Arsenic

A shiny gray element with atomic symbol As, atomic number 33, and atomic weight 75. It occurs throughout the universe, mostly in the form of metallic arsenides. Most forms are toxic. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), arsenic and certain arsenic compounds have been listed as known carcinogens. (From Merck Index, 11th ed)

Also Known As:

Networked: 5904 relevant articles (169 outcomes, 1047 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Waalkes, Michael P: 69 articles (04/2020 - 02/2002)
2.	Ahsan, Habibul: 68 articles (01/2022 - 07/2003)
3.	Hsueh, Yu-Mei: 67 articles (10/2021 - 04/2002)
4.	Chen, Chien-Jen: 64 articles (12/2021 - 04/2002)
5.	Navas-Acien, Ana: 58 articles (01/2022 - 12/2005)
6.	Chen, Yu: 53 articles (01/2022 - 07/2003)
7.	Smith, Allan H: 49 articles (01/2019 - 05/2002)
8.	Karagas, Margaret R: 48 articles (01/2022 - 03/2002)
9.	Graziano, Joseph H: 48 articles (12/2019 - 07/2003)
10.	Parvez, Faruque: 45 articles (01/2022 - 03/2006)

Related Diseases

1.	Acute Promyelocytic Leukemia 11/01/2018 - "Although arsenic has shown remarkable therapeutic efficacy in patients with acute promyelocytic leukemia (APL), its side effects are rarely reported. " 02/01/2005 - "Arsenic, a natural substance that has been used as a drug for over 2000 years, has been revived because of its remarkable therapeutic efficacy in patients with acute promyelocytic leukemia (APL). " 05/01/2013 - "Although arsenic is effective in the treatment of acute promyelocytic leukemia (APL), as a well-known environmental toxicant, the side effects of arsenic treatment and arsenic methylation metabolism of the patients are rarely reported. " 11/01/2001 - "Arsenic is effective in the treatment of acute promyelocytic leukemia. " 09/15/2000 - "Arsenic has been used effectively as a chemotherapeutic drug for the treatment of acute promyelocytic leukemia patients. "
2.	Neoplasms (Cancer) 01/01/1981 - "The chance to induce cancer by medical treatment in dermatology is considered to be very low since arsenic has been eliminated." 08/03/2009 - "In contrast, inorganic arsenic significantly decreased the incidence of tumors in liver (0%) and adrenal glands (0%) of male mice continuously exposed from gestation through one year, as compared to levels in control (30 and 65%, respectively) and gestation only (33 and 55%, respectively) exposed mice. " 06/01/2006 - "However, a five-year follow-up study showed no more significant improvement of skin lesions, while the potential risk of arsenic-induced cancers after cutting off high-arsenic exposure was still uncertain and indefinite. " 07/01/1976 - "Furthermore, a recent trend has been to consider arsenic as beneficial in cancer prevention and in maintaining the health of farm animals, and, perhaps, humans. " 11/01/2003 - "The paradox of arsenic is that it has also a valuable therapeutic efficacy in cancer treatment. "
3.	Inflammation (Inflammations) 03/15/2022 - "Based on the present findings, arsenic intake appears to cause gastric toxicity via oxidative stress and inflammation, and the application of GSE offers significant protection against arsenic toxicity in a mouse model by attenuating the oxidative stress and inflammatory response. " 01/01/2017 - "Thus, the present study was conducted to investigate the protective effects of EGCG against arsenic-induced inflammation and immunotoxicity in mice. " 01/01/2015 - "In continuation to that the present study has therefore been focused to investigate the protective efficacy of amla in arsenic induced inflammation and immunotoxicity in mice. " 01/01/2022 - "Rosa roxburghii Tratt (RRT), a traditional Chinese edible fruit with potential immunoregulatory activities, was considered as a dietary supplement to explore its protective effects and possible mechanism in arsenic-induced dysregulated inflammation responses. " 01/01/2022 - "Increasing evidence supports the role of arsenic in dysregulated immune and inflammation responses, while, safe and effective treatments have not been fully examined. "
4.	Body Weight (Weight, Body) 01/01/2007 - "Grasshoppers consumed significantly greater amounts of the frond tissue, produced more fecal pellets and had increased body weight on control plants compared with grasshoppers fed arsenic-treated ferns. " 05/01/2019 - "In continuation of previous studies, this study demonstrates that perinatal exposures (GD6-PD21) to arsenic (2 or 4 mg/kg body weight, p.o.) cause hypo-activity in arsenic-exposed rats on PD22. " 04/01/2006 - "The Food and Agriculture Organization/World Health Organization (FAO/WHO) provisional tolerable weekly intake (PTWI) values of arsenic in our study were 3.32, 5.75 and 12.9 microg/kg body weight/day from mild, moderate and high arsenic-affected families, respectively, which is higher than the recommended PTWI value of arsenic (2.1 microg/kg body weight/day)." 06/01/2023 - "Monte Carlo sensitivity analysis and cluster analysis showed that the most significant factor regulating health risk is 'concentration of arsenic' than 'exposure duration', 'body weight' and 'intake rate'. " 01/01/2023 - "Mice exposed to arsenic at 10 mg/kg body weight showed development of anxiety-like behavior and memory impairment compared to control mice in elevated plus maze and Morris water maze tests, respectively. "
5.	Poisoning 01/01/2023 - "Thus, the aim of this study was to determine the medicinal efficacy of broccoli extract in arsenic-induced brain poisoning. " 01/01/2008 - "The problem of arsenic contamination in the Bengal River Basin illustrates a classic conundrum in environmental health, namely, that development projects can have double effects: on one hand development of tube wells eliminated bacterial pathogens and on the other it exposed the population to poisoning from arsenic. " 06/01/2022 - "He served as an expert and well-known scientific investigator in important legal trials involving alleged poisonings with arsenic and other chemical substances. " 09/01/2018 - "The aim of this study is to investigate whether arsenic (As) could induce testicular poisoning and influence the oxidative stress, apoptosis and autophagy in chickens. " 05/01/2018 - "This paper describes the resources, scientific spaces, and experts involved in the study of a mass poisoning caused by the drinking of arsenic-contaminated wine exported from Spain to France in 1932. "

Related Drugs and Biologics

1.	Arsenic Trioxide (Trisenox)
2.	Tretinoin (Retinoic Acid)
3.	Antioxidants
4.	Succimer (Dimercaptosuccinic Acid)
5.	Drinking Water
6.	Sulfides (Thioethers)
7.	Mercury
8.	Carcinogens
9.	Iron
10.	sodium arsenite (sodium metaarsenite)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Oral Administration
4.	Chinese Traditional Medicine (Traditional Chinese Medicine)
5.	Renal Dialysis (Hemodialysis)