Arsenamide (Thiacetarsamide)

10/01/1986 - "This approach may lead to improved clinical use of thiacetarsamide, and it should facilitate evaluation of new drugs for this important infection."
06/01/1993 - "Seventeen dogs with naturally acquired infections of Dirofilaria immitis (heartworms) were studied before and after thiacetarsamide treatment, using physical examinations, arterial blood gas analyses, thoracic radiography, and pulmonary hemodynamic and arteriographic tests. "
02/01/1987 - "Thiacetarsamide treatment of heartworm infection in dogs."
03/15/1962 - "Treatment of canine lungworm infection with thiacetarsamide."
05/01/1952 - "Arsenamide in the treatment of infections with the periodic form of the filaria, Wuchereria bancrofti."

04/24/1954 - "Arsenamide treatment of filariasis due to W. "
04/01/1952 - "Arsenamide in the treatment of canine filariasis."
02/01/1969 - "This is apparently the first report of systematic screening of antifilarial compounds against an avian filariasis.3. Tartar emetic (10 mg/kg intravenously, daily for 6 days) and arsenamide (5 mg/kg intraperitoneally, daily for 6 days) proved to be effective in killing adult worms. "
03/01/1956 - "[Treatment of Wuchereria bancrofti filariasis by sodium thiacetarsamide in French Oceania]."

11/01/1984 - "Thoracic radiographs were taken before and at 1, 2, and 3 weeks after thiacetarsamide treatment to evaluate lung disease. "
06/01/1993 - "Because melarsomine dihydrochloride (RM340) has been shown to be more effective in killing Dirofilaria immitis (heartworms) than the traditional approved adulticide, thiacetarsamide, an attempt was made to determine whether this new adulticide induced more severe lung disease. "
11/01/1984 - "A combination of aspirin and prednisolone was used in an attempt to modify the pulmonary disease produced by thiacetarsamide treatment of heartworm-infected dogs. "

06/01/1986 - "Before thiacetarsamide was given to the dogs, indocyanine green (ICG), an anionic dye that is eliminated almost entirely by hepatobiliary excretion, was administered IV at a dosage of 0.5 mg/kg of body weight. "

06/01/1993 - "We concluded that dogs with a high worm burden were more likely to have pulmonary thromboembolism after thiacetarsamide treatment and that dogs with a low worm burden were more likely to have minimal changes. "
07/01/1983 - "Light and scanning electron microscopies were used to study the pulmonary embolism occurring in Dirofilaria immitis-infected dogs after treatment with thiacetarsamide. "
07/01/1983 - "Treatment of canine dirofilariasis: pulmonary thromboembolism caused by thiacetarsamide--microscopic changes."
10/01/1985 - "Eighteen of 416 dogs (4.3%) presented with clinical evidence of pulmonary thromboembolism or heart failure prior to the thiacetarsamide therapy. "
04/15/2000 - "Thirty-two of the dogs were treated with thiacetarsamide and 39 were treated with melarsomine, and no differences were found in terms of drug efficacy or complication rate; nine stage II dogs suffered pulmonary thromboembolism and one suffered acute liver disease and there were six fatalities. "