Aortic Coarctation

A birth defect characterized by the narrowing of the AORTA that can be of varying degree and at any point from the transverse arch to the iliac bifurcation. Aortic coarctation causes arterial HYPERTENSION before the point of narrowing and arterial HYPOTENSION beyond the narrowed portion.

Also Known As:

Networked: 805 relevant articles (25 outcomes, 65 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Pathologic Constriction (Stenosis)
2.	Pulmonary Valve Stenosis (Pulmonary Stenosis)
3.	Aortic Aneurysm (Aneurysm, Aortic)
4.	Turner Syndrome (Turner's Syndrome)
5.	Chylothorax

Experts

1.	Butera, Gianfranco: 9 articles (04/2015 - 02/2006)
2.	Carminati, Mario: 9 articles (05/2014 - 02/2006)
3.	Ewert, Peter: 6 articles (01/2011 - 10/2004)
4.	Rao, P Syamasundar: 5 articles (05/2015 - 01/2003)
5.	Piazza, Luciane: 5 articles (04/2015 - 02/2006)
6.	Chessa, Massimo: 5 articles (05/2014 - 02/2006)
7.	Budts, Werner: 4 articles (07/2014 - 09/2011)
8.	Trojnarska, Olga: 4 articles (07/2014 - 01/2007)
9.	Peters, Bjoern: 4 articles (10/2008 - 10/2004)
10.	Berger, Felix: 4 articles (10/2008 - 02/2006)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Aortic Coarctation:

1.	Coenzyme A (CoA)IBA 12/01/2008 - "Little is known about the precise morphometric data of the aortic arch at which the transcatheter pressure gradient is relieved in patients with aortic coarctation (CoA). " 11/01/2014 - "Previous studies have suggested endothelial dysfunction in adult patients after repair of aortic coarctation (CoA). " 07/15/2014 - "Three study groups: aortic coarctation (CoA), right ventricular outflow tract pre-stenting for percutaneous revalvulation (RVOT), and miscellaneous. " 03/01/2014 - "The aim of this study was to determine associations between aortic morphometry evaluated by cardiovascular magnetic resonance (CMR) and pregnancy outcomes in women with aortic coarctation (CoA). " 01/01/2014 - "The aim of the current study was to evaluate the effect of surgical repair of CoA on QTc-d, JTc-d in severe aortic coarctation newborns with no associated congenital cardiac malformations. "
2.	Catechin (Z 7300)IBA 08/01/2014 - "The results showed that catechin treatment (50, 100 mg/kg/day) markedly improved myocardial function in rats treated with abdominal aortic coarctation. "
3.	ReninIBA 10/01/2000 - "In the aortic coarctation model, inactive renin comprised 68 % of TRC in the right kidney and no or very little prorenin was found in the left kidney. " 04/01/1993 - "We conclude that reduction of perfusion pressure after abdominal aortic coarctation acutely enhances renin gene expression and downregulates AT1 receptor gene expression.(ABSTRACT TRUNCATED AT 250 WORDS)" 10/01/1987 - "Peripheral renin activity was measured at operation, just before the correction of aortic coarctation, 1/2, 1 h, 1, 3, 7 days, 2 and 6 months after the correction operation. " 09/01/1982 - "We studied plasma renin activity (PRA) in eight children before and after surgical correction of aortic coarctation. " 08/01/1995 - "L-159,913 was antihypertensive in high renin hypertensive rats (aortic coarctation). "
4.	Nitric Oxide (Nitrogen Monoxide)FDA Link 07/01/1998 - "These results suggest that shear stress induced nitric oxide release in lower aortic segments from aortic coarctation-induced hypertensive rats." 07/01/1998 - "[The effect of aortic coarctation on nitric oxide production by the vascular endothelium]." 09/01/2001 - "Enhanced nitric oxide inactivation in aortic coarctation-induced hypertension." 08/01/2006 - "Despite high-frequency oscillatory ventilation plus nitric oxide and uneventful repair of the hernia, the infant died after 6 days of uncontrolled pulmonary hypertension and severe aortic coarctation that developed postnatally." 01/01/2007 - "One infant after repair of ventricular septal defect and aortic coarctation had pulmonary hypertension non-responsive to nitric oxide, another infant and 3.5 year child following palliative surgery for congenital heart disease with univentricular physiology were treated with inhaled nitric oxide and had severe systemic desaturations associated with endotracheal suctioning. "
5.	Angiotensin IIIBA 01/01/2015 - "Activation of upregulated angiotensin II type 2 receptors decreases carotid pulse pressure in rats with suprarenal abdominal aortic coarctation." 01/01/2012 - "We investigated the effect of inter-renal aortic coarctation on the function and expression of vascular α(1A)- and α(1D)-adrenoceptors and plasma angiotensin II (ATII) in rats. " 05/01/1986 - "The present study was designed: (a) to examine the contribution of the renin-angiotensin system (RAS) to elevated regional vascular resistance during the onset of aortic coarctation hypertension, and (b) to determine the role of angiotensin II (Ang II)-neural interactions during the maintenance of high arterial pressure (AP). " 08/01/1991 - "These data suggest that a prostanoid-mediated and endothelium-dependent mechanism of vasoconstriction contributes to the constrictor effect of angiotensin II in aortic rings of rats in the early phase of aortic coarctation-induced hypertension." 03/01/1989 - "Exaggerated renal thromboxane and prostaglandin release by angiotensin II in suprarenal aortic coarctation hypertension."
6.	Messenger RNA (mRNA)IBA 07/30/2004 - "No changes in GAL mRNA expression were observed in petrosal and nodose ganglia following aortic coarctation. " 03/01/1987 - "In response to aortic coarctation, there was a rapid induction of the beta-MHC mRNA followed by the appearance of comparable levels of the beta-MHC protein in parallel to an increase in the left ventricular weight. " 07/01/2006 - "Time course analysis, showed an increase in TH mRNA expression in the NTS 7 days after aortic coarctation when compared to 2 h and 3 days groups, as well as an increase in LC 3 days and 7 days following coarctation hypertension in comparison with the 2 h group. " 04/01/2004 - "In this study we have employed in situ hybridization to analyze changes in mRNA expression of NPY receptor subtypes Y1 and Y2 in the nucleus tractus solitarii (NTS), paraventricular nucleus of the hypothalamus (PVN) and petrosal and nodose ganglions 2 h, 3 and 7 days after aortic coarctation induced hypertension. " 03/01/1996 - "Increased ventricular workload, produced by aortic coarctation for 5 days, resulted in ventricular hypertrophy (heart/body weight, 4.05 +/- 0.19 vs. 3.42 +/- 0.16 mg/g; P < 0.02) and a 3.4-fold increase in betaMHC messenger RNA content. "
7.	glucuronyl glucosamine glycan sulfate (Vessel)IBA 12/01/2008 - "Morphometric analysis of aortic coarctation: determination of the target vessel diameter required to relieve the pressure gradient." 03/31/1981 - "Two cases of mesenteric syndrome were observed in 41 patients undergoing correction of aortic coarctation at the School of Heart and Large Vessel Surgery of the 1st Medical Faculty of Naples University. " 06/01/1992 - "The purpose of this study was to test a new transballoon catheter ultrasonic imaging system capable of on-line direct visualization of lumen diameter and vessel wall structure for imaging before, during, and after dilation in an acute animal model of aortic coarctation. " 02/01/2004 - "However, restenosis frequently occurs after balloon angioplasty for native aortic coarctation in small infants, and sometimes develops after stent implantation because of vessel growth. " 06/01/2003 - "Surgical treatment of aortic coarctation associated with multi-vessel brachiocephalic involvement in takayasu's arteritis."
8.	12- (4'- azido- 2'- nitrophenoxy)dodecanoyl- coenzyme AIBA 01/01/2013 - "This study aimed to provide data for imaging diagnosis and clinical surgical plans by reconstructing a three-dimensional (3-D) digital visible heart model of single ventricle (SV) connection with aortic coarctation (CoA) and characterizing the myocardial and vascular wall pathological characteristics. " 12/01/2015 - "These hemodynamic parameters were studied in a pre-treated aortic coarctation (CoA) and after several virtual interventions using computational fluid dynamics (CFD), to demonstrate the effect of different dilatation options on the flow field. " 09/01/2015 - "These hemodynamic parameters were studied in a pre-treated aortic coarctation (CoA) and after several virtual interventions using computational fluid dynamics (CFD), to demonstrate the effect of different dilatation options on the flow field. " 09/01/2015 - "Aortic wall complications can occur in unrepaired aortic coarctation (CoA) and after surgical repair or endovascular treatment. " 12/01/2009 - "We evaluated the feasibility of 3D echography in assessing intraoperative morphological details of aortic coarctation (CoA) and its repair. "
9.	Atrial Natriuretic Factor (ANF)IBA 12/01/1997 - "Our recent partial cloning of the ovine BNP gene has enabled us to study changes in cardiac tissue concentration, together with tissue and circulating molecular forms of ANP and BNP, in response to cardiac overload induced by rapid ventricular pacing (n = 7) and aortic coarctation (n = 6). " 10/01/1989 - "To study the occurrence of atrial natriuretic peptide (ANP) in overloaded ventricles, suprarenal aortic coarctation was performed on adult rats (n = 60) to induce overloaded left ventricle. " 11/01/1996 - "In conclusion, suprarenal aortic coarctation leads to progressive hypertension resulting in LVH, progressive increases in plasma ANP and BNP and, in most cases, death from heart failure." 09/01/2007 - "To address this question, the foetal gene programme, of which atrial natriuretic peptide (ANP), the beta-isoform of myosin heavy chain (beta-MHC), and the alpha-skeletal muscle isoform of actin (skACT) are classical members, was induced by thoracic aortic coarctation (TAC) in C57BL/6 mice, or by phenylephrine, a selective alpha(1)-adrenoceptor agonist, in cultured rat neonatal cardiomyocytes. " 07/01/1997 - "To dissociate humoral effects from the effects of mechanical loading on cardiac hypertrophic responses, we examined expression of ANP and BNP at both mRNA and protein levels and proportions of myosin isoforms in transplanted cervical hearts that were mechanically unloaded under conditions with or without hypertension by aortic coarctation. "
10.	CalciumIBA 11/01/1988 - "Direct correlation between calcium content and blood pressure: a study of aortic coarctation in rats." 10/01/1997 - "Rings of thoracic aortae taken from rats made hypertensive by aortic coarctation express a calcium-dependent basal tone. " 11/01/1988 - "On the distal, low pressure side of the aortic coarctation, calcium was reduced significantly. " 08/01/1990 - "This study examined the calcium dependency of contractions in arteries from rats made hypertensive by aortic coarctation and in rats with genetic hypertensive (stroke-prone spontaneously hypertensive rats). " 10/01/1997 - "Contribution of constrictor prostanoids to the calcium-dependent basal tone in the aorta from rats with aortic coarctation-induced hypertension: relationship to nitric oxide."

Therapies and Procedures

1.	Balloon Angioplasty 03/15/1999 - "Based on our experience and recent reports, balloon angioplasty is safe and effective in most children older than 7 months and should be considered a viable alternative to operation for discrete aortic coarctation. " 03/01/1992 - "Our experience suggests that balloon angioplasty of native aortic coarctation in adolescents and young adults is safe and highly effective with sustained improvement on intermediate-term follow-up." 11/01/2002 - "Recent data and studies have showed that percutaneous balloon angioplasty is a safe and effective treatment for aortic coarctation. " 07/01/2007 - "Balloon angioplasty is a safe and effective alternative treatment for native aortic coarctation, even during the neonatal period. " 10/01/1987 - "Balloon angioplasty is thus a safe and effective method of relieving unoperated aortic coarctation. "
2.	Stents 07/01/2008 - "Covered stent implantation for treatment of aortic coarctation is safe and highly effective in selected patients. " 04/01/2011 - "Stent implantation for aortic coarctation in adults is a safe and effective alternative to surgical correction." 10/01/2008 - "Feasibility and efficacy of stent redilatation in aortic coarctation." 05/01/2014 - "The present study, reports comparatively 15-year experience of bare and covered stent implantation for aortic coarctation in a single tertiary referral center. " 01/01/2013 - "Although the treatment of aortic coarctation in adults with the use of stents has shown favourable results and reduced complications, there have been few studies involving elderly patients. "
3.	Balloon Dilation 01/01/2006 - "Balloon dilation of native aortic coarctation has been employed safely and effectively in selected patients and with good results during follow-up. " 01/01/2002 - "Balloon dilation is an effective and safe alternative to treat aortic coarctation. " 06/01/2009 - "Our aim was to investigate whether emergency balloon dilation improved the prognosis of neonates with aortic coarctation who present with multiorgan failure. " 04/15/2010 - "Effectiveness and safety of balloon dilation of native aortic coarctation in premature neonates weighing < or = 2,500 grams." 04/01/2008 - "Operational techniques for aortic coarctation include 42 patients of patch aortoplasty, 30 patients of resection and end-to-end anastomosis, 6 patients of subclavian flap aortoplasty, 3 patients of vascular bypass, and 1 patient of balloon dilation. "
4.	Angioplasty (Angioplasty, Transluminal) 12/01/2014 - "He underwent successful management abroad consisting of aortic coarctation treatment by percutaneous angioplasty and resection of the subaortic ring by traditional surgical approach without any mitral valve repair. " 07/01/2011 - "Emergency surgical intervention after unsuccessful percutaneous transluminal angioplasty and stenting of aortic coarctation." 08/01/2010 - "Aortic coarctation: angioplasty and stenting of a total occlusion." 06/01/2010 - "Critical aortic coarctation and VSD were diagnosed in a neonate, and coarctation angioplasty was successfully performed. " 11/01/2007 - "A 29-year-old patient with aortic coarctation was admitted for angioplasty, which was performed successfully. "
5.	Extracorporeal Membrane Oxygenation (ECMO) 06/01/1998 - "Depending on its anatomic location and severity, an aortic coarctation associated with life-threatening CDH may limit the physiological efficacy of venoarterial ECMO. " 06/01/1998 - "The authors present two cases of aortic coarctation associated with CDH requiring ECMO that illustrate the management challenges of these coincident diagnosis. " 12/01/1994 - "The authors encountered a peculiar problem caused by a single carotid artery in a post-ECMO patient during the surgical correction of aortic coarctation with hypoplastic distal aortic arch. " 12/01/1994 - "Surgical repair of an aortic coarctation in a patient after treatment with extracorporeal membrane oxygenation." 01/01/2008 - "After surgical repair of an aortic coarctation a term infant presented with severe pulmonary hypertension and cyanosis unresponsive to treatment including extracorporeal membrane oxygenation. "