Anesthetics (Anesthetic Agents)

Agents that are capable of inducing a total or partial loss of sensation, especially tactile sensation and pain. They may act to induce general ANESTHESIA, in which an unconscious state is achieved, or may act locally to induce numbness or lack of sensation at a targeted site.

Also Known As:

Networked: 2485 relevant articles (104 outcomes, 201 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Bosnjak, Zeljko J: 10 articles (11/2015 - 05/2003)
2.	Warltier, David C: 10 articles (03/2010 - 01/2002)
3.	Xie, Zhongcong: 9 articles (07/2013 - 04/2006)
4.	Morita, Kiyoshi: 9 articles (12/2008 - 07/2002)
5.	Zuo, Zhiyi: 8 articles (01/2015 - 06/2007)
6.	Lee, H Thomas: 8 articles (01/2012 - 12/2004)
7.	Stowe, David F: 7 articles (03/2014 - 01/2002)
8.	Eckenhoff, Roderic G: 7 articles (03/2013 - 09/2004)
9.	Kim, Mihwa: 7 articles (01/2012 - 01/2007)
10.	Kersten, Judy R: 7 articles (03/2010 - 01/2002)

Related Diseases

1.	Pain (Aches) 12/01/1992 - "This review provides information about the adverse effects of topical ocular anesthetics and answers the questions: are topical anesthetics practical and effective in ocular irritancy protocols, is long-term use contraindicated, will topical anesthetics alter the response of a test substance, and are there significant side-effects which might cause pain and suffering in test animals? " 05/01/2014 - "Pain management after TKA remains challenging and the efficacy of continuously infused intraarticular anesthetics remains a controversial topic. " 01/01/2011 - "Efficacy of anesthetic agents to delay pain onset after periodontal surgery." 01/01/1988 - "The paper summarizes medical care system approaches to pain in labor and birth: leading textbooks, prevailing topics in the journal literature, and empirical research reports are consistent in giving primary emphasis to analgesic and anesthetic drugs, accepting childbirth preparation, and questioning the efficacy of other approaches. " 11/01/2015 - "Comparing control patients who did not use topical anesthetics to study patients who did use topical anesthetics, this meta-analysis found no significant difference in pain scores (standardized mean difference -1.01 [95% confidence interval {CI} -2.39 to 0.38), corneal healing (OR 1.31 [95% CI 0.53-3.27), or persistent symptoms (OR 0.98 [95% CI 0.06-16.69). "
2.	Ischemia 05/01/2006 - "However, recent basic researche has demonstrated several beneficial effects of anesthetics, including organ protection against ischemia and subsequent reperfusion, and anesthetic preconditioning, as well as clarified mechanisms of acute and delayed cell death, and apoptosis. " 01/01/2014 - "Volatile anesthetics (VA) are long known for their cardioprotective effects, as demonstrated by improved mitochondrial and cellular functions, and by reduced necrotic and apoptotic cell death during cardiac ischemia and reperfusion (IR) injury. " 04/01/2004 - "Furthermore, decreased mitochondrial ROS formation during ischemia and reperfusion in hearts preconditioned by volatile anesthetics might underlie the improved postischemic structure and function. " 07/01/2003 - "PKC has been implicated as a target of volatile anesthetics as well as in anesthetic protection against ischemia. " 01/01/2004 - "The great resistance of muscle to ischemia was used to study blood flow-dependent phenomena produced by anesthetic drugs in this condition. "
3.	Seizures (Seizure) 03/01/2013 - "The mainstay of treatment is the administration of anesthetic agents titrated to electrographic seizure control. " 12/01/2012 - "This finding prompted the authors to explore the preclinical efficacy of common anesthetics that function by reducing the TXA-mediated inhibition to prevent or modify postsurgical seizures." 08/01/1993 - "We compared the efficacy of four different classes of anesthetics to arrest the progression of brain damage after chemoconvulsant-induced seizures in rats. " 05/01/1992 - "The efficacy of ECT requires a knowledge of anesthetic precepts, an understanding of the interaction between anesthetic drugs and seizure activity, and an awareness of the physiologic effects of ECT as well as the treatment of those effects." 04/01/2014 - "Since there is a relative paucity of studies devoted to this issue, our aim was to compare different anesthetics for ECT regarding their impact on seizure quality and different seizure parameters. "
4.	Postoperative Pain 01/01/2012 - "The aim of this study was to compare the efficacy of continuous infusions of local anesthetic drugs by paravertebral and epidural routes in controlling postoperative pain in patients undergoing hip surgeries. " 04/01/1992 - "Inference has been made to the efficacy of topical vasoconstrictive and combined vasoconstrictor-anesthetic agents as a diagnostic and prognostic aid for postoperative pain relief. " 01/01/2011 - "The aim of this study was to evaluate the influence of 2 anesthetic agents on patients' postoperative pain perception after periodontal surgery. " 11/05/2010 - "This study warrants further investigations into the role of anesthetics to induce nociceptor sensitization and to foster postoperative pain." 01/01/1996 - "If it is generally accepted that adequate postoperative pain relief will improve outcome from surgery, several controlled trials demonstrated this only for lower body surgical procedures with epidural and spinal anesthetics. "
5.	Reperfusion Injury 08/01/2006 - "A growing body of evidence indicates that volatile anesthetics exert protective effects against ischemia-reperfusion injury in vivo. " 12/01/2004 - "Differential protective effects of volatile anesthetics against renal ischemia-reperfusion injury in vivo." 02/01/2014 - "Volatile anesthetics have been reported to provide protection against ischemia-reperfusion injury and have been safely used in the ICU to provide sedation in trials with shorter wake-up times. " 06/01/2015 - "Volatile anesthetics and ischemia-reperfusion injury." 01/01/2014 - "Mitochondrial targets for volatile anesthetics against cardiac ischemia-reperfusion injury."

Related Drugs and Biologics

1.	Opioid Analgesics (Opioids)
2.	Propofol (Diprivan)
3.	Isoflurane
4.	Lidocaine (Xylocaine)
5.	Intravenous Anesthetics
6.	Ketamine
7.	EMLA
8.	Local Anesthetics
9.	Analgesics (Analgesic Drugs)
10.	desflurane (I 653)

Related Therapies and Procedures

1.	Anesthesia
2.	General Anesthesia
3.	Injections
4.	Photorefractive Keratectomy
5.	Nerve Block (Nerve Blocks)