Arsphenamine (Salvarsan)

03/01/1991 - "The Wassermann test was "invented" for serologic diagnosis, and Paul Ehrlich proved that salvarsan, or 606, was effective for the treatment of syphilis. "
10/01/2010 - "The year 2009 marks the centenary of the discovery of the experimental anti-syphilitic activity of Salvarsan and the first clinical studies showing its efficacy against syphilis. "
06/30/1925 - "STUDIES IN EXPERIMENTAL SYPHILIS : III. FURTHER OBSERVATIONS ON THE POSSIBILITY OF CURE OF SYPHILIS IN THE RABBIT WITH ARSPHENAMINE."
06/01/2014 - "The treatment of syphilis with salvarsan."
01/01/2014 - "The first drug, Salvarsan, was developed by Ehrlich using rabbits infected with the organism causing syphilis. "

01/01/1946 - "Salvarsan agranulocytosis cured."
08/19/1955 - "[Early recognition and prevention of salvarsan agranulocytosis]."
02/28/1951 - "[Syndrome of agranulocytosis following arsenobenzol therapy; therapeutic trial of vitamin B12]."
01/01/1950 - "[Salvarsan allergy (ninth-day erythema and agranulocytosis)]."

05/01/1985 - "In 1911 a campaign against yaws, probably the first such campaign in the world involving treatment with salvarsan, was organized. "
01/06/1912 - "SALVARSAN IN YAWS."
08/01/1911 - "2. On experimental and clinical grounds, it appears that yaws can be cured with a smaller dose of salvarsan than is necessary to cure syphilis. "
04/01/1911 - "THE TREATMENT OF YAWS (FRAMBOESIA) WITH ARSENOBENZOL (SALVARSAN)."

03/01/1914 - "THE TREATMENT OF TABES DORSALIS AND GENERAL PARESIS WITH SALVARSAN."
01/01/1996 - "In 1917, spirochaetal neurosyphilis was treated successfully with malariotherapy in combination with salvarsan or bismuth. "
06/01/1991 - "Early neurosyphilis, characterized by meningitis, cranial nerve abnormalities, and cerebrospinal accidents, was first described in patients with syphilis who received inadequate courses of arsphenamine. "
06/01/2001 - "After 1853, Western medicine was rapidly introduced into Japan, and great achievements by Japanese medical doctors soon followed, such as the serum therapy for tetanus, the discovery of the plague and dysentery bacilli, the invention of Salvarsan for the treatment of syphilis, and the demonstration of the neurosyphilis spirochete."

01/01/1990 - "The incidence figures fell rapidly after 1920 and reached a low of less than 30 cases per 100,000 in the mid 1920s, probably as a result of systemic treatment with Salvarsan in conjunction with vigorous contact tracing, two important measures to bring an infectious disease under epidemiological control. "
04/01/2009 - "Paul Ehrlich (1854-1915), a German microbiologist who was awarded a 1908 Nobel Prize in Physiology/Medicine for his pioneer work on the antibody production, pioneered the modern chemotherapy by discovering his magic bullet for syphilis, called "606" or "Salvarsan" in 1909 with a Japanese young scientist, Sahachiro Hata (1873-1938) from "Denken" (Institute for Infectious Diseases, now called IMS for Institute for Medical Sciences) in Tokyo. "
12/10/2013 - "The development of chemical compounds for the treatment of infectious diseases may be divided into three phases: a) the discovery in the 1600s in South America of alkaloid extracts from the bark of the cinchona tree and from the dried root of the ipecacuanha bush, which proved effective against, respectively, malaria (quinine) and amoebic dysentery (emetine); b) the development of synthetic drugs, which mostly took place in Germany, starting with Paul Ehrlich's (1854-1915) discovery of salvarsan (1909), and crowned with Gerhard Domagk's (1895-1964) discovery of the sulfonamides (1930s); and c) the discovery of antibiotics. "