Tricyclic Antidepressive Agents (Tricyclic Antidepressants)

Substances that contain a fused three-ring moiety and are used in the treatment of depression. These drugs block the uptake of norepinephrine and serotonin into axon terminals and may block some subtypes of serotonin, adrenergic, and histamine receptors. However the mechanism of their antidepressant effects is not clear because the therapeutic effects usually take weeks to develop and may reflect compensatory changes in the central nervous system.

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Networked: 1570 relevant articles (190 outcomes, 153 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Barrot, Michel: 6 articles (02/2015 - 03/2008)
2.	Dworkin, Robert H: 6 articles (02/2015 - 11/2003)
3.	Berger, Ariel: 6 articles (01/2012 - 04/2004)
4.	Oster, Gerry: 6 articles (01/2012 - 04/2004)
5.	Jensen, T S: 6 articles (09/2010 - 10/2000)
6.	Jensen, Troels S: 5 articles (02/2015 - 08/2004)
7.	Yalcin, Ipek: 5 articles (02/2015 - 03/2008)
8.	Edelsberg, John: 5 articles (01/2012 - 03/2007)
9.	Sampaio, C: 5 articles (11/2006 - 06/2001)
10.	Sindrup, S H: 5 articles (12/2005 - 10/2000)

Related Diseases

1.	Pain (Aches) 04/01/2004 - "Based on criteria of evidence-based medicine, psychotherapy and/or tricyclic antidepressants seem to be the most promising treatment approaches for the functional somatic pain syndromes." 01/01/1989 - "Although tricyclic antidepressants are especially useful in the treatment of chronic pain conditions, most of the work about its mechanism of action has been made on acute pain tests. " 01/01/2000 - "A significant amount of evidence supports the use of the traditional tricyclic antidepressants (TCAs) in the management of chronic pain, but because of their acute synaptic effects on multiple, nontherapeutic receptor systems, they are associated with numerous undesirable side effects. " 12/01/1997 - "(3) Were tricyclic antidepressants beneficial for chronic pain, and was that response dependent on a particular dose? " 05/01/2001 - "Pain relief was as effective with this therapy as with the tricyclic antidepressants. "
2.	Neuralgia (Stump Neuralgia) 02/01/2003 - "Several weeks of therapy may be required before antinociception occurs, but tricyclic antidepressants in optimal doses appear to be the most effective treatment for neuropathic pain; this is supported by systematic reviews comparing them with other agents. " 09/01/2015 - "Tricyclic antidepressants are the first-line treatment option for neuropathic pain. " 03/01/2014 - "Tricyclic antidepressants (TCAs) are first-line treatment for neuropathic pain. " 03/01/2013 - "Tricyclic antidepressants and anti-epileptic drugs have demonstrated efficacy in several types of neuropathic pain. " 04/01/2007 - "Tricyclic antidepressants are often considered first-line treatment for neuropathic pain. "
3.	Panic Disorder (Panic Attack) 06/01/1998 - "Tricyclic antidepressants (TCAs) are beneficial in the treatment of panic disorder. " 01/01/1996 - "Tricyclic antidepressants which are recommended as first-line treatment in panic disorder by the literature are preferred by 74% of the psychiatrists, but only by 24% of the non-psychiatric physicians. " 12/01/1990 - "Finally, panic attacks may predict better responses to MAOIs and poorer responses to conventional tricyclic antidepressants. " 12/01/1990 - "Seven patients were treated with tricyclic antidepressants and demonstrated marked global clinical improvement and a reduction in the frequency of sleep panic attacks. " 09/01/1987 - "The effect of tricyclic antidepressants on stress-induced heart rate changes in panic disorder patients."
4.	Anxiety Disorders (Anxiety Disorder) 06/01/1990 - "Some tricyclic antidepressant drugs appear to be effective against generalized anxiety disorders in man, and in animal models, chronic administration of some anxiolytic drugs produces activities predictive of antidepressant potential. " 01/01/2008 - "From 1972 to 2007, we found 23 trials that evaluated the efficacy of psychotropic medication (mainly non-tricyclic antidepressants) involving youth with MDD, 7 pertaining to youth with OCD, and 10 pertaining to youth with other anxiety disorders (N = 2533 patients in placebo arms). " 01/01/2013 - "They were mostly concerned with tricyclic antidepressants (TCA; 18/22) and involved different anxiety disorders. " 06/01/2009 - "There was no robust evidence that the incidence differed between SSRIs and tricyclic antidepressants, or that there was a higher incidence in anxiety disorders. " 01/01/1991 - "Tricyclic antidepressants have been shown to enhance the effect of exposure therapy upon agoraphobic patients, and it can be argued that the therapeutic success of cognitive therapy in the treatment of anxiety disorders depends upon guided exposure to threatening situations. "
5.	Depressive Disorder (Melancholia) 03/26/2005 - "In a meta-analysis of 39 controlled studies, tricyclic antidepressants (TCAs) were found to be effective in the treatment of depressive disorders at dosages under 100 mg/day. " 05/01/2003 - "Review: Low dose tricyclic antidepressants may be effective for adults with acute depressive disorder." 07/01/2009 - "Tricyclic antidepressants are particularly useful in the treatment of endogenous depression. " 03/01/1993 - "Haemodynamic examinations turned out to be useful in predictions of the somatic tolerance of tricyclic antidepressants and to be helpful in understanding the reason for several complains involving the circulatory system in patients with endogenous depression. " 11/01/2001 - "Several reviews and at least two meta-analyses have examined the available evidence surrounding SAMe in the therapy of depression for trials completed prior to 1994 and concluded that SAMe was superior to placebo in treating depressive disorders and approximately as effective as standard tricyclic antidepressants. "

Related Drugs and Biologics

1.	Anticonvulsants (Antiepileptic Drugs)
2.	Serotonin Uptake Inhibitors (Serotonin Reuptake Inhibitors)
3.	Monoamine Oxidase Inhibitors (Monoamine Oxidase Inhibitor)
4.	Serotonin (5 Hydroxytryptamine)
5.	Antidepressive Agents (Antidepressants)
6.	gabapentin (Neurontin)
7.	Opioid Analgesics (Opioids)
8.	Norepinephrine (Noradrenaline)
9.	Amitriptyline (Elavil)
10.	Benzodiazepines

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Analgesia
3.	Transcutaneous Electric Nerve Stimulation (TENS)
4.	Hemoperfusion
5.	Aftercare (After-Treatment)