Apudoma

08/01/1987 - "Radioiodinated I-123 metaiodobenzylguanidine (MIBG) has been used for diagnostic purposes for detection of apudomas. "
07/01/1986 - "Unsuccessful iodine-131 MIBG imaging of carcinoid tumors and apudomas."
09/01/1988 - "We suspect that occasional parathyroid adenomas, like other APUDomas, may give false positive results when MIBG imaging is used to search for pheochromocytomas. "
07/01/2013 - "Metaiodobenzylguanidine (MIBG) was developed initially as a tracer for oncological imaging; when labeled with 123 I or 131 I, it may detect APUDomas, such as pheochromocytomas and paragangliomas. "
04/01/1995 - "I-131 MIBG, a specific radiopharmaceutical agent for scintigraphic imaging and treatment of pheochromocytoma and neuroblastoma may be useful for detection of apudomas. "

08/22/1982 - "[Apudoma of the stomach producing pancreatic polypeptide hormone]."
09/01/1980 - "Pancreatic-polypeptide-producing apudoma of the liver."
01/01/1980 - "Pancreatic polypeptide as screening marker for pancreatic polypeptide apudomas in multiple endocrinopathies."
04/01/1988 - "[A case of malignant pancreatic apudoma producer of serotonin and pancreatic polypeptide]."
08/01/1981 - "Effective streptozocin therapy for metastatic pancreatic polypeptide apudoma."

09/01/1993 - "Increasing understanding of the origins of APUDomas as well as the biochemistry and physiology of the hormones they produce, has led to improved methods of detection, imaging and treatment of afflicted patients."
01/01/1986 - "Routine light microscopy in most cases provides for apudoma verification, estimation of its differentiation and tissue origin, occasional identification of a secreted hormone."
01/01/1974 - "Polypeptide hormone production by "carcinoid" apudomas and their relevant cytochemistry."
03/01/2000 - "The tumor had a negative Grimelius reaction, suggesting no differentiation into a hormone-producing carcinoma known as an apudoma (Amine Precursor Uptake and Decarboxylation (APUD)). "
01/01/1984 - "37 patients suffering from apudomas of the pancreas are reported (18 insulinomas, 6 isletcell-hyperplasias, 9 Zollinger-Ellison syndroms, 1 glucagonoma, 3 without hormone production). "

08/01/1981 - "Effective streptozocin therapy for metastatic pancreatic polypeptide apudoma."
08/01/1981 - "An apparently complete remission of metastases in the liver from a resected pure pancreatic polypeptide apudoma occurred following intra-arterial and intravenous administration of streptozocin to a patient in a family with multiple endocrine adenopathy, type 1. Plasma concentrations of human pancreatic polypeptide constitute an excellent marker system for the detection and assessment of tumor status before and after surgical and streptozocin therapy."

04/01/1990 - "While a multicentric primary apudoma secreting ACTH was a putative diagnosis, detailed and extensive microscopic post-mortem studies revealed a more likely primary tumor site in the pancreatic tail."
01/01/1982 - "A study was undertaken of five patients with Cushing syndrome due to adrenocorticotropin (ACTH) production by thymic carcinoid tumor (primary mediastinal APUDomas), including two recent patients examined by computed tomography (CT) of the chest. "
09/01/1995 - "Tumor cells of well-differentiated apudomas produce serotonin, less frequently calcitonin, poorly differentiated ones produce only ACTH. "
03/01/1984 - "A series of 25 apudomas of the gastrointestinal tract (22 cases), bronchus (2 cases), and thymus (1 case) were subjected to staining with silver impregnation (Masson-Fontana and Grimelius) techniques and with the commercial immunoperoxidase kits for the peptide hormones adrenocorticotropin, calcitonin, gastrin, glucagon, growth hormone, human chorionic gonadotropin (hCG), insulin, somatostatin, and vasoactive intestinal peptide. "

02/01/1991 - "Ten patients with gastro-pancreatic apudomas were prospectively treated with SMS 201-995 at the dose of 25-50 mg/12 h. "
01/01/1991 - "Eight patients suffering gastroenteropancreatic apudomas were prospectively treated with subcutaneous SMS 201-995 at a dose of 25-50 mg/12 hours, before breakfast and dinner during two months. "
01/01/1990 - "Twenty-four patients with 26 apudomas have been treated with Sandostatin (octreotide) in Belfast. "
08/01/1986 - "SMS 201-995 will be useful in the palliative treatment of apudomas."
12/01/1995 - "In the present study, a group of 18 patients with carcinoid tumours and gastrointestinal (GI) apudomas was investigated to assess the accuracy of Octreotide scintigraphy in localizing primitive, recurrent or metastatic lesions. "

03/01/1983 - "DTIC is a useful agent for treatment of malignant APUDomas, and may be the drug of choice for islet cell carcinoma of the pancreas."
11/01/1988 - "Thus, the chemo-responsiveness of MTC may be akin to that of other APUD carcinomas (APUDomas) and treatment of metastatic MTC and other APUDomas with the combination of dacarbazine and 5-fluorouracil appears to merit further study."

01/01/1995 - "Mitoxantrone in metastatic apudomas: a phase II study of the EORTC Gastro-Intestinal Cancer Cooperative Group."

11/01/1988 - "Thus, the chemo-responsiveness of MTC may be akin to that of other APUD carcinomas (APUDomas) and treatment of metastatic MTC and other APUDomas with the combination of dacarbazine and 5-fluorouracil appears to merit further study."

03/01/1989 - "The author draws attention to the possibility of using somatostatin not only in the treatment of apudomas but also of haemorrhage into the gastrointestinal tract and in the treatment of fistulae. "
08/01/1986 - "Observations on the effect of a somatostatin analog in the Zollinger-Ellison syndrome: implications for the treatment of apudomas."
02/01/1991 - "[Pharmacological treatment of gastroenteropancreatic apudomas with an analog of somatostatin, SMS 201-995 (octreotide)]."
06/01/1989 - "The long-acting somatostatin (SMS) analog, SMS 201-995 has beneficial effects on APUDomas. "
12/10/1988 - "[Treatment of pancreatic apudomas with a somatostatin analog SMS 201-995]."

03/01/1989 - "Liver transplantation for primary and secondary hepatic apudomas."
10/01/1992 - "The authors report their experience in 59 adult patients submitted to liver transplantation for irreversible liver disease in advanced stage (49 with cirrhosis, 10 with HCC; 5 with cholestatic hepatopathy; 3 with fulminant hepatitis; 1 with Budd-Chiari syndrome; 1 with metastatic APUDoma). "
03/01/1989 - "Four patients underwent liver transplantation in the Cambridge/King's College Hospital programme for malignant primary and secondary apudomas, secreting various peptide hormones and uncontrollable by standard treatment techniques. "

06/06/1982 - "[Catheter embolization of apudoma liver metastases]."

09/01/1983 - "We found six cases of apudomas in a series of 1028 renal transplants from three medical centers (0.58%). "

07/26/1991 - "The woman had a metastasizing pancreatic apudoma, requiring partial pancreas resection with splenectomy. "

08/01/1986 - "SMS 201-995 will be useful in the palliative treatment of apudomas."