Aortopulmonary Septal Defect

A developmental abnormality in which the spiral (aortopulmonary) septum failed to completely divide the TRUNCUS ARTERIOSUS into ASCENDING AORTA and PULMONARY ARTERY. This abnormal communication between the two major vessels usually lies above their respective valves (AORTIC VALVE; PULMONARY VALVE).

Also Known As:

Networked: 9 relevant articles (0 outcomes, 0 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Transposition of Great Vessels (Great Vessels Transposition)
2.	Tetralogy of Fallot (Fallot Tetralogy)
3.	Pulmonary Hypertension (Ayerza Syndrome)
4.	Ventricular Heart Septal Defects (Ventricular Septal Defect)
5.	Patent Ductus Arteriosus

Experts

1.	Feng, Yuan: 1 article (01/2014)
2.	Li, Xiao: 1 article (01/2014)
3.	Zhu, Da: 1 article (01/2014)
4.	Sugimoto, Kaoru: 1 article (02/2008)
5.	Takayasu, Hajime: 1 article (02/2008)
6.	Sato, Hideaki: 1 article (02/2008)
7.	Puri, Prem: 1 article (02/2008)
8.	Sharma, J: 1 article (03/2002)
9.	Saleh, M: 1 article (03/2002)
10.	Das, B B: 1 article (03/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Aortopulmonary Septal Defect:

1.	Coenzyme A (CoA)IBA 04/01/1997 - "Two infants with aorticopulmonary septal defect (APSD) and coarctation of the aorta (CoA) underwent primary surgical repair and their aortic arches were reconstructed in a manner of end-to-end anastomosis. "
2.	Patau syndromeIBA 03/01/2002 - "We report on 2-day-old neonate with trisomy 13 with coexistent distal aortopulmonary septal defect, aortic origin of the right pulmonary artery, interrupted aortic arch, intact ventricular septum, and a patent ductus arteriosus diagnosed by two-dimensional and color Doppler echocardiography. "
3.	Pulmonary venous return anomalyIBA 01/01/1975 - "The following cardiovascular lesions were operated: large aortopulmonary septal defects, localized just above the valvular rings in 2 patients with severe pulmonary hypertension, with very good effect in both; tetralogy of Fallot - in 2 babies, in one with good effect; congenital mitral obstruction with pulmonary hypertension in one case, with good effect; total anomalous pulmonary venous return of supracardiac type in one child, decreased 1 week following operation; type 1 complete transposition of great arteries in one baby, deceased one day following operation; large ventricular septal defects, with systemic or nearly systemic pulmonary hypertension in 5 children, in one with long-term good effect. "
4.	Conotruncal cardiac defectsIBA 09/01/2000 - "There is a wide spectrum of remarkable heart defects between truncus arteriosus communis and aortopulmonary septal defect." 09/01/2000 - "A cross between truncus arteriosus communis and aortopulmonary septal defect: a hitherto undescribed entity."
5.	Coarctation of the aortaIBA 04/01/1997 - "[Primary surgical repair of aorticopulmonary septal defect with coarctation of the aorta]." 04/01/1997 - "Two infants with aorticopulmonary septal defect (APSD) and coarctation of the aorta (CoA) underwent primary surgical repair and their aortic arches were reconstructed in a manner of end-to-end anastomosis. "
6.	nitrofen (TOK)IBA 02/01/2008 - "In addition, the GATA4/GATA6 double heterozygous mutant embryo model displayed a spectrum of cardiovascular malformations similar to those seen in human CDH and nitrofen-induced animal models, including ventricular and aortopulmonary septal defects and thin ventricular myocardium. "

Therapies and Procedures

1.	Septal Occluder Device 01/01/2014 - "Transcatheter closure of late-onset residual aortopulmonary septal defect using a muscular ventricular septal occluder."
2.	Transplants (Transplant) 08/01/1994 - "Aortopulmonary septal defect, interruption of the aortic arch, and anomalous origin of the right pulmonary artery from the aorta comprised a challenging constellation of defects in a 13-day-old neonate, who underwent complete repair without homograft tissue or synthetic graft. "
3.	Homologous Transplantation (Allograft) 08/01/1994 - "Aortopulmonary septal defect, interruption of the aortic arch, and anomalous origin of the right pulmonary artery from the aorta comprised a challenging constellation of defects in a 13-day-old neonate, who underwent complete repair without homograft tissue or synthetic graft. "
4.	Sutures (Suture) 09/01/1981 - "Operative techniques included ligation, direct suture, and patch closure of the aortopulmonary septal defect. "
5.	Ligation 09/01/1981 - "Operative techniques included ligation, direct suture, and patch closure of the aortopulmonary septal defect. "