Arachidonate 15-Lipoxygenase (Arachidonate 15 Lipoxygenase)

An enzyme that catalyzes the oxidation of arachidonic acid to yield 15-hydroperoxyarachidonate (15-HPETE) which is rapidly converted to 15-hydroxy-5,8,11,13-eicosatetraenoate (15-HETE). The 15-hydroperoxides are preferentially formed in NEUTROPHILS and LYMPHOCYTES.

Also Known As:

Networked: 325 relevant articles (5 outcomes, 27 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Zhu, Daling: 23 articles (09/2015 - 05/2003)
2.	Nadler, Jerry L: 20 articles (09/2014 - 03/2004)
3.	Praticò, Domenico: 11 articles (03/2015 - 09/2002)
4.	Natarajan, Rama: 11 articles (01/2010 - 06/2003)
5.	Ma, Jun: 10 articles (09/2013 - 01/2005)
6.	van Leyen, Klaus: 9 articles (12/2015 - 12/2006)
7.	Zhang, Lei: 9 articles (08/2014 - 08/2010)
8.	Lo, Eng H: 7 articles (12/2015 - 12/2006)
9.	Ma, Cui: 7 articles (09/2015 - 10/2011)
10.	Obrosova, Irina G: 7 articles (04/2012 - 10/2007)

Related Diseases

1.	Carcinoma (Carcinomatosis) 01/01/2006 - "We further found that 15-lipoxygenase activity was reduced in carcinoma cells when compared with normal primary cultured keratinocytes. " 01/01/2006 - "Reduced expression of 15-lipoxygenase 2 in human head and neck carcinomas." 01/01/2006 - "In the present study, we report a significant reduction of 15-lipoxygenase 2 (15-LOX-2) in seven carcinoma cell lines of the human head and neck when compared with normal primary cultured keratinocytes, and 18 primary head and neck squamous cell carcinomas (HNSCC) when compared with matched normal mucosa. " 05/01/2003 - "Elevated expression of 12/15-lipoxygenase and cyclooxygenase-2 in a transgenic mouse model of prostate carcinoma." 09/01/2007 - "Recently, studies have reported that human breast carcinomas aberrantly express LOX and cyclooxygenase-2 (COX-2), and that decreased levels of 15-lipoxygenase (15-LOX) and raised levels of COX-2 and 12-LOX have prognostic value in patients with breast cancer. "
2.	Fatty Liver 01/01/2014 - "Reduced dietary omega-6 to omega-3 fatty acid ratio and 12/15-lipoxygenase deficiency are protective against chronic high fat diet-induced steatohepatitis." 02/01/2014 - "The activities of inflammatory marker enzymes like cyclooxygenase, 15-lipoxygenase in monocytes and myeloperoxidase, C-reactive protein and ceruloplasmin levels in serum were found to be decreased on treatment with AL. Histopathological studies revealed that lycopene from this alga could reduce fatty liver and aortic plaque when compared to the drug and TL. "
3.	Squamous Cell Carcinoma (Epidermoid Carcinoma) 01/01/2006 - "In the present study, we report a significant reduction of 15-lipoxygenase 2 (15-LOX-2) in seven carcinoma cell lines of the human head and neck when compared with normal primary cultured keratinocytes, and 18 primary head and neck squamous cell carcinomas (HNSCC) when compared with matched normal mucosa. "
4.	Osteoporosis 07/01/2006 - "As one example, analysis of a murine genetic model of osteoporosis demonstrated that genetic variation within the 15-lipoxygenase (Alox15) gene affected peak bone mass, and that treatment with inhibitors of this enzyme improved bone mass and quality in rodent models. " 01/09/2004 - "These results suggest that drugs targeting the 12/15-lipoxygenase pathway merit investigation as a therapy for osteoporosis." 09/01/2005 - "Genome-wide mapping efforts have identified the low-density lipoprotein receptor-related protein 5, bone morphogenetic protein 2, and 15-lipoxygenase as potential susceptibility genes for osteoporosis in the past few years, providing a rich new base for understanding bone biology. "
5.	Acute Lung Injury 10/01/2009 - "Improved survival and reduced vascular permeability by eliminating or blocking 12/15-lipoxygenase in mouse models of acute lung injury (ALI)." 01/01/2012 - "Eliminating or blocking 12/15-lipoxygenase reduces neutrophil recruitment in mouse models of acute lung injury."

Related Drugs and Biologics

1.	Arachidonic Acid (Vitamin F)
2.	Enzymes
3.	Messenger RNA (mRNA)
4.	Cyclooxygenase 2 (Cyclooxygenase-2)
5.	Arachidonate 5-Lipoxygenase (5 Lipoxygenase)
6.	Arachidonate 12-Lipoxygenase (12 Lipoxygenase)
7.	baicalein
8.	Lipoxygenase (Lipoxygenase-1)
9.	Apolipoproteins
10.	Lipoxygenases

Related Therapies and Procedures

1.	Denervation
2.	Transplants (Transplant)
3.	Intraperitoneal Injections