Dissecting Aneurysm

Aneurysm caused by a tear in the TUNICA INTIMA of a blood vessel leading to interstitial HEMORRHAGE, and splitting (dissecting) of the vessel wall, often involving the AORTA. Dissection between the intima and media causes luminal occlusion. Dissection at the media, or between the media and the outer adventitia causes aneurismal dilation.

Also Known As:

Networked: 363 relevant articles (14 outcomes, 11 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Necrosis
2.	Rupture
3.	Pica
4.	Aneurysm (Aneurysms)
5.	Hypertension (High Blood Pressure)

Experts

1.	Shin, Yong Sam: 4 articles (06/2015 - 07/2009)
2.	Yang, Xinjian: 4 articles (01/2015 - 03/2009)
3.	Li, Youxiang: 4 articles (01/2015 - 03/2009)
4.	Sugiu, Kenji: 3 articles (12/2015 - 04/2004)
5.	Chung, Joonho: 3 articles (06/2015 - 09/2010)
6.	McDougall, Cameron G: 3 articles (05/2015 - 06/2005)
7.	Albuquerque, Felipe C: 3 articles (05/2015 - 06/2005)
8.	Jiang, Chuhan: 3 articles (01/2015 - 03/2009)
9.	Li, Chuanhui: 3 articles (01/2015 - 01/2014)
10.	Wu, Zhongxue: 3 articles (01/2015 - 03/2009)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Dissecting Aneurysm:

1.	glucuronyl glucosamine glycan sulfate (Vessel)IBA 10/01/2009 - "This case further confirms the need for careful preoperative imaging study of the dissection and all segments of the dissected vessel in patients requiring trapping of a VA dissecting aneurysm, as well as preservation of VA anterograde flow." 10/01/2007 - "The Pkd1(nl/nl) mouse reveals that polycystin1 is implicated in maintenance of the vessel wall structural integrity, and it is a useful model for dissecting aneurysm formation studies." 08/01/2015 - "HRMRI provides further information about the vessel wall and the lumen of the unruptured intracranial vertebral artery dissecting aneurysm, which was treated by an endovascular approach in the 2 current cases. " 03/01/2014 - "The defect included a left-to-right shunting anomalous vessel between the ascending aorta and main pulmonary artery, along with a dissecting aneurysm of the main and right pulmonary artery. " 02/01/2014 - "The present case illustrates that observation and follow-up vascular imaging can be an important treatment strategy, allowing healing of the vessel wall and disappearance of the dissecting aneurysm."
2.	ElastinIBA 08/01/2008 - "Elastin is not only one of fundamental components of arterial wall but also an albuminoid substance related to diseases such as aortic dissecting aneurysm. " 02/01/1993 - "The aim was to investigate whether changes in elastin distribution in the thoracic aorta are associated with occurrence of dissecting aneurysms. " 02/01/1993 - "Increased elastin content and decreased elastin concentration may be predisposing factors in dissecting aneurysms of human thoracic aorta." 01/10/2012 - "This study demonstrates that there are partly quantitative differences, particularly with a statistically significant increase in cystic medial necrosis (p<0.001) and elastin fragmentation (p<0.001), between aortas from dissecting aneurysms and the normal aging aorta, which may help to identify genetically predisposed relatives of patients with a dissection of the aorta." 06/01/1990 - "The main pathologic features of the aortic media in dissecting aneurysm included a higher grade of elastin fragmentation (offensive factor) and less fibrosis (defensive factor). "
3.	Phenobarbital (Luminal)FDA Link 01/01/2001 - "In both patients the dissecting aneurysm disappeared, and at follow-up improved luminal patency was observed." 03/01/1991 - "It is suggested that, if angiography demonstrates luminal narrowing or vascular occlusion in a patient with unexplained SAH, a dissecting aneurysm of the carotid system should be considered as a cause of the hemorrhage." 08/01/1990 - "Seven cases of the VA group demonstrated aneurysmal dilatation and luminal stenosis, and so they were diagnosed as having dissecting aneurysm of VA.(ABSTRACT TRUNCATED AT 250 WORDS)" 03/01/2014 - "The purpose of this study was to investigate vessel wall imaging features combined with the luminal shapes of intracranial dissecting aneurysms (IDAs) by using 3 Tesla (3T) high-resolution magnetic resonance imaging (MRI) and digital subtraction angiography (DSA). " 02/01/2015 - "Independently we found that, unlike the gradual luminal expansion typical for human aneurysms, the outer diameter increase of angiotensin II-induced dissecting aneurysms in mice was related to one or several intramural haematomas. "
4.	PlatinumIBA 12/22/2001 - "We conclude that detachable platinum coil embolization at the dissection site is more effective than proximal occlusion for treatment of ruptured vertebral dissecting aneurysms because of immediate cessation of blood flow to the dissection site. " 03/01/2009 - "P2 dissecting aneurysms can be treated with PVO in the cases in which selective embolization of the aneurismal sac with detachable platinum coils or surgical clipping cannot be achieved." 01/01/2001 - "Detachable platinum coil embolization may be more effective than proximal occlusion for treatment of ruptured vertebral dissecting aneurysms because of immediate cessation of blood flow to the dissection site; however, in patients with bilateral dissections or hypoplastic contralateral vertebral arteries, prior bypass surgery orstent placement to preserve the artery will be needed." 01/01/1997 - "The dissecting aneurysm was embolized with an IDC and additional platinum coils. "
5.	LectinsIBA 01/01/1987 - "[Dissecting aneurysm of the aorta: histochemical study using a set of lectins with different carbohydrate specificity]."
6.	Rubber (Elastica)IBA 11/01/2003 - "Dissecting aneurysm of the intracranial vertebral artery associated with proximal focal degeneration of the elastica: a comparative pathological study of the vertebral artery in patients with and without aneurysms."
7.	CholesterolIBA 01/01/1991 - "The study population consisted of 60 with coronary artery disease (CAD), 36 with hypertension (HT), 28 with hypercholesterolemia (HC, total cholesterol greater than or equal to 230 mg/dl), eight with dissecting aneurysm, nine with true aneurysm and two with aortitis syndrome. "
8.	AminopropionitrileIBA 04/01/1992 - "The BAPN-treated rats (lathyritic rats) died of dissecting aneurysm, and the victims with hypertensive treatment was greater in number and died earlier than those without the treatment, indicating that the rise of blood pressure promoted the onset of dissecting aneurysm. " 02/01/1983 - "Sixty-five percent of the males and 21% of the females fed BAPN died of dissecting aneurysms; blood pressure, heart rate, and dp/dt max were not altered as a result of feeding BAPN. " 01/01/1983 - "When fed B-aminopropionitrile (BAPN), aortic tensile strengths are lowered, and a high percentage of the turkeys die from aortic dissecting aneurysms. " 12/01/2012 - "Nine BAPN-treated rats died of aortic dissecting aneurysm rupture during the experiment. " 01/01/1970 - "Beta-aminopropionitrile-induced dissecting aneurysms of turkeys: treatment with propranolol."
9.	Coarctation of the aortaIBA 04/01/1991 - "Coarctation of the aorta with dissecting aneurysm and haemopericardium: an account by Joseph Jordan, Manchester, 1830." 01/01/1980 - "Dissecting aneurysm of aorta complicating coarctation of the aorta. " 04/07/1972 - "[Dissecting aneurysm in coarctation of the aorta]." 11/01/1967 - "Dissecting aneurysm distal to coarctation of the aorta, with long survival." 05/01/1952 - "Coarctation of the aorta complicated by dissecting aneurysm in pregnancy: report of a case with survival, studied by arteriography."
10.	Polyethylene Terephthalates (Polyethylene Terephthalate)IBA 12/01/2003 - "The only ACA dissecting aneurysm, on A2, was successfully treated with a Dacron cuff. " 03/01/1992 - "The operation consisted of opening the sac of the aneurysm, dissecting the wall of the left ventricle from the fibrous wall of the sac, leaving a cuff of fibrous tissue suitable to hold sutures, and closing the defect with a Dacron patch." 09/01/1978 - "An intraluminal graft made of woven tubular Dacron with cloth-covered grooved rings at both ends is used to repair dissecting aneurysms of the thoracic aorta. " 02/01/1975 - "Resection of a dissecting aneurysm of the descending thoracic aorta (Type III) was accomplished in a uremic patient on hemodialysis with reconstruction of blood flow through extrathoracic bilateral axillary-subclavian-iliac Dacron grafts. " 05/01/1993 - "61 Bentall's operation were done, resection of the aneurysm with dacron grafts replacement were performed in 10 cases, including 7 cases of DeBakey type III dissecting aneurysms. "

Therapies and Procedures

1.	Stents 01/01/2015 - "Stent alone treatment as a potential and disputable alternative therapeutic option for the treatment of BA dissection and dissecting aneurysms, although technically feasible, was effective in only certain lesions, and this treatment carries substantial risks of complications and a high failure rate. " 06/01/2012 - "Enterprise stent is very useful for endovascular embolization of intracranial wide-necked saccular and dissecting aneurysms because it is easy to navigate and place precisely. " 08/01/2008 - "We describe our experience with 4 ruptured and 2 unruptured VA dissecting aneurysms and discuss the efficacy of endovascular surgery using stents. " 12/01/2001 - "To report the increased efficacy of oversized, overlapping stents to treat an internal carotid artery (ICA) dissecting aneurysm. " 12/22/2000 - "We aimed at increasing the efficacy of stenting for treatment of an internal carotid artery (ICA) dissecting aneurysm by reducing the stent porosity through placement of oversized overlapping stents. "
2.	Transplants (Transplant) 02/01/1998 - "Composite graft insertion has become the gold standard for treating Marfan-patients with non-dissecting and dissecting aneurysms of the aortic root. " 01/01/2014 - "[A case of STA-A3 bypass with a STA interposition graft and endovascular trapping for a ruptured A2 dissecting aneurysm]." 06/01/2011 - "She underwent aortic graft replacement for the treatment of a dissecting aneurysm. " 01/01/2007 - "[Grafting of aorta using multibranch graft without circulatory arrest at the patient with giant dissecting aneurysm of ascending part and arch of aorta]." 02/01/2006 - "A 78-year-old woman who had previously undergone prosthetic graft replacement of the total aortic arch was admitted to repair a chronic expanding type IIIb dissecting aneurysm. "
3.	Cardiopulmonary Bypass (Heart-Lung Bypass) 12/01/2008 - "Bentall operation combined with total arch replacement and stented elephant trunk implantation is safe and effective for serious Debakey I aortic dissecting aneurysm, while good organs protection and consummate cardiopulmonary bypass were taken." 06/01/1991 - "Two patients underwent aortic arch replacement for the dissecting aneurysm of the aorta using a simplified cardiopulmonary bypass (CPB) technique with partial brachiocephalic perfusion, moderate systemic cooling (22 degrees to 23 degrees C), and open aortic anastomosis were reported. " 03/01/1970 - "Retrograde false channel perfusion: a complication of cardiopulmonary bypass during repair of dissecting aneurysms." 09/01/1978 - "Total cardiopulmonary bypass was utilized in repairing dissecting aneurysms of the ascending aorta and left heart bypass was used in patients with dissecting aneurymsms of the descending aorta. " 01/01/1992 - "We describe a patient who could not be weaned from cardiopulmonary bypass without mechanical circulatory assistance because of severe cardiac failure after surgical repair of a dissecting aneurysm of the descending aorta. "
4.	Renal Dialysis (Hemodialysis) 01/01/1996 - "The authors describe their first experience of a one-step prosthezing of the aortal valve and plication of the dissecting aneurysm of the ascending part of the aorta in the patient receiving the regular hemodialysis during 5 years as well as the positive results of this original operation in dynamics of the first year of observations." 01/01/1996 - "[Aortic valve prosthesis and the plication of a dissecting aneurysm of the ascending aorta in a patient with infectious endocarditis against a background of chronic kidney failure and its management by regular hemodialysis]." 02/01/1975 - "Resection of a dissecting aneurysm of the descending thoracic aorta (Type III) was accomplished in a uremic patient on hemodialysis with reconstruction of blood flow through extrathoracic bilateral axillary-subclavian-iliac Dacron grafts. "
5.	Prostheses and Implants (Prosthesis) 06/01/1987 - "[Intra-aortic prosthesis in dissecting aneurysm of the descending thoracic aorta (experimental study)]." 03/01/1983 - "Intraluminal sutureless prosthesis in the management of dissecting aneurysms." 01/01/1983 - "[Clinical evaluation of a new endoluminal tubular prosthesis in the surgical treatment of dissecting aneurysms of the aorta]." 07/01/1978 - "[Aortic arch prosthesis for dissecting aneurysm. " 10/01/1992 - "In this case, dissecting aneurysm of the ascending aorta occurred 4 years after aortic valve replacement, which was performed with mechanical prosthesis because of infective endocarditis, and it was repaired successfully by the modified Cabrol's method. "