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Antigen-Antibody Complex (Immune Complex)

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The complex formed by the binding of antigen and antibody molecules. The deposition of large antigen-antibody complexes leading to tissue damage causes IMMUNE COMPLEX DISEASES.

Also Known As:

Immune Complex; Antigen-Antibody Complexes; Immune Complexes; Antigen Antibody Complex; Antigen Antibody Complexes; Complex, Antigen-Antibody; Complex, Immune; Complexes, Antigen-Antibody; Complexes, Immune

Networked: 9438 relevant articles (263 outcomes, 690 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	Novak, Jan: 22 articles (07/2015 - 08/2002)
2.	Julian, Bruce A: 20 articles (07/2015 - 08/2002)
3.	Anders, Hans-Joachim: 17 articles (11/2015 - 02/2003)
4.	Tomino, Yasuhiko: 16 articles (10/2014 - 03/2003)
5.	Suzuki, Hitoshi: 14 articles (10/2014 - 03/2006)
6.	Quigg, Richard J: 13 articles (05/2015 - 04/2004)
7.	Haas, Mark: 13 articles (06/2012 - 01/2003)
8.	Mestecky, Jiri: 13 articles (05/2012 - 08/2002)
9.	Monteiro, Renato C: 12 articles (01/2015 - 12/2003)
10.	Tomana, Milan: 12 articles (11/2011 - 08/2002)

Related Diseases

1.	Glomerulonephritis 10/01/2005 - "Perhaps the best treatment for glomerulonephritis is the identification and correction of any underlying inflammatory, immune-mediated or neoplastic disease that results in the deposition or formation of glomerular immune complexes. " 01/01/1996 - "Glomerular structural damage expressed as glomerular damage index was significantly greater in rats with immune complex glomerulonephritis when compared with controls (immune complex glomerulonephritis 0.91 +/- 0.13; control 0.60 +/- 0.08; P < 0.05), but was uneffected by the treatment with the CEI (immune complex) glomerulonephritis + CEI 1.02 +/- 0.26; control + CEI 0.63 +/- 0.11). " 11/22/2003 - "Assuming that a decrease in CD2AP attenuates clearance of glomerular immune complexes, patients with other types of idiopathic glomerulonephritis should also have a CD2AP mutation. " 07/01/1982 - "Impairment of glomerular clearance of macroaggregates in immune complex glomerulonephritis." 08/01/2015 - "In conclusion, the results of the present study suggested that the activation of NF-κB and upregulation of UCH-L1 in podocytes may be vital in podocyte injury associated with immune complex-mediated glomerulonephritis."
2.	Systemic Lupus Erythematosus (Libman-Sacks Disease) 01/01/2013 - "Abnormalities in complement activation and clearance of immune complexes by erythrocytes are the central pathogenic mechanisms in systemic lupus erythematosus (SLE). " 12/01/2005 - "Hypocomplementaemia and low expression of CR1 on erythrocytes (E) of patients with systemic lupus erythematosus (SLE) are associated with defective clearance of circulating immune complexes (IC) and so they may have pathogenic significance. " 12/01/2000 - "Fcgamma receptor polymorphisms in systemic lupus erythematosus: association with disease and in vivo clearance of immune complexes." 01/01/2014 - "Despite rapid accumulation of knowledge about complex immune dysregulation in systemic lupus erythematosus (SLE) and major primary lupus syndromes, and a plethora of promising new treatments reaching preclinical and early clinical studies, advanced-phase trials of new biologic agents have repeatedly failed to achieve their clinical end points. " 11/01/2002 - "Studies of an Icelandic cohort showed that susceptibility to systemic lupus erythematosus (SLE) in individuals with C4A deficiency was increased only in the presence of increased concentrations of immune complexes. "
3.	Infection 07/01/1993 - "An alternative hypothesis is the possible role of defective clearance of immune complexes in the development of severe infections. " 07/01/1993 - "Pathogenesis can be related to occult infection, loss of mucosal barrier function, defective clearance of immune complexes, or aberrant immune responses. " 01/01/2014 - "The aim of the present study was to evaluate whether an autoimmune process follows the initial infection, by means of analyzing immune complexes. " 11/01/2011 - "In this study, we quantified circulating HIV-1 virion-immune complexes (ICs), present in approximately 90% of AHI subjects, and compared the levels and antibody specificity to those in chronic infection. " 07/01/2004 - "These studies suggest that the presence of immune complexes in infection or autoimmunity may radically alter the nature of CD163-dependent monocyte/macrophage processes. "
4.	Proteinuria 10/01/2008 - "Mice treated with CoPP displayed a significant reduction in proteinuria and a marked amelioration of glomerular lesions, accompanied by attenuated immune-complex deposition. " 12/01/2015 - "The results indicated that tIL12rβ1 treatment effectively delayed the proteinuria onset and induced a significant remission of proteinuria, autoantibody production, and immune complex deposition in the mouse model. " 01/01/2001 - "Calorie, protein, and especially fat restriction, caused a significant reduction in immune-complex deposition in the kidney, reduced proteinuria and prolongation of the mice's life span. " 11/01/1977 - "A control group of 20 immunized rats, also observed for 13 weeks, did not receive MS. MS treatment significantly decreased the incidence of heavy proteinuria (p less than 0.001), the severity of proteinuria at each week throughout the course of the disease (p less than 0.001), the amount of immune complex deposition in the glomeruli, and also delayed the onset of proteinuria (p less than 0.001). " 03/01/2011 - "The aim of the present study was to demonstrate that human HGF is antigenic to rodents and that immune complex formation causes proteinuria. "
5.	Autoimmune Diseases (Autoimmune Disease) 03/01/1983 - "These results suggest that the beneficial effects of androgen on autoimmune disease are not due solely to improved clearance of immune complexes. " 02/01/1981 - "In order to understand better the role of immune complex metabolism in the pathogenesis of autoimmune diseases, we have investigated the early stages of immune complex uptake by the liver, the major organ responsible for clearance of soluble complexes in the mouse. " 07/01/2006 - "Recent studies have demonstrated that the defect in the clearance of immune complexes and apoptotic cells is associated with autoimmune disease. " 07/01/2012 - "Genetic deficiency of any early component of the classical pathway (C1q, C1r/s, C2, C4, and C3) is associated with autoimmune diseases due to the failure of clearance of immune complexes (IC) and apoptotic materials, and the impairment of normal humoral response. " 05/15/2012 - "This meta-analysis implicates the clearance of immune complex in the etiology of non-organ-specific autoimmune disease."

Related Drugs and Biologics

1.	Immunoglobulin G (IgG)
2.	Complement System Proteins (Complement)
3.	Antibodies
4.	Immunoglobulin A (IgA)
5.	Antigens
6.	Autoantibodies
7.	Immunoglobulin M (IgM)
8.	Antigen-Antibody Complex (Immune Complex)
9.	DNA (Deoxyribonucleic Acid)
10.	Rheumatoid Factor

Related Therapies and Procedures

1.	Plasmapheresis
2.	Plasma Exchange
3.	Drug Therapy (Chemotherapy)
4.	Splenectomy
5.	Intravenous Injections