Antimycin A

An antibiotic substance produced by Streptomyces species. It inhibits mitochondrial respiration and may deplete cellular levels of ATP. Antimycin A1 has been used as a fungicide, insecticide, and miticide. (From Merck Index, 12th ed)

Also Known As:

Networked: 230 relevant articles (2 outcomes, 15 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Choi, Eun Mi: 6 articles (06/2014 - 09/2011)
2.	Lee, Young Soon: 4 articles (06/2014 - 09/2011)
3.	Capaccioli, Sergio: 4 articles (12/2012 - 07/2003)
4.	Papucci, Laura: 4 articles (12/2012 - 07/2003)
5.	Witort, Ewa: 4 articles (12/2012 - 07/2003)
6.	Han, Yong Hwan: 4 articles (01/2010 - 09/2008)
7.	Park, Woo Hyun: 4 articles (01/2010 - 09/2008)
8.	Johnson, Ali C M: 3 articles (01/2016 - 06/2005)
9.	Schiavone, Nicola: 3 articles (09/2012 - 07/2003)
10.	Tanno, Masaya: 3 articles (06/2012 - 10/2005)

Related Diseases

1.	Hypoxia (Hypoxemia) 01/01/2020 - "Rat cardiac cell line H9c2 cells were cultured and exposed to oxidative conditions (Antimycin A (AA), H2O2, CoCl2, or cold hypoxia/reoxygenation (H/R)) in vitro. " 01/01/2020 - "HCAECs under chemical hypoxia (antimycin A, 0.01 mmol/L) were exposed to HBO (2.5 atmosphere absolute; ATA) for 2-4 hours. " 08/01/2009 - "Although antimycin A did not inhibit lipid peroxidation, it inhibited cell membrane damage during the hypoxia phase but not during the reoxygenation phase. " 07/04/2006 - "In this regard, the gene is down-regulated by hypoxia and also by the inhibition of the flow of electrons through the respiratory chain using antimycin A. " 07/01/2006 - "We identified antimycin A1 as an inhibitor of the hypoxia-response element (HRE) from screening using a reporter under the control of HRE under hypoxic conditions. "
2.	Infarction (Infarctions) 10/01/2005 - "Pre-ischemic exposure to antimycin A caused a significant reduction in subsequent infarction (I:R%) compared to vehicle on both the mkk3(-/-) and mkk3(+/+) background (23.7+/-2.9 and 22.8+/-4.6 compared to 50.7+/-4.0 and 49.6+/-5.4 P=0.001, respectively). " 10/01/2005 - "In C57Bl6 mice, antimycin A prior to ischemia reduced infarct size compared to vehicle (22.8 +/- 6.1 vs. 48.3+/-5.2 P=0.01, respectively), an effect abolished by coincident SB203580. "
3.	Mitochondrial Diseases (Mitochondrial Disease) 10/18/2021 - "To achieve this, C2C12 myotubes were exposed to a mitochondrial channel blocker, antimycin A (6.25 µM), for 12 h to induce mitochondrial dysfunction. " 01/01/2021 - "Furthermore, ACO3 contributed to plant tolerance against ultraviolet B (UV-B) or antimycin A-induced mitochondrial dysfunction. " 01/01/2019 - "Antimycin A-induced mitochondrial dysfunction activates vagal sensory neurons via ROS-dependent activation of TRPA1 and ROS-independent activation of TRPV1." 01/01/2019 - "Mitochondrial ROS was an upstream mediator of senescence since treatment of hCPC-1% with mitochondrial inhibitor antimycin A recapitulated mitochondrial dysfunction and senescence observed in hCPC-21%. " 07/01/2013 - "Protection from antimycin A-induced mitochondrial dysfunction by Nelumbo nucifera seed extracts."
4.	Insulin Resistance 05/07/2015 - "Celastrol Protects against Antimycin A-Induced Insulin Resistance in Human Skeletal Muscle Cells." 05/07/2015 - "The aim of the present study was to evaluate the functional roles of an anti-inflammatory compound, celastrol, in mitochondrial dysfunction and insulin resistance induced by antimycin A (AMA) in human skeletal muscle cells. " 07/01/2007 - "In order to better understand the impact of reduced mitochondrial function for the development of insulin resistance and cellular metabolism, human myotubes were established from lean, obese, and T2D subjects and exposed to mitochondrial inhibitors, either affecting the electron transport chain (Antimycin A), the ATP synthase (oligomycin) or respiratory uncoupling (2,4-dinitrophenol). " 04/01/2014 - "In vitro, we tested 4 models of insulin resistance that are linked to mitochondrial dysfunction in cultured skeletal muscle cells including antimycin A, C2-ceramide, ferutinin, and palmitate. " 03/25/2011 - "Mitochondrial dysfunction resulting from genetic (mitochondrial DNA depletion) or metabolic inhibition (Rotenone or Antimycin A) induced insulin resistance in hepatocytes via a reduction in the expression of IRS-1 protein. "
5.	Neuroblastoma 11/01/2013 - "In the present study we show that treating human SH-SY5Y neuroblastoma cells with the electron transport chain inhibitor antimycin A decreased levels of NAA as measured by HPLC. " 09/15/2020 - "Incubation of neuroblastoma cell line Tet21N in the presence of 1 μM AnaCTDH binding echinenone decreased antimycin A ROS production by 25% (p < 0.05). " 12/15/2015 - "Here, we investigated the impact of different mitochondrial respiratory inhibitors, namely rotenone and antimycin A, on the O2(-)mediated degradation of MeHg in human neuroblastoma cells SH-K-SN. " 08/01/2011 - "To this end we used neuroblastoma cells (SK-N-MC) that were treated with low doses of a combination of antimycin A1 and 2-deoxy-D: -glucose. " 03/01/2014 - "Early stage of rodent stroke model and neuroblastoma chemical hypoxia model was established by middle cerebral artery occlusion and antimycin A. "

Related Drugs and Biologics

1.	Superoxides (Superoxide)
2.	DNA (Deoxyribonucleic Acid)
3.	Superoxide Dismutase
4.	Rotenone
5.	oligomycin A
6.	Glucose (Dextrose)
7.	Oligomycins
8.	Reactive Oxygen Species (Oxygen Radicals)
9.	Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone (FCCP)
10.	Proteins (Proteins, Gene)

Related Therapies and Procedures

1.	Lab-On-A-Chip Devices
2.	Therapeutics
3.	Microelectrodes
4.	Lasers (Laser)
5.	Spinal Injections