Angiotensinogen

An alpha-globulin of about 453 amino acids, depending on the species. It is produced by the liver and secreted into blood circulation. Angiotensinogen is the inactive precursor of natural angiotensins. Upon successive enzyme cleavages, angiotensinogen yields angiotensin I, II, and III with amino acids numbered at 10, 8, and 7, respectively.

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Networked: 1430 relevant articles (10 outcomes, 250 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kobori, Hiroyuki: 47 articles (06/2015 - 02/2002)
2.	Urushihara, Maki: 18 articles (06/2015 - 08/2008)
3.	Navar, L Gabriel: 17 articles (08/2015 - 02/2002)
4.	Nishiyama, Akira: 15 articles (04/2015 - 01/2003)
5.	Ohashi, Naro: 14 articles (11/2015 - 05/2007)
6.	Sigmund, Curt D: 13 articles (07/2013 - 02/2002)
7.	Ingelfinger, Julie R: 10 articles (10/2015 - 12/2002)
8.	Satou, Ryousuke: 10 articles (08/2015 - 06/2007)
9.	Kumar, Ashok: 10 articles (02/2015 - 09/2002)
10.	Lalouel, Jean-Marc: 10 articles (06/2012 - 01/2002)

Related Diseases

1.	Hypertension (High Blood Pressure) 06/01/1997 - "Covariate analysis revealed an independent relationship between the M235T genotype and systolic, diastolic, and mean ambulatory BP. Ambulatory monitoring improved the analytic power of our study and allowed detection of a clear and consistent relationship between angiotensinogen polymorphism and hypertension with a relatively small sample size." 12/01/2015 - "The aim of this study was to investigate the contribution of the polymorphisms localized in the angiotensinogen (AGT) gene, a main component of the renin-angiotensin-aldosterone system, in inducing the susceptibility to essential hypertension (EH) among isolated populations (Yi and Hani minorities) with low prevalence rate from the remote region of Yunnan in China. " 01/01/2015 - "The A-20C polymorphism in the angiotensinogen (AGT) gene has been associated with increased risk of essential hypertension in several studies; however, these studies gave inconsistent results. " 01/01/2015 - "Numerous studies have evaluated the association between the angiotensinogen (AGT) G-217A gene polymorphism and essential hypertension risk. " 01/01/2013 - "Recent studies using experimental animal models have documented the involvement of angiotensinogen in the intrarenal renin-angiotensin system activation and development of hypertension. "
2.	Pre-Eclampsia (Preeclampsia) 01/01/2015 - "Improved Assay for Quantifying a Redox Form of Angiotensinogen as a Biomarker for Pre-Eclampsia: A Case-Control Study." 09/01/2015 - "The aim of this study is to investigate the relation between urinary angiotensinogen (UAGT) levels, an indicator of local renin-angiotensin system (RAS) activity in the kidney, and blood pressure and urinary protein excretion in preeclampsia. " 01/01/2008 - "Genetic analysis of the angiotensinogen gene in pre-eclampsia: study of german women and review of the literature." 07/01/2007 - "Previous studies have shown that the angiotensinogen (AGT) Thr235 mutation is associated with abnormal remodeling of the uterine spiral arteries and occurs at higher frequencies in preeclampsia. " 07/01/2002 - "Our study shows that the M235T variant in the gene encoding angiotensinogen could be a risk factor in mild and severe pre-eclampsia."
3.	Anoxia (Hypoxia) 02/25/2000 - "In the present study, the effect of chronic hypoxia on the expression of RAS components, particularly at the levels of its precursor angiotensinogen and its receptor subtypes AT(1) and AT(2), were investigated in the rat pancreas. " 06/01/2014 - "Hypoxia-induced endothelial progenitor cell function is blunted in angiotensinogen knockout mice." 01/12/2001 - "Chronic hypoxia induced down-regulation of angiotensinogen expression in rat epididymis." 02/25/2000 - "Results from western blot and semi-quantitative reverse-transcription polymerase chain reaction (RT-PCR) analyses unequivocally showed that chronic hypoxia caused a marked increase in angiotensinogen both at the protein and gene levels when compared with that in the normoxic pancreas. " 01/12/2001 - "Results from RT-PCR analysis demonstrated that chronic hypoxia caused a marked decrease (60%) in the expression of angiotensinogen mRNA, when compared with that in the normoxic epididymis. "
4.	Obesity 10/01/2009 - "In humans, body fat is correlated with levels of angiotensinogen, a precursor of Ang-II. Thus, the treatment of obesity could be improved through the use of substances that interfere with Ang-II." 10/01/2002 - "As obesity is a common finding in diabetic individuals, and obesity has been linked to an increase in plasma angiotensinogen levels, we enrolled diabetic subjects with a wide range of body mass index (BMI) for this study. " 12/01/2012 - "Adipocyte angiotensinogen deficiency had no effect on diet-induced obesity. " 09/01/2010 - "Adipose tissue-specific dysregulation of angiotensinogen by oxidative stress in obesity." 08/01/2009 - "In addition, interactions among angiotensinogen, fat mass and obesity associated gene, GNB3, and uncoupling protein 3 genes were found in a significant four-locus generalized multifactor dimensionality reduction model among the obese population (p = 0.001). "
5.	IGA Glomerulonephritis (IGA Nephropathy) 09/01/2003 - "Angiotensinogen gene variation and renoprotective efficacy of renin-angiotensin system blockade in IgA nephropathy." 06/22/2007 - "This study was performed to determine whether immunoreactivity of intrarenal hemeoxygenase-1 and angiotensinogen are increased in IgA nephropathy (IgAN) patients. " 06/01/2015 - "Changes in urinary angiotensinogen posttreatment in pediatric IgA nephropathy patients." 04/01/2014 - "The association between angiotensinogen (AGT) M235T gene polymorphism and IgA nephropathy (IgAN) risk remains elusive. " 04/01/2014 - "Association of angiotensinogen gene M235T polymorphism with the risk of IgA nephropathy: a meta-analysis."

Related Drugs and Biologics

1.	Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)
2.	Renin
3.	Messenger RNA (mRNA)
4.	Angiotensins
5.	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)
6.	candesartan
7.	Endothelins (Endothelin)
8.	eplerenone (Inspra)
9.	bosentan (Tracleer)
10.	Type 1 Angiotensin Receptor

Related Therapies and Procedures

1.	Transplants (Transplant)
2.	Kidney Transplantation
3.	Ligation
4.	Heart Transplantation (Grafting, Heart)
5.	Coronary Balloon Angioplasty (Percutaneous Transluminal Coronary Angioplasty)