Antitussive Agents (Antitussives)

06/01/2006 - "Like other over the counter antitussives, SO did not result in marked improvement in cough symptoms."
07/01/2001 - "This method offers many distinct advantages to evaluate efficacy of antitussive drugs including the fact that no surgery is required, it takes only 15-20 min to complete an experiment, and it can be used to simultaneously profile antitussive and side effect liabilities of drugs developed for the treatment of cough."
10/01/2012 - "Unfortunately, therapeutic options for acute cough in children are severely limited due to the absence of drugs shown to be effective antitussives with an acceptable safety profile. "
06/01/2008 - "[Lower airway nervous system as a putative target of antitussive drugs effective for treatment of chronic cough]."
09/01/1992 - "The device may be useful in the study into the efficacy of new antitussive drugs and the assessment of cough clearance. "

05/01/2014 - "Guidelines have been published regularly since 2010 by the ANSM (the Health Products Safety Agency) advising against antitussive drugs for infants because of their inefficacy and their side effects (convulsions, respiratory congestion). "
10/11/1988 - "The results demonstrate that caramiphen is a potent anticonvulsant against generalized convulsions and, like other non-opioid antitussives, will enhance the anticonvulsant properties of diphenylhydantoin. "
07/01/1989 - "Two antitussives, dextromethorphan and carbetapentane, which have been reported to bind to a common binding site in brain tissue and produce anticonvulsant effects in rats, were evaluated for their anticonvulsant effects against maximal electroshock-induced seizures, for their neurological impairing effects on the horizontal screen test, and their protective effects against N-methyl-D-aspartic acid (NMDA)-induced lethality in mice. "
09/24/1986 - "The non-opioid antitussives dextromethorphan and carbetapentane, the active ingredients of several over-the-counter cough suppressants, provide a dose-related protection against maximal electroshock seizures in rats. "

01/01/2006 - "Peripheral and central antitussive agents can be useful in patients with chronic bronchitis, but can have little efficacy in patients with cough due to upper respiratory infection. "
01/01/1987 - "For pathologic cough in man, predominantly studied in patients with chronic bronchitis, the following non-specific antitussive drugs have been shown to be effective: aerosolized ipratropium bromide, all narcotics of the phenanthrene alkaloid group (e.g., morphine and codeine), and the non-narcotics, dextromethorphan, glaucine, diphenhydramine, caramiphen, viminol and diviminol. "

05/01/2003 - "The following data was extracted from them; presenting symptoms, number of visits, names of asthma medications, whether doses were documented or not and number of times antitussives were prescribed. "
07/01/1996 - "In these pairs, antitussives showed a significant association with asthma exacerbations, with an OR of 3.1. "
04/01/1956 - "The use of antitussives in the management of bronchial asthma."
07/01/1996 - "This study confirms that antitussives and antihistamines are commonly used by asthmatics and indicates that both classes are associated with increased occurrence of asthma exacerbations; assessing causality from present data is, however, difficult. "
01/01/2008 - "Antibiotics, antitussives and mucolytics are commonly used in asthma, despite limited evidence for their effectiveness. "

06/01/2001 - "Seventeen (23.6%) patients were noted to have an upper respiratory tract infection before the attack, and 25 (34.7%) patients had taken antitussive agents. "
09/01/1989 - "Sometimes, antitussives can be a valid adjuvant to respiratory tract infections treatment. "
01/01/2009 - "There has been a long tradition in acute cough usually due to upper respiratory tract infections to use symptom-related antitussives. "
10/01/1997 - "This presents a problem because the support for codeine's antitussive activity comes from studies on cough in animals, and chronic and induced cough models in man, whereas antitussives are almost exclusively used for the treatment of cough associated with acute upper respiratory tract infection (URTI). "
01/01/2004 - "There is also recent evidence that standard antitussive agents, such as codeine, may not reduce cough during upper respiratory infections. "