Antimony Sodium Gluconate (Sodium, Stibogluconate)

Antimony complex where the metal may exist in either the pentavalent or trivalent states. The pentavalent gluconate is used in leishmaniasis. The trivalent gluconate is most frequently used in schistosomiasis.

Also Known As:

Sodium, Stibogluconate; Antimony Gluconic Acid; Antimony Sodium Gluconates; Myostibin; Pentostam; Solustibosan; Stibatin; Stibogluconate Sodium; Triostam; Sodium Gluconates, Antimony; Stibogluconate, Sodium; Antimony Gluconate Sodium; Sodium Stibogluconate

Networked: 386 relevant articles (67 outcomes, 45 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Balasegaram, Manica: 7 articles (03/2017 - 10/2006)
2.	Hailu, Asrat: 6 articles (01/2021 - 11/2010)
3.	Ritmeijer, Koert: 6 articles (03/2017 - 08/2006)
4.	Wasunna, Monique: 5 articles (10/2018 - 06/2011)
5.	Omollo, Raymond: 5 articles (03/2017 - 11/2010)
6.	Yi, Taolin: 5 articles (12/2011 - 11/2002)
7.	Rijal, S: 5 articles (03/2010 - 05/2003)
8.	Mohammed, Rezika: 4 articles (01/2021 - 05/2014)
9.	Ranawaka, Ranthilaka R: 4 articles (02/2019 - 09/2010)
10.	Alvar, Jorge: 4 articles (10/2018 - 10/2008)

Related Diseases

1.	Visceral Leishmaniasis (Kala Azar) 04/01/2007 - "In most of the Indian subcontinent, the first line treatment for visceral leishmaniasis (VL) is sodium stibogluconate (SSG), an antimonial drug, but the efficacy of the drug varies according to region. " 06/01/1996 - "The implementation of action plan not only established declining trends in morbidity and mortality due to Visceral Leishmaniasis in the district but also successfully contained the cases unresponsive to first line treatment with Sodium Stibogluconate by reducing the prevalence of such cases from 12.42% in 1992 to 8.59% in 1994. " 03/01/1998 - "Results of the study show that treatment of cases of Kala-azar with sodium stibogluconate in a dosage of 20 mg/kg/day for a longer period of 30 days is effective with a higher cure rate and minimum side effects, for treatment of cases of Kala-azar in this eastern part of Nepal, endemic for the disease." 01/01/2016 - "After getting full dose of sodium stibogluconate as per the national visceral leishmaniasis treatment guideline, was clinically cured. " 01/01/1977 - "At low concentrations, sodium stibogluconate, the drug of choice for kala azar treatment in Iraq proved to be poorly effective in the prevention of promastigotes growth in vitro. "
2.	Cutaneous Leishmaniasis 01/01/1983 - "We conclude that this high dose sodium stibogluconate regimen is safe and effective for treating cutaneous leishmaniasis caused by L. " 07/01/1988 - "We recommend intralesional Pentostam as a safe and effective method of treating acute cutaneous leishmaniasis." 01/01/2021 - "The first-line treatment for Leishmania donovani-induced cutaneous leishmaniasis (CL) in Sri Lanka is intra-lesional sodium stibogluconate (IL-SSG). " 10/01/2010 - "Efficacy of short-duration (twice weekly) intralesional sodium stibogluconate in treatment of cutaneous Leishmaniasis in India." 07/01/2007 - "Comparative efficacy of intralesional sodium stibogluconate (SSG) alone and its combination with intramuscular SSG to treat localized cutaneous leishmaniasis: Results of a pilot study."
3.	Leishmaniasis 07/01/1994 - "Sodium stibogluconate is the mainstay of treatment for all forms of leishmaniasis. " 01/01/2021 - "After the diagnostic process, positive serological tests were found for leishmaniasis, with improvement in the picture after the use of sodium stibogluconate. " 12/01/1998 - "Safety and efficacy of intravenous sodium stibogluconate in the treatment of leishmaniasis: recent U.S. " 03/01/2011 - "Leishmaniasis of the lip diagnosed by lymph node aspiration and treated with a combination of oral ketaconazole and intralesional sodium stibogluconate." 11/01/2008 - "Furthermore, a field isolate of Leishmania donovani resistant to sodium stibogluconate (SbV), one of the drugs most commonly used to treat leishmaniasis, is equally susceptible to the tested PIs compared with a sensitive strain, thus suggesting that resistance to SbV does not result in cross-resistance to PIs. "
4.	Infections 05/01/2000 - "He was successfully cleared of the infection by the administration of sodium stibogluconate, with no deterioration of renal function or other complications." 06/01/1989 - "Therefore in the present study, the effect of LK on infected macrophages from BALB/c mice following specific infection and subsequent treatment with sodium stibogluconate has been investigated. " 01/01/2020 - "Results show that macaques treated with D35 plus 5mg/kg sodium stibogluconate (SbV) for 10 days had smaller lesions and reduced time to re-epithelization after infection with Leishmania major. " 01/01/2015 - "Cationic liposomal sodium stibogluconate (SSG), a potent therapeutic tool for treatment of infection by SSG-sensitive and -resistant Leishmania donovani." 04/01/2014 - "This treatment regimen resulted in good control of VL and HIV-1 infection, while the conventional protocol of sodium stibogluconate treatment was not able to prevent multiple VL relapses. "
5.	Mucocutaneous Leishmaniasis 02/01/2012 - "Intravenous sodium stibogluconate (SbV) is the mainstay of treatment for mucocutaneous leishmaniasis. " 04/01/2010 - "The clinical picture, plus the pathologic findings, and the response to sodium stibogluconate confirmed mucocutaneous leishmaniasis. " 04/01/2010 - "A 64-year-old man presented with a destructive ulceration of the central face of 23 years' duration, who was diagnosed to have mucocutaneous leishmaniasis, and showed dramatic response to intramuscular injections of sodium stibogluconate. " 12/09/2006 - "The patient was treated for mucocutaneous leishmaniasis by a 28-day course of intravenous sodium-stibogluconate therapy. " 04/01/2013 - "For patients at risk for progression to mucocutaneous leishmaniasis, first-line treatment in the United States entails the use of sodium stibogluconate (SSG), which is obtained from the Centers for Disease Control and Prevention (CDC) under an investigational drug protocol. "

Related Drugs and Biologics

1.	Antimony Sodium Gluconate (Sodium, Stibogluconate)
2.	Meglumine Antimoniate
3.	Paromomycin (Paromomycin Sulfate)
4.	Amphotericin B (Amphotericin)
5.	Antimony
6.	Allopurinol (Remid)
7.	liposomal amphotericin B
8.	Liposomes (Liposome)
9.	Surface-Active Agents (Surfactants)
10.	Meglumine

Related Therapies and Procedures

1.	Therapeutics
2.	Cryotherapy (Therapy, Cold)
3.	Drug Therapy (Chemotherapy)
4.	Gas Lasers
5.	Aftercare (After-Treatment)