Antifungal Agents

Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues.

Also Known As:

Networked: 1685 relevant articles (189 outcomes, 131 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Walsh, Thomas J: 19 articles (02/2015 - 07/2002)
2.	Kontoyiannis, Dimitrios P: 15 articles (09/2013 - 12/2003)
3.	Lewis, Russell E: 13 articles (09/2013 - 08/2002)
4.	Roilides, Emmanuel: 11 articles (02/2015 - 07/2002)
5.	Gupta, Aditya K: 11 articles (09/2005 - 05/2002)
6.	Gupta, A K: 10 articles (03/2004 - 01/2000)
7.	Kauffman, Carol A: 9 articles (10/2015 - 04/2004)
8.	Mylonakis, Eleftherios: 7 articles (12/2015 - 10/2006)
9.	Benjamin, Daniel K: 7 articles (05/2015 - 10/2003)
10.	Walsh, T J: 7 articles (06/2014 - 01/2000)

Related Diseases

1.	Infection 10/15/2015 - "When screening high-risk patients for IA with GM and PCR tests, the absence of any positive test can obviate the need for antifungal agents with a negative predictive value of 100%, whereas the presence of at least 2 positive results is highly suggestive of an active infection with a positive predictive value of 88%." 07/01/2010 - "Although superficial fungal infections of the skin and nails are common and are for the most part treated successfully with existing antifungal agents, serious fungal infections are becoming a growing danger for human health. " 07/01/2005 - "Most cases of PZ in such patients develop as breakthrough infections if treatment with antifungal agents effective against Aspergillus species is administered. " 09/01/2007 - "These results suggest that KET, AmpB, CAS, and VOR demonstrated excellent activity against all Candida spp. Taken together; these antifungal agents should be effective in the treatment of a broad range of Candida infections." 12/29/1995 - "Identification of state-of-the-art management is also a difficult task for the clinical scientist involved in the assessment of optimal strategies to prevent and to treat those invasive fungal infections, although major progress has occurred in the last 5 years with the development of new, safe, and effective antifungal agents. "
2.	Aspergillosis 06/01/2015 - "Novel methodologies, such as volatile organic compound detection and lateral flow devices, have recently been developed and promise noninvasive and rapid diagnosis of aspergillosis, while diagnostic algorithms that incorporate both GM and PCR have proven to be effective in early randomized trials as screening methods and can reduce the use of antifungal agents. " 09/01/2005 - "Several important obstacles underlie the correlation of in vitro susceptibility testing with in vivo efficacy of individual antifungal agents in the treatment of invasive aspergillosis. " 05/01/2013 - "This immune-competent patient showed multiple enhancing CNS aspergillosis in the cerebral hemisphere, which had a good outcome with antifungal agents. " 02/01/2012 - "Over the last decade, advances in diagnostic systems and the introduction of new antifungal agents have significantly improved outcomes in immunocompromised patients who develop invasive aspergillosis. " 12/01/2001 - "Because of its much larger dynamic range, the qPCR assay is superior to traditional CFU determination for monitoring the progression of disseminated aspergillosis and evaluating the activity of antifungal antibiotics against A. "
3.	Onychomycosis (Tinea Unguium) 01/01/2004 - "Antifungal agents are beneficial in the treatment of onychomycosis in the general population, as well as in children, the elderly, and immunocompromised individuals. " 02/15/2001 - "With careful monitoring, patients treated with the newer antifungal agents have a good chance of achieving relief from onychomycosis and its complications." 07/01/2011 - "We therefore suggest that we have established an in vivo model of onychomycosis that is useful for the evaluation of the efficacy of antifungal agents." 09/01/2004 - "Despite the relevant increase in clinical trials on the efficacy of various systemic and/or topical antifungal agents in onychomycosis therapy, the evaluation of the results is largely subjective. " 01/01/2004 - "We searched MedLine (1966 to April 2003) for clinical studies evaluating the efficacy of oral and topical antifungal agents to treat onychomycosis. "
4.	Mycoses (Diseases, Fungus) 05/01/2000 - "Surgical resection, in combination with antifungal agents, is a safe and effective form of therapy for invasive mycoses. " 06/01/2006 - "The availability of new antifungal agents with novel mechanisms of action and improved tolerability has widened the possibilities for combination therapy for difficult-to-treat opportunistic mycoses. " 07/01/2004 - "The availability of new antifungal agents with unique mechanisms of action and improved tolerability has widened the possibilities for the use of combination antifungal therapy for difficult-to-treat opportunistic mycoses. " 01/01/2003 - "Development of new antifungal agents and combination therapies may result in improvement in the management of subcutaneous mycoses in the future." 08/01/2006 - "Antifungal combinations are increasingly used in clinical practice to improve outcomes for refractory mycoses because of the suboptimal efficacy of current antifungal agents. "
5.	Dermatomycoses (Dermatophytosis) 01/01/1984 - "This criterion was favorably comparable with that based on local symptoms and, therefore, proved to be useful as a more objective and quantitative measure for assessment of therapeutic efficacy of such antifungal agents in the animal model of dermatophytosis." 01/01/2003 - "The occurrence of dermatomycoses and the in-vitro therapeutic efficacy of some antifungal agents on dermatomycotic organisms were investigated. " 01/01/2005 - "brasiliensis opens the possibility that they could be helpful for the developing of new antifungal agents for treating the difficult to eradicate dermatomycoses produced by E. " 10/01/2013 - "Efficacy of topical antifungal agents in the treatment of dermatophytosis--reply." 10/01/2013 - "Efficacy of topical antifungal agents in the treatment of dermatophytosis: an incomplete meta-analysis."

Related Drugs and Biologics

1.	Amphotericin B (Amphotericin)
2.	voriconazole (Vfend)
3.	Anti-Bacterial Agents (Antibiotics)
4.	caspofungin (Cancidas)
5.	Ketoconazole (Nizoral)
6.	Fluconazole (Zonal)
7.	Itraconazole (Sporanox)
8.	terbinafine (Lamisil)
9.	Azoles
10.	micafungin (FK463)

Related Therapies and Procedures

1.	Transplants (Transplant)
2.	Drug Therapy (Chemotherapy)
3.	Chemoprevention
4.	Catheters
5.	Vitrectomy