Antihypertensive Agents (Antihypertensives)

Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.

Also Known As:

Networked: 4831 relevant articles (306 outcomes, 722 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Bakris, George L: 24 articles (10/2014 - 12/2002)
2.	Mancia, Giuseppe: 22 articles (12/2015 - 11/2002)
3.	Ruilope, Luis M: 19 articles (10/2015 - 01/2002)
4.	Messerli, Franz H: 13 articles (07/2014 - 12/2003)
5.	Calhoun, David A: 12 articles (07/2015 - 03/2004)
6.	Zanchetti, Alberto: 12 articles (07/2015 - 05/2002)
7.	Papademetriou, Vasilios: 11 articles (12/2015 - 05/2008)
8.	Böhm, Michael: 11 articles (12/2015 - 10/2011)
9.	Mahfoud, Felix: 11 articles (12/2015 - 10/2011)
10.	Chrysant, Steven G: 11 articles (07/2015 - 08/2003)

Related Diseases

1.	Hypertension (High Blood Pressure) 10/01/2003 - "We conclude that the combination of event reduction from large-scale clinical trials, adequate 24 h BP reduction, and improved tolerability compared to most other classes of anti-hypertensive agents, make the ARBs a suitable initial treatment for patients with hypertension." 03/01/2015 - "Subgroup analysis showed that patients with resistant hypertension or receiving antihypertensive drugs benefited most from CPAP. " 03/01/2014 - "Additionally, their ability to increase the efficacy of nearly all other classes of antihypertensives makes them a highly versatile therapeutic intervention in the treatment of hypertension." 10/01/2012 - "Despite major advances in understanding the pathophysiology of hypertension and availability of effective and safe antihypertensive drugs, suboptimal blood pressure (BP) control is still the most important risk factor for cardiovascular mortality and is globally responsible for more than 7 million deaths annually. " 08/18/2007 - "Despite the availability of effective and safe antihypertensive drugs, hypertension and its concomitant risk factors remain uncontrolled in most patients."
2.	Stroke (Strokes) 06/01/2009 - "Although meta-analyses suggest that BP reduction, per se, is the most important determinant for stroke risk reduction, the question is if specific classes of antihypertensive drugs offer special protection against stroke is still controversial. " 01/01/2003 - "However, it is not known which antihypertensive agents are most effective in preventing stroke. " 08/01/1995 - "Specific alterations of the coronary circulation may account for the relative failure of antihypertensive drugs, despite their proven efficacy in other systems (e.g., stroke prevention). " 07/01/2011 - "Stroke: are antihypertensives beneficial in acute stroke?" 04/01/2008 - "This study shows that mention of PROGRESS therapy in the discharge summary must be improved as it is associated with a higher use of these anti-hypertensive agents 1 year after stroke/TIA."
3.	Heart Failure 11/01/2003 - "Although control of blood pressure (BP) is a primary goal of therapy, evidence from several clinical trials suggests that certain antihypertensive agents provide clinical benefits independent of their effect on BP. In the recently reported Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT), an ACE inhibitor, a CCB, and an alpha-blocker reduced coronary events and mortality to a similar extent as a thiazide-type diuretic, but the diuretic reduced one or more major cardiovascular events, especially heart failure, more than the other agents. " 05/01/2014 - "In multivariate analysis, MPR difference was inversely related to the preindex MPR, the number of other antihypertensive drugs, and congestive heart failure. " 03/01/2014 - "Optimising of chronic heart failure therapy with diuretic and antihypertensive drugs leaded to recompensation. " 01/01/2014 - "Although MR antagonists were developed as antihypertensive agents, they are now considered to be important therapeutic options for patients with heart failure. " 10/01/2012 - "Thirty-five thousand and forty-one patients treated with antihypertensive drugs, and 18 512 untreated patients, aged 30-75 years, without previous heart failure, followed for 6 years until 2009. "
4.	Left Ventricular Hypertrophy (Ventricular Hypertrophy, Left) 01/01/1988 - "However, not all antihypertensive drugs seem equally effective in bringing about coronary regression of left ventricular hypertrophy (LVH). " 01/01/1987 - "However, not all antihypertensive drugs seem equally effective in bringing about coronary regression of left ventricular hypertrophy. " 12/01/1985 - "However, not all antihypertensive drugs seem equally effective in bringing about coronary regression of left ventricular hypertrophy (LVH). " 04/01/2012 - "Blood pressure and left ventricular hypertrophy (LVH) improved and the use of anti-hypertensive drugs decreased. " 05/01/1993 - "The efficacy of many antihypertensive drugs to decrease blood pressure and to reduce left ventricular hypertrophy has already been demonstrated. "
5.	Cardiovascular Diseases (Cardiovascular Disease) 07/15/2004 - "New anti-hypertensive drugs, although more expensive than conventional treatments, have significant benefits in the management of cardiovascular disease. " 01/01/2015 - "The limitations of current therapies have stimulated the research and development of new classes of antihypertensive agents, with different mechanisms of action, that provide a better blood pressure control, greater protection against organ damage, better tolerability and more effective prevention of cardiovascular diseases. " 01/01/2012 - "Although pharmacological treatments, including statins and anti-hypertensive drugs, have improved the prognosis for patients with cardiovascular disease, it remains a leading cause of mortality in those aged 65 years and over. " 08/01/1998 - "The knowledge of antihypertensive drugs on the cardiac sympathetic nervous system appears to be helpful in selecting appropriate treatment in cardiovascular diseases." 12/01/1989 - "This review considers the efficacy of various antihypertensive agents in blacks, with particular reference to the impact of these agents on cardiovascular disease risk factors and on associated diseases often encountered in black hypertensives. "

Related Drugs and Biologics

1.	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)
2.	Diuretics
3.	Angiotensin Receptor Antagonists
4.	Calcium Channel Blockers (Blockers, Calcium Channel)
5.	Antihypertensive Agents (Antihypertensives)
6.	Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)
7.	Calcium
8.	Amlodipine (Norvasc)
9.	Nifedipine (Adalat)
10.	Indapamide

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Carotid Endarterectomy
3.	Denervation
4.	Renal Dialysis (Hemodialysis)
5.	Angioplasty (Angioplasty, Transluminal)