Antimycin A

An antibiotic substance produced by Streptomyces species. It inhibits mitochondrial respiration and may deplete cellular levels of ATP. Antimycin A1 has been used as a fungicide, insecticide, and miticide. (From Merck Index, 12th ed)

Also Known As:

Networked: 159 relevant articles (2 outcomes, 8 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Witort, Ewa: 4 articles (12/2012 - 07/2003)
2.	Capaccioli, Sergio: 4 articles (12/2012 - 07/2003)
3.	Papucci, Laura: 4 articles (12/2012 - 07/2003)
4.	Han, Yong Hwan: 4 articles (01/2010 - 09/2008)
5.	Park, Woo Hyun: 4 articles (01/2010 - 09/2008)
6.	Schiavone, Nicola: 3 articles (09/2012 - 07/2003)
7.	Tanno, Masaya: 3 articles (06/2012 - 10/2005)
8.	Spitz, Douglas R: 3 articles (07/2009 - 12/2006)
9.	Kamat, Amrita: 2 articles (11/2013 - 10/2011)
10.	Zhang, Bin-Xian: 2 articles (11/2013 - 10/2011)

Related Diseases

1.	Anoxia (Hypoxia) 08/01/2009 - "Although antimycin A did not inhibit lipid peroxidation, it inhibited cell membrane damage during the hypoxia phase but not during the reoxygenation phase. " 07/04/2006 - "In this regard, the gene is down-regulated by hypoxia and also by the inhibition of the flow of electrons through the respiratory chain using antimycin A. " 07/01/2006 - "We identified antimycin A1 as an inhibitor of the hypoxia-response element (HRE) from screening using a reporter under the control of HRE under hypoxic conditions. " 05/01/2004 - "They were increased under hypoxia and antimycin A treatment. " 05/01/2003 - "The effect of hypoxia was assessed in vitro by incubating LLC-PK1 cells with antimycin A, an inhibitor of mitochondrial oxidative phosphorylation. "
2.	Infarction 10/01/2005 - "Pre-ischemic exposure to antimycin A caused a significant reduction in subsequent infarction (I:R%) compared to vehicle on both the mkk3(-/-) and mkk3(+/+) background (23.7+/-2.9 and 22.8+/-4.6 compared to 50.7+/-4.0 and 49.6+/-5.4 P=0.001, respectively). "
3.	Insulin Resistance 01/01/2015 - "The aim of the present study was to evaluate the functional roles of an anti-inflammatory compound, celastrol, in mitochondrial dysfunction and insulin resistance induced by antimycin A (AMA) in human skeletal muscle cells. " 01/01/2015 - "Celastrol Protects against Antimycin A-Induced Insulin Resistance in Human Skeletal Muscle Cells." 04/01/2014 - "In vitro, we tested 4 models of insulin resistance that are linked to mitochondrial dysfunction in cultured skeletal muscle cells including antimycin A, C2-ceramide, ferutinin, and palmitate. " 01/01/2011 - "Mitochondrial dysfunction resulting from genetic (mitochondrial DNA depletion) or metabolic inhibition (Rotenone or Antimycin A) induced insulin resistance in hepatocytes via a reduction in the expression of IRS-1 protein. " 07/01/2007 - "In order to better understand the impact of reduced mitochondrial function for the development of insulin resistance and cellular metabolism, human myotubes were established from lean, obese, and T2D subjects and exposed to mitochondrial inhibitors, either affecting the electron transport chain (Antimycin A), the ATP synthase (oligomycin) or respiratory uncoupling (2,4-dinitrophenol). "
4.	Starvation 09/01/2012 - "In vitro experiments were carried out on cultured ARPE-19 or RGC-5 cells pretreated with CoQ10 before eliciting apoptosis by UV- and γ-radiation, chemical hypoxia (Antimycin A) and serum starvation. " 07/25/2003 - "In this study, we have verified this hypothesis by evaluating the antiapoptotic effects of CoQ10 in response to apoptotic stimuli, serum starvation, antimycin A, and ceramide, which do not generate free radicals, in comparison to control, free radical-generating UVC irradiation. " 01/04/2013 - "Further in vivo assays using flow cytometry showed that both methanol and acetic acid maintained the fluorescence of oxidized DCF in H(2)O(2)-, antimycin A-, and serum starvation-treated human lung adenocarcinoma A549 cells and human microvascular endothelial HMEC-1 cells. " 02/01/1990 - "Under starvation conditions and with the cytochrome chain partially inhibited by antimycin A,(anti-A) the addition addition of glucose also increased oxygen utilization by CA-I/72 epimastigotes. " 12/01/2001 - "Therefore, the effects of chemical and physical factors such as oxygen, light, carbonyl cyanide m-chlorophenyl hydrazone and antimycin A on ATP synthesis were examined in cells subjected to different starvation periods to reduce the endogenous ATP pool below the luciferase ATP saturation level (< or =0.2 mM). "
5.	Neuroblastoma 11/01/2013 - "In the present study we show that treating human SH-SY5Y neuroblastoma cells with the electron transport chain inhibitor antimycin A decreased levels of NAA as measured by HPLC. " 12/15/2015 - "Here, we investigated the impact of different mitochondrial respiratory inhibitors, namely rotenone and antimycin A, on the O2(-)mediated degradation of MeHg in human neuroblastoma cells SH-K-SN. " 08/01/2011 - "To this end we used neuroblastoma cells (SK-N-MC) that were treated with low doses of a combination of antimycin A1 and 2-deoxy-D: -glucose. " 03/01/2014 - "Early stage of rodent stroke model and neuroblastoma chemical hypoxia model was established by middle cerebral artery occlusion and antimycin A. " 01/01/2008 - "Cerebral but not RGC-5 or neuroblastoma cells increased superoxide production in response to the complex I inhibitor rotenone, while neuroblastoma but not cerebral or RGC-5 cells dramatically decreased superoxide production in response to the complex III inhibitor antimycin A. "

Related Drugs and Biologics

1.	Superoxides (Superoxide)
2.	DNA (Deoxyribonucleic Acid)
3.	Superoxide Dismutase
4.	Rotenone
5.	Glucose (Dextrose)
6.	Oligomycins
7.	coenzyme Q10 (CoQ10)
8.	Calpain
9.	Fluorescein (Funduscein)
10.	Tyrosine (L-Tyrosine)

Related Therapies and Procedures

1.	Microelectrodes
2.	Spinal Injections
3.	Injections
4.	Aftercare (After-Treatment)