Arbaprostil

A synthetic prostaglandin E analog that protects the gastric mucosa, prevents ulceration, and promotes healing of peptic ulcers. The protective effect is independent of acid inhibition. It is also a potent inhibitor of pancreatic function and can inhibit the growth of experimental tumors.

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Networked: 22 relevant articles (6 outcomes, 12 trials/studies)

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Bio-Agent Context: Research Results

Related Diseases

1.	Hemorrhage 01/09/1989 - "Placebo controlled trials of arbaprostil in acute upper gastrointestinal haemorrhage have failed to demonstrate any reduction in numbers of patients whose bleeding stopped, numbers with rebleeding or transfusion requirement. " 11/09/1985 - "Controlled trial of arbaprostil in bleeding peptic ulcer." 10/19/1985 - "Controlled trial of arbaprostil in bleeding peptic ulcer." 12/07/1985 - "Arbaprostil in bleeding peptic ulcer." 01/01/1987 - "In the treatment of acute upper gastrointestinal bleeding, arbaprostil was not more effective than placebo in spite of several case reports suggesting that prostaglandin E analogues would be helpful in these situations. "
2.	Peptic Ulcer (Peptic Ulcers) 11/01/1991 - "The data indicate that arbaprostil is a potent, long-acting orally active antisecretory drug that may be useful for the treatment of peptic ulcer disease." 11/09/1985 - "Controlled trial of arbaprostil in bleeding peptic ulcer." 10/19/1985 - "Controlled trial of arbaprostil in bleeding peptic ulcer." 12/07/1985 - "Arbaprostil in bleeding peptic ulcer." 01/01/1987 - "In nearly all trials natural prostaglandin E2 as well as the synthetic prostaglandin analogues arbaprostil, misoprostol, enprostil, rioprostil, trimoprostil, and rosaprostol accelerated the healing of peptic ulcers compared with placebo. "
3.	Ulcer 08/01/1987 - "At the end of the study, healing of the ulcer was observed in 69.2% of the arbacet-treated patients and in 60.4% of patients in the placebo treated group. " 07/01/1989 - "Ulcer healing was documented in 64.3%, 85.7%, and 31.2% of the 100-micrograms arbaprostil, 50-micrograms arbaprostil, and placebo treatment groups (p value vs. placebo = 0.003 and 0.002, respectively). " 08/01/1987 - "The ulcers of 16 patients in both the placebo and the arbacet-treated group healed after 14 days of treatment. " 08/01/1982 - "Similarly, the ulcer size, measured endoscopically, was much smaller after arbaprostil administration than in the group receiving placebo after both 14 and 28 days (p less than 0.001). " 08/01/1982 - "Arbaprostil increased the incidence of ulcer healing to approximately the same degree as reported in most extensive studies with cimetidine. "
4.	Stomach Ulcer (Gastric Ulcer) 04/01/1989 - "This trial documents that a 10-micrograms dose of arbaprostil (which may be considered cytoprotective because of its small effect on gastric acid secretion), although safe and associated with no side effects, is not efficacious in healing acute gastric ulcers." 07/01/1988 - "Healing occurred in four patients from the Arbacet group and three patients in the placebo group at 3 wk. A cytoprotective dose of Arbacet (40 micrograms daily) is not significantly better than placebo in healing gastric ulcers." 07/01/1988 - "Five of nine patients (56%) taking Arbacet and seven of 11 patients (64%) in the placebo group had complete healing of their gastric ulcer. " 07/01/1988 - "Failure of a cytoprotective dose of Arbacet to heal acute gastric ulcers." 02/01/1986 - "These results indicate that arbaprostil, at either antisecretory or even acid stimulating doses, is effective in preventing the development of acute gastric erosions and in accelerating the healing of chronic gastric ulcers."
5.	Duodenal Ulcer (Curling's Ulcer) 02/01/1990 - "Six hundred and thirty patients were enrolled in a randomized double-blind placebo-controlled trial evaluating two arbaprostil dosages (25 micrograms and 50 micrograms) qid for 4 wk for the treatment of acute duodenal ulcers. " 02/01/1990 - "An evaluation of arbaprostil at multiple doses for the treatment of acute duodenal ulcer: a randomized double-blind placebo-controlled international trial." 02/01/1990 - "Arbaprostil at these two dosage levels, when given for 4 wk, appears to be a safe and efficacious agent for the treatment of acute duodenal ulcers." 07/01/1989 - "A single nighttime administration of arbaprostil seems to be a safe and efficacious agent for the treatment of acute duodenal ulcer." 08/01/1987 - "We conclude that cytoprotective doses of arbacet with minimal antisecretory properties are not effective in duodenal ulcer healing."

Related Drugs and Biologics

1.	Acids
2.	Dinoprostone (PGE2)
3.	Aspirin (Acetylsalicylic Acid)
4.	Misoprostol (Cytotec)
5.	Enprostil
6.	Rioprostil
7.	trimoprostil
8.	Synthetic Prostaglandins E
9.	Synthetic Prostaglandins (Prostaglandin Analogues)
10.	Cimetidine (Biomet)

Related Therapies and Procedures

1.	Therapeutics
2.	Enema (Enemas)