Arcus Senilis

01/01/2016 - "Decreased cholesterol efflux capacity was associated with the presence of corneal arcus after adjusting for age and sex. "
10/01/2010 - "The presence of corneal arcus was significantly associated with age (P = 0.03) and high levels of total cholesterol (over 200 mg/dl, P < 0.01). "
10/01/2005 - "The multivariate hazard ratio for 5 years of age was 1.59 (CI 1.43-1.77); for heavy job-related physical activity it was 0.96 (CI 0.79-1.18); for 10 cigarettes smoked per day 1.16 (CI 1.05-1.28); for 20 mm Hg of systolic blood pressure 1.38 (CI 1.25-1.52); for 1 mmol/l of serum cholesterol 1.19 (CI 1.09-1.30); for 0.25 l/m2 of height of vital capacity 0.87 (CI 0.78-0.97); for the presence of corneal arcus 1.36 (CI 1.03-1.79). "
07/01/2004 - "Total serum cholesterol and triglyceride levels were not associated with corneal arcus. "
02/01/2004 - "Corneal arcus was significantly associated with progressively higher levels of total cholesterol over 5 mmol/l. "

07/01/1985 - "This study demonstrates that arcus senilis does not have a higher prevalence rate in diabetics than non-diabetics in spite of the increased cardiovascular risk in insulin-dependent diabetics."
07/01/1985 - "The prevalence of corneal arcus senilis in known insulin-dependent diabetic patients."

07/01/2004 - "The mean serum HDL-cholesterol (HDL-C) in the group with corneal arcus was 1.04 +/- 0.30 mmol/l as opposed to 1.31 +/- 0.38 mmol/l in the group without arcus (p < 0.005 for difference). "
12/01/1992 - "Although their serum HDL cholesterol levels were remarkably high, ranging from 2.67 to 3.58 mmol/L, three patients had CHD and corneal arcus was present in seven patients. "
07/25/1991 - "A proband with plasma apoA-I and HDL cholesterol that are below 15% of normal levels and with marked bilateral arcus senilis was shown to be heterozygous for a 45-base pair deletion in exon four of the apoA-I gene. "
10/01/1990 - "After excluding those with clinically manifest CHD at baseline, corneal arcus was strongly associated with CHD and CVD mortality only in hyperlipidemic men ages 30-49 years, for whom the relative risk for CHD and CVD death was 3.7 and 4.0, respectively, after adjusting for age, total cholesterol, HDL cholesterol, and smoking status using a Cox proportional hazards model. "
01/01/2009 - "Independently of total cholesterol, serum high-density lipoprotein cholesterol and smoking, corneal arcus has been suggested as a predictor of coronary heart disease among hyperlipidemic men. "

07/01/2004 - "To determine whether an association exists between plasma lipoprotein constituents and the prevalence of corneal arcus in dyslipidaemic patients. "
01/01/1986 - "Thus the clinical findings of xanthelasma or corneal arcus, especially in young people, seem to identify persons with plasma lipoprotein abnormalities."
01/01/1980 - "[Lipid and lipoprotein anomalies associated with arcus senilis]."
01/01/1978 - "Plasma low-density lipoprotein and the composition of human corneal arcus."
12/01/1993 - "Lipid deposits lacking apolipoprotein B in peripheral cornea suggest that if accumulated corneal arcus lipid is derived from extracellular deposition of plasma low density lipoprotein, the low density lipoprotein is altered such that it looses its immunoreactive apolipoprotein B. "

03/01/1993 - "Association of corneal arcus with ultrasonographically assessed arterial wall thickness and serum lipids."
01/01/1985 - "This technique can be used therefore as a diagnostic tool to detect pathologies of skin lipids, or of tissue lipid metabolism, as for example in normolipidemic patients presenting corneal arcus or xanthelasmas."
08/16/1969 - "Arcus senilis corneae--its relationship to serum lipids in the South African Bantu."
08/01/1962 - "The lipids of arcus senilis."
10/17/1964 - "Corneal arcus and serum lipids were studied in 121 men, aged 30 to 80, with atherosclerotic coronary heart disease (CHD), and in healthy controls. "

03/01/1993 - "Old age and high LDL cholesterol concentration were associated with the presence of corneal arcus. "
06/01/1992 - "It is concluded that while corneal arcus is primarily an age-related change, its formation is accelerated by high serum LDL-cholesterol so that in people under 50 years it is a marker for the condition."
01/01/1986 - "Both xanthelasma and corneal arcus were associated with increased levels of plasma cholesterol and low-density lipoprotein cholesterol (LDL-C), especially in young males. "
02/01/2002 - "These included increased cholesterol concentrations, in particular of LDL-cholesterol, in combination with the presence of tendon xanthoma, corneal arcus, xanthelasmata and a history of early CAD. "
10/01/2009 - "Subjects with higher levels of total-cholesterol, low-density lipoprotein cholesterol (LDL-C), non-high-density lipoprotein cholesterol (non-HDL-C), and total/HDL cholesterol ratio had increased risk of having corneal arcus, whereas subjects with higher systolic blood pressure (SBP) and diastolic blood pressure had decreased risk. "

05/01/1993 - "It allows too the differentiation between primary and secondary (Tangier disease, apo A-I deficiency, A-I and C-III deficiency) LCAT deficiencies, which may be all associated with a Corneal arcus. "
07/25/1991 - "A proband with plasma apoA-I and HDL cholesterol that are below 15% of normal levels and with marked bilateral arcus senilis was shown to be heterozygous for a 45-base pair deletion in exon four of the apoA-I gene. "
02/01/2008 - "Homozygotes presented markedly decreased HDL cholesterol levels, undetectable plasma apoA-1, tuboeruptive and planar xanthomas, mild corneal arcus and opacification, and severe premature coronary artery disease. "
08/01/2014 - "We report a novel apolipoprotein (apo) A-I truncation (apoA-IMytilene) due to a heterozygous nonsense mutation (c.718C > T, p.Gln216*) in a 68-year-old male proband with premature coronary heart disease (CHD), corneal arcus, and very low plasma concentrations of HDL cholesterol (HDL-C) and apoA-I. Two family members also had the same mutation. "

08/01/2007 - "Corneal arcus is a lipid-rich and predominantly extracellular deposit that forms at the corneoscleral limbus. "
01/01/2009 - "Corneal arcus is a lipid-rich deposit at the corneoscleral limbus that shares some similarities with the lipid deposition of atherosclerosis. "
01/01/1992 - "Because of the high frequency of dislipidemia in patients with Dupuytren's disease and arcus senilis, which are apparently two well-distinguished disease, the authors suggest that a lipid disorder may be a common aetiopathogenic factor. "
03/01/1972 - "A corneal arcus is a lipid deposition mainly consisting of cholesterol and phospholipid. "

06/01/2002 - "No association between corneal arcus and fasting plasma glucose was found in all ages and both sexes. "
06/01/2002 - "The presence of corneal arcus was determined by hand-held slitlamp, serum lipids and serum plasma glucose collected on the same day as corneal arcus detection. "
12/01/1983 - "No associations were found between corneal arcus and other coronary artery disease risk factors such as triglyceride, high-density lipoprotein, very low-density lipoprotein, weight, Quetelet's ratio, glucose, and smoking."
01/01/1986 - "There was no consistent univariate association of xanthelasma and corneal arcus with smoking, alcohol consumption, blood pressure, obesity, sedentary lifestyle, family history of ischemic heart disease, or glucose and uric acid plasma concentrations. "
10/01/2010 - "After adjustment for age, gender, total cholesterol, serum glucose, and current smoking, many cardiovascular risk factors significantly associated with corneal arcus, including male gender (odds ratio [OR] 1.65, 95% confidence interval [CI] 1.27-2.03), older age (per 10 years, OR 4.49, 95% CI 3.91-5.15), higher body mass index (per kg/m(2), OR 1.02, 95% CI 1.00-1.04), higher levels of CRP (per 10 mg/L, OR 1.36, 95% CI 1.13-1.64), total cholesterol (per mmol/L, OR 1.21, 95% CI 1.11-1.32), low-density lipoprotein cholesterol (per mmol/L, OR 1.94, 95% CI 1.38-2.74), presence of peripheral artery disease (OR 3.85, 95% CI 1.29-11.5), chronic kidney disease (OR 1.14, 95% CI 1.03-1.38), and current smoking (OR 1.29, 95% CI 1.02-1.69). "

07/01/1977 - "[Serum cholesterol-triglycerides and their relation to age, skinfold, arcus senilis, blood pressure and electrocardiogram, in the population of homes for the aged (author's transl)]."
04/01/2015 - "The corneal arcus consists of cholesterol, phospholipids and triglycerides. "
09/01/1980 - "The following characteristics of the family support the classification of the disorder as familial hypercholesterolemia : hypercholesterolemia, increased levels of phospholipids an beta-lipoproteins, normal values of triglycerides, pre-beta-lipoproteins and blood sugar, xanthomas, xanthelasmas, corneal arcus and early appearance of ischemic heart disease. "

06/30/1977 - "and pseudocapsular exfoliation for elderly men but elderly men with arcus senilis were less likely to have developed S.D.C. "

06/01/1966 - "Significance of arcus senilis under anesthesia."