Aniline Hydroxylase

A drug-metabolizing, cytochrome P-450 enzyme which catalyzes the hydroxylation of aniline to hydroxyaniline in the presence of reduced flavoprotein and molecular oxygen. EC 1.14.14.-.

Also Known As:

Networked: 65 relevant articles (2 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Balasubramanian, M P: 1 article (01/2010)
2.	Firdous, Alikunjhi P: 1 article (01/2010)
3.	Karrunakaran, C M: 1 article (01/2010)
4.	Kumar, S Selva: 1 article (01/2010)
5.	Kuttan, Ramadasan: 1 article (01/2010)
6.	Ramnath, Viswanathan: 1 article (01/2010)
7.	Rao, M Ram Krishna: 1 article (01/2010)
8.	Sindhu, Edakkadath R: 1 article (01/2010)
9.	Govindwar, Sanjay P: 1 article (08/2008)
10.	Patil, Arun J: 1 article (08/2008)

Related Diseases

1.	Neoplasms (Cancer) 09/01/1995 - "GIV-A depressed aniline hydroxylase and aminopyrine demethylase activities of the hepatic microsomal drug-metabolizing system in tumor-bearing mice. " 06/01/1991 - "Cepharanthin depressed aniline hydroxylase and aminopyrine demethylase activities of the hepatic microsomal drug-metabolizing system in tumor-bearing mice. " 12/01/1982 - "The content of cytochrome P-450 and the activities of cyclophosphamide oxidase, benzo[a]pyrene hydroxylase, aniline hydroxylase and benzphetamine N-demethylase were markedly decreased in tumor-bearing nude mice in accordance with previous observations in tumor-bearing rats and mice. " 08/01/2000 - "The obtained results have shown an overall decrease of liver microsomal cytochrome P450, cytochrome b5, NADPH-cytochrome P450 reductase, NADH-cytochrome b5 reductase, and aniline hydroxylase with a subsequent decrease of phase II enzymes, glutathione-S-transferase and UDP-glucuronyl transferase in cancer-bearing animals. " 01/01/2010 - "Reduction in tumor weight was noted in Group III as compared to II. The levels of cytochrome C in liver and kidney, the levels of cytochrome P450 and cytochrome b5 in liver microsomes, phase I biotransformation enzymes NADPH-cytochrome P450, NADPH-cytochrome b5, and aniline hydroxylase, and the phase II enzymes glutathione-S-transferase and UDP glucuronyl transferase indicated that their modulation played a role in the therapeutic efficacy of Indigofera aspalathoides against experimental fibrosarcoma."
2.	Peritonitis 03/01/1988 - "It was found that in experimental peritonitis the activities of hepatic amidopyrine-N-dimethylase, aniline hydroxylase and NADPN cytochrome-C-reductase as well as the contents of cytochromes P-450 and B5 in the microsomal fraction of the liver significantly decrease and also there is prolongation of the half-life and reduction of the clearance of antipyrine. "
3.	Fibrosarcoma 01/01/2010 - "Reduction in tumor weight was noted in Group III as compared to II. The levels of cytochrome C in liver and kidney, the levels of cytochrome P450 and cytochrome b5 in liver microsomes, phase I biotransformation enzymes NADPH-cytochrome P450, NADPH-cytochrome b5, and aniline hydroxylase, and the phase II enzymes glutathione-S-transferase and UDP glucuronyl transferase indicated that their modulation played a role in the therapeutic efficacy of Indigofera aspalathoides against experimental fibrosarcoma."
4.	Weight Gain 01/01/1982 - "The weight gain and the activity of aminopyrine demethylase, aniline hydroxylase and the content of cytochrome P-450 was decreased only in young rats fed 10% casein and 10% oil containing diets. " 01/01/1997 - "In the gavage study, the 200 mg/kg/d rats showed depressed weight gain, increased relative liver and kidney weights, decreased relative thymus weights, and elevated levels of serum gamma-glutamyltransferase (gamma-GT), hepatic aniline hydroxylase (AH), aminopyrine N-demethylase (APDM), pentoxyresorufin O-dealkylase (PROD), glutathione S-transferase (GST), and UDP-glucuronosyltransferase (UDPGT) activities. "
5.	Liver Diseases (Liver Disease) 01/01/1981 - "The aim of this study was to look for correlations between the metabolic clearance rate of antipyrine and (a) the concentration of cytochrome P-450, and (b) the NADPH cytochrome c reductase, aminopyrine demethylase, and aniline hydroxylase activities in the liver microsomes of 20 patients without liver diseases. "

Related Drugs and Biologics

1.	Cytochromes c (Cytochrome c)
2.	Cytochrome P-450 Enzyme System (Cytochrome P450)
3.	Aminopyrine (Aminophenazone)
4.	Glucuronosyltransferase (UDP Glucuronosyltransferase)
5.	Glutathione Transferase (Glutathione S-Transferase)
6.	Antipyrine (Phenazone)
7.	Enzymes
8.	Cytochromes
9.	Cytochromes b5 (Cytochrome b5)
10.	Oxidoreductases (Dehydrogenase)

Related Therapies and Procedures

1.	Ligation
2.	Intraperitoneal Injections
3.	Hypnosis (Mesmerism)