Anisomycin

06/01/2007 - "It was also shown that the amount of Akt protein slightly decreased by either hypoxia or anisomycin treatment. "
05/29/2007 - "Anisomycin protects cortical neurons from prolonged hypoxia with differential regulation of p38 and ERK."
03/01/2007 - "Compared to wild-type cells, Atf-2(-/-) mouse embryonic fibroblasts (MEFs) were more resistant to hypoxia- and anisomycin-induced apoptosis but remained equally susceptible to other stresses, including UV. "
08/01/1993 - "Induction of hypoxia-binding activity was abolished by Anisomycin, a potent protein synthesis inhibitor, suggesting that de novo protein synthesis is necessary for the activation process. "
05/29/1992 - "Anisomycin and cycloheximide (100 micrograms/ml) offered, respectively, a 97 +/- 4% and 26 +/- 13% protection against anoxia-induced neuronal death."

10/01/1989 - "It has recently been suggested that intraperitoneal (IP) injection of anisomycin (ANI) in the chick produces amnesia for a one-trial passive avoidance task in a state-dependent manner. "
07/27/2012 - "The administration of the protein synthesis inhibitor anisomycin followed by a reminding procedure (presentation of the conditioned stimulus) led to the development of amnesia that persist for 2 weeks or longer. "
04/01/2009 - "Applying this paradigm, we demonstrate here that infusing anisomycin into the dorsal hippocampus induces amnesia by impairing memory storage, not retrieval."
01/01/2009 - "Interestingly, rats treated with anisomycin 6 and 12 h post-retrieval exhibited amnesia for the running skill. "
01/01/2009 - "Similarly, PSI impaired the post-retrieval reconsolidation of the rotarod-running skill: well-trained rats treated with anisomycin 0 h but not 0.5, 2 and 4 h after the task performance exhibited amnesia for the running skill later on. "

07/15/2009 - "A low dose of anisomycin was also remarkably effective in treating established mammary tumor in the mice. "
06/01/2013 - "The aim of this study was to explore the potential of anisomycin to treat tumors in vivo and its mechanism(s) of action. "
01/01/2013 - "To characterize modulated cancer cells phenotype changes two methods were applied: Wound Healing Assay and the stimulation to the apoptosis with anisomycin. "
05/01/2013 - "Taken together, the findings show that anisomycin sensitizes TRAIL-mediated hepatoma cell apoptosis via the mitochondria-associated pathway, involving the cleavage of Bid and activation of the c-Jun/AP-1 pathway, indicating that this compound can be used as an anti-tumor agent in combination with TRAIL."
12/18/2007 - "Because the primary substrate of p38, the MK2 kinase, is also transiently (1-2 hr) activated by anisomycin in both normal and cancer cells, checkpoint disruption in transformed cells occurs downstream of MK2. "

01/01/2001 - "Dose-response and time course studies of the effects of heat shock and anisomycin treatment showed a close correlation of the activation of JNK and hyperphosphorylation of HSF1. "
10/02/2013 - "However, anisomycin had no effect on fear reinstatement tested 2 h after the reminder shock. "
01/01/2006 - "On Test 1 the rats were either removed from the shock compartment immediately after entry or retained in the shock context for 200 sec, and intrahippocampal infusions of the protein synthesis inhibitor anisomycin (75 microg/side) were administered immediately after the test. "
11/01/1999 - "Pretraining with a low foot shock intensity (0.2 mA) 24 hr before training, prevented the amnestic effect of anisomycin injected at 15 min before or 3 hr after training. "
10/01/1999 - "The net repressor is regulated by nuclear export in response to anisomycin, UV, and heat shock."

03/01/2012 - "In the present study, we show that Golgi disassembly during pro-apoptotic stress induced by TNFα (tumour necrosis factor α) and anisomycin results in decreased levels of CERT at the Golgi region. "
10/15/2002 - "In the present study we have examined the effects of the protein synthesis inhibitor anisomycin and tumour necrosis factor-alpha (TNF-alpha) on the phosphorylation of eEF2 kinase. "
01/15/2007 - "Inhibition of the pathway indicated that the p38 pathway is necessary for various signals to induce ATF3, including anisomycin, IL-1beta (interleukin 1beta), TNFalpha (tumour necrosis factor alpha) and H2O2. "
01/01/2006 - "However, activation of JNK and p38 MAPK by non-ER stress stimuli including UV irradiation, anisomycin, and TNF-alpha (tumour necrosis factor-alpha) was found to be independent of PERK. "
09/15/2005 - "Stimulation of mouse embryonic fibroblasts with PMA, EGF (epidermal growth factor), TNF (tumour necrosis factor) or anisomycin resulted in induction of the Nur77 mRNA. "