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Arachidonate 5-Lipoxygenase (5 Lipoxygenase)

An enzyme that catalyzes the oxidation of arachidonic acid to yield 5-hydroperoxyarachidonate (5-HPETE) which is rapidly converted by a peroxidase to 5-hydroxy-6,8,11,14-eicosatetraenoate (5-HETE). The 5-hydroperoxides are preferentially formed in leukocytes.
Also Known As:
5 Lipoxygenase; Arachidonate 5 Lipoxygenase; Arachidonic Acid 5-Lipoxygenase; LTA4 Synthase; Leukotriene A Synthase; Leukotriene A4 Synthase; Leukotriene A4 Synthetase; 5-Lipoxygenase, Arachidonate; 5-Lipoxygenase, Arachidonic Acid; Arachidonic Acid 5 Lipoxygenase; Synthase, LTA4; Synthase, Leukotriene A; Synthase, Leukotriene A4; Synthetase, Leukotriene A4; 5-Lipoxygenase; Arachidonate:oxygen 5-oxidoreductase
Networked: 1268 relevant articles (39 outcomes, 154 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Werz, Oliver: 29 articles (01/2022 - 08/2005)
2. Praticò, Domenico: 19 articles (07/2018 - 04/2008)
3. Steinhilber, Dieter: 18 articles (10/2020 - 08/2005)
4. Rossi, Antonietta: 16 articles (01/2022 - 06/2003)
5. Sautebin, Lidia: 16 articles (01/2019 - 06/2003)
6. Ghosh, Jagadananda: 11 articles (01/2020 - 01/2002)
7. Cuzzocrea, Salvatore: 10 articles (01/2007 - 06/2003)
8. Peters-Golden, Marc: 9 articles (01/2020 - 01/2002)
9. Hofmann, Bettina: 9 articles (01/2019 - 04/2009)
10. Chu, Jin: 9 articles (01/2016 - 01/2011)

Related Diseases

1. Inflammation (Inflammations)
2. Asthma (Bronchial Asthma)
3. Carcinogenesis
4. Psoriasis (Pustulosis Palmaris et Plantaris)
5. Infections

Related Drugs and Biologics

1. Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)
2. Proteins (Proteins, Gene)
3. Cyclooxygenase Inhibitors
4. Enzymes
5. Arachidonic Acid (Vitamin F)
6. Leukotriene B4
7. zileuton (Zyflo)
8. Lipoxygenase Inhibitors
9. MK-886
10. Cyclooxygenase 2 (Cyclooxygenase-2)

Related Therapies and Procedures

1. Drug Therapy (Chemotherapy)
2. Oral Administration
3. Therapeutics
4. Chemoprevention
5. Microspheres (Microsphere)