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Antisocial Personality Disorder (Antisocial Personality)

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A personality disorder whose essential feature is a pervasive pattern of disregard for, and violation of, the rights of others that begins in childhood or early adolescence and continues into adulthood. The individual must be at least age 18 and must have a history of some symptoms of CONDUCT DISORDER before age 15. (From DSM-IV, 1994)

Also Known As:

Antisocial Personality; Antisocial Personalities; Personality Disorders, Antisocial; Psychopathic Personality; Sociopathic Personality; Antisocial Personality Disorders; Behavior, Dyssocial; Behaviors, Dyssocial; Disorder, Antisocial Personality; Disorders, Antisocial Personality; Dyssocial Behaviors; Personalities, Antisocial; Personalities, Psychopathic; Personalities, Sociopathic; Personality, Antisocial; Personality, Psychopathic; Personality, Sociopathic; Psychopathic Personalities; Sociopathic Personalities; Dyssocial Behavior; Personality Disorder, Antisocial

Networked: 638 relevant articles (9 outcomes, 113 trials/studies)

Relationship Network

Disease Context: Research Results

Mental Disorders: 2989
- Personality Disorders: 1168
  - Antisocial Personality Disorder: 638

Related Diseases

1.	Substance-Related Disorders (Drug Abuse)
2.	Borderline Personality Disorder (Personality Disorders, Borderline)
3.	Personality Disorders (Personality Disorder)
4.	Attention Deficit Disorder with Hyperactivity (Attention Deficit Hyperactivity Disorder)
5.	Cocaine-Related Disorders (Cocaine Addiction)

Experts

1.	Grant, Bridget F: 13 articles (09/2015 - 06/2005)
2.	Lilienfeld, Scott O: 10 articles (04/2015 - 02/2002)
3.	Goldstein, Risë B: 10 articles (07/2010 - 10/2003)
4.	Hodgins, Sheilagh: 8 articles (12/2014 - 01/2004)
5.	Kumari, Veena: 8 articles (02/2014 - 03/2005)
6.	Edens, John F: 7 articles (04/2015 - 11/2006)
7.	Moeller, F Gerard: 7 articles (06/2013 - 09/2002)
8.	Swann, Alan C: 7 articles (06/2013 - 09/2002)
9.	Cetin, Mesut: 7 articles (11/2011 - 11/2007)
10.	Gelernter, Joel: 6 articles (06/2014 - 01/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Antisocial Personality Disorder:

1.	4-aminospiroperidolIBA 03/01/2008 - "Antisocial personality disorder (ASPD) is associated with suicide, violence, and risk-taking behavior and can slow response to first-line treatment for Axis I disorders. " 05/01/2015 - "Despite the fact that new criteria of antisocial personality disorder (ASPD) in diagnostic and statistical manual of mental disorders-fifth edition (DSM-5) were resulted from five-factor model (FFM), there is a small amount of studies that investigate the relations between proposed personality traits and FFM. " 01/01/2015 - "The current study compares the 2 diagnostic approaches (Section II vs. Section III) included in the Diagnostic and Statistical Manual for Mental Disorders-5 (DSM-5; American Psychiatric Association, 2013) for diagnosis of antisocial personality disorder (ASPD) in terms of their relations with psychopathic traits and externalizing behaviors (EBs). " 04/30/2014 - "Because almost all studies focused on children with conduct problems or adult psychopaths, however, little is known about cognitive control mechanisms among the majority of persistent violent offenders who present an antisocial personality disorder (ASPD). " 04/01/2014 - "The present study sought to (1) inform current debates regarding the role of boldness in the definition of psychopathy and (2) clarify boundaries between psychopathy and antisocial personality disorder (ASPD). "
2.	pamidronate (APD)FDA LinkGeneric 02/01/2014 - "Previous studies have emphasized that antisocial personality disorder (APD) and psychopathy overlap highly but differ critically in several features, notably negative emotionality (NEM) and possibly amygdala reactivity to social signals of threat and distress. " 05/01/2012 - "Although anecdotal case accounts suggest that evidence concerning Antisocial Personality Disorder (APD), sociopathy and psychopathy is frequently introduced by the prosecution in capital murder trials, to date there has been no systematic research to determine the actual prevalence, role, or perceived impact of such evidence in these cases. " 06/01/2011 - "The aim of this study was to contribute to clarification of the relations between antisocial personality disorder (APD) and its potential risk factors in a population of 560 French male prisoners. " 02/01/2011 - "This study tests the hypothesis that sex differences in ventral and middle frontal gray volume contribute to sex differences in antisocial personality disorder (APD) and crime. " 04/01/2010 - "The present study examined the application of the Antisocial Personality Disorder (APD) diagnosis to adolescents and investigated the possibility of subtypes of APD adolescents. "
3.	Carbon MonoxideIBA 03/01/2015 - "Offense histories and severity of offending were compared among participants diagnosed with a single mental illness (or no mental illness), co-occurring mental illness and substance use, and co-occurring disorders plus antisocial personality disorder. " 01/01/2015 - "Antisocial personality disorder often co-exists with drug and alcohol use disorders. " 08/01/2013 - "Conscious knowledge influences decision-making differently in substance abusers with and without co-morbid antisocial personality disorder." 11/01/2009 - "Use of integrated dual disorder treatment via assertive community treatment versus clinical case management for persons with co-occurring disorders and antisocial personality disorder." 11/01/2002 - "Association between spouses for lifetime symptoms and DSM-III criteria of CCD, AAB, antisocial personality disorder and co-morbid psychiatric diagnoses was examined with bivariate and multivariate logistic regression analyses. "
4.	Methadone (Dolophine)FDA LinkGeneric 12/01/2012 - "Significant correlations were observed between increased methadone dosage and antisocial personality disorder. " 08/01/2002 - "The utility of traits associated with Antisocial Personality Disorder in making risk assessments of violent and nonviolent crimes was examined in 254 subjects sampled from a methadone maintenance population. " 09/01/1995 - "A total of 37 men and 57 women methadone patients were diagnosed according to DSM-III-R, DSM-III, and RDC antisocial personality disorder criteria. " 09/01/1995 - "Gender differences in diagnosing antisocial personality disorder in methadone patients." 02/01/1994 - "Prevalence, symptoms and correlates of antisocial personality disorder among methadone maintenance clients."
5.	Desipramine (Pertofrane)FDA LinkGeneric 04/01/1994 - "The most promising results emerge when specific agents, such as desipramine, are matched appropriately to specific patient characteristics, such as depression or antisocial personality disorder. " 03/01/1994 - "Pharmacotherapy response was compared in 94 cocaine-abusing methadone patients with (n = 75) and without (n = 19) antisocial personality disorder (ASP), in a 12-week, randomized, double-blind trial using desipramine 150 mg daily (n = 30), amantadine 300 mg daily (n = 33), and placebo (n = 31). "
6.	Risperidone (Risperdal Consta)FDA LinkGeneric 04/01/2001 - "Effective treatment of aggression and impulsivity in antisocial personality disorder with risperidone."
7.	Clozapine (Clozaril)FDA LinkGeneric 10/01/2014 - "Clozapine: an effective treatment for seriously violent and psychopathic men with antisocial personality disorder in a UK high-security hospital." 10/01/2014 - "There is no published literature on the treatment of antisocial personality disorder (ASPD) with clozapine. "
8.	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA 11/01/2013 - "ACE inhibitors could be therapeutic for antisocial personality disorder."
9.	Cocaine (Cocaine HCl)IBA 02/01/2014 - "Multivariable models identified 4 or more arrests (adjusted odds ratio [AOR] = 2.8; 95% confidence interval [CI] = 1.29, 5.97), adult antisocial personality (AOR = 9.0; 95% CI = 2.08, 38.79), and lifetime comorbid cocaine and opiate use (AOR = 2.9 [1.62, 5.20]) as risk factors; employment (AOR = 0.4; 95% CI = 0.22, 0.77) lowered the risk of PSM. " 07/01/2012 - "Crack users presented a higher rate of antisocial personality disorder (25%) than powder cocaine (9%) and non-cocaine PAS users (9%), even when adjusted for confounding factors (Pr = 2.6; 95% CI 1.10-6.40). " 01/01/2009 - "Cocaine-dependent patients with frequent marijuana use also used more cocaine and alcohol, and reported more medical, legal, and psychiatric problems, including antisocial personality disorder. " 09/01/2008 - "Apparent underreporting of recent cocaine use was associated with inpatient hospitalization for the participant's most recent quit attempt, younger age, identifying as African American or other, and not having a diagnosis of antisocial personality disorder. " 02/27/2006 - "These results highlight important sex differences in the association between antisocial personality and distress processing in cocaine-dependent individuals."
10.	Monoamine Oxidase (MAO)IBA 03/01/2011 - "Preclinical and human family studies clearly link monoamine oxidase A (MAOA) to aggression and antisocial personality (ASP). " 03/01/2015 - "Monoamine oxidase A gene promoter methylation and transcriptional downregulation in an offender population with antisocial personality disorder." 12/01/2014 - "Monoamine oxidase A alleles in violent offenders with antisocial personality disorder: high activity associated with proactive aggression." 06/20/2012 - "Our findings suggest that the role of MAO A in pathological aggression may be mediated by changes in NMDAR subunit composition in the PFC, and point to a critical function of this receptor in the molecular bases of antisocial personality." 07/01/2011 - "Gene environment interactions with a novel variable Monoamine Oxidase A transcriptional enhancer are associated with antisocial personality disorder."

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 10/01/2014 - "A literature search of MEDLINE/PubMed (1966-present) was conducted using the MeSH search terms psychopathy and antisocial personality disorder alone and in combination with the subheading drug therapy. " 01/01/1995 - "Treatment, comprising pharmacotherapy and an educational program based on cognitive behavior therapy, of four psychopathic, criminal men fulfilling the criteria for borderline personality disorder and antisocial personality disorder is described. " 03/01/1994 - "Antisocial personality disorder as a prognostic factor for pharmacotherapy of cocaine dependence." 06/01/2009 - "Children with ADHD are at greater risk than children without ADHD for substance abuse and delinquency whether or not they receive drug therapy; however, early treatment with psychoeducation as well as drug therapy and/or behavioral intervention may decrease negative outcomes of ADHD, including the rate of conduct disorder and adult antisocial personality disorder. " 08/01/2012 - "Most were relatively small randomized, controlled trials examining atypical antipsychotics for borderline personality disorder; however, the search also yielded two Cochrane reviews examining pharmacotherapy for borderline personality disorder and antisocial personality disorder as well as three other meta-analyses. "
2.	Nursing Care 05/11/1978 - "Nursing care study: psychopathic personality with paranoid traits." 09/04/1975 - "Nursing care study: a psychopathic personality." 12/01/1979 - "[Nursing care of patients with antisocial behavior as a manifestation of psychopathic personality]."
3.	Aftercare (After-Treatment) 04/01/1998 - "Four years after treatment, 61% of the study group met the DSM-III-R criteria for antisocial personality disorder. " 01/01/1997 - "Specifically, men with high scores on borderline personality, antisocial personality, and avoidant personality fared least well after treatment. " 08/01/1994 - "Clinical research and wisdom suggest that alcoholics with antisocial personality (ASPs) disorders have poorer drinking outcomes after treatment than alcoholics without this disorder. "
4.	Neurofeedback 01/01/2009 - "This study provides the first evidence for positive effects of neurofeedback treatment in antisocial personality disorders. " 01/01/2009 - "Our study is to determine if subjects with antisocial personality disorders will benefit from quantitative EEG (qEEG) guided neurofeedback treatment. "
5.	Art Therapy 01/01/2012 - "The present study assesses the impact of methamphetamine (METH) on antiretroviral therapy (ART) adherence among HIV+ persons, as well as examines the contribution of neurocognitive impairment and other neuropsychiatric factors [i.e., major depressive disorder (MDD), antisocial personality disorder (ASPD), and attention deficit disorder (ADHD)] for ART non-adherence. "