Aphakia

Absence of crystalline lens totally or partially from field of vision, from any cause except after cataract extraction. Aphakia is mainly congenital or as result of LENS DISLOCATION AND SUBLUXATION.

Also Known As:

Networked: 865 relevant articles (37 outcomes, 52 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Cataract (Cataracts)
2.	Pseudophakia
3.	Refractive Errors (Refractive Error)
4.	Myopia
5.	Keratoconus

Experts

1.	Lambert, Scott R: 19 articles (11/2015 - 12/2003)
2.	Infant Aphakia Treatment Study Group: 17 articles (08/2015 - 01/2010)
3.	Lynn, Michael J: 13 articles (08/2015 - 01/2010)
4.	Wilson, M Edward: 11 articles (04/2015 - 12/2003)
5.	Plager, David A: 7 articles (04/2015 - 12/2003)
6.	Buckley, Edward G: 7 articles (04/2015 - 12/2003)
7.	Kim, Kwang-Soo: 7 articles (01/2014 - 02/2005)
8.	DuBois, Lindreth: 6 articles (04/2015 - 12/2003)
9.	Hartmann, E Eugenie: 5 articles (04/2015 - 07/2010)
10.	Trivedi, Rupal H: 5 articles (06/2014 - 08/2005)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Aphakia:

1.	SiliconesIBA 09/01/2007 - "Proposal and evaluation of a sutureless, no port technique of silicone oil removal in aphakia." 04/01/2005 - "Risk factors are longer duration of oil in the eye, aphakia, silicone oil in the anterior chamber, and extensive and multiple surgeries. " 12/01/2004 - "Removal of silicone oil from aphakia: use of a self-sealing corneal incision." 06/01/2003 - "[Modification of silicone oil removal via limbus of corneal with aphakia]." 05/01/2000 - "Univariate regression revealed that significant (p<0.05) risk factors included aphakia, presence of preoperative PVR, size of detachment, the use of silicone oil, and high vitreous protein level. "
2.	ArgonIBA 05/01/1999 - "The possibility of YAG laser interventions on the posterior capsule of the lens with subsequent argon laser coagulation of the retina in patients with aphakia and artiphakia is studied. " 08/01/1980 - "[Value of systematic photocoagulation with argon laser of peripheral retina in aphakia (author's transl)]." 03/01/1997 - "This study evaluated the efficacy of argon laser trabeculoplasty (ALT) in patients with aphakia or pseudophakia. " 02/01/2001 - "Risk factors for failure were defined as: (1) age less than 40 years old, (2) black race, (3) diabetes mellitus, (4) miotic therapy > or = 18 months, (5) sympathomimetic therapy > or = 6 months, (6) pseudophakia or aphakia, (7) previous failed filtration procedure, (8) argon laser trabeculoplasty, (9) previous ocular surgery and (10) high-risk glaucoma (angle recession glaucoma, uveitic glaucoma and neovascular glaucoma). "
3.	Polymethyl Methacrylate (Sol)IBA 03/01/1999 - "Lens centration and PCO in these eyes were compared with those in eyes with conventional poly(methyl methacrylate) (PMMA) intraocular lenses (IOLs) or aphakia in the fellow eyes. " 07/01/2000 - "These results suggest that implantation of a HSM PMMA IOL is an alternative to correct aphakia also in children with uveitis." 11/01/2009 - "Customized PMMA iris print and iris clipped anterior chamber IOL is a possible solution to repair aniridia with or without correction of aphakia and corneal astigmatism" 11/01/1996 - "Fluorine modification of PMMA IOLs is an effective and safe method to reduce the cicatricial response when IOL implantation is used to correct pediatric aphakia." 03/01/1994 - "Following a review of the literature regarding extended wear rigid lenses (PMMA and oxygen permeable) for the aphakic patient, this paper presents results of fitting high DK (92 x 10-11) rigid contact lenses worn from 1-2 months prior to removal on 11 patients (six with aphakia, five following penetrating keratoplasty). "
4.	CosmeticsIBA 01/01/1988 - "Six types of blended lenticular aspheric lenses for the correction of aphakia were assessed with respect to mass, spectacle magnification, off-axis power errors, peripheral distortion, visual field size and cosmetic appearance. " 09/01/2005 - "Artificial iris-lens diaphragm implantation effectively improved postoperative outcomes by correcting aphakia, reducing glare disability, and addressing cosmetic issues faced by iris-deficient, and aphakic or cataract patients. " 05/01/2009 - "Functional deficits for individual adjustments include diplopia, problem of accommodation, abnormality of eyelids, tearing, cosmetic problems from cornea opacity, glare, aphakia, and dark-adaptation. " 04/01/2002 - "Prosthesis or cosmetic shells were needed for 8 of 31 patients with aphakia, for none of the patients with pseudophakia and for 2 of 28 of the nonoperated children (P =.003). " 06/01/2012 - "Thus, managing posttraumatic aniridia with aphakia by means of haptic fixation of a foldable intraocular lens on a custom-tailored iris prosthesis is a promising approach for visual rehabilitation and cosmetic improvement."
5.	Mitomycin (Mitomycin-C)FDA LinkGeneric 01/01/2003 - "To evaluate the safety and efficacy of trabeculectomy with or without mitomycin-C (MMC) in the management of glaucoma in aphakia and pseudophakia following congenital cataract surgery. " 01/01/2003 - "Trabeculectomy with or without mitomycin-C for paediatric glaucoma in aphakia and pseudophakia following congenital cataract surgery."
6.	FluorineIBA 11/01/1996 - "Comparison of fluorine-surface-modified and unmodified lenses for implantation in pediatric aphakia." 11/01/1996 - "Fluorine modification of PMMA IOLs is an effective and safe method to reduce the cicatricial response when IOL implantation is used to correct pediatric aphakia."
7.	Retinaldehyde (Retinal)IBA 10/01/1997 - "The purpose of this study was to examine the effects of aphakia and changes in retinal permeability and vitreous diffusivity on drug distribution in the vitreous humor of the human eye. " 10/01/1997 - "Drug distribution in the vitreous humor of the human eye: the effects of aphakia and changes in retinal permeability and vitreous diffusivity." 01/01/1994 - "We measured sensitivity to blue and yellow lights presented on bright yellow backgrounds at several retinal eccentricities in both eyes of an observer with long-standing unilateral aphakia. " 09/01/1981 - "A case of traumatic ocular perforation and aphakia resulting in enucleation after six weeks is used to demonstrate histopathological details of an early stage of a typical foveal involvement with grossly visible petaloid swelling of the central retina, separation of the inner limiting membrane with some exudate, massive swelling and early cystoid degeneration of Henle's fiber layer and a vertical retinal fold of the outer retinal layers extending downward from the foveola. " 08/01/1981 - "Possible role in the vitreo-retinal pathology in aphakia."
8.	Levodopa (L Dopa)FDA LinkGeneric 07/01/2007 - "We show that chronic L-DOPA treatment induces novel dyskinetic behaviors in aphakia mouse with selective nigrostriatal deficit mimicking PD. " 01/01/2006 - "We now report that the locomotor deficit of aphakia mice is established by 40 days of age and that it can be rescued by injection of l-dopa. " 02/23/2005 - "Here, we demonstrate that Pitx3-deficient aphakia (ak) mice, which have been shown previously to exhibit a major loss of substantia nigra dopaminergic neurons, display motor deficits that are reversed by L-DOPA and evidence of "dopaminergic supersensitivity" in the striatum. " 01/01/2006 - "Striatal neuroadaptation and rescue of locomotor deficit by L-dopa in aphakia mice, a model of Parkinson's disease." 01/01/2014 - "Parkinson's disease (PD) is characterized by selective death of the substantia nigra dopaminergic neurons, and previously we have shown that aphakia mice, which harbor spontaneous Pitx3 gene mutation, show specific degeneration of the substantia nigra dopaminergic neurons accompanied by behavioral deficits that is reversed by L-DOPA treatment or transplantation of dopaminergic neural precursors. "
9.	Peters anomalyIBA 10/01/1997 - "The clinical picture and pathology study indicated this case as a Peters' anomaly presenting congenital aphakia." 01/01/2005 - "To describe two cases of secondary congenital aphakia in association with Peters anomaly. " 10/01/1997 - "Congenital aphakia in Peters' anomaly syndrome. " 01/01/1972 - "A typical case of Peters' anomaly with primary aphakia." 01/01/2005 - "Secondary congenital aphakia from corneal perforation should be considered in the presentation of severe Peters anomaly."
10.	OxygenIBA 03/01/2008 - "Hyper oxygen-permeable rigid contact lenses as an alternative for the treatment of pediatric aphakia." 01/15/1986 - "Silico-acrylate rigid EWCL with high oxygen transmissibility have been used in this study to correct aphakia and higher astigmatic errors. " 03/01/1994 - "Following a review of the literature regarding extended wear rigid lenses (PMMA and oxygen permeable) for the aphakic patient, this paper presents results of fitting high DK (92 x 10-11) rigid contact lenses worn from 1-2 months prior to removal on 11 patients (six with aphakia, five following penetrating keratoplasty). "

Therapies and Procedures

1.	Intraocular Lenses (Intraocular Lens) 06/01/2001 - "This suggest that, as in adults, intraocular lens implant would be the best treatment for aphakia." 09/01/1997 - "The distribution of best-corrected final visual acuities among the eyes showed statistically significant differences based on the type of intraocular lens (IOL) used, with posterior chamber IOL greater than anterior chamber IOL, and anterior chamber IOL greater than aphakia. " 03/01/2012 - "Scleral fixated intraocular lens (SFIOL) is a safe and effective option for managing optical aphakia. " 01/01/1996 - "Placement of contemporary-style, secondary intraocular lenses in children and young adults appears to provide a safe and effective alternative for correction of aphakia in children who become contact lens or spectacle-intolerant." 09/01/2013 - "Improvement in surgical tools and techniques as well as in intraocular lens (IOL) implantation has led to correction of the aphakia by IOL implantation. "
2.	Contact Lenses 11/01/2013 - "To evaluate the efficacy of high-plus contact lenses as a form of optical penalization in children with unilateral aphakia. " 03/01/1990 - "Contact lenses are a versatile, safe, successful, and cost effective treatment for aphakia in infancy against which, before their widespread introduction for primary optical correction of infant aphakia, other methods of aphakic treatment need to be compared." 04/29/1977 - "The correction of unilateral and bilateral aphakia with contact lenses has given good results. " 07/01/1993 - "Daily wear contact lenses were found to be safe and effective in the treatment of infantile surgical aphakia. " 06/01/2014 - "Patients randomized to receive contact lenses in the Infant Aphakia Treatment Study (IATS) were retrospectively analyzed. "
3.	Intraocular Lens Implantation 01/01/2010 - "Secondary iris claw intraocular lens implantation is clinically safe and effective to correct aphakia in vitrectomized eyes without capsular support. " 06/01/1998 - "Intraocular lens implantation appeared to be a safe and effective alternative to contact lens or spectacle correction of aphakia in children younger than 2 years of age. " 01/01/2010 - "The purpose of this study was to evaluate the safety and efficacy of iris claw intraocular lens implantation for correction of aphakia in vitrectomized eyes without capsular support. " 04/01/2014 - "[Retropupillary iris claw intraocular lens implantation technique for aphakia]." 10/01/2013 - "The aim was to evaluate the results of three different secondary intraocular lens implantation (IOL) procedures in aphakic eyes without capsular support In this retrospective comparative case series, 90 eyes of 90 patients who underwent secondary IOL implantation for correction of aphakia were enrolled. "
4.	Cataract Extraction 12/01/2006 - "Visual outcomes after congenital cataract extraction have improved dramatically with earlier surgery, greater attention to optical correction of the aphakia, and part-time occlusion therapy of the phakic eye. " 04/01/2012 - "Predictors of adherence to occlusion therapy 3 months after cataract extraction in the Infant Aphakia Treatment Study." 03/01/2005 - "Further studies with a larger pediatric patient group are necessary to confirm the optimal treatment of aphakia after unilateral congenital cataract extraction." 10/01/2004 - "To study the incidence of aphakia after cataract extraction and evaluate the relative risk for this outcome in subgroups of patients based on preoperative conditions. " 04/01/2001 - "A randomized clinical trial, the Infant Aphakia Treatment Study, is planned to further study the optimal treatment for aphakia following unilateral cataract extraction during infancy."
5.	Epikeratophakia 04/01/1988 - "In older pediatric patients, epikeratophakia appears to be a safe and effective procedure for the correction of aphakia." 04/01/1988 - "A nationwide study of epikeratophakia for aphakia in older children was conducted from March 1984 to March 1986. " 04/01/1988 - "The nationwide study of epikeratophakia for aphakia in older children." 03/15/1987 - "The nationwide study of epikeratophakia for aphakia in adults." 03/15/1987 - "In the nationwide study of epikeratophakia, 97 surgeons performed a total of 335 procedures in 314 eyes for the correction of aphakia in children under the age of 8 years 1 month. "