HOME PRODUCTS SERVICES COMPANY CONTACT FAQ

Angioedema

Swelling involving the deep DERMIS, subcutaneous, or submucosal tissues, representing localized EDEMA. Angioedema often occurs in the face, lips, tongue, and larynx.

Also Known As:

Angioneurotic Edema; Angioedemas; Angioneurotic Edemas; Edema, Angioneurotic; Edema, Quincke's; Edemas, Angioneurotic; Giant Urticaria; Giant Urticarias; Quincke Edema; Quinckes Edema; Urticarias, Giant; Quincke's Edema; Urticaria, Giant

Networked: 1816 relevant articles (71 outcomes, 116 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Urticaria (Hives)
2.	Hereditary Angioedemas
3.	Pruritus (Itching)
4.	Edema
5.	Asthma (Bronchial Asthma)

Experts

1.	Cicardi, Marco: 22 articles (11/2015 - 08/2002)
2.	Kaplan, Allen P: 14 articles (06/2015 - 01/2002)
3.	Bernstein, Jonathan A: 14 articles (03/2015 - 01/2008)
4.	Farkas, Henriette: 13 articles (01/2015 - 09/2004)
5.	Zanichelli, Andrea: 12 articles (11/2015 - 09/2002)
6.	Bouillet, Laurence: 11 articles (07/2015 - 09/2004)
7.	Bouillet, L: 11 articles (11/2014 - 01/2003)
8.	Bas, M: 10 articles (12/2015 - 10/2004)
9.	Fain, Olivier: 10 articles (11/2015 - 06/2006)
10.	Kojda, G: 10 articles (10/2015 - 10/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Angioedema:

1.	BradykininIBA 11/01/2011 - "Novel therapies are becoming available that for the first time provide effective treatment for bradykinin-mediated angioedema. " 11/01/2015 - "Our objective was to determine the main characteristics of ACEI-AAE attacks and, in doing so, the factors associated with likelihood of hospital admission from the emergency department (ED) after a visit for an attack.A prospective, multicenter, observational study (April 2012-December 2014) was conducted in EDs of 4 French hospitals in collaboration with emergency services (SAMU 93) and a reference center for bradykinin-mediated angioedema. " 08/01/2013 - "Different studies indicate that ACEI-induced angioedema is associated with high levels of bradykinin of different origin and this preferentially occurs in females and in African-American populations. " 11/01/2011 - "This study describes the clinical characteristics and pathophysiology of bradykinin-mediated angioedema. " 01/01/2011 - "The consensus was led by the Spanish Study Group on Bradykinin-Induced Angioedema, a working group of the Spanish Society of Allergology and Clinical Immunology. "
2.	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA 01/01/2014 - "In this case report, we will be looking at the delayed onset of angioedema as a result of ACE inhibitors that occurred during dental treatment. " 07/01/1996 - "Delayed onset of angioedema with angiotensin-converting enzyme inhibitors: case report and review of the literature." 08/01/2012 - "In head-to-head comparison in 7 trials, risk of angioedema with ACE inhibitors was 2.2 times higher than with ARBs (95% confidence interval [CI] 1.5 to 3.3). " 07/01/1997 - "Of the 40 patients presenting with angioedema in this study, 15 cases were caused by ACE inhibitors. " 07/01/1993 - "The purpose of this study was to establish what proportion of patients who present to the emergency department (ED) with angioedema were concomitantly taking any of the ACE inhibitors and to show how this group differed in presentation and response to treatment from the larger population of patients with non-ACE inhibitor-related angioedema. "
3.	omalizumab (Xolair)FDA Link 07/01/2013 - "Complete remission of severe chronic recurrent angioedema of unknown cause with omalizumab." 01/01/2014 - "It was observed that the use of omalizumab 300 mg lowered the weekly scores of urticarial activity in 19.9 vs. 6.9 on placebo (p <0.01), 19 vs 8.5 and 20.7 vs 8.01 in three studies, the weekly ISS (-9.2 vs. - 3.5, p <0.001, -9.8 vs -5.1 p < 0.01, -8.6 vs -4.0 and -9.4 vs -3.63 p <0.001 in four studies), and the percentage of angioedema-free days (omalizumab 95.5% vs. placebo 89.2% p <0.001, and 91.95% vs. 88.1% p <0.001 in two of the studies respectively). " 05/01/2015 - "Positive response to omalizumab in patients with acquired idiopathic nonhistaminergic angioedema." 04/01/2014 - "Omalizumab in recurring larynx angioedema: a case report." 10/01/2007 - "Successful treatment of 3 patients with recurrent idiopathic angioedema with omalizumab."
4.	Histamine Antagonists (Antihistamines)IBA 01/01/2015 - "A case of angioedema is reported here, in which allergic etiology was excluded by the non-response to antihistamines. " 04/01/2014 - "In idiopathic recurring angioedema presenting with frequent attacks, prophylaxis with H1 antihistamines recommended. " 12/01/2013 - "A total of 142 women had idiopathic angioedema unresponsive to antihistamines. " 01/01/2012 - "His angioedema began to ameliorate soon after antihistamines were introduced without any critical involvement, such as laryngeal obstruction." 07/01/2011 - "It is associated with acral and facial angioedema, dermatographism, favorable response to antihistamines, and a self-limited course. "
5.	Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)IBA 07/01/2015 - "The purpose of this study was to review consecutive cases of angiotensin-converting enzyme (ACE) inhibitor angioedema admitted to an intensive care unit. " 06/01/2015 - "The study objective was to generate pilot data to evaluate the effectiveness and safety of C1-esterase-inhibitor concentrate (C1-INH) compared to standard treatment in patients with angiotensin-converting enzyme inhibitor (ACEi)-induced angioedema affecting the upper aerodigestive tract. " 02/01/2015 - "This study aimed to determine the duration of use, presentation, and management of angiotensin converting enzyme (ACE) inhibitor-related angioedema patients at an urban academic medical center. " 11/01/2013 - "The objective of this study was to better understand the presenting signs and symptoms of angiotensin converting enzyme (ACE) inhibitor-induced gastrointestinal angioedema, review the medical literature related to this condition, and bring this diagnosis to the attention of clinicians. " 09/01/2013 - "The objective of this study was to identify genetic variants associated with angiotensin-converting enzyme (ACE) inhibitor-associated angioedema. "
6.	Danazol (Azol)FDA LinkGeneric 05/01/2002 - "The danazol treatment relieved the symptoms of angioedema and increased the C1 INH activity and concentration with the normalization of CH50, C1q and C4 levels. " 04/01/1990 - "She responded well to danazol and had no further attacks of angioedema." 05/01/2012 - "Although the anabolic steroid, danazol, is useful in increasing the concentration of C4 and reducing the episodes of angioedema in HAE and AAE, it has expected adverse effects. " 11/01/2003 - "The angioedema was controlled with Danazol and Stanasol. " 06/01/2003 - "The angioedema was controlled with Danazol and Stanasol. "
7.	icatibantIBA 10/10/2011 - "Randomised, controlled trials are warranted to document the efficacy of icatibant in ACE-i angioedema." 09/01/2015 - "Commentary regarding: A randomized trial of icatibant in ACE-inhibitor-induced angioedema." 01/29/2015 - "A randomized trial of icatibant in ACE-inhibitor-induced angioedema." 01/01/2015 - "Here, the efficacy and safety of icatibant for multiple HAE attacks was evaluated across the controlled and open-label extension phases of the For Angioedema Subcutaneous Treatment (FAST)-3 study (NCT00912093). " 08/01/2014 - "The open-label extension (OLE) phase of the For Angioedema Subcutaneous Treatment (FAST)-1 trial (NCT00097695) evaluated the efficacy and safety of repeated icatibant exposure in adults with multiple HAE attacks. "
8.	Epinephrine (Adrenaline)FDA LinkGeneric 08/01/2015 - "Upper airway angioedema may potentially require endotracheal intubation or cricothyrotomy, and is usually unresponsive to adrenaline. " 10/01/2012 - "Angioedema regressed with intravenous epinephrine infusion and did not relapse after extubation. " 10/01/2012 - "Pressure-induced angioedema associated with endotracheal tube: successful treatment with epinephrine in two cases." 06/01/2011 - "To describe presentation and management of ED patients with angioedema and determine factors associated with epinephrine administration, hospital admission and SIE prescription. " 11/01/2002 - "Angioedema can be life-threatening but more times than not it can be managed with conservative treatment measures including specifically the discontinuation of the medication and/or administration of an antihistamine and/or epinephrine. "
9.	Adrenal Cortex Hormones (Corticosteroids)IBA 09/01/2007 - "We discuss the diagnosis of C1 inhibitor deficiency in angioedema, with reference to a case in which the diagnosis was initially masked by the use of corticosteroids, which normalized the C1 inhibitor level." 12/01/2004 - "The diagnosis of chronic angioedema (localised and reversible oedema) is sometimes very difficult when there is no efficiency of anti-histaminics and corticosteroids. " 11/01/2001 - "The patient presented with symptoms of angioedema and was treated with corticosteroids. " 08/02/1989 - "This history and the rapid disappearance of symptoms after intravenous corticoids were suggestive of Quincke's edema. " 12/01/2006 - "The patient suffered from summer rhinoconjunctivitis since seven years; in January 2006, ten minutes after eating bread and honey she developed angioedema of the lips and tongue, runny nose, cough, dyspnoea, and collapse, requiring hospitalization and treatment with high dose corticosteroids and anti-histamines. "
10.	SteroidsIBA 08/01/2001 - "All patients were treated with steroids and exhibited a good response, without relapse of angioedema and with normalization of plasma levels of C1-INH. " 05/01/2001 - "A 35- and a 29-year-old woman presented with longstanding recurrent angioedema refractory to therapy with steroids and antihistaminic drugs. " 07/01/1991 - "However, several additional diagnostic possibilities should be pursued in patients with angioedema, such as hereditary angioedema caused by C1-esterase inhibitor deficiency, because anabolic steroids are effective in the treatment of these conditions." 01/01/2008 - "This single-centre prospective study included adults (1) presenting chronic urticaria as defined by the French consensus conference committee on chronic urticaria (2003), (2) exhibiting at least two of the following three criteria: sleep disturbance due to itching, repeated angioedema, general symptoms; (3) unresponsive or mildly improved by antihistaminic (anti-H1) therapy; (4) receiving oral steroids at least three days per month. " 01/01/1976 - "Our patient and those of Agnello et al. had identical clinical symptoms such as erythema multiforme, arthralgias and angioneurotic edema and both differed from systemic lupus erthematosus in several important points, i.e., in spite of marked hypocomplementemia the nephropathy is not prominent and it needs high-dose steroids to eliminate the clinical and serological abnormalities. "

Therapies and Procedures

1.	Injections 06/01/1913 - "A CASE OF ANGIONEUROTIC EDEMA CURED BY INJECTIONS OF HORSE SERUM." 01/01/2010 - "We present 5 cases of women with a history of filler injections who presented a hard and persistent angioedema followed by local subcutaneous nodules. " 01/01/2010 - "[Facial angioedema after filler injections. " 12/01/2011 - "The most common causes of allergic angioedema are bee and wasp stings, reactions to medications or injections for sensitivity testing, and certain foods (especially eggs, shellfish and nuts). " 01/01/2010 - "The frequency of angioedema after filler injections among patients with angioedema in the Unit of Asthma Allergy and Clinical Immunology was 0.5%."
2.	Drug Therapy (Chemotherapy) 01/01/2013 - "Chemotherapy helped prevent subsequent episodes, but three years later she redeveloped angioedema. " 08/01/2007 - "The current pharmacotherapy of nonallergic angioedema is not satisfactory, thus requiring the identification of effective agents in clinical trials. " 06/01/2010 - "The median duration of suspected drug therapy before the development of angioedema was 1 day with the range of 10 min to 23 days. " 11/01/2007 - "Novel pharmacotherapies may allow a causal treatment of the ACE-inhibitor induced angioedema in the future." 04/01/2013 - "Current pharmacotherapy of bradykinin-mediated angioedema."
3.	Immunotherapy 01/01/2014 - "Initial specific immunotherapy had to be stopped due to severe anaphylaxis (hypotension, dyspnea, and angioedema). " 07/01/1997 - "Six patients were re-stung while receiving venom immunotherapy: only one had a mild systemic reaction (angioedema) after a Vespula sting. " 04/01/2006 - "Systemic immunotherapy with a Tricophyton/Candida vaccin was completely cleared the urticaria/angioedema and decreased specific IgE from more than 100 KUA/I to 7.6 to Tricophyton and from 4.5 KUA/I to 0.7 KUA to Candida after immunotherapy." 06/01/2008 - "New therapeutic approaches to AD, urticaria, and angioedema have been reported, including use of sublingual immunotherapy, anti-IgE, and a kallikrein inhibitor." 05/01/2000 - "Pretreatment with fexofenadine during venom immunotherapy reduces local allergic reactions and generalized symptoms of the urticaria and angioedema type."
4.	Renal Dialysis (Hemodialysis) 10/01/2007 - "These drugs have a variety of acute adverse effects, the nature of which depends on the clinical context, and which include angioedema, anaphylactoid reactions in hemodialysis patients, and severe hypotensive reactions during blood product transfusions. " 11/01/2006 - "In conclusion, this paper highlights the complexity of HSR in hemodialysis, suggesting, as with angioedema, that these rare, but life-threatening adverse events are governed by several metabolic and genetic factors." 08/01/2004 - "Though the therapeutic administration of C1-inhibitor concentrate was effective in controlling her angioedema, seemed ineffective in preventing her from developing ESRD requiring hemodialysis treatment. " 01/01/1990 - "Only 3 among the 7 positive patients had adverse reactions related to the hemodialysis (one suffered from itching, one from urticaria and the third from angioedema and hypotension). " 05/01/1997 - "We report the case of a hemodialysis patient who previously had angioedema after therapy with ACE inhibitors and again had angioedema while taking losartan. "
5.	Ovariectomy (Oophorectomy) 10/01/2004 - "She had suffered recurrent episodes of angioedema over a long period and had been scheduled for elective caesarean hysterectomy and bilateral oophorectomy at 37 weeks' gestation. " 10/01/2004 - "In most cases surgical oophorectomy provides prolonged relief from the recurrent angioedema and dermatological manifestations that are typical of autoimmune progesterone dermatitis. "