Antiviral Agents (Antivirals)

Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly.

Also Known As:

Networked: 47706 relevant articles (3927 outcomes, 5394 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Zeuzem, Stefan: 124 articles (02/2022 - 04/2002)
2.	Neyts, Johan: 109 articles (01/2022 - 08/2002)
3.	Wedemeyer, Heiner: 84 articles (06/2022 - 11/2004)
4.	Kao, Jia-Horng: 84 articles (05/2022 - 01/2003)
5.	Zoulim, Fabien: 79 articles (11/2022 - 02/2002)
6.	Pol, Stanislas: 79 articles (06/2022 - 01/2006)
7.	De Clercq, Erik: 79 articles (11/2021 - 01/2002)
8.	Chung, Raymond T: 78 articles (01/2021 - 12/2003)
9.	Yu, Ming-Lung: 77 articles (09/2022 - 08/2009)
10.	Sarrazin, Christoph: 75 articles (05/2022 - 05/2004)

Related Diseases

1.	Infections 11/01/2021 - "In preclinical studies we analyzed the antiviral efficacy of drug candidates of a novel compound class of HPIs for the treatment of HSV to identify the most active eutomer structure in an intranasal infection mouse lethal challenge model. " 02/20/2009 - "In this study, we describe a novel CD4-targeting bifunctional human immunodeficiency virus (HIV-1) fusion inhibitor (CD4-BFFI) that blocks HIV-1 entry by inhibiting both HIV-1 attachment and fusion and is highly potent against both R5 and X4 HIV-1 viruses in various antiviral assays, including peripheral blood mononuclear cell (PBMC) infection assays. " 03/05/2023 - "The advent of highly efficacious direct-acting antivirals and their success in the treatment of hepatitis C virus infection, generated soon an optimism. " 12/01/2022 - "Direct-acting antivirals (DAA) are highly effective against hepatitis C virus (HCV) infection among persons with human immunodeficiency virus (PWH). " 08/01/2022 - "The current treatment for HCV infection with direct-acting antivirals (DAAs) is highly effective and safe. "
2.	COVID-19 10/01/2023 - "The lack of any effective cure for the infectious COVID-19 disease has created a sense of urgency and motivated the search for effective antiviral drugs. " 01/01/2022 - "Thus, NTL-125 is a highly potential antiviral compound of natural origin against SARS-CoV-2 and may serve as an important therapeutic for management of COVID-19." 07/01/2021 - "Nevertheless, no antiviral treatment has yet been proven effective for treating COVID-19 and symptomatic supportive cares have been the most common treatment. " 02/01/2021 - "The most recently published papers on the distribution of ACE2 in the human body and documented binding of GZ to this receptor, as well as its antiviral activity, suggest that GZ can be used as a therapeutic for COVID-19 and as a preventive agent against SARS-CoV-2." 01/01/2021 - "Although clinical trials to assess the efficacy of these antivirals are ongoing, this review highlights important information including docking and modeling analyses, in vitro studies, as well as results from clinical uses of these antivirals against COVID-19 pandemic."
3.	Chronic Hepatitis C 05/01/2023 - "The introduction of direct-acting antiviral (DAA) drugs has dramatically improved chronic hepatitis C (CHC) treatment. " 01/01/2022 - "The new generation of direct-acting antivirals has improved dramatically the rates of cure for chronic hepatitis C. " 10/01/2021 - "Direct-acting antivirals are new drugs, highly effective and safe against chronic hepatitis C. " 05/14/2021 - "The introduction of direct-acting antiviral drugs into clinical practice has revolutionized the treatment of chronic hepatitis C, making it highly effective and safe for patients. " 01/01/2021 - "Direct-acting antivirals (DAAs) are highly effective in treating chronic hepatitis C virus (HCV)-infected patients. "
4.	Virus Diseases (Viral Diseases) 01/01/2022 - "Reverse-transcription quantitative real-time PCR is the most commonly used method for detecting virus infection and assessing antiviral efficacy with high accuracy. " 01/01/2022 - "Although treatment with direct-acting antivirals represents remarkable progress, many patients are still infected and even those who cleared the viral infection must be followed due to their previous hepatic lesions, especially regarding the disturbances of lobular architecture and the sanguineal and lymphatic vessels. " 12/01/2020 - "The diversity and complexity of natural products (NPs) offer remarkable efficacy and specificity to target viral infection steps and serve as excellent source for antiviral agents. " 10/01/2020 - "Taking advantage of an invertebrate species, the Pacific oyster (Crassostrea gigas), in which we evidenced one of the longest and most effective periods of protection against viral infection observed in an invertebrate, we provide the first comprehensive transcriptomic analysis of antiviral innate immune priming. " 09/01/2000 - "The successful development of effective antivirals to treat the most common external ocular viral infections have dramatically reduced morbidity and sight loss. "
5.	Hepatitis C 01/01/2023 - "Most patients (65.4%) trusted the efficacy of directly acting antivirals for hepatitis C. " 10/04/2022 - "The all-oral direct acting antivirals for HCV are highly effective and safe, thus the remaining challenge with hepatitis C is case identification and linkage to care. " 01/01/2022 - "With the advent of highly effective antiviral treatment for hepatitis C, many people have undergone treatment and been cured. " 01/01/2021 - "In recent years, the advent of direct-acting antivirals (DAAs) has dramatically improved the therapeutic outcomes in hepatitis C patients. " 01/01/2021 - "Treatment of hepatitis C with direct-acting antivirals is safe and highly efficacious, resulting in viral clearance (sustained virological response [SVR]) in the vast majority of patients. "

Related Drugs and Biologics

1.	Interferons
2.	Vaccines
3.	Ribavirin (Virazole)
4.	Antiviral Agents (Antivirals)
5.	Acyclovir (Aciclovir)
6.	Nucleosides
7.	Lamivudine (Epivir)
8.	DNA (Deoxyribonucleic Acid)
9.	Proteins (Proteins, Gene)
10.	Anti-Bacterial Agents (Antibiotics)

Related Therapies and Procedures

1.	Therapeutics
2.	Liver Transplantation
3.	Drug Therapy (Chemotherapy)
4.	Transplantation
5.	Immunotherapy