Arachidonate 12-Lipoxygenase (12 Lipoxygenase)

An enzyme that catalyzes the oxidation of arachidonic acid to yield 12-hydroperoxyarachidonate (12-HPETE) which is itself rapidly converted by a peroxidase to 12-hydroxy-5,8,10,14-eicosatetraenoate (12-HETE). The 12-hydroperoxides are preferentially formed in PLATELETS.

Also Known As:

Networked: 200 relevant articles (3 outcomes, 12 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Honn, Kenneth V: 11 articles (09/2014 - 01/2002)
2.	Honn, K V: 8 articles (07/2013 - 03/2000)
3.	Nie, D: 6 articles (07/2013 - 03/2000)
4.	Nadler, Jerry L: 5 articles (03/2015 - 03/2002)
5.	Nie, Daotai: 5 articles (09/2014 - 01/2003)
6.	Jankun, Jerzy: 5 articles (01/2014 - 05/2006)
7.	Skrzypczak-Jankun, Ewa: 4 articles (01/2014 - 05/2006)
8.	Tang, Keqin: 4 articles (07/2006 - 01/2003)
9.	Zacharek, Alex: 4 articles (07/2006 - 01/2003)
10.	Pidgeon, Graham P: 4 articles (07/2003 - 05/2002)

Related Diseases

1.	Neoplasms (Cancer) 04/01/2000 - "Third, an inhibitor of 12-lipoxygenase has been found effective against metastatic prostate tumor growth, and the inhibition of 12-lipoxygenase is related with the reduction of tumor angiogenesis. " 01/01/2015 - "Literature search was performed in Pubmed, Embase and other databases for studies evaluating the association between the Gln261Arg polymorphism in 12-lipoxygenase gene and cancer risk. " 01/01/2015 - "Many studies suggest that the Gln261Arg polymorphism in 12-lipoxygenase gene is assicated with cancer susceptibility, but the results are inconclusive. " 01/01/2015 - "This meta-analysis suggests that the Gln261Arg polymorphism in 12-lipoxygenase gene contributes to cancer susceptibility, specifically in Asian populations. " 01/01/2015 - "This meta-analysis aimed to investigate the overall association between the Gln261Arg polymorphism in 12-lipoxygenase gene and cancer risk. "
2.	Breast Neoplasms (Breast Cancer) 10/01/2006 - "Also it has been recorded that human breast cancer expresses high level of cox-2 and 12-lipoxygenase which may be beneficial in future therapy plan for those patients. " 10/01/2006 - "Elevated levels of cox-2 and 12-lipoxygenase expression were detected in human breast cancer. " 01/01/2005 - "Compounds 2, 3, and 4 were evaluated for their ability to inhibit the enzyme 12-lipoxygenase and 3 and 4 showed moderate activity at 30 microg/ml. Compound 2 was evaluated against a panel of colorectal and breast cancer cell lines and IC50 values ranged from 5.8 to 37.6 microg/ml. Against a panel of fast-growing mycobacteria and a standard ATCC strain of Staphylococcus aureus, compound 6 exhibited minimum inhibitory concentrations in the range of 64-128 microg/ml." 09/09/1999 - "Furthermore, the data suggest an anti-carcinogenic action of 12-lipoxygenase in human cervix, in contrast to its reported pro-carcinogenic action in breast cancer." 10/23/1998 - "Enhanced angiogenesis and growth of 12-lipoxygenase gene-transfected MCF-7 human breast cancer cells in athymic nude mice."
3.	Leukemia 08/06/1991 - "Improved purification of 12-lipoxygenase from rat basophilic leukemia cells and conditions for optimal enzyme activity." 09/22/1992 - "12-Lipoxygenase from rat basophilic leukemia cells has many features in common with 12-lipoxygenase from bovine leukocytes. " 09/22/1992 - "Rat basophilic leukemia cells exhibit 12-lipoxygenase activity only upon cell disruption. " 09/22/1992 - "12-Lipoxygenase from rat basophilic leukemia cells, an oxygenase with leukotriene A4-synthase activity." 08/06/1991 - "12-Lipoxygenase from rat basophilic leukemia cells was purified about 300-fold by protein-HPLC in a single run. "
4.	Inflammation 03/01/2015 - "Targeting 12-lipoxygenase as a novel strategy to combat the effects of inflammation on beta cells in diabetes." 03/01/2015 - "12-Lipoxygenase (12-LO) induces inflammation and has been implicated in diabetes development. " 04/01/1999 - "The availability of new specific inhibitors and murine lines that lack expression of the homologous 12-lipoxygenase will allow confirmation of many of these effects with in vivo models of inflammation." 05/01/2013 - "Previously, we observed significant increases in spinal 12-lipoxygenase (LOX) metabolites, in particular, hepoxilins, which contribute to peripheral inflammation-induced tactile allodynia. " 05/11/2004 - "The functional significance of hepA(3) to target PMNs to the lumen of the gut at sites of inflammation was demonstrated by the finding that disruption of the 12-lipoxygenase pathway (required for hepA(3) production) could dramatically reduce PMN-mediated tissue trauma, demonstrating that hepA(3) is a key regulator of mucosal inflammation."
5.	Prostatic Neoplasms (Prostate Cancer) 09/01/2014 - "[Selective 12-lipoxygenase inhibition potentiates the effect of radiation on human prostate cancer cells in vitro and in vivo]." 07/28/2013 - "Radiosensitivity of human prostate cancer cells can be modulated by inhibition of 12-lipoxygenase." 01/01/2013 - "The concentration of 12-lipoxygenase in platelet rich plasma as an indication of cancer of the prostate." 04/01/2011 - "The presence of arachidonate 12-lipoxygenase (12-LOX) potentiates prostate cancer (PCa) progression and therefore may be a good therapeutic target and/or a potential diagnostic predictor for PCa. " 04/01/2011 - "Arachidonate 12-lipoxygenase may serve as a potential marker and therapeutic target for prostate cancer stem cells."

Related Drugs and Biologics

1.	Cyclooxygenase 2 (Cyclooxygenase-2)
2.	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)
3.	Arachidonate 12-Lipoxygenase (12 Lipoxygenase)
4.	Arachidonate 15-Lipoxygenase (Arachidonate 15 Lipoxygenase)
5.	NF-kappa B (NF-kB)
6.	Lipoxygenases
7.	Estrogens (Estrogen)
8.	NADPH Oxidase (NAD(P)H oxidase)
9.	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)
10.	Progesterone

Related Therapies and Procedures

1.	Ligation
2.	Lasers (Laser)