Aortic Valve Prolapse

The downward displacement of the cuspal or pointed end of the trileaflet AORTIC VALVE causing misalignment of the cusps. Severe valve distortion can cause leakage and allow the backflow of blood from the ASCENDING AORTA back into the LEFT VENTRICLE, leading to aortic regurgitation.

Also Known As:

Networked: 8 relevant articles (0 outcomes, 0 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Prolapse
2.	Atrioventricular Block
3.	Pulmonary Valve Stenosis (Pulmonary Stenosis)
4.	Hypothermia
5.	Ventricular Heart Septal Defects (Ventricular Septal Defect)

Experts

1.	Finucane, Kirsten: 1 article (04/2010)
2.	Rumball, Elizabeth: 1 article (04/2010)
3.	Kale, Suresh Babu: 1 article (04/2010)
4.	Gentles, Tom: 1 article (04/2010)
5.	Chan, Tee-ling: 1 article (04/2010)
6.	Butera, Gianfranco: 1 article (12/2005)
7.	Negura, Diana: 1 article (12/2005)
8.	Carminati, Mario: 1 article (12/2005)
9.	Drago, Manuela: 1 article (12/2005)
10.	Chessa, Massimo: 1 article (12/2005)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Aortic Valve Prolapse:

1.	Insulin (Novolin)FDA Link 01/01/1989 - "In young insulin-treated patients (11%) with labile glycemia, an obvious mitral prolapse and, perhaps, also aortic valve prolapse were detected. "
2.	Coarctation of the aortaIBA 11/01/2004 - "The most common associated cardiac abnormalities were infundibular pulmonary stenosis (5.8%), aortic valve prolapse (3.6%), pulmonary valvar stenosis (2.7%), osteum secundum atrial septal defect (2.2%), persistent ductus arteriosus (1.9%), and coarctation of the aorta (1.5%). "
3.	antineoplaston A10 (A 10)IBA 03/01/2003 - "Both anyplane 2-D images produced by a 3-D reconstruction system and surgical views for 21 patients with eccentric AR (11 with aortic valve prolapse, group A; 10 without prolapse, group B) were analyzed prospectively. "
4.	1-(1-mercaptocyclohexaneacetic acid)-2-(O- methyl-L-tyrosine)-8-L-arginine- vasopressin (AAVP)IBA 12/01/1984 - "The presence and degree of AVP were defined using 3 quantitative terms: aortic valve prolapse distance (AVPD), area (AVPA) and volume (AVPV). "
5.	osteumIBA 11/01/2004 - "The most common associated cardiac abnormalities were infundibular pulmonary stenosis (5.8%), aortic valve prolapse (3.6%), pulmonary valvar stenosis (2.7%), osteum secundum atrial septal defect (2.2%), persistent ductus arteriosus (1.9%), and coarctation of the aorta (1.5%). "
6.	tranilast (N 5')IBA 08/01/1995 - "Surgery was performed in 28 patients at a median age of 50 months because of significant left to right shunt (n = 5), or the development of obstruction in right ventricle (n = 9), aortic valve prolapse (n = 3), or combinations (n = 11). "

Therapies and Procedures

1.	Catheters 12/19/2005 - "The procedure was not performed in 3 patients with perimembranous VSD because of the impossibility of achieving an adequate long sheath position in 1 patient, onset of complete atrioventricular (AV) block during catheter manipulation in 1 patient, and the presence of aortic valve prolapse preventing a safe device placement in 1 patient. "
2.	Homologous Transplantation (Allograft) 04/22/2004 - "From October 1994 to November 2003, 20 cases of Ross procedure were performed to treat with congenital aortic disease, Male: 15 cases; Female: 5 cases; age: 25 years; congenital heart disease (CHD), aortic abnormalities: 12 cases; aortic valve prolapse: 5 cases; aortic valve hypogenesis: 3 cases; combined with subacute bacterial endocarditis (SBE): 4 cases, and ventricle septal defect (VSD): 2 cases; UCG showed aortic stenosis(AS) and/or aortic insufficience (AI) (moderate to severe), Left ventricle diastole diameter (LVDD): (60.51 +/- 11.87) mm, the grade pressure across aortic valve: (27.04 +/- 6.80) mmHg, heart function (NYHA): Class II: 13 cases; Class III: 3 cases; all cases were performed under CPB and moderate hypothermia, the operation procedure was following: (1) taking off auto-pulmonary artery valve; (2) removing dysfunctional aortic valve and auto-transplantation of pulmonary valve on aortic root; (3) putting a pulmonary homograft to rebuild right ventricular outflow tract. "
3.	Transplantation (Transplant Recipients) 04/22/2004 - "From October 1994 to November 2003, 20 cases of Ross procedure were performed to treat with congenital aortic disease, Male: 15 cases; Female: 5 cases; age: 25 years; congenital heart disease (CHD), aortic abnormalities: 12 cases; aortic valve prolapse: 5 cases; aortic valve hypogenesis: 3 cases; combined with subacute bacterial endocarditis (SBE): 4 cases, and ventricle septal defect (VSD): 2 cases; UCG showed aortic stenosis(AS) and/or aortic insufficience (AI) (moderate to severe), Left ventricle diastole diameter (LVDD): (60.51 +/- 11.87) mm, the grade pressure across aortic valve: (27.04 +/- 6.80) mmHg, heart function (NYHA): Class II: 13 cases; Class III: 3 cases; all cases were performed under CPB and moderate hypothermia, the operation procedure was following: (1) taking off auto-pulmonary artery valve; (2) removing dysfunctional aortic valve and auto-transplantation of pulmonary valve on aortic root; (3) putting a pulmonary homograft to rebuild right ventricular outflow tract. "
4.	Sutures (Suture) 04/01/2010 - "A midterm retrospective analysis of the transaortic primary suture repair of perimembranous or conal ventricular septal defects with aortic valve prolapse was conducted. "