo arterial occlusions as evidenced with ankle brachial index improvement from 0.48 pre-to 0.93 postintervention and 0.95 at latest follow-up (P < 0.001). " 04/01/2008 - "Duplex guided balloon angioplasty and stent placement appears to be a safe and effective technique for treatment of femoral-popliteal and infrapopliteal arterial occlusive disease." 03/01/2007 - "-guided balloon angioplasty and stent placement appears to be a safe and effective technique for the treatment of femoral-popliteal and infrapopliteal arterial occlusive disease. "
3.	Thrombectomy 01/01/2018 - "Five recently published relevant clinical trials have demonstrated the efficacy of mechanical thrombectomy in proximal arterial occlusions; all these trials used different imaging techniques to select patients. " 01/01/2023 - "Safety and Efficacy of Rotational Thrombectomy for Treatment of Arterial Occlusions of the Lower Extremities: A Large Single-Center Retrospective Study. " 12/01/2015 - "Mechanical thrombectomy holds promise for children with large cerebral arterial occlusions, although there are few reports in this population. " 11/12/2014 - "Mechanical thrombectomy holds promise for children with large cerebral arterial occlusions, although there are few reports in this population. " 06/01/2001 - "Mechanical thrombectomy as a first-line treatment for arterial occlusion."
4.	Catheters 04/01/2003 - "Although conventional catheter arteriography remains the gold standard for distinguishing total arterial occlusion from hairline residual lumen, CT angiography (CTA) is able to make this distinction noninvasively and more sensitively than either unenhanced MR angiography or ultrasound. " 08/01/2007 - "This study demonstrates that local lysis of acute arterial occlusions using the Lysus Peripheral Catheter System is safe and effective. " 05/01/1980 - "A new improved coil for tapered-tip catheter for arterial occlusion." 11/01/2005 - "The objective of this study was to evaluate the safety and the effectiveness of the Outback catheter for intraluminal re-entry after subintimal dissection in the crossing of chronic arterial occlusions. " 04/01/2005 - "In a randomized, double-blind, controlled study, we compared heparinized and nonheparinized infusions for the maintenance of perioperative arterial catheter patency and the incidence of subsequent radial arterial occlusion. "
5.	Thrombolytic Therapy 03/01/1994 - "The procedure was most effective in patients with smaller arterial occlusions: 7 of 10 patients with MCA branch occlusions (M2 to M4) achieved recanalization compared to only 2 of 10 with distal ICA or M1 occlusions, which should be an important issue for the critical evaluation of the efficacy of thrombolytic therapy (TT). " 06/01/1994 - "These benefits were achieved without an appreciable increase in the duration of hospitalization and with only modest increases in hospital cost, suggesting that thrombolytic therapy may offer a safe and effective alternative to operation in the initial treatment of patients diagnosed with acute limb-threatening peripheral arterial occlusion." 10/29/1982 - "The thrombolytic efficacy of this regimen compares favourably with earlier experience on fibrinolytic therapy in arterial occlusions." 09/01/2012 - "A literature search in Medline, Embase, and the Cochrane database identified case series, observational studies, and treatment arms of randomized trials of anterior circulation arterial occlusion treated with thrombolytic therapy. " 09/01/1999 - "In addition, studies have been published evaluating new drug doses and regimens aimed at broadening the scope of thrombolytic therapy in patients with acute arterial occlusion."