Antitubercular Agents

Drugs used in the treatment of tuberculosis. They are divided into two main classes: "first-line" agents, those with the greatest efficacy and acceptable degrees of toxicity used successfully in the great majority of cases; and "second-line" drugs used in drug-resistant cases or those in which some other patient-related condition has compromised the effectiveness of primary therapy.

Also Known As:

Networked: 363 relevant articles (14 outcomes, 26 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Khuller, G K: 11 articles (12/2008 - 01/2001)
2.	Sharma, Sadhna: 6 articles (09/2007 - 01/2003)
3.	Pandey, Rajesh: 6 articles (05/2006 - 01/2003)
4.	Nacy, Carol A: 3 articles (01/2015 - 08/2006)
5.	Einck, Leo: 3 articles (01/2015 - 08/2006)
6.	Tyagi, Anil K: 3 articles (01/2011 - 01/2009)
7.	Khare, Garima: 3 articles (01/2011 - 01/2009)
8.	Ahmad, Zahoor: 3 articles (12/2008 - 08/2006)
9.	Mulvey, Matthew C: 2 articles (01/2015 - 01/2012)
10.	Calderón, Angela I: 2 articles (01/2015 - 03/2014)

Related Diseases

1.	Tuberculosis (Tuberculoses) 11/01/1990 - "Combined treatment with tuberculostatic agents for 5 months resulted in complete remission of the tuberculosis." 01/01/2015 - "Tuberculosis: current treatment, diagnostics, and newer antitubercular agents in clinical trials." 08/01/2006 - "The purpose of this study was to determine interactions of SQ109, a new asymmetric diamine tuberculosis (TB) drug candidate, with existing antitubercular drugs in vitro and assess its potential to improve combination drug activities against Mycobacterium tuberculosis. " 02/01/1986 - "In 186 patients with intestinal tuberculosis, clinical features, radiological findings and complications were carefully recorded and compared with those from earlier studies with a view to study any possible changes after the liberal use of antitubercular drugs. " 05/01/1977 - "On the basis of the data of the study it was conlcuded that concentrations of the tuberculostatic agents in the healthy ares of the lung tissue and the walls of the tuberculosis focus were much higher after the drug administration by the routine methods and remained at the minimum bacteriostatic level for 48 hours. "
2.	Infection 12/01/1974 - "[Mycoplasma pneumoniae infections, serologic studies, the anti-mycoplasma effect of various antitubercular drugs]." 09/01/2015 - "While PAS was initially a first-line TB drug, the introduction of more potent antitubercular agents relegated PAS to the second-line tier of agents used for the treatment of drug-resistant Mycobacterium tuberculosis infections. " 06/01/2014 - "Despite significant pharmacokinetic interactions between antiretrovirals and antitubercular drugs, adequate clinical response of both infections can be achieved with an acceptable safety profile when the pharmacological characteristics of drugs are known, and appropriate combination regimens, dosing, and timing of initiation are used. " 03/01/2014 - "In conclusion, high dose IFNγ therapy in combination with antitubercular drugs led to resolution of BCG infection in a patient with dominant partial IFNγ deficiency." 10/01/2009 - "A questionnaire regarding what antitubercular drugs, their dosage and for how long was asked to attending faculty in an International Conference on musculoskeletal infections. "
3.	Pulmonary Tuberculosis 01/01/1998 - "[In vitro study of the modulating effect of antitubercular agents on the rosette formation response in patients with pulmonary tuberculosis]." 10/01/1994 - "One striking feature of the study was that one third of the cases were misdiagnosed as pulmonary tuberculosis and were treated with antitubercular drugs for varying periods of time. " 05/01/1968 - "[Clinical studies on the ketogenic effect of certain antitubercular drugs in patients with diabetes and pulmonary tuberculosis]." 01/01/1963 - "[Studies on the metabolism of phosphate compounds in experimental pulmonary tuberculosis and the effect of various kinds of antitubercular agents]." 03/01/2014 - "She was diagnosed with pulmonary tuberculosis and treated with antitubercular drugs. "
4.	Acquired Immunodeficiency Syndrome (AIDS) 11/01/2011 - "Sex, AIDS status or smoking history had no significant effects on the magnitude of ELF concentrations of antitubercular agents. " 02/01/1999 - "[Problems produced by the use of antitubercular agents in a reference service for HIV/AIDS in Abidjan (Côte d'Ivoire)]." 07/01/2010 - "The dismal outcome of tuberculosis of the spine in the pre-antibiotic era has improved significantly because of the use of potent antitubercular drugs, modern diagnostic aids and advances in surgical management. " 10/15/1994 - "[Recurrent Mycobacterium tuberculosis bacteremia in AIDS: subtherapeutic concentrations of antitubercular agents?]." 11/01/2011 - "The range of mean ELF concentrations of itraconazole and posaconazole following oral administration was 0.2-1.9 μg/mL, and the ELF to plasma concentration ratios were <1. A series of studies have evaluated the intrapulmonary penetration of first- and second-line oral antitubercular agents in healthy adult subjects and patients with AIDS. "
5.	Iron Overload 10/01/2013 - "Scientific studies have shown amla to be effective in preventing/ameliorating the toxic effects of hepatotoxic agents like ethanol, paracetamol, carbon tetrachloride, heavy metals, ochratoxins, hexachlorocyclohexane, antitubercular drugs and hepatotoxicity resulting from iron overload. "

Related Drugs and Biologics

1.	Carbon Monoxide
2.	poly(lactide) (polylactide)
3.	Heavy Metals
4.	Ochratoxins
5.	Carbon Tetrachloride (Tetrachloromethane)
6.	Lindane (gamma-Hexachlorocyclohexane)
7.	Ethanol (Ethyl Alcohol)
8.	Acetaminophen (Paracetamol)
9.	Anti-Bacterial Agents (Antibiotics)
10.	Indomethacin (Indometacin)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Art Therapy
3.	Nephrectomy
4.	Oral Administration
5.	Intravitreal Injections