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Aprindine

A cardiac depressant used in arrhythmias.

Also Known As:

Amidonal; Christiaens Brand of Aprindine Hydrochloride; Fiboran; Nycomed Brand of Aprindine Hydrochloride; PCR Brand of Aprindine Hydrochloride; 1,3-Propanediamine, N-(2,3-dihydro-1H-inden-2-yl)-N',N'-diethyl-N-phenyl-

Networked: 107 relevant articles (18 outcomes, 10 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Inoue, Hiroshi: 4 articles (11/2015 - 06/2002)
2.	Fujiki, Akira: 3 articles (11/2015 - 09/2004)
3.	Sakabe, Masao: 3 articles (11/2015 - 09/2004)
4.	Mizumaki, Koichi: 3 articles (11/2015 - 09/2004)
5.	Nishida, Kunihiro: 2 articles (11/2015 - 12/2004)
6.	Komatsu, Takashi: 2 articles (10/2015 - 04/2003)
7.	Sugi, Kaoru: 2 articles (04/2006 - 06/2002)
8.	Tsuneda, Takayuki: 2 articles (12/2004 - 09/2004)
9.	Nakatani, Yosuke: 1 article (11/2015)
10.	Yamaguchi, Yoshiaki: 1 article (11/2015)

Related Diseases

1.	Ventricular Tachycardia 07/01/1989 - "Aprindine significantly decreased the incidence of ventricular tachycardia and fibrillation, compared with control (2/10, p less than 0.01 and 1/10, p less than 0.05, respectively). " 09/01/1999 - "Because aprindine hydrochloride was effective in preventing ventricular tachycardias, we also tested the effect of the drug on WT HERG (I(Kr)) and KvLQT1/KCNE1 (I(Ks)) currents expressed in COS7. " 03/01/1981 - "In conclusion, administration of intravenous aprindine to patients with ventricular tachycardia is helpful in predicting the subsequent response to oral aprindine. " 02/01/1983 - "In this report, we describe our experience with aprindine therapy in seven patients with ventricular tachycardia in whom standard antiarrhythmic agents had proven either ineffective or had caused intolerable side effects. " 02/01/1983 - "Aprindine therapy for refractory ventricular tachycardia."
2.	Tachycardia (Tachyarrhythmias) 11/01/1989 - "In conclusion, the administration of a relatively small dose of aprindine and, consequently, low plasma concentration levels, are effective for cardiac tachyarrhythmias in Japanese patients." 01/01/1992 - "Aprindine, however, did not cause anterograde blockade of conduction over the slow AV nodal pathway during tachycardia. " 04/01/1990 - "Aprindine hydrochloride is a potent antiarrhythmic agent against various atrial and ventricular tachyarrhythmias. " 11/01/1989 - "Aprindine hydrochloride (aprindine) was administered orally in 17 Japanese patients with supraventricular or ventricular tachyarrhythmias, and the clinical effects and plasma concentration levels were evaluated. " 11/01/1989 - "[Clinical effects and plasma concentration levels of aprindine hydrochloride in patients with tachyarrhythmias]."
3.	Atrial Fibrillation 02/01/1999 - "In order to clarify the mechanisms by which the class Ib antiarrhythmic drug aprindine shows efficacy against atrial fibrillation (AF), we examined the effects of the drug on the repolarizing K+ currents in guinea-pig atrial cells by use of patch-clamp techniques. " 06/01/1995 - "However aprindine exaggerated atrial vulnerability in some patients, such that atrial fibrillation was induced." 01/01/1990 - "A 73-year-old man had been treated with Aprindine because of paroxysmal atrial fibrillation. " 04/01/1985 - "Aprindine was given orally to an 88-year-old patient with atrial fibrillation and ventricular premature depolarizations. " 06/01/1995 - "The effects of aprindine on atrial vulnerability were studied in 11 patients; 9 with paroxysmal atrial fibrillation (PAF), and 2 with Wolff-Parkinson-White syndrome, aged 19 to 69 (55.9 +/- 16.5; mean +/- SD). "
4.	Ventricular Fibrillation 03/01/1985 - "With the highest concentration of aprindine tested (0.56 mumol/l), protection against electrically-induced ventricular fibrillation was achieved in 4 out of 6 hearts after 60 min exposure to the drug. " 07/01/1977 - "During the first 30 min of ischaemia 5 of the 22 untreated animals died because of ventricular fibrillation against 1 of the 23 animals pretreated with aprindine (P=0.09). " 08/01/1975 - "The similarly determined ventricular fibrillation threshold was increased from a control value of 2.45 +/- 0.78 mA to a maximum of 5.68 +/- 1.47 mA 30 minutes after aprindine, 5 mg/kg i.v. (P less than .025). " 12/01/1977 - "A study was designed to investigate whether long-term use of aprindine can prevent sudden death from primary ventricular fibrillation. " 03/01/1985 - "Sixty-four patients with a history of ventricular tachycardia and ventricular fibrillation refractory to conventional therapy received aprindine to abolish recurrent episodes of symptomatic ventricular tachycardia. "
5.	Myocardial Infarction 07/01/1977 - "It is concluded that aprindine is effective in reducing ventricular arrhythmias and that further investigations on its preventive use after the onset of myocardial infarction are justified." 01/01/1974 - "[Anti-arrhythmic efficacy of aprindine during the acute phase of myocardial infarct]." 04/01/1987 - "Although antiarrhythmic treatment with aprindine of high-risk patients after myocardial infarction does not affect 1 year survival, mortality appears to be delayed; thus there may be a role for short-term treatment before more definitive therapy such as surgery." 10/10/1975 - "Absorption, half-life, and toxicity of oral aprindine in patients with acute myocardial infarction." 12/01/1983 - "[Aprindine, an anti-arrhythmia agent for arrhythmia associated with myocardial infarct]."

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Related Therapies and Procedures

1.	Intravenous Infusions
2.	Ligation
3.	Electric Countershock (Cardioversion)
4.	Premedication
5.	Renal Dialysis (Hemodialysis)