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Polyomavirus Transforming Antigens

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Polyomavirus antigens which cause infection and cellular transformation. The large T antigen is necessary for the initiation of viral DNA synthesis, repression of transcription of the early region and is responsible in conjunction with the middle T antigen for the transformation of primary cells. Small T antigen is necessary for the completion of the productive infection cycle.

Also Known As:

Antigens, Polyomavirus Transforming; Polyomaviruses Large T Proteins; Polyomaviruses Middle T Proteins; Polyomaviruses Small T Proteins; Antigens, Polyomavirus Tumor; Antigens, SV40 T; Proteins, Polyomavirus T; Proteins, SV40 T; T Antigens, SV40; T Proteins, Polyomavirus; T Proteins, SV40; Transforming Antigens, Polyomavirus; Tumor Antigens, Polyomavirus; Polyomavirus Large T Antigens; Polyomavirus Middle T Antigens; Polyomavirus Small T Antigens; Polyomavirus T Proteins; Polyomavirus Tumor Antigens; SV40 T Antigens; SV40 T Proteins; Simian Sarcoma Virus Proteins

Networked: 13 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Bader, Augustinus: 1 article (09/2014)
2.	Giri, Shibashish: 1 article (09/2014)
3.	Fischer, Nicole: 1 article (03/2014)
4.	Schmidt, Claudia: 1 article (03/2014)
5.	Grundhoff, Adam: 1 article (03/2014)
6.	Wimmer, Peter: 1 article (03/2014)
7.	Borchert, Sophie: 1 article (03/2014)
8.	Neumann, Friederike: 1 article (03/2014)
9.	Czech-Sioli, Manja: 1 article (03/2014)
10.	Dobner, Thomas: 1 article (03/2014)

Related Diseases

1.	Papilloma (Papillomatosis) 09/01/2014 - "Immortalization of human fetal hepatocytes cell line by ectopic expression of human telomerase reverse transcriptase (hTERT), human papilloma virus gene (E7) and simian virus 40 large T (SV40 T) antigens is main goal of present study. "
2.	Neoplasms (Cancer) 03/01/2014 - "High-affinity Rb binding, p53 inhibition, subcellular localization, and transformation by wild-type or tumor-derived shortened Merkel cell polyomavirus large T antigens." 11/01/1988 - "Lens-specific expression of SV40 T antigens results in malignant lens tumors or phakomas, that of a murine c-mos protooncogene in a characteristic defect of lens fiber differentiation." 06/01/1983 - "Tumor induction by hybrid cells that expressed both Ad2 and SV40 T-antigens was reduced in adult syngeneic hamsters and abrogated in adult allogeneic hamsters. " 01/01/1983 - "Tumor formation by SV40-transformed human cells in nude mice: the role of SV40 T antigens." 10/15/1981 - "IF assays with hamster anti-SV40 tumor sera showed that TF pSB10 C7 and TF pSB15 C10 strongly expressed SV40 T antigens in over 90% of the cells, TF pSB10 C3 expressed SV40 T antigens in a minority of the cells, and TF pSB15 C1 did not express SV40 T antigens at all. "
3.	Carcinoma (Carcinomatosis) 04/01/2004 - "We investigated these factors by using array comparative genomic hybridization to measure genomic aberrations in genetically engineered mouse models of pancreatic islet cell carcinoma, in which oncogenic transformation is elicited by the SV40 T antigens expressed under the control of the rat insulin promoter (RIP-Tag). " 12/01/2001 - "Carcinomas that develop in the pancreatic islets of transgenic mice expressing the SV40 T-antigens (Tag) under transcriptional control of the rat insulin II promoter (RIP) progress through well-characterized stages that are similar to aspects of human tumor progression, including hyperplastic growth, increased angiogenesis and reduced apoptosis. "
4.	Adult T-Cell Leukemia-Lymphoma (Leukemia Lymphoma, T Cell, Acute, HTLV I Associated) 06/01/1988 - "The LTR-directed gene expression of HIV-2/SIV is not only transactivated by their own tat gene and by HIV-1 tat gene but also by factors in human T cell leukemia/lymphoma virus type I (HTLV-I) and simian virus 40 (SV40) infected cells, involving HTLV-I tat gene and SV40 T antigens, respectively. "
5.	Retinoblastoma (Glioblastoma, Retinal) 07/01/1993 - "Relative mitogenic activities of wild-type and retinoblastoma binding-defective SV40 T antigens in serum-deprived and senescent human diploid fibroblasts."

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