Aortic Coarctation

A birth defect characterized by the narrowing of the AORTA that can be of varying degree and at any point from the transverse arch to the iliac bifurcation. Aortic coarctation causes arterial HYPERTENSION before the point of narrowing and arterial HYPOTENSION beyond the narrowed portion.

Also Known As:

Coarctation of Aorta; Coarctation of Aorta Dominant; Coarctation of the Aorta; Aorta Coarctation; Aorta Coarctations; Aorta Dominant Coarctation; Aorta Dominant Coarctations; Aortic Coarctations; Coarctation, Aortic; Coarctations, Aortic

Networked: 2080 relevant articles (70 outcomes, 195 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Hypertension (High Blood Pressure)
2.	Turner Syndrome (Turner's Syndrome)
3.	Congenital Heart Defects (Congenital Heart Defect)
4.	Pathologic Constriction (Stenosis)
5.	Ventricular Heart Septal Defects (Ventricular Septal Defect)

Experts

1.	Butera, Gianfranco: 15 articles (12/2021 - 12/2005)
2.	Egbe, Alexander C: 14 articles (04/2022 - 10/2017)
3.	Berger, Felix: 13 articles (05/2022 - 02/2006)
4.	Connolly, Heidi M: 13 articles (04/2022 - 12/2003)
5.	Ewert, Peter: 11 articles (01/2022 - 06/2003)
6.	McBride, Kim L: 11 articles (01/2021 - 09/2004)
7.	Carminati, Mario: 11 articles (01/2020 - 12/2005)
8.	Roos-Hesselink, Jolien W: 10 articles (01/2022 - 04/2005)
9.	Schubert, Stephan: 9 articles (05/2022 - 10/2004)
10.	Budts, Werner: 9 articles (01/2022 - 05/2009)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Aortic Coarctation:

1.	Coenzyme A (CoA)IBA 01/23/2023 - "Survival of patients after repair of coarctation of Aorta (CoA) has improved significantly over the decades, but patients have decreased life expectancy as compared to the general population. " 04/01/2005 - "More information is needed to clarify whether stenting is superior to balloon angioplasty (BA) for unoperated coarctation of the aorta (CoA). " 09/01/2015 - "Although surgical results for repair of coarctation of the aorta (CoA) have steadily improved, management of this condition remains controversial. " 01/01/2015 - "Although aortography is well known as the "gold standard" for the diagnosis of coarctation of aorta (CoA), the method is invasive, expensive and not readily accepted by some patients. " 09/01/2011 - "Resection with end-to-end anastomosis (RWEA) is the gold standard for coarctation of the aorta (CoA) repair, but may lead to altered WSS indices that contribute to morbidity. "
2.	PlatinumIBA 05/12/2015 - "The Coarctation of the Aorta Stent Trial (COAST) was designed to assess the safety and efficacy of the Cheatham Platinum stent when used in children and adults with native or recurrent coarctation. " 04/30/2010 - "The purpose of this study was to determine the safety and efficacy of the Cheatham Platinum covered stent in adults with coarctation of the aorta. " 01/01/2021 - "We report up to 5 years of postimplant follow-up in patients enrolled into the COAST (Coarctation of the Aorta Stent Trial) and the COAST II trial (Covered Cheatham-Platinum Stents for Prevention or Treatment of Aortic Wall Injury Associated With Coarctation of the Aorta), evaluating the bare and Covered Cheatham-Platinum Stents for the treatment of coarctation of the aorta and associated aortic wall injury. " 11/15/2012 - "Participants of the multicenter Coarctation of the Aorta Stent Trial (COAST) had access to investigational large-diameter, balloon-expandable, covered stents (covered Cheatham-platinum stents; NuMed, Inc., Hopkinton, New York) on an emergency-use basis. " 10/01/2023 - "Long-term follow-up after endovascular treatment of aortic coarctation with bare and covered Cheatham platinum stents."
3.	12- (4'- azido- 2'- nitrophenoxy)dodecanoyl- coenzyme AIBA 01/01/2023 - "We aimed to assess current prenatal detection rate (DR) of aortic coarctation (CoA) and its impact on neonatal outcome in the Netherlands to evaluate the efficacy of the Dutch screening protocol in which the cardiac four-chamber view, outflow tracts and three-vessel view are compulsory. " 07/01/2023 - "The aim was to study pregnancy outcomes in women with coarctation of the aorta (CoA) and associations to hypertensive disorders of pregnancy. " 09/12/2022 - " The aim of this study was to investigate fetal echocardiographic findings in predicting the need for surgical repair in fetuses with coarctation of the aorta (CoA) and to evaluate perinatal outcomes. " 05/16/2017 - "BACKGROUND The purpose of this study was to evaluate the utility of multi-detector computed tomography (MDCT) angiography and transthoracic echocardiography (TTE) in the diagnosis of congenital coarctation of the aorta (CoA) and accompanying malformations in infants. " 07/01/2015 - "This study aimed to explore the arterial-left ventricular (LV)-left atrial (LA) interaction in adolescents and young adults late after intervention for coarctation of the aorta (CoA) and interrupted aortic arch (IAA). "
4.	nitinolIBA 11/01/2010 - "Our model uses the shape memory response of nitinol clips to reproducibly induce an aortic coarctation and allow subsequent focal control over WSS in the aorta. " 09/01/2017 - "Midterm to long-term safety and efficacy of self-expandable nitinol stent implantation for coarctation of aorta in adults." 01/01/2017 - "Percutaneous treatment for repair of aortic coarctation was successfully performed with deployment of self-expanding nitinol stents. " 01/01/2015 - "To present perioperative and long-term results of percutaneous treatment of adult isthmic coarctation of the aorta by means of a self-expandable closed-web uncovered nitinol stent (Sinus-XL, Optimed, Esslingen, Germany). " 01/01/2015 - "Percutaneous treatment of adult isthmic aortic coarctation: acute and long-term clinical and imaging outcome with a self-expandable uncovered nitinol stent."
5.	ProstaglandinsIBA 05/01/1995 - "After resumption of prostaglandin El, with an attenuated juxtaductal aortic coarctation, the left ventricular contractility and the systemic perfusion improved. " 10/01/2023 - "Therapeutic options are limited for the management of extremely low-birth-weight infants with critical aortic coarctation despite high doses of prostaglandin infusion. " 01/01/2020 - "Prostaglandin Infusion in Neonate With Severe Coarctation of the Aorta With Closed Ductus Arteriosus-A Case Report and Review of the Literature." 09/18/2019 - "Prostaglandins are widely used in aortic coarctation to maintain ductal patency and preserve systemic perfusion until surgical intervention can be performed. " 09/18/2019 - "Prostaglandin E 2 in a preterm infant with coarctation of the aorta."
6.	ReninIBA 03/01/1976 - "Studies of plasma renin activity in coarctation of the aorta." 10/01/2000 - "In the aortic coarctation model, inactive renin comprised 68 % of TRC in the right kidney and no or very little prorenin was found in the left kidney. " 04/01/1993 - "We conclude that reduction of perfusion pressure after abdominal aortic coarctation acutely enhances renin gene expression and downregulates AT1 receptor gene expression.(ABSTRACT TRUNCATED AT 250 WORDS)" 10/01/1987 - "Peripheral renin activity was measured at operation, just before the correction of aortic coarctation, 1/2, 1 h, 1, 3, 7 days, 2 and 6 months after the correction operation. " 09/01/1982 - "We studied plasma renin activity (PRA) in eight children before and after surgical correction of aortic coarctation. "
7.	esmolol (Brevibloc)FDA LinkGeneric 08/01/2008 - "We report the first prospective multi-institutional trial addressing the safety and efficacy of esmolol after repair of coarctation of the aorta in infants and children. " 08/01/2008 - "The safety, efficacy, and pharmacokinetics of esmolol for blood pressure control immediately after repair of coarctation of the aorta in infants and children: a multicenter, double-blind, randomized trial." 08/01/2008 - "Esmolol can be administered safely to patients younger than 6 years after repair of coarctation of the aorta. " 07/01/2006 - "The objective of this study was to evaluate the effectiveness and safety of esmolol-induced negative ino- and chronotropism during stent/balloon angioplasty for aortic coarctation. " 07/01/2006 - "Esmolol-assisted balloon and stent angioplasty for aortic coarctation."
8.	AldosteroneIBA 11/01/1980 - "[Plasma renin activity and aldosterone excretion in coarctation of the aorta]." 05/01/2010 - "Once rare causes have been eliminated (such as pheochromocytoma, licorice, adult coarctation of the aorta), the cause will usually be found by intelligent interpretation (in the light of medications then being taken) of plasma renin and aldosterone.If" 01/01/1983 - "This study suggests that the renin-aldosterone-system does not have a major role in the maintenance of the hypertension associated with coarctation of the aorta." 11/01/2001 - "These causes (which constitute frequently asked questions for medical students) include coarctation of the aorta, aldosterone and corticosteroid-producing tumors of the adrenal glands, lesions producing decreased renal blood flow, and pheochromocytoma. " 04/01/2012 - "Because there was possibility that post coarctectomy syndrome would occur after repair of coarctation of aorta, administration of depressor that acts on renin-angiotensin-aldosterone and careful observation were needed postoperatively. "
9.	Labetalol (Normodyne)FDA LinkGeneric 11/01/2022 - "Intravenous labetalol is a fast, effective, and safe drug to treat hypertension following aortic coarctation repair. " 05/01/2008 - "We report a case of a large labetalol overdose in an eight-month-old infant that was being treated for hypertension following surgery for coarctation of the aorta. " 09/01/1988 - "Intravenous labetalol for the control of hypertension following repair of coarctation of the aorta." 12/01/2020 - "Labetalol Infusion Controls Paradoxical Hypertension and Decreases Plasma Renin Activity Following Repair of Coarctation of the Aorta in Children." 12/01/2020 - "Labetalol Infusion Attenuates Paradoxical Hypertension and Decreases Plasma Renin Activity After Repair of Coarctation of the Aorta in Children."
10.	BESIBA 01/01/2022 - "This study sought to compare the safety and efficacy of the balloon-expandable stent (BES) and the self-expandable stent (SES) in the endovascular treatment of coarctation of aorta. " 01/01/2022 - "In the present open-label, parallel-group, blinded endpoint randomized pilot clinical trial, adult patients with de novo native aortic coarctation were randomized into Cheatham-platinum BES and uncovered nitinol SES groups. "

Therapies and Procedures

1.	Stents 07/01/2008 - "Covered stent implantation for treatment of aortic coarctation is safe and highly effective in selected patients. " 08/01/2017 - "In our cohort, stent placement for relief of recurrent coarctation of the aorta resulted in a significant improvement in exercise capacity. " 11/01/2005 - "Therefore, we conclude that stent implantation for coarctation of the aorta is safe and effective with sustained good midterm results." 06/01/2019 - "As for simple coarctation of the aorta, stent implantation was feasible and effective in an adult patient with coarctation of the 5th aortic arch." 02/01/2004 - "Use of balloon angioplasty or stent implantation has been reported to be effective in relieving coarctation of the aorta. "
2.	Therapeutics 08/01/2006 - "The combined use of MR and X-ray imaging is effective for anatomic and functional evaluation of aortic coarctation dilation, which may be crucial for optimal therapy." 12/03/2021 - "The gold standard treatment for coarctation of the aorta in these patients is being replaced - from open surgery to endovascular therapy. " 03/01/1995 - "Aortic coarctation may be relieved by surgery or by balloon angioplasty; in asymptomatic patients, therapy during the ages of 2 and 5 years is suggested. " 11/01/2010 - "The aim of this study was to compare the results of endovascular therapy (covered stenting) with surgical technique to repair aortic coarctation in adults. " 03/01/2021 - "A Comparison of Hemodynamic and Clinical Outcomes After Transcatheter Versus Surgical Therapy in Adults in Coarctation of Aorta."
3.	Catheters 01/01/2019 - "The purpose of the study was to evaluate the association between fetal echocardiographic measurements and the need for intervention (primary coarctation repair, staged coarctation repair, or catheter intervention) in prenatally diagnosed coarctation of the aorta. " 06/01/1992 - "The purpose of this study was to test a new transballoon catheter ultrasonic imaging system capable of on-line direct visualization of lumen diameter and vessel wall structure for imaging before, during, and after dilation in an acute animal model of aortic coarctation. " 01/01/1992 - "An intravascular ultrasound study was performed in a patient, to assess the anatomy of aortic coarctation and the results obtained after percutaneous dilation with a balloon catheter. " 10/01/2022 - "Determine outcomes of catheter intervention for aortic coarctation in infants. " 12/01/2021 - "The Use of Regional Catheters in Children Undergoing Repair of Aortic Coarctation."
4.	Operative Surgical Procedures 01/01/1996 - "Patch aortoplasty is an effective and safe surgical procedure for primary repair of isthmic aortic coarctation when other surgical techniques cannot be performed." 01/01/2020 - "Nowadays, the management of aortic coarctation is very difficult because the surgical procedures are different in infancy, childhood and adult age. " 10/01/2009 - "Coarctation of the aorta accounts for almost 5% of all congenital cardiac malformations, and it is usually treated by open surgical procedures. " 01/01/2003 - "Patients' psychomotor development following surgery for aortic coarctation is not affected by type of surgical procedure. " 01/01/1997 - "Definitive surgical procedure for correction of aortic coarctation presenting initially in teenagers, remains an issue. "
5.	Denervation 09/01/1993 - "Dystrophic degenerations appear to depend on the type of deteriorations in intracellular enzymatic systems, which are regulated by cAMP, as shown by dissimilar response of myocardium to the agonist effect; this effect was increased in dystrophy caused by denervation and was altered only slightly after aorta coarctation and novodrine administration." 04/01/1988 - "[Hemodynamic effect of denervation of the aortic arch with special reference to reconstruction of coarctation of the aorta]." 02/01/2015 - "Studies and case reports published between 2002 and 2014 utilizing the TR access during transcatheter structural and congenital heart disease interventions during alcohol septal ablation (ASA), ventricular septal defect (VSD), renal denervation (RD), paravalvular leak (PVL) closure, transcatheter aortic valve implantation (TAVI, secondary access) and endovascular repair of aortic coarctation (ERAC, secondary access) were evaluated. " 01/01/2016 - "Renal denervation substantially ameliorates the development of hypertension in animal models such as renovascular, spontaneously hypertensive, and steroid-induced hypertension in rats and aortic coarctation in dogs. "