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Appetite Depressants (Anorectics)

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Agents that are used to suppress appetite.

Also Known As:

Anorectics; Appetite Suppressants; Anorectic Agents; Anorexic Drugs; Anorexigenic Drugs; Appetite-Depressing Drugs; Appetite-Suppressant Drugs; Agents, Anorectic; Appetite Depressing Drugs; Appetite Suppressant Drugs; Depressants, Appetite; Drugs, Anorexic; Drugs, Anorexigenic; Drugs, Appetite-Depressing; Drugs, Appetite-Suppressant; Suppressants, Appetite

Networked: 254 relevant articles (13 outcomes, 16 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Chemical Actions and Uses
- Pharmacologic Actions: 56
  - Therapeutic Uses: 297
    - Central Nervous System Agents: 29
      - Anti-Obesity Agents: 256
        Appetite Depressants: 254

Experts

1.	Bracht, Adelar: 2 articles (03/2014 - 01/2013)
2.	Comar, Jurandir Fernando: 2 articles (03/2014 - 01/2013)
3.	de Oliveira, Andrea Luiza: 2 articles (03/2014 - 01/2013)
4.	Peralta, Rosane Marina: 2 articles (03/2014 - 01/2013)
5.	Rodgers, R J: 2 articles (11/2010 - 10/2003)
6.	Abbate-Daga, Giovanni: 2 articles (05/2009 - 07/2004)
7.	Fassino, Secondo: 2 articles (05/2009 - 07/2004)
8.	Halmi, Katherine A: 2 articles (01/2008 - 01/2003)
9.	Wideman, R F: 2 articles (01/2008 - 12/2006)
10.	Chapman, M E: 2 articles (01/2008 - 12/2006)

Related Diseases

1.	Weight Loss (Weight Reduction) 03/01/1996 - "Recent studies have documented the safety and efficacy of certain appetite suppressants for assisting in long-term weight loss and maintenance of weight loss. " 11/02/1987 - "This study compared the effects of chronic administration of anorexigenic drugs on weight loss in mice. " 07/01/2015 - "D1 and D2 antagonists reverse the effects of appetite suppressants on weight loss, food intake, locomotion, and rebalance spiking inhibition in the rat NAc shell." 01/01/2013 - "The fruit extracts of Citrus aurantium (bitter orange) are traditionally used as weight-loss products and as appetite suppressants. " 04/01/2011 - "Appetite suppressants as adjuncts for weight loss."
2.	Obesity 01/01/2008 - "If appetite suppressants are to become a more important tool in obesity treatment, agents that do not lose efficacy when administered for extended periods of time must be identified." 10/01/1993 - "The apparent short-term efficacy of these appetite-suppressant drugs and the lack of severe adverse drug effects or addiction suggest that they may be useful in the treatment of obesity. " 01/01/1951 - "Obesity in diabetes: a study of therapy with anorexigenic drugs." 06/01/2014 - "Generally, anti-obesity medications are classified as appetite suppressants or fat absorption blockers. " 01/01/2013 - "Many drugs for the treatment of obesity, which mainly act through CNS as appetite suppressants, have failed during development or been removed from the market due to unacceptable adverse effects. "
3.	Type 2 Diabetes Mellitus (MODY) 09/01/1997 - "Adjunct treatments comprise a few pharmacological approaches which may help to improve glycaemic control by correcting some abnormalities frequently associated with NIDDM, such as obesity (serotoninergic anorectic agents) and hyperlipidaemia (benfluorex). " 12/01/1992 - "Anorectic agents have been shown to improve insulin action in NIDDM, irrespective of weight reduction. " 02/01/1992 - "Anorectic agents have been shown to improve insulin action in NIDDM, irrespective of weight reduction. "
4.	Bulimia (Binge Eating) 12/01/1986 - "We undertook a study to see if putative anorectic agents could attenuate binge eating episodes in bulimic patients. " 06/01/2003 - "All participants were women 15 to 18 years old: 58 anorectics (35 restricting, 23 binge eating/purging) and 59 matched healthy controls. " 03/01/2000 - "No significant differences were found between pure bulimics and binge eating-purging anorectics. " 06/01/2004 - "Restrictor anorectics are characterized by high Persistence (P) and a relatively higher SD, and bulimics by higher Novelty Seeking (NS) and the lowest SD, while binge/purging and purging anorectics share some traits with anorexia and some with bulimia. " 02/01/2002 - "For the time being, the combination of cognitive behavioural therapy and behavioural strategies for weight loss is the most effective procedure to reduce binge eating and to facilitate short-term weight loss; the addition of anti-depressive medication or appetite suppressants seems to give a moderate increase in weight loss. "
5.	Hyperphagia 01/01/2003 - "To date, neither CNS stimulants nor anorectic agents have been effective in treating hyperphagia, in part because hyperphagia in Prader-Willi syndrome is attributed to decreased satiation as opposed to increased hunger. " 05/06/1985 - "Dopaminergic and serotoninergic anorectics differentially antagonize insulin- and 2-DG-induced hyperphagia." 03/01/1977 - "Anorectic agents such as d-amphetamine and fenfluramine showed a remarkably higher effect in rats with hyperphagia after lesioning the ventromedial hypothalamus. " 01/01/1973 - "Hyperphagia in cats induced by injection of sodium pentobarbital into cerebral ventricles as a method for testing anorectics." 05/06/1985 - "It was found that anorectics that act through a serotoninergic mechanism, i.e., d- and d-l-fenfluramine, p-chloroamphetamine, quipazine and fluoxetine antagonize both insulin- and 2-DG-induced overeating, while anorectics acting through the dopaminergic system, i.e., d-amphetamine, diethylpropion, lisuride, bromocriptine and mazindol, antagonize the hyperphagia induced by 2-DG but not that induced by insulin. "

Related Drugs and Biologics

1.	Insulin (Novolin)
2.	Benzocaine (Americaine)
3.	Diuretics
4.	Peptides
5.	benfluorex (S 780)
6.	neuropeptide Y5 receptor
7.	Leptin
8.	Hormones
9.	Biogenic Amines (Biogenic Amine)
10.	Fenfluramine

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Therapeutics
3.	Off-Label Use
4.	Polypharmacy
5.	Gastric Balloon