Angina Pectoris

The symptom of paroxysmal pain consequent to MYOCARDIAL ISCHEMIA usually of distinctive character, location and radiation. It is thought to be provoked by a transient stressful situation during which the oxygen requirements of the MYOCARDIUM exceed that supplied by the CORONARY CIRCULATION.

Also Known As:

Networked: 6308 relevant articles (564 outcomes, 851 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Hypertension (High Blood Pressure)
2.	Myocardial Ischemia (Ischemic Heart Diseases)
3.	Myocardial Infarction
4.	Heart Failure
5.	Coronary Artery Disease (Coronary Atherosclerosis)

Experts

1.	Nygård, Ottar: 12 articles (06/2015 - 08/2008)
2.	Kaski, Juan Carlos: 11 articles (12/2013 - 08/2003)
3.	Poldermans, Don: 10 articles (06/2011 - 02/2003)
4.	Veselka, Josef: 8 articles (02/2014 - 05/2002)
5.	Ogawa, Hisao: 8 articles (02/2011 - 07/2002)
6.	Yoshiyama, Minoru: 8 articles (11/2010 - 01/2002)
7.	Bax, Jeroen J: 8 articles (05/2009 - 02/2003)
8.	Jia, Yongliang: 7 articles (11/2015 - 12/2011)
9.	Seifert, Reinhard: 7 articles (06/2015 - 10/2010)
10.	Schartum-Hansen, Hall: 7 articles (06/2015 - 10/2010)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Angina Pectoris:

1.	Nifedipine (Adalat)FDA LinkGeneric 01/01/2006 - "Professor Hashimoto demonstrated that nifedipine could increase coronary blood flow even in extremely low dosages, and Professor Kimura found that nifedipine is highly efficacious in preventing anginal attacks in patients with angina pectoris, particularly those with variant form of angina. " 01/01/1987 - "For patients with angina pectoris, a plasma concentration range that is associated with optimal treatment has not been defined, since large inter-individual variations in the nifedipine plasma concentration were observed in effectively treated patients. " 08/01/1990 - "These salutary hemodynamic responses of nifedipine appear to be beneficial for patients with effort angina pectoris." 01/16/1989 - "Results from a 14-week, open-label, crossover multicenter trial completed by 91 patients with chronic stable angina pectoris demonstrate that patients treated with standard nifedipine capsules may be switched to equivalent total 24-hour doses of nifedipine GITS and achieve comparable or improved efficacy (due to improved compliance) with a more favorable side-effects profile. " 04/01/1988 - "To assess the dosing equivalency and the early and late antianginal efficacy of a gastrointestinal therapeutic system for once-daily, continuous-release nifedipine (N-GITS), 10 patients with stable angina pectoris, who were previously receiving chronic treatment with nifedipine, completed a 12-week trial comparing N-GITS with standard nifedipine. "
2.	Nitroglycerin (Dynamite)FDA LinkGeneric 02/01/1992 - "The nitroglycerin patches administration was effective for stable angina pectoris with excellent patient's compliance." 01/01/1988 - "Nitroglycerin patch demonstrated significant improvement of exercise tolerance comparing to placebo, in exercise time to the onset of angina pectoris and ST-segment depression of greater than or equal to 1.0 mm (+45% and +47%), in maximum walking time (+13%), as well as in diminished severity of maximum angina (-38%), in lower maximal ST-segment depression (-32%) and in faster recovery of ST-depression 3 and 6 minutes after the test (-28% and -44%). " 01/01/1988 - "The study demonstrated the efficacy of sustained-release buccal nitroglycerin in effort-induced stable angina pectoris, and an absence of (+) tolerance to the therapeutic effects of this mode of nitrate administration." 01/01/1988 - "The efficacy of a 2.5 mg sustained-release buccal nitroglycerin preparation given 8-hourly in effort-induced stable angina pectoris was investigated by means of graded exercise testing in 15 patients. " 01/01/1986 - "The efficacy of a once daily transdermally applied nitroglycerin system and of sustained release nitroglycerin capsules was assessed by ergometer stress testing in 12 patients with stable angina pectoris in a double-blind crossover study. "
3.	Propranolol (Inderal)FDA LinkGeneric 08/01/1986 - "Seventy three patients (63 males and 10 females) aged 41-75 years with established stable exertional angina pectoris were studied in a double-blind fashion to confirm the efficacy of 80 mg propranolol administered three times daily and also to examine its effect on ST-segment changes in the electrocardiogram by ambulatory ST-segment monitoring and exercise testing using on-line computer analysis. " 06/01/1994 - "Intranasal propranolol has been shown to improve exercise tolerance in patients with angina pectoris. " 11/01/1993 - "Improvement in exercise tolerance and immediate beta-adrenergic blockade with intranasal propranolol in patients with angina pectoris." 02/01/1989 - "[Comparative study of various schedules of administration of propranolol to patients with stenocardia (a cooperative study)]." 04/01/1988 - "In the present study, the incidence and clinical significance of ST-segment fluctuation were studied before and after propranolol in 52 patients with angina pectoris. "
4.	Verapamil (Calan)FDA LinkGeneric 11/01/1982 - "The combined evidence from all these studies indicates that verapamil is a highly effective and safe drug for the treatment of stable effort-related angina pectoris." 10/01/1990 - "In eight of ten patients, diastolic blood pressure rises during exercise were significantly lowered during verapamil treatment in Phase I. In a limited population of patients followed for long periods of time, our data show that verapamil remains acceptably effective in the treatment of angina pectoris. " 02/01/1992 - "Efficacy of conventional and sustained-release verapamil in stable angina pectoris." 03/01/1987 - "The efficacy of a once daily, sustained release formulation of verapamil (Verapamil SR, 360 mg) was evaluated in 19 patients with chronic angina pectoris using a double-blind placebo-controlled crossover protocol. " 02/01/1987 - "Efficacy of sustained-release verapamil in chronic stable angina pectoris."
5.	NitratesIBA 01/01/1977 - "Is the use of long acting nitrates beneficial in the patient with angina pectoris? " 01/01/1977 - "Is the use of long acting nitrates beneficial in the patient with angina pectoris? " 06/01/2012 - "The meta-analysis of 18 eligible RCTs demonstrates moderate evidence that ginseng is more effective than nitrates for treating angina pectoris. " 07/01/1988 - "Organic nitrates are effective in the treatment and prophylaxis of angina pectoris. " 06/01/1984 - "Nitrates are effective in the management of exertional angina pectoris primarily due to their peripheral effects i.e. "
6.	CalciumIBA 08/01/1985 - "PY-108-068 (PY) has calcium antagonist and coronary dilatory activity in animals, suggesting that it may be useful for the treatment of angina pectoris. " 02/01/1983 - "[Are calcium inhibitors useful in the treatment of effort angina pectoris]." 08/01/1980 - "Calcium flux antagonists: a new treatment for some patients with angina pectoris?" 02/01/1987 - "[Relation between the antianginal efficacy of calcium antagonists in angina pectoris patients and the length of treatment]." 05/01/1989 - "In an open non-comparative clinical study, 19 patients with spontaneous angina pectoris admitted to hospital with attacks lasting greater than 10 minutes, unresponsive to nitrate and/or calcium antagonist treatment, at least 2 ECG readings of raised (greater than or equal to 1.5 mm) or lowered (greater than or equal to 1 mm) ST segment not attributable to earlier AMI in the same area, were treated after the interruption of conventional treatment (mean 47 +/- 34.2 min) with 2 million IU endovenous UK in 15 mins followed by 1 million IU endovenous UK in 60 mins. "
7.	Diltiazem (Cardizem)FDA LinkGeneric 01/01/1985 - "Long-term efficacy of high-dose diltiazem for chronic stable angina pectoris: 16-month serial studies with placebo controls." 03/01/1984 - "Improved efficacy of high-dose versus medium- and low-dose diltiazem therapy for chronic stable angina pectoris." 07/01/1995 - "Patients with stable angina pectoris receiving twice-daily sustained-release (SR) diltiazem were switched to equivalent doses of once-daily controlled-delivery (CD) diltiazem or to diltiazem SR. Patients who were switched from diltiazem SR to diltiazem CD (n = 28) experienced a 5% increase in time to termination (p = 0.0004) on the exercise tolerance test (ETT), as well as an 8% improvement in time to onset of angina (p < 0.0001) on the ETT. " 07/01/1982 - "Thus, diltiazem is effective in treating chronic stable angina pectoris. " 07/01/1982 - "To evaluate the therapeutic efficacy 3 hours after a single oral dose of 120 mg, 12 men with chronic stable angina pectoris performed a maximal exercise test on a bicycle ergometer after ingesting either placebo or diltiazem administered in a double-blind fashion. "
8.	Atenolol (Tenormin)FDA LinkGeneric 03/01/1980 - "The physiology, pharmacokinetics and efficacy of atenolol, a cardioselective beta-adrenergic blocking agent, were evaluated in 10 patients with stable angina pectoris in a single-blind, dose-ranging study. " 03/01/2009 - "and atenolol at the commonly used dosage in clinical practice in patients with chronic stable angina pectoris produced additional efficacy with no untoward effect on safety or tolerability." 01/01/1981 - "In order to assess the therapeutical efficacy of atenolol in stable angina pectoris of effort, we studied 40 patients with a positive exercise stress test. " 12/06/1996 - "To evaluate the efficacy and safety of this formulation and to compare this with the beta-blocker atenolol, we conducted a double-blind, randomised, multi-centre study in 129 male patients with documented exercise induced angina pectoris. " 05/01/1983 - "The efficacy and safety of atenolol was evaluated in 16 patients with exertional angina pectoris in a single-blind, once daily, increasing dose study. "
9.	Isosorbide Dinitrate (Isordil)FDA LinkGeneric 11/01/1994 - "Efficacy of eccentric dosing with sustained-release isosorbide dinitrate in patients with angina pectoris." 03/01/1991 - "A quadruple blind randomized cross-over study evaluated the therapeutic efficacy of twice a day long acting sustained release isosorbide dinitrate (SRISDN) in comparison with 4 times daily of the short acting isosorbide dinitrate in 18 patients with stable angina pectoris (NYHA class II-III) with a positive exercise treadmill test. " 01/01/2012 - "Meta-Analysis of Randomized Controlled Trials on the Efficacy of Di'ao Xinxuekang Capsule and Isosorbide Dinitrate in Treating Angina Pectoris." 01/01/2000 - "[Evaluation of antianginal efficacy of long-term therapy with low dose isosorbide dinitrate in patients with stable angina pectoris]." 01/01/1992 - "[The clinical evaluation of the efficacy of Isoket in patients with vasospastic stenocardia]."
10.	Metoprolol (Lopressor)FDA LinkGeneric 01/01/2006 - "We conclude that metoprolol might exert a significantly greater therapeutic effect on stress-induced angina pectoris in men than in women and this difference should be taken into account when prescribing this beta-blocker." 01/01/1981 - "To assess the duration of improved exercise tolerance by metoprolol given in a new sustained-release formulation, 40 in-patients affected by stable exercise-induced angina pectoris received single-blind placebo in day 1 and thereafter, in double-blind cross-over once daily administration, metoprolol RETARD 100 mg and 200 mg in days 3 and 5. Symptom-limited cycloergometric exercise tests were performed at 3 and 24 hours after placebo and after each of the two doses of metoprolol RETARD. " 01/01/1981 - "These findings indicate that once daily administration of metoprolol Durules is an effective and safe therapy in angina pectoris." 01/01/1981 - "A dose-response study on metoprolol in angina pectoris." 08/01/1976 - "An eighteen months' study of the clinical response to metoprolol, a selective beta1-receptor blocking agent, in patients with angina pectoris."

Therapies and Procedures

1.	Coronary Artery Bypass (Coronary Artery Bypass Surgery) 02/12/1996 - "The greatest improvement in quality of life after coronary artery bypass grafting appeared in those patients with the most impaired exercise capacity, those with the most severe angina pectoris, and women. " 01/01/1985 - "Aortocoronary bypass procedures have been proven to be effective in relieving angina pectoris. " 12/01/1979 - "For example, several studies have shown that coronary artery bypass grafting is more effective than medical treatment in relieving the symptoms of chronic disabling angina pectoris. " 07/01/1995 - "Coronary artery bypass grafting (CABG) is generally accepted as effective in relieving patients from angina pectoris, and in improving survival in subgroups. " 08/01/1990 - "Compared with coronary artery bypass grafting, PTCA was very useful for the patient having malignant disease combined with angina pectoris because of little surgical stress and no delay of operation."
2.	Counterpulsation (External Counterpulsation) 12/17/2003 - "External counterpulsation significantly improved vascular endothelial function in CAD patients with refractory angina pectoris, thereby suggesting that improved anginal symptoms may be the result of such a mechanism." 01/01/2015 - "Enhanced External Counterpulsation Is an Effective Treatment for Depression in Patients With Refractory Angina Pectoris." 05/01/2006 - "Enhanced external counterpulsation (EECP) is a noninvasive, well-tolerated treatment, effective for managing patients with refractory angina pectoris. " 10/01/2006 - "External counterpulsation is a safe and effective method of alleviating angina pectoris, but the mechanism of benefit is not understood. " 07/01/2005 - "Enhanced external counterpulsation (EECP), a noninvasive treatment for patients with angina pectoris, provides long-term benefits of decreased anginal frequency and improved exercise tolerance. "
3.	Transplants (Transplant) 11/01/1985 - "Among 500 patients who received aortocoronary saphenous vein grafts at the Montreal heart Institute between September 1969 and August 1972, the condition in 88% of survivors with respect to angina pectoris was improved 1 year after surgery and 47% were still better after 12 years. " 06/10/1972 - "The improvement in left ventricular function assessed objectively correlates positively with vein-graft patency, as does freedom from angina pectoris." 06/23/1998 - "Most interestingly, we found 85.4% freedom from angina pectoris after 7 years, which is considerably lower than the results of studies in which vein grafts, single ITA grafts, or double ITA grafts are used. " 06/01/2013 - "Although coronary bypass graft (CABG) surgery und percutaneous coronary interventions (PCI) are established therapies to treat CAD, 10 years after CABG or PCI 40% of the patients still have angina pectoris. " 06/01/2009 - "The clinical data of 135 post-CABG patients with bypass graft occlusion and angina pectoris symptoms admitted to our department between June 2003 and June 2007 were analyzed. "
4.	Aftercare (After-Treatment) 06/01/2007 - "After treatment for 4 weeks, both group of patients showed improvement in the severity of angina pectoris and TCM symptoms and signs, and there was a significant difference of the total effective rate in clinical improvement between the two groups, whereas no difference of the total effective rate in ECG improvement between the two groups was found. " 04/01/2007 - "After treatment for 4 weeks, both group of patients showed improvement in the severity of angina pectoris and TCM symptoms and signs, but there was a significant difference in the two groups' rates of clinical improvement, whereas the rate of ECG improvement of the two groups showed no difference. " 01/01/2011 - "After 12 months of the follow-up, patients of the study group had no recurrent angina pectoris, while among the controls 4(16%) patients had recurrent angina of FC III. After surgical intervention at discharge and 12 months after treatment patients of both groups improved systolic and diastolic functions of the left ventricle. " 01/01/2012 - "The CCS class after treatment improved in all patients (16 patients angina pectoris CCS from III to II and four patients from IV to III). " 05/01/2015 - "At the same time scores for blood stasis syndrome (BSS) and the incidence of angina pectoris were evaluated before treatment, at month 1, 3, 6, 9, and 12 after treatment. "
5.	Coronary Balloon Angioplasty (Percutaneous Transluminal Coronary Angioplasty) 01/01/1993 - "While percutaneous transluminal coronary angioplasty is effective in improving symptoms of angina pectoris, beneficial effects on survival have not yet been shown. " 01/01/1983 - "A comparison of clinical data has shown that percutaneous transluminal coronary angioplasty can be performed with equally good results in unstable and stable angina pectoris. " 07/01/1996 - "The time course of improvement in fatty acid metabolism after percutaneous transluminal coronary angioplasty (PTCA) was investigated using echocardiography and fatty acid metabolic imaging with iodine-123-betamethyl-p-iodophenyl-pentadecanoic acid (123I-BMIPP) before, 1 week and 3 months after PTCA in 31 patients with angina pectoris. " 10/01/1995 - "Although QOL instruments have been used to assess the efficacy of percutaneous transluminal coronary angioplasty (PTCA), they have not been used previously to compare the impact of PTCA with that of medical therapy in patients with angina pectoris. " 07/01/1993 - "Percutaneous transluminal coronary angioplasty or coronary by-pass surgery in the management of chronic angina pectoris."